TB-Profiler result

Run: SRR1175074
Summary

Run ID: SRR1175074

Sample name:

Date: 2024-10-04T11:38:34.038715

Number of reads: 495576

Percentage reads mapped: 52.22

Median coverage: 11.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1 Euro-American (S-type) None 0.89
lineage4.4.1.1 Euro-American None 0.58
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Gln497Arg Assoc w R
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781822 p.Lys88Arg missense_variant 0.6 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance Mutation from literature
embB 4248003 p.Gln497Arg missense_variant 0.53 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.4 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.37 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.41 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.52 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.53 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.5 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.44 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.44 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.41 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.41 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.39 isoniazid
dnaA 1098 c.1098A>G synonymous_variant 0.39 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.39 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.39 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.39 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.33 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.29 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.28 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.32 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.32 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.35 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.35 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.33 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.44 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.45 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.32 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.32 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.32 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.32 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.32 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.32 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.33 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.35 isoniazid
gyrB 6130 c.891T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6144 p.His302Arg missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6196 c.957C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8891 c.1590G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.27 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9182 c.1881T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
mshA 575117 c.-231T>C upstream_gene_variant 0.64 isoniazid
ethionamide
mshA 575118 c.-230_-228delACGinsGCC upstream_gene_variant 0.58 isoniazid
ethionamide
mshA 575124 c.-224_-222delGGGinsCGC upstream_gene_variant 0.64 isoniazid
ethionamide
mshA 575137 c.-211C>G upstream_gene_variant 0.64 isoniazid
ethionamide
ccsA 619579 c.-312G>C upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619584 c.-307A>T upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.56 kanamycin
capreomycin
amikacin
ccsA 619594 c.-297G>T upstream_gene_variant 0.56 kanamycin
capreomycin
amikacin
ccsA 619609 c.-282G>C upstream_gene_variant 0.67 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.67 kanamycin
capreomycin
amikacin
ccsA 619645 c.-246G>C upstream_gene_variant 0.6 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>G upstream_gene_variant 0.58 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>T synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.47 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.44 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.44 kanamycin
capreomycin
amikacin
Rv0565c 656511 c.960T>C synonymous_variant 0.38 ethionamide Not assoc w R - Interim
hadA 731774 c.-156T>C upstream_gene_variant 0.42 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.48 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.45 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.42 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.36 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.33 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.5 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.55 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.55 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.5 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.45 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.47 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.64 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.65 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.61 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.54 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.6 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.6 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.61 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.71 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.72 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.75 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.69 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.39 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.35 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.33 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.65 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.54 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.56 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.52 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.6 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.61 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.64 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.64 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.5 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.48 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.45 rifampicin
rpoB 760472 c.666C>T synonymous_variant 0.56 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.61 rifampicin Uncertain significance
rpoB 760547 c.741G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.52 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.52 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.52 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.53 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.5 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.47 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.56 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.44 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.56 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.44 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.53 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.5 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.46 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.5 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.52 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761848 p.Cys681Ser missense_variant 0.6 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.55 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.62 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.58 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.58 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.58 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.54 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.54 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.5 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.65 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.67 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.56 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.59 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.62 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.67 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.6 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.6 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.59 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.52 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.54 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.55 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.5 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.54 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.5 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.58 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.5 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.38 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.5 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.54 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.58 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.5 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.39 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.43 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.41 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.56 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.7 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.75 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.74 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.7 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.7 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.65 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.63 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.38 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.52 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.43 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.45 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.48 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.5 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.5 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.5 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.67 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.67 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.7 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.7 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.7 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.7 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 0.82 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.82 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.44 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.5 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.64 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.56 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765364 c.1995G>A synonymous_variant 0.65 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.67 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.7 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.68 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.57 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.5 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.47 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.5 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.56 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.6 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.68 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.53 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.53 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.61 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.61 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.73 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.65 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.55 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.52 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.5 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.43 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.43 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.53 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.44 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.44 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.44 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.47 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.47 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.47 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.5 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.47 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.54 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.47 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.5 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.56 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.41 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.5 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
mmpL5 776660 c.1821C>G synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 776672 c.1809G>C synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 776675 c.1806G>A synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 776684 c.1797G>A synonymous_variant 0.44 bedaquiline
clofazimine
mmpL5 776687 p.Trp598Phe missense_variant 0.47 bedaquiline
clofazimine
mmpL5 776738 c.1743C>T synonymous_variant 0.44 bedaquiline
clofazimine
rpsL 781715 c.156T>C synonymous_variant 0.56 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.61 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.53 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.5 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.53 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.53 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.5 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.53 streptomycin
rplC 800582 c.-227C>G upstream_gene_variant 0.75 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.59 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.56 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.5 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.47 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.42 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.33 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.29 linezolid
rplC 800844 c.36T>C synonymous_variant 0.4 linezolid
rplC 800865 c.57A>G synonymous_variant 0.36 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.36 linezolid
rplC 800874 c.66A>G synonymous_variant 0.38 linezolid
rplC 800875 p.Val23Ile missense_variant 0.38 linezolid
rplC 800880 c.72A>G synonymous_variant 0.38 linezolid
rplC 800889 c.81C>G synonymous_variant 0.4 linezolid
rplC 800892 c.84G>C synonymous_variant 0.38 linezolid
rplC 800907 c.99C>G synonymous_variant 0.32 linezolid
rplC 800916 c.108A>G synonymous_variant 0.32 linezolid
rplC 801321 c.513C>T synonymous_variant 0.33 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.37 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.53 linezolid
rplC 801402 c.594T>C synonymous_variant 0.44 linezolid
rplC 801405 c.597T>C synonymous_variant 0.44 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.69 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.61 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.61 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
inhA 1673901 c.-301A>G upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.62 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.67 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.73 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.73 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.69 isoniazid
ethionamide
inhA 1673946 c.-256C>G upstream_gene_variant 0.64 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.69 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.64 isoniazid
ethionamide
inhA 1674561 c.360C>T synonymous_variant 0.53 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.58 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.75 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.73 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.65 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.67 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.54 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.68 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.7 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.64 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.56 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.71 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.74 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.53 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.5 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.69 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.64 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.5 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.5 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.5 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.47 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.47 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.56 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.46 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.46 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.43 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064993 c.-265T>C upstream_gene_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101939 c.1104A>G synonymous_variant 0.55 isoniazid
delamanid
ethionamide
ndh 2101960 c.1083A>G synonymous_variant 0.54 isoniazid
delamanid
ethionamide
ndh 2101963 c.1080G>A synonymous_variant 0.5 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.5 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.5 isoniazid
delamanid
ethionamide
ndh 2102990 p.Val18Ala missense_variant 1.0 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
katG 2155695 c.417C>G synonymous_variant 0.5 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.47 isoniazid
katG 2156117 c.-6A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.52 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.41 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.41 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.4 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.4 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.53 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.53 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.47 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.43 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.5 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.47 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.47 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.44 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.47 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.47 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.62 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.47 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.5 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.47 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.37 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.4 isoniazid
kasA 2519108 p.Asp332Gln missense_variant 0.4 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.44 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.5 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.43 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.4 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.53 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.5 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.5 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.5 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.5 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.53 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.5 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.4 isoniazid
Rv2477c 2782957 c.1086A>G synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.47 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.78 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.75 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.72 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.72 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.57 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067355 c.591A>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067442 c.504C>T synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.5 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.42 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.53 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.76 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.58 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.46 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625714 c.-804C>T upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.47 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.46 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625777 c.-867C>G upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.69 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625843 c.-933C>G upstream_gene_variant 0.83 rifampicin
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.83 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.69 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.65 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.72 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626945 c.-332C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.69 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3627056 c.294C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.74 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.65 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.47 rifampicin
bedaquiline
fbiB 3642656 c.1122G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiB 3642719 c.1185T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
rpoA 3877515 c.993G>C synonymous_variant 0.35 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.47 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.63 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.71 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.75 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.68 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.7 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.6 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.61 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.7 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.71 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.62 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.59 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.56 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.56 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.62 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.57 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.6 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.54 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.54 rifampicin
rpoA 3878226 c.282C>G synonymous_variant 0.31 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.32 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.41 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.35 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.43 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.43 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.43 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.55 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.57 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.56 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.5 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.64 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.68 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.72 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.72 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.67 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.67 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.56 rifampicin
clpC1 4038239 c.2466T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.6 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.5 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.5 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.63 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.65 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.7 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.67 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.73 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.73 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.73 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.62 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.48 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.41 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.3 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.29 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.38 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.48 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.5 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.79 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.87 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.76 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.6 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.35 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.33 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.53 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039718 c.987C>A synonymous_variant 0.59 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.56 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.45 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.54 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.33 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.26 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.26 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.62 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.6 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.47 pyrazinamide
glpK 4138718 c.1038T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138763 c.993G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138769 c.987G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139651 p.His35Glu missense_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242764 p.Val968Leu missense_variant 0.43 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.46 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.5 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.42 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.48 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.56 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.64 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.59 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.57 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.57 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.61 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.5 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.53 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.55 ethambutol Not assoc w R - Interim
embB 4246292 c.-222A>G upstream_gene_variant 0.47 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.5 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.46 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.46 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.44 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.5 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.53 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.64 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.69 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.71 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.73 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.73 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embB 4247940 p.Leu476Trp missense_variant 0.42 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.39 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.41 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.42 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.43 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.5 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.46 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.46 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.5 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.5 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.69 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.57 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.54 ethambutol