TB-Profiler result

Run: SRR1181289
Summary

Run ID: SRR1181289

Sample name:

Date: 2024-10-04T22:08:19.164163

Number of reads: 705665

Percentage reads mapped: 64.54

Median coverage: 16.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 846 c.846T>C synonymous_variant 0.47 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.5 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.48 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.46 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.44 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.48 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.48 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.48 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.48 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.35 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.4 isoniazid
gyrB 6142 c.903G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6649 c.-653T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>T upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.43 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7868 c.567C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9065 c.1764C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9365 c.2064G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
fgd1 491569 p.Asp263His missense_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491578 p.Ile266Leu missense_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491603 p.Ala274Glu missense_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
hadA 731774 c.-156T>C upstream_gene_variant 0.35 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.32 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.32 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.33 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.27 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.26 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.32 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.3 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.43 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.43 isoniazid
nusG 734532 c.279A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.4 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.33 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.32 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.48 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.43 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.4 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.33 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.33 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.38 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.31 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.36 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.33 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.36 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.36 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.39 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.38 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.44 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.39 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.46 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.46 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.44 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.46 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.41 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.59 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761531 c.1725C>G synonymous_variant 0.47 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.62 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761603 c.1797C>G synonymous_variant 0.56 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.61 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.56 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761660 c.1854G>A synonymous_variant 0.53 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.41 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.44 rifampicin
rpoB 761969 c.2163G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.39 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.39 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.39 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.39 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.42 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.53 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.38 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.41 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.38 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.31 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.28 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.32 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762476 c.-894C>A upstream_gene_variant 0.33 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.29 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.42 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.42 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.48 rifampicin Uncertain significance
rpoB 762833 c.3027C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.5 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.44 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.34 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.28 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.64 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.5 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.52 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.5 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.33 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.33 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.33 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.33 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.36 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763501 c.132C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.42 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.34 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.62 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.53 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.47 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.5 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.59 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.47 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>A synonymous_variant 0.39 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.47 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.44 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.5 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.48 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 765421 c.2052C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.65 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.45 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.44 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.39 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.4 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.29 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.31 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.35 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.42 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 765778 c.2409C>G synonymous_variant 0.36 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.33 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.35 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.33 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.55 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.52 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.42 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.47 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.47 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.47 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.44 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.44 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.44 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.45 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.5 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.52 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.48 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.53 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.47 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781718 c.159C>T synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.42 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.38 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.47 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.47 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.42 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.37 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.38 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.4 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.29 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.35 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.32 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.35 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.3 linezolid
fbiC 1303785 c.855G>T synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
atpE 1461219 c.175T>C synonymous_variant 0.38 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.44 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475275 n.1618_1619delCTinsTC non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833667 c.126C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.35 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.38 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.39 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.41 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.3 pyrazinamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155680 c.432G>C synonymous_variant 0.47 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.47 isoniazid
katG 2155692 c.420C>T synonymous_variant 0.47 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.5 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.5 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.58 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>T upstream_gene_variant 0.5 isoniazid
kasA 2517950 c.-165C>T upstream_gene_variant 0.55 isoniazid
folC 2747394 p.Ile69Val missense_variant 0.35 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.35 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.5 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.33 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.79 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.62 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
thyA 3074031 c.441T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.33 para-aminosalicylic_acid
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3626804 c.546A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626849 c.-236C>T upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.32 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.38 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.35 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.25 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.26 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.41 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.32 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.33 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878950 c.-443C>T upstream_gene_variant 0.39 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.44 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.33 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.4 rifampicin
clpC1 4038997 c.1708T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039010 c.1695G>A synonymous_variant 0.4 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.35 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.31 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.5 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.4 pyrazinamide
panD 4044084 c.198T>C synonymous_variant 0.41 pyrazinamide
panD 4044093 c.189A>G synonymous_variant 0.4 pyrazinamide
panD 4044096 c.186C>T synonymous_variant 0.38 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.32 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.33 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.33 pyrazinamide
panD 4044135 c.147C>T synonymous_variant 0.35 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.38 pyrazinamide
glpK 4139581 p.Asn59Asp missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139627 c.129G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139630 c.126C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139636 c.120C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.37 ethambutol
aftB 4269177 c.-341G>C upstream_gene_variant 0.44 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.62 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R