TB-Profiler result

Run: ERR1023236
Summary

Run ID: ERR1023236

Sample name:

Date: 2024-04-14T13:52:06.610980

Number of reads: 4338116

Percentage reads mapped: 82.55

Median coverage: 118.0

Strain: lineage6.1.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.3 West-Africa 2 RD702 1.0
lineage6 West-Africa 2 RD702 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embC p.Ala307Thr Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance Mutation from literature
embC 4240781 p.Ala307Thr missense_variant 0.87 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6649 c.-653T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6964 c.1725C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6965 p.Ser576Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7013 c.1774_1776delGAGinsCA frameshift_variant&missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7143 p.Gln635Arg missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7514 c.213C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8330 c.1029C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8408 c.1107A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8806 p.Asp502Gly missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9389 c.2088C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491265 c.483G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491280 c.498C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.17 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491316 c.534C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491590 p.Lys270Glu missense_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491668 p.Lys296Glu missense_variant 0.91 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.15 ethionamide
isoniazid
Rv0565c 656432 p.Gly347Ser missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.98 ethionamide
nusG 734424 c.171G>A synonymous_variant 0.14 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.18 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.19 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.19 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.19 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.25 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.14 rifampicin
rpoB 760121 c.315T>G synonymous_variant 0.14 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760280 c.474C>G synonymous_variant 0.17 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.16 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.16 rifampicin
rpoB 760322 c.516G>A synonymous_variant 0.17 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.16 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.2 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.19 rifampicin
rpoB 760457 c.651C>G synonymous_variant 0.19 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760590 p.Val262Leu missense_variant 0.15 rifampicin
rpoB 760855 p.Thr350Ile missense_variant 0.87 rifampicin Uncertain significance
rpoB 760859 c.1053T>C synonymous_variant 0.14 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.2 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>T synonymous_variant 0.16 rifampicin
rpoB 760938 c.1132C>T synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760969 p.Ser388Leu missense_variant 0.82 rifampicin Not assoc w R
rpoB 760991 c.1185G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761030 c.1224G>C synonymous_variant 0.14 rifampicin
rpoB 761051 c.1245G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.21 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.18 rifampicin
rpoB 761657 c.1851C>A synonymous_variant 0.18 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.18 rifampicin
rpoB 761718 p.Ala638Thr missense_variant 0.14 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.14 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762053 c.2247T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762068 c.2262C>T synonymous_variant 0.15 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.18 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>G synonymous_variant 0.14 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.16 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>G synonymous_variant 0.14 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.16 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.15 rifampicin
rpoC 762965 c.-405T>C upstream_gene_variant 0.16 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.18 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.19 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.17 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.14 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>T synonymous_variant 0.18 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.14 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763894 c.525A>G synonymous_variant 0.14 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.18 rifampicin
rpoC 763927 c.558C>T synonymous_variant 0.17 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.17 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.19 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.18 rifampicin
rpoC 763949 p.Arg194Lys missense_variant 0.18 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.2 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.2 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764002 c.633C>T synonymous_variant 0.22 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764029 c.660G>A synonymous_variant 0.27 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.27 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.26 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.24 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764095 c.726C>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.16 rifampicin
rpoC 764269 c.900G>T synonymous_variant 0.16 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.17 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.18 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.18 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764341 c.972G>T synonymous_variant 0.17 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.19 rifampicin
rpoC 764392 c.1023C>T synonymous_variant 0.18 rifampicin
rpoC 764405 c.1036_1038delAGGinsCA frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.18 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.19 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.22 rifampicin
rpoC 764509 c.1140G>A synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.21 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.19 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.18 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764663 p.Val432Ile missense_variant 0.14 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764770 c.1401G>A synonymous_variant 0.18 rifampicin
rpoC 764791 c.1422C>A synonymous_variant 0.18 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.16 rifampicin Not assoc w R
rpoC 764812 c.1443C>A synonymous_variant 0.16 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.18 rifampicin
rpoC 764836 c.1467G>A synonymous_variant 0.19 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764902 c.1533C>T synonymous_variant 0.16 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.15 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>A synonymous_variant 0.2 rifampicin
rpoC 765007 c.1638T>A synonymous_variant 0.19 rifampicin
rpoC 765008 c.1639T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.19 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765346 c.1977C>A synonymous_variant 0.18 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765400 c.2031G>C synonymous_variant 0.2 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.2 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765425 p.Lys686Glu missense_variant 0.24 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.16 rifampicin
rpoC 765961 c.2592G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.18 rifampicin
rpoC 765991 c.2622C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.16 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.15 rifampicin
rpoC 766051 c.2682G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766423 c.3054T>C synonymous_variant 0.19 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.17 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.17 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.17 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.17 rifampicin
rpoC 766494 p.Gly1042Asp missense_variant 0.16 rifampicin Uncertain significance
rpoC 766514 p.Val1049Ile missense_variant 0.17 rifampicin
rpoC 766528 c.3159T>A synonymous_variant 0.15 rifampicin
rpoC 766921 c.3552G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>G synonymous_variant 0.15 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.16 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.16 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.16 rifampicin
rpoC 766996 c.3627C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.18 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.18 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.16 streptomycin
rplC 800232 c.-577G>T upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.14 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303488 c.558G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303506 c.576C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303536 c.606G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303542 c.612C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471929 n.84C>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472041 n.196C>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453delGinsCT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472301 n.456C>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472311 n.466delCinsTG non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsGT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444_1445delTCinsCGTTG non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474290 n.633T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474292 n.636_646delTCCTCTCCGGA non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474715 n.1058T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474716 n.1059A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475521 n.1864T>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476100 n.2443A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476106 n.2449A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674434 p.Val78Ala missense_variant 0.99 ethionamide Uncertain significance
isoniazid Not assoc w R
inhA 1674934 p.Leu245Val missense_variant 0.13 ethionamide
isoniazid
rpsA 1833658 c.117C>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>A synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834009 c.468C>A synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834012 c.471G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834045 c.504G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834300 c.759G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834402 c.861C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.14 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834558 c.1017C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834619 c.1078T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918688 p.Ala250Gly missense_variant 1.0 capreomycin
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.16 isoniazid
kasA 2518570 c.456_457insACC conservative_inframe_insertion 0.16 isoniazid
kasA 2518573 c.460_462delATC conservative_inframe_deletion 0.17 isoniazid
kasA 2518588 c.474T>A synonymous_variant 0.16 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.16 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.18 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.19 isoniazid
kasA 2518612 c.498C>T synonymous_variant 0.2 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.19 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.15 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.14 isoniazid
ahpC 2726312 c.120T>C synonymous_variant 0.16 isoniazid
Rv2477c 2783440 c.603T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783533 c.510G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783851 c.192G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783854 c.189C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783857 c.186C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067814 c.132T>C synonymous_variant 0.14 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625729 c.885A>G synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625762 c.852A>G synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626930 c.-317A>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
mtrB 3626987 c.-374C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626993 c.-380G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627002 c.-389G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627026 c.324G>A synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627110 c.-497G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627131 c.-518C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.17 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.17 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.18 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877677 c.829_831delGCGinsTA frameshift_variant&missense_variant 0.16 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877701 c.807G>A synonymous_variant 0.18 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.15 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.14 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.14 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.17 rifampicin
rpoA 3877848 c.660C>G synonymous_variant 0.16 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.16 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.17 rifampicin
rpoA 3877886 c.622C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877893 c.615C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.14 rifampicin
rpoA 3877956 c.552G>A synonymous_variant 0.15 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.15 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878013 c.495T>C synonymous_variant 0.18 rifampicin
rpoA 3878019 c.489A>C synonymous_variant 0.17 rifampicin
rpoA 3878025 c.483C>G synonymous_variant 0.16 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.16 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.16 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.17 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.16 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.17 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.17 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.18 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 0.14 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878283 c.225G>A synonymous_variant 0.16 rifampicin
rpoA 3878304 c.204G>T synonymous_variant 0.15 rifampicin
rpoA 3878313 c.195G>T synonymous_variant 0.15 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.14 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.15 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879145 c.-638G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879163 c.-656C>G upstream_gene_variant 0.15 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.14 rifampicin
clpC1 4038842 c.1863G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.15 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038932 c.1773G>A synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039178 c.1527G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 0.88 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 0.98 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338602 c.-81A>C upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338656 c.-136delG upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance