TB-Profiler result

Run: ERR2513724
Summary

Run ID: ERR2513724

Sample name:

Date: 2024-04-14T02:12:01.584984

Number of reads: 2473523

Percentage reads mapped: 77.71

Median coverage: 73.0

Strain: lineage4.3.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4.3.2 Euro-American (LAM) None 1.0
lineage4.3.2.1 Euro-American (LAM) RD761 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6700 c.-602T>C upstream_gene_variant 0.11 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.11 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.11 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>A upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7033 c.-269G>C upstream_gene_variant 0.11 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 7054 c.1815C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7060 c.1821T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7222 c.1983C>T synonymous_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.11 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.11 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
nusG 734445 c.192C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.16 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760382 c.576G>C synonymous_variant 0.12 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.14 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.14 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.14 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>A synonymous_variant 0.16 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.17 rifampicin
rpoB 760508 c.702G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.19 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760547 c.741G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.13 rifampicin
rpoB 760567 c.761delCinsGGG frameshift_variant&missense_variant 0.13 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.14 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.15 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.15 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.15 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.15 rifampicin
rpoB 760607 c.801G>C synonymous_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.12 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.15 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.15 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.24 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.21 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.14 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.14 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.14 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.14 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.14 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.12 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.12 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.12 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.11 rifampicin
rpoB 761990 c.2184G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.13 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.14 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.14 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.13 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.12 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.13 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.12 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.17 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.16 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.17 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.17 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.17 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.15 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>A upstream_gene_variant 0.2 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.14 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.15 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.14 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.13 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.13 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.13 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.14 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.12 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.18 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.18 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.16 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.2 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.17 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.18 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.15 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764810 c.1441_1443delCCCinsGT frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.13 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 765886 c.2517C>G synonymous_variant 0.12 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.15 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.15 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
atpE 1461113 c.69C>T synonymous_variant 0.14 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.16 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.15 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.15 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.13 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.12 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.78 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473676 n.19G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473684 n.27G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473696 n.39_40delTCinsCTA non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473699 n.43delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473707 n.50T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474292 n.636_649delTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052_1057delGTGGTGinsAATAAGT non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833709 c.168C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.16 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833751 c.210C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833760 c.219C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.26 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.14 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.15 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.12 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.11 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.13 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 0.93 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877587 c.921A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.14 rifampicin
rpoA 3877602 c.906C>T synonymous_variant 0.15 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.15 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.16 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.14 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>T synonymous_variant 0.14 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.15 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.15 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.15 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.13 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.12 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877974 c.534G>C synonymous_variant 0.13 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4039085 c.1620A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.13 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.13 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>G synonymous_variant 0.12 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.11 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.12 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.11 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.11 pyrazinamide
clpC1 4039339 p.Thr456Pro missense_variant 0.11 pyrazinamide
clpC1 4039346 p.Arg453Ser missense_variant 0.11 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.12 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.13 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.12 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.12 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039552 c.1153C>T synonymous_variant 0.12 pyrazinamide
clpC1 4039553 c.1152C>T synonymous_variant 0.12 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039565 c.1140G>A synonymous_variant 0.13 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.13 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039814 c.891C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040132 c.573C>T synonymous_variant 0.14 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R