TB-Profiler result

Run: ERR2513229
Summary

Run ID: ERR2513229

Sample name:

Date: 2024-04-13T23:44:45.116089

Number of reads: 507029

Percentage reads mapped: 44.52

Median coverage: 14.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
rpoC p.Ile491Thr Uncertain significance Mutation from literature
isoniazid inhA c.-770T>C Assoc w R - Interim Alias fabG1_c.-8T>C. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide pncA p.Trp68Gly Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-770T>C Assoc w R - Interim Alias fabG1_c.-8T>C
ethA c.1386delA Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.47 rifampicin Assoc w R
rpoC 764841 p.Ile491Thr missense_variant 0.54 rifampicin Uncertain significance Mutation from literature
rpsL 781687 p.Lys43Arg missense_variant 0.88 streptomycin Assoc w R
inhA 1673432 c.-770T>C upstream_gene_variant 1.0 ethionamide Assoc w R - Interim Alias fabG1_c.-8T>C
isoniazid Assoc w R - Interim Alias fabG1_c.-8T>C. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
pncA 2289040 p.Trp68Gly missense_variant 1.0 pyrazinamide Assoc w R
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
ethA 4326087 c.1386delA frameshift_variant 1.0 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760176 p.Ala124Ser missense_variant 0.26 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.26 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.27 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.25 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760256 p.Asp150Glu missense_variant 0.23 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.3 rifampicin Uncertain significance
rpoB 760282 p.Thr159Ser missense_variant 0.32 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.23 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.21 rifampicin
rpoB 760368 p.Ser188Ala missense_variant 0.35 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.33 rifampicin
rpoB 760389 p.Ser195Ala missense_variant 0.35 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760434 p.Val210Ile missense_variant 0.3 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760503 p.Lys233Gln missense_variant 0.41 rifampicin
rpoB 760515 p.Trp237Val missense_variant 0.39 rifampicin
rpoB 760521 p.Ser239Arg missense_variant 0.4 rifampicin Uncertain significance
rpoB 760527 p.Gln241Glu missense_variant 0.4 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Ala missense_variant 0.35 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761014 p.Val403Ala missense_variant 0.48 rifampicin
rpoB 761027 c.1221A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.43 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.43 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.52 rifampicin
rpoB 761178 c.1372_1374delTCAinsAGT synonymous_variant 0.52 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.61 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761243 c.1437G>C synonymous_variant 0.6 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.33 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.32 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.3 rifampicin Uncertain significance
rpoB 762051 c.2245_2247delCATinsTC frameshift_variant&missense_variant 0.42 rifampicin
rpoB 762065 c.2259T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762137 c.2331C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.57 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.54 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.53 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.42 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.53 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.52 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.38 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.66 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.67 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.65 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.77 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.78 rifampicin
rpoB 763160 c.3354G>A synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763181 c.-189G>C upstream_gene_variant 0.6 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.6 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.4 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.4 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.58 rifampicin
rpoC 763619 p.Arg84Lys missense_variant 0.55 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764544 p.Thr392Asn missense_variant 0.61 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.61 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.75 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.64 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.62 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764763 p.His465Leu missense_variant 0.49 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.43 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764812 c.1443C>G synonymous_variant 0.38 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.42 rifampicin
rpoC 764857 c.1488G>T synonymous_variant 0.42 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.34 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.3 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.29 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.3 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.29 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765908 p.Leu847Ala missense_variant 0.33 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>C synonymous_variant 0.4 rifampicin
rpoC 765946 c.2577C>T synonymous_variant 0.4 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.4 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.5 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800633 c.-176T>C upstream_gene_variant 0.22 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.31 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.3 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80delTinsCAG non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471929 n.84C>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471930 n.85G>C non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471931 n.86G>T non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472017 n.172C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472070 n.225G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473130 n.1285G>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444_1445delTCinsGTGA non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867_2868insT non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833673 c.132C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833991 c.450C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834046 p.Ile169Val missense_variant 0.35 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834285 c.744G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834361 c.820_822delTTGinsCC frameshift_variant&missense_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834366 c.825A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.52 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.4 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>G synonymous_variant 0.4 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.44 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.52 pyrazinamide
rpsA 1834561 c.1020C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.61 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.5 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.5 pyrazinamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155716 c.396T>C synonymous_variant 0.45 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.43 isoniazid
katG 2155737 c.375C>G synonymous_variant 0.45 isoniazid
katG 2155741 p.Gly124His missense_variant 0.47 isoniazid
katG 2155765 p.His116Ser missense_variant 0.45 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.37 isoniazid
kasA 2517921 c.-194_-192delACCinsGTG upstream_gene_variant 0.33 isoniazid
ald 3086731 c.-89A>G upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3568795 c.-116A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3627067 c.-454C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627074 c.-461G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627094 p.Thr86Ser missense_variant 0.37 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.4 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.4 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.43 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.39 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.39 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.41 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.4 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.39 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.39 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.39 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.5 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.46 rifampicin
rpoA 3878185 p.Gly108Ala missense_variant 0.48 rifampicin
rpoA 3878188 p.Ala107Gly missense_variant 0.48 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.5 rifampicin Uncertain significance
rpoA 3878202 c.306G>C synonymous_variant 0.48 rifampicin
rpoA 3878217 c.289_291delCTAinsGC frameshift_variant&missense_variant 0.48 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.43 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.37 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.37 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.41 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.39 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038795 p.Ser637Thr missense_variant 0.45 pyrazinamide
clpC1 4038810 p.Gln632Pro missense_variant 0.52 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038941 c.1764G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.75 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.8 pyrazinamide
clpC1 4038980 c.1725C>T synonymous_variant 0.8 pyrazinamide
clpC1 4038986 p.Asp573Glu missense_variant 0.8 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039021 c.1684C>T synonymous_variant 0.75 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.75 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4039067 c.1638G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.65 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039103 c.1602T>G synonymous_variant 0.65 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039116 p.Lys530Arg missense_variant 0.62 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.44 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.61 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039772 c.933G>A synonymous_variant 0.59 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039802 c.903G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.872_874delCCTinsGC frameshift_variant&synonymous_variant 0.53 pyrazinamide
clpC1 4039835 c.869_870insT frameshift_variant 0.5 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039856 c.849C>T synonymous_variant 0.67 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039916 c.789T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.3 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.34 pyrazinamide
clpC1 4039994 c.709_711delGAGinsAC frameshift_variant&missense_variant 0.39 pyrazinamide
clpC1 4040001 p.His235Ser missense_variant 0.39 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040051 c.654C>G synonymous_variant 0.46 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.45 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243346 c.114A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R