TB-Profiler result

Run: ERR2229542
Summary

Run ID: ERR2229542

Sample name:

Date: 2024-04-15T23:40:21.147475

Number of reads: 1147201

Percentage reads mapped: 71.55

Median coverage: 29.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.8 Euro-American (mainly T) RD219 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.817_819delACGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303747 c.817_819delACGinsGC frameshift_variant&missense_variant 0.81 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.19 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.28 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.24 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.26 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.21 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.2 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.26 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.16 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.17 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.21 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.29 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.29 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.29 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.28 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.26 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.26 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.28 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.28 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.27 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.25 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.25 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.28 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.26 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.23 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1413 c.1413A>C synonymous_variant 0.21 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.21 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.19 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.21 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.15 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.16 isoniazid
gyrB 6268 c.1029C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6649 c.-653T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8093 c.792C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.33 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.23 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.23 levofloxacin
moxifloxacin
fgd1 491130 c.348C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491173 c.391C>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
mshA 575812 c.465C>T synonymous_variant 0.33 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.42 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.21 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.22 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575959 c.612G>A synonymous_variant 0.22 ethionamide
isoniazid
ccsA 619645 c.-246G>C upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.3 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.28 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.27 ethionamide
hadA 731789 c.-141A>G upstream_gene_variant 0.18 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.17 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.19 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.21 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.18 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.21 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.19 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.27 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.25 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.39 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.36 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.35 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.35 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.34 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.29 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.23 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.17 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.27 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.2 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.28 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.28 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.41 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.42 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.44 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.42 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.44 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.31 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.3 rifampicin
rpoB 761373 p.Val523His missense_variant 0.36 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.31 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.27 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.23 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.17 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.21 rifampicin
rpoB 762032 c.2226C>T synonymous_variant 0.27 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.32 rifampicin
rpoB 762246 c.2440C>T synonymous_variant 0.23 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.2 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.2 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.22 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.23 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.37 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.38 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.38 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.38 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.37 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.4 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.33 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.29 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.2 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.24 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.29 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.23 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.16 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.17 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.26 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.26 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764083 c.714A>G synonymous_variant 0.44 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.33 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.26 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.41 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.33 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.34 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.43 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.38 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.3 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.29 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.3 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.32 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.34 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.38 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.39 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.36 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.32 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.28 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.34 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.22 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.18 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.19 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.26 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.45 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.47 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.34 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.32 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.4 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.4 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.41 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.43 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.33 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.32 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.33 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.38 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.5 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.5 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.4 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.36 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.31 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.33 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.19 rifampicin
rpoC 766168 c.2799C>T synonymous_variant 0.22 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.2 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.2 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.22 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.26 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.29 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.26 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.19 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.23 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.21 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 767134 c.3765C>A synonymous_variant 0.36 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.29 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.33 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776664 p.Thr606Gly missense_variant 0.23 clofazimine
bedaquiline
mmpL5 776678 c.1803G>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 776693 p.Val596Ala missense_variant 0.23 clofazimine
bedaquiline
mmpL5 776705 c.1776C>T synonymous_variant 0.26 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.32 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.31 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.31 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.22 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.25 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.26 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.27 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.21 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800693 c.-116A>G upstream_gene_variant 0.22 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.23 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 800814 c.6A>G synonymous_variant 0.18 linezolid
rplC 800817 c.9A>T synonymous_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 801339 c.531T>C synonymous_variant 0.22 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.23 linezolid
rplC 801357 c.549T>C synonymous_variant 0.29 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.28 linezolid
rplC 801402 c.594T>C synonymous_variant 0.22 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
fbiC 1304553 c.1623C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
fabG1 1673346 c.-94C>G upstream_gene_variant 0.2 ethionamide
isoniazid
fabG1 1673349 c.-91G>C upstream_gene_variant 0.23 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.29 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.21 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.32 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.23 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.19 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.21 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.19 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.21 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.21 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.2 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.2 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.2 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.19 capreomycin
bacA 2064933 c.-205A>G upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101804 c.1239T>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.28 ethionamide
delamanid
isoniazid
PPE35 2168728 p.Gly629Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170048 p.Leu189Val missense_variant 0.56 pyrazinamide
PPE35 2170053 p.Thr187Ser missense_variant 0.54 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.34 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.28 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.3 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.26 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.27 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.28 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.27 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.26 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.28 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.19 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.19 isoniazid
folC 2747314 c.285A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747335 c.264G>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.23 para-aminosalicylic_acid
Rv2477c 2783146 c.897G>A synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783605 c.438T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065064 c.1128G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065087 c.1105A>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid Not assoc w R - Interim
Rv2752c 3065088 c.1104A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065481 c.711T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067325 c.621A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.41 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.44 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.35 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.32 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.29 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.23 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.29 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.16 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.2 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.19 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.22 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
lpqB 3625240 c.-330T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627071 c.279G>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.22 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.32 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.31 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.32 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.3 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.24 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.3 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.24 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.24 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.19 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.23 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.22 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.17 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.18 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.36 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.48 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.48 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.34 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.37 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.34 rifampicin
clpC1 4038486 p.Gly740Asn missense_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.28 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.37 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.23 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.25 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.39 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039469 c.1236T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.24 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.26 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.21 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.21 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.19 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.2 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.23 pyrazinamide
glpK 4138565 c.1191G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241089 c.1227C>G synonymous_variant 0.22 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.22 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.27 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.17 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.18 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.18 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.19 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.2 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245101 c.1869G>C synonymous_variant 0.17 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.24 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.25 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.26 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.22 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.22 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.24 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.23 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.27 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
embA 4245282 p.Ile684Val missense_variant 0.19 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.19 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.19 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.21 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.21 ethambutol
embB 4247629 c.1116C>G synonymous_variant 0.2 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.21 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.42 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.26 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.26 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.26 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.26 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.26 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.29 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.3 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.28 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.28 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.28 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.28 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.28 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R