TB-Profiler result

Run: ERR9787030
Summary

Run ID: ERR9787030

Sample name:

Date: 2024-04-15T21:53:38.825475

Number of reads: 1918455

Percentage reads mapped: 79.84

Median coverage: 78.0

Strain: lineage6.1.2

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.2 West-Africa 2 RD702 0.72
lineage6 West-Africa 2 RD702 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.22 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6215 p.Ser326Thr missense_variant 0.14 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6388 c.-914T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6397 c.1158G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6398 p.Val387Ile missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6416 p.Thr393Gly missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6430 c.-872A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6440 p.Thr401Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6445 p.Asp402Glu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6446 p.Ala403Ser missense_variant 0.84 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6452 p.Val405Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6478 c.-824G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6481 c.-821G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6487 c.1248C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6490 c.-812T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6511 c.-791A>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6541 c.1302C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6547 c.-755T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6896 p.Arg553Lys missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7568 c.267C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7700 c.399G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7710 c.409T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 0.99 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 656432 p.Gly347Ser missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 656609 p.Pro288Ser missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734183 c.-71C>T upstream_gene_variant 1.0 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.15 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.15 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.16 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.17 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Ala missense_variant 0.14 rifampicin
rpoB 760855 p.Thr350Ile missense_variant 0.98 rifampicin Uncertain significance
rpoB 760969 p.Ser388Leu missense_variant 0.9 rifampicin Not assoc w R
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.2 rifampicin
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.19 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.21 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.21 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.22 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.2 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.21 rifampicin
rpoB 761217 c.1411_1413delCCGinsGC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.18 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.15 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 761792 c.1986T>G synonymous_variant 0.14 rifampicin
rpoB 762062 c.2256T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.16 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762249 c.2443C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.22 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.2 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.14 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.78 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.14 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.27 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.28 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.29 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.29 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.3 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.3 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.35 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.34 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.34 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.35 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.35 rifampicin
rpoC 763822 c.453C>G synonymous_variant 0.33 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.32 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.29 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.29 rifampicin
rpoC 763849 c.480G>A synonymous_variant 0.26 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.25 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763870 c.501C>T synonymous_variant 0.22 rifampicin
rpoC 763871 p.Gly168Ser missense_variant 0.22 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.22 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.24 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763910 p.Leu181Met missense_variant 0.27 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.24 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.24 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.24 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.2 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.19 rifampicin
rpoC 764084 p.Asn239Asp missense_variant 0.14 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.14 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>T synonymous_variant 0.17 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.15 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764452 c.1083T>C synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>T synonymous_variant 0.18 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.2 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.21 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.26 rifampicin
rpoC 764713 c.1344G>A synonymous_variant 0.29 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764857 c.1488G>T synonymous_variant 0.18 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.16 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.14 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.16 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.15 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.15 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.16 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.16 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.15 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766486 c.3117A>G synonymous_variant 0.14 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.15 rifampicin
rpoC 766494 p.Gly1042Asp missense_variant 0.15 rifampicin Uncertain significance
rpoC 766996 c.3627C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>T synonymous_variant 0.2 rifampicin
rpoC 767023 c.3654C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800232 c.-577G>T upstream_gene_variant 1.0 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1304817 c.1887T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304835 c.1905G>A synonymous_variant 0.13 clofazimine
pretomanid
delamanid
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_454delGT non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472303 n.458_470delGGTTCTCTCGGATinsTGAGG non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444T>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445_1446insAA non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473596 n.-62G>A upstream_gene_variant 1.0 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474710 n.1053delTinsACAA non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474955 n.1298T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474956 n.1299C>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474957 n.1301_1306delACCTTG non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474990 n.1333C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474995 n.1338T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474997 n.1340A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474999 n.1342C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475008 n.1351C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475009 n.1352G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475010 n.1353G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475015 n.1358_1360delCCGinsTTCA non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674434 p.Val78Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Not assoc w R
inhA 1674750 c.549T>G synonymous_variant 0.13 ethionamide
isoniazid
rpsA 1833874 c.333T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.19 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.14 pyrazinamide
rpsA 1834556 p.Ala339Gln missense_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.15 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.16 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.14 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.98 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
bacA 2063303 c.1426C>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2783077 c.966T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625183 c.-273G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625186 c.-276T>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625207 c.-297C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
alr 3840637 p.Pro262Ser missense_variant 1.0 cycloserine
rpoA 3877686 c.822A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.18 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.19 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>T synonymous_variant 0.21 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>C synonymous_variant 0.14 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.16 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.22 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.505_507delTCAinsAGC synonymous_variant 0.17 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.17 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.16 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.16 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.16 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.15 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.18 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.18 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.2 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.16 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.16 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.16 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.16 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.19 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.19 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.19 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.18 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.17 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.16 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.16 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.14 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038613 p.Asn698His missense_variant 0.14 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.15 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.15 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.14 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038713 c.1992T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.19 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039031 c.1674T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.17 pyrazinamide
clpC1 4039646 c.1059G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039691 c.1014G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039769 c.936C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.14 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039808 c.897G>A synonymous_variant 0.14 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040225 c.480A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040228 c.477G>A synonymous_variant 0.14 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040243 c.462C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040249 c.456A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 0.71 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance