TB-Profiler result

Run: ERR9896144
Summary

Run ID: ERR9896144

Sample name:

Date: 2024-04-16T12:59:15.435300

Number of reads: 1859559

Percentage reads mapped: 84.74

Median coverage: 76.0

Strain: lineage3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid p.Leu79Ser Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.21 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305494 c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant&stop_lost&splice_region_variant 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.17 ethambutol Mutation from literature
gid 4407967 p.Leu79Ser missense_variant 1.0 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8225 c.924T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8279 c.978G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9596 c.2295G>T synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13277 c.282T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491601 c.819T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575674 c.327G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.21 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.24 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.17 ethionamide
isoniazid
Rv0565c 657081 c.390G>A synonymous_variant 0.97 ethionamide Not assoc w R - Interim
hadA 732389 p.Ser154Thr missense_variant 0.14 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.14 isoniazid
nusG 734354 p.Pro34Leu missense_variant 1.0 rifampicin Not assoc w R
nusG 734421 c.168A>G synonymous_variant 0.16 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.15 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.16 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.15 rifampicin
nusG 734481 c.228C>T synonymous_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.18 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 0.99 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.21 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.18 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760337 c.531C>G synonymous_variant 0.15 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.18 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.16 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.17 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.17 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760533 p.Val243Ile missense_variant 0.15 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760634 c.828T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.25 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.19 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>G synonymous_variant 0.2 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.18 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.18 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761772 p.His656Asp missense_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.16 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.16 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.15 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.2 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.19 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.19 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.26 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.29 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.18 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.18 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.15 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.15 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762512 c.-858C>A upstream_gene_variant 0.14 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.23 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.24 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.2 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.21 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.14 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.16 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.17 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.18 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.16 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.16 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.16 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>C synonymous_variant 0.17 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.19 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.23 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.18 rifampicin
rpoC 764181 p.Asp271Gly missense_variant 0.84 rifampicin Not assoc w R
rpoC 764188 c.819A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.16 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.16 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764209 c.840C>G synonymous_variant 0.17 rifampicin
rpoC 764212 c.843C>T synonymous_variant 0.17 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.21 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.22 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.18 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.22 rifampicin
rpoC 764905 c.1536C>T synonymous_variant 0.22 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.14 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.14 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 0.14 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.19 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.19 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.19 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.22 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.22 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.21 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.18 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.15 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.16 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.16 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.15 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.18 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.18 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.18 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.18 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.18 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.16 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.28 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.28 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.3 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.27 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.24 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.23 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.23 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.17 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.22 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.23 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.23 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.19 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.23 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.23 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.23 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.21 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.18 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.17 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.17 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.16 streptomycin
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 801174 c.366T>C synonymous_variant 0.15 linezolid
rplC 801192 c.384G>A synonymous_variant 0.17 linezolid
rplC 801195 c.387G>C synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.17 linezolid
rplC 801249 c.441T>C synonymous_variant 0.18 linezolid
rplC 801255 c.447C>T synonymous_variant 0.17 linezolid
rplC 801258 c.450C>G synonymous_variant 0.17 linezolid
rplC 801270 c.462T>C synonymous_variant 0.17 linezolid
rplC 801276 c.468G>C synonymous_variant 0.17 linezolid
rplC 801282 c.474G>C synonymous_variant 0.16 linezolid
rplC 801348 c.540T>G synonymous_variant 0.17 linezolid
rplC 801357 c.549T>C synonymous_variant 0.15 linezolid
Rv1129c 1254522 c.6_12dupGCGGAGT frameshift_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303674 c.744C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303713 c.783C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303812 c.882C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303878 c.948G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305051 c.2121G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674324 c.123C>T synonymous_variant 0.14 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833703 c.162C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833745 c.204G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833913 c.372G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833953 c.412C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.15 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834531 c.990C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.16 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.16 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.15 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.15 linezolid
tsnR 1853395 c.-211T>C upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102275 c.768C>T synonymous_variant 0.98 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517917 c.-198G>C upstream_gene_variant 0.17 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.15 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.16 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.15 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.17 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.21 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.21 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.21 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.23 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.28 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.29 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.33 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.34 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.32 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.32 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.32 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.29 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.25 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.25 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.27 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.27 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.26 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
folC 2747053 c.546C>T synonymous_variant 0.14 para-aminosalicylic_acid
folC 2747792 c.-194G>T upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782498 c.1545C>T synonymous_variant 0.97 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2783040 p.Ala335Thr missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783668 c.375G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783740 c.303C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859801 c.618G>C synonymous_variant 0.16 clofazimine
bedaquiline
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449066 c.565delG frameshift_variant 1.0 ethionamide Uncertain significance
Rv3083 3449260 p.Lys253* stop_gained 1.0 ethionamide Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625465 c.-555T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625489 c.-579A>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625510 c.-600T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625587 c.-677C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.29 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625648 c.-738T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625657 c.-747C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626627 c.-14A>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626972 c.-359A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.17 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.21 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.18 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.18 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.16 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.15 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.16 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.15 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.15 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.16 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.16 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.16 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878734 c.-229_-227delATCinsGG upstream_gene_variant 0.23 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.24 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878785 c.-278T>A upstream_gene_variant 0.2 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.22 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.17 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.19 rifampicin
rpoA 3878953 c.-446C>T upstream_gene_variant 0.19 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.16 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879004 c.-497G>C upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879028 c.-521C>T upstream_gene_variant 0.17 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.16 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.15 rifampicin
clpC1 4038368 c.2337T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038416 c.2289C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.2 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.24 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.22 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.26 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.2 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.2 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.26 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039592 c.1113G>T synonymous_variant 0.28 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039840 c.865C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039943 c.762G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040144 c.561G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040222 c.483G>A synonymous_variant 0.21 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.16 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
panD 4044291 c.-10G>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138541 c.1215C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138565 c.1191G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>T synonymous_variant 0.87 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240880 p.Ala340Thr missense_variant 0.15 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.17 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.17 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.16 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.15 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.15 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.17 ethambutol
embC 4241008 c.1146G>C synonymous_variant 0.16 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.17 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.18 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.17 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.16 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.16 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.16 ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247395 c.882C>G synonymous_variant 0.15 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.16 ethambutol
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.17 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.16 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.16 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.16 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.16 ethambutol
embB 4247800 c.1287A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247803 c.1290G>C synonymous_variant 0.17 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.17 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.15 ethambutol
embB 4247875 c.1362G>A synonymous_variant 0.15 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.16 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.16 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.16 ethambutol
embB 4247908 c.1395C>T synonymous_variant 0.15 ethambutol
embB 4247915 p.Arg468Lys missense_variant 0.16 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.16 ethambutol
embB 4248133 c.1620C>T synonymous_variant 0.16 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.16 ethambutol
embB 4248149 p.Thr546Ala missense_variant 0.17 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248163 c.1650G>C synonymous_variant 0.16 ethambutol
embB 4248175 c.1662G>C synonymous_variant 0.17 ethambutol
embB 4248206 c.1693_1695delAGCinsGA frameshift_variant&missense_variant 0.16 ethambutol
embB 4248211 c.1698G>T synonymous_variant 0.16 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.16 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.16 ethambutol
embB 4248232 c.1719G>C synonymous_variant 0.16 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R