Run ID: ERR9896144
Sample name:
Date: 2024-04-16T12:59:15.435300
Number of reads: 1859559
Percentage reads mapped: 84.74
Median coverage: 76.0
Strain: lineage3
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage3 | East-African-Indian | RD750 | 0.96 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.His312Arg | Mutation from literature | |
pyrazinamide | ||||
streptomycin | rrs | n.462C>T | Uncertain significance | Mutation from literature |
gid | p.Leu79Ser | Uncertain significance | Mutation from literature | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | fbiC | c.859_861delATCinsGG | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
fbiC | 1303789 | c.859_861delATCinsGG | frameshift_variant&missense_variant | 0.21 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
fbiC | 1305494 | c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | frameshift_variant&stop_lost&splice_region_variant | 1.0 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.21 | streptomycin | Uncertain significance | Mutation from literature |
embB | 4247448 | p.His312Arg | missense_variant | 0.17 | ethambutol | Mutation from literature | |
gid | 4407967 | p.Leu79Ser | missense_variant | 1.0 | streptomycin | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8225 | c.924T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8228 | c.927G>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8279 | c.978G>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9191 | c.1890G>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9204 | p.Ser635Thr | missense_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9230 | c.1929T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9596 | c.2295G>T | synonymous_variant | 0.97 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
Rv0010c | 13277 | c.282T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
fgd1 | 491601 | c.819T>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491603 | p.Ala274Glu | missense_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491610 | c.828A>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491620 | p.Ile280Val | missense_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
mshA | 575674 | c.327G>C | synonymous_variant | 0.21 | ethionamide | |
isoniazid | ||||||
mshA | 575692 | c.345G>C | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
mshA | 575695 | c.348C>G | synonymous_variant | 0.21 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575704 | c.357T>C | synonymous_variant | 0.21 | ethionamide | |
isoniazid | ||||||
mshA | 575705 | c.358T>C | synonymous_variant | 0.21 | ethionamide | |
isoniazid | ||||||
mshA | 575713 | c.366G>A | synonymous_variant | 0.2 | ethionamide | |
isoniazid | ||||||
mshA | 575734 | c.387T>G | synonymous_variant | 0.27 | ethionamide | |
isoniazid | ||||||
mshA | 575737 | c.390T>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575770 | c.423G>C | synonymous_variant | 0.24 | ethionamide | |
isoniazid | ||||||
mshA | 575771 | p.Val142Ser | missense_variant | 0.24 | ethionamide | |
isoniazid | ||||||
mshA | 575779 | c.432A>G | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575782 | c.435G>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575785 | c.438T>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575812 | c.465C>T | synonymous_variant | 0.28 | ethionamide | |
isoniazid | ||||||
mshA | 575821 | c.474G>C | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575824 | c.477T>A | synonymous_variant | 0.26 | ethionamide | |
isoniazid | ||||||
mshA | 575845 | c.498C>G | synonymous_variant | 0.25 | ethionamide | |
isoniazid | ||||||
mshA | 575864 | c.517T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 0.97 | ethionamide | Not assoc w R - Interim |
hadA | 732389 | p.Ser154Thr | missense_variant | 0.14 | isoniazid | |
hadA | 732396 | p.Gly156Ala | missense_variant | 0.14 | isoniazid | |
nusG | 734354 | p.Pro34Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
nusG | 734421 | c.168A>G | synonymous_variant | 0.16 | rifampicin | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.15 | rifampicin | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.16 | rifampicin | |
nusG | 734460 | c.207G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
nusG | 734472 | c.219T>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734481 | c.228C>T | synonymous_variant | 0.17 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
nusG | 734538 | c.285C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.18 | rifampicin | |
nusG | 734580 | c.327T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 759746 | c.-61C>T | upstream_gene_variant | 0.99 | rifampicin | Not assoc w R |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760244 | c.438G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760253 | c.447T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760274 | c.468G>A | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760337 | c.531C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760370 | c.564C>G | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoB | 760380 | p.Thr192Leu | missense_variant | 0.16 | rifampicin | |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760463 | c.657C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760469 | c.663C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760520 | c.714C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoB | 760533 | p.Val243Ile | missense_variant | 0.15 | rifampicin | |
rpoB | 760547 | c.741G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760563 | p.Arg253Met | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.17 | rifampicin | |
rpoB | 760634 | c.828T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761097 | c.1291_1293delAGCinsTCG | synonymous_variant | 0.25 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.24 | rifampicin | |
rpoB | 761129 | c.1323G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761153 | c.1347G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761171 | c.1365C>G | synonymous_variant | 0.2 | rifampicin | |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761234 | c.1428G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761258 | c.1452G>A | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761264 | c.1458C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761300 | c.1494G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761327 | c.1521A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761772 | p.His656Asp | missense_variant | 0.16 | rifampicin | |
rpoB | 761778 | p.Asn658Asp | missense_variant | 0.16 | rifampicin | |
rpoB | 761791 | p.Arg662His | missense_variant | 0.2 | rifampicin | |
rpoB | 761885 | c.2079T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761891 | c.2085G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761999 | c.2193G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 762008 | c.2202C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762017 | c.2211A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.26 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762149 | c.2343G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 762254 | c.2448T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.29 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762296 | c.2490G>A | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762329 | c.2523G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.21 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 762398 | c.-972T>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 762404 | c.2598T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 762416 | c.2610A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762434 | c.2628T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 762449 | c.2643C>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 762512 | c.-858C>A | upstream_gene_variant | 0.14 | rifampicin | |
rpoB | 762799 | p.Ala998Gly | missense_variant | 0.23 | rifampicin | Uncertain significance |
rpoB | 762812 | c.3006C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762813 | p.Met1003Val | missense_variant | 0.24 | rifampicin | |
rpoB | 762818 | c.3012C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762827 | c.3021G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762860 | c.3054G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762863 | c.3057T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762957 | c.3151C>T | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.21 | rifampicin | |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.14 | rifampicin | |
rpoC | 763853 | c.484_486delGTCinsAT | frameshift_variant&missense_variant | 0.16 | rifampicin | |
rpoC | 763858 | c.489A>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763872 | p.Gly168Ala | missense_variant | 0.17 | rifampicin | |
rpoC | 763876 | p.Glu169Asp | missense_variant | 0.18 | rifampicin | |
rpoC | 763879 | c.510A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763888 | c.519G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763891 | c.522G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763900 | c.531G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763933 | c.564C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764059 | c.690G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764102 | p.Val245Ile | missense_variant | 0.19 | rifampicin | |
rpoC | 764112 | p.Tyr248Phe | missense_variant | 0.23 | rifampicin | |
rpoC | 764116 | c.747C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764131 | c.762T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764140 | c.771C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764161 | c.792G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764181 | p.Asp271Gly | missense_variant | 0.84 | rifampicin | Not assoc w R |
rpoC | 764188 | c.819A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764195 | p.Ser276Ile | missense_variant | 0.16 | rifampicin | |
rpoC | 764203 | c.834G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764206 | c.837T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764209 | c.840C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764212 | c.843C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764266 | c.897T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764269 | c.900G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764278 | c.909A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764293 | c.924G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764338 | c.969G>A | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764381 | c.1012_1013delTCinsAG | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764387 | c.1018T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764405 | c.1036_1038delAGGinsCC | frameshift_variant&missense_variant | 0.17 | rifampicin | |
rpoC | 764419 | c.1050C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764428 | c.1059G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764656 | c.1287C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764905 | c.1536C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764923 | c.1554A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | c.1639T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765052 | c.1683C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 765404 | p.Leu679Val | missense_variant | 0.14 | rifampicin | |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765452 | p.Ala695Ser | missense_variant | 0.14 | rifampicin | |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765562 | c.2193G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765580 | c.2211G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765583 | c.2214G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765613 | p.His748Gln | missense_variant | 0.2 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.21 | rifampicin | |
rpoC | 765658 | c.2289C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765751 | c.2382C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765753 | p.Asp795Ala | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765778 | c.2409C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766483 | c.3114G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766484 | c.3115_3117delGTAinsAC | frameshift_variant&missense_variant | 0.16 | rifampicin | |
rpoC | 766492 | c.3123T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766495 | c.3126C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766528 | c.3159T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766531 | c.3162G>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766543 | c.3174C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766583 | p.Gly1072Ser | missense_variant | 0.15 | rifampicin | |
rpoC | 766597 | c.3228C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.16 | rifampicin | |
rpoC | 766645 | c.3276A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766894 | c.3525T>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766895 | c.3526T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 766918 | c.3549C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766978 | c.3609C>A | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.17 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.22 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.23 | rifampicin | |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.23 | rifampicin | |
rpoC | 767191 | c.3822C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 767206 | c.3837C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767209 | c.3840T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767212 | c.3843G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781733 | c.174G>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781742 | c.183C>T | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781814 | c.255C>T | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781838 | c.279G>T | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781841 | c.282C>G | synonymous_variant | 0.16 | streptomycin | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.16 | linezolid | |
rplC | 801174 | c.366T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 801192 | c.384G>A | synonymous_variant | 0.17 | linezolid | |
rplC | 801195 | c.387G>C | synonymous_variant | 0.18 | linezolid | |
rplC | 801222 | c.414T>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801249 | c.441T>C | synonymous_variant | 0.18 | linezolid | |
rplC | 801255 | c.447C>T | synonymous_variant | 0.17 | linezolid | |
rplC | 801258 | c.450C>G | synonymous_variant | 0.17 | linezolid | |
rplC | 801270 | c.462T>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801276 | c.468G>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801282 | c.474G>C | synonymous_variant | 0.16 | linezolid | |
rplC | 801348 | c.540T>G | synonymous_variant | 0.17 | linezolid | |
rplC | 801357 | c.549T>C | synonymous_variant | 0.15 | linezolid | |
Rv1129c | 1254522 | c.6_12dupGCGGAGT | frameshift_variant | 1.0 | moxifloxacin | Uncertain significance |
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1303674 | c.744C>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303686 | c.756C>G | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303695 | c.765T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303704 | c.774T>C | synonymous_variant | 0.24 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303708 | c.778T>C | synonymous_variant | 0.23 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303713 | c.783C>G | synonymous_variant | 0.23 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303731 | c.801A>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303732 | p.Ser268Ala | missense_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303740 | c.810C>G | synonymous_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303746 | c.816T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303749 | c.819G>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303752 | c.822A>G | synonymous_variant | 0.21 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
fbiC | 1303755 | c.825T>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303785 | c.855G>T | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303788 | c.858T>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303794 | c.864A>G | synonymous_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303812 | c.882C>T | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303818 | c.888C>G | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303827 | c.897A>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303846 | p.Phe306Val | missense_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303854 | c.924T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303860 | c.930A>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303878 | c.948G>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303881 | c.951G>C | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303884 | c.954T>G | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304742 | c.1812T>C | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304787 | c.1857T>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304790 | c.1860C>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304796 | c.1866G>A | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304832 | c.1902C>G | synonymous_variant | 0.18 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
fbiC | 1304853 | c.1923C>T | synonymous_variant | 0.15 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304869 | c.1939C>T | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304880 | c.1950C>T | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304893 | p.Gly655Ser | missense_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304907 | c.1977C>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304910 | c.1980G>C | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304916 | c.1986T>C | synonymous_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304925 | c.1995G>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304928 | c.1998T>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304937 | c.2007G>C | synonymous_variant | 0.23 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304940 | c.2010A>G | synonymous_variant | 0.23 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304955 | c.2025G>A | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304983 | c.2053C>T | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304994 | c.2064A>G | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304995 | c.2065T>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305012 | c.2082G>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305014 | p.Thr695Ser | missense_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305021 | c.2091C>A | synonymous_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305033 | c.2103T>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305042 | c.2112A>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305045 | c.2115A>G | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305051 | c.2121G>C | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305063 | c.2133G>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.16 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.16 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.18 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473813 | n.156C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473944 | n.287G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1473966 | n.309T>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1473971 | n.314G>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1473981 | n.324delGinsTT | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1474036 | n.379G>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1474040 | n.383G>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1474054 | n.397T>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474093 | n.436G>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1474099 | n.442G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1474111 | n.454T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1474956 | n.1299C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474961 | n.1304T>G | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474963 | n.1306G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474964 | n.1307T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474970 | n.1313G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1475006 | n.1349A>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475013 | n.1356G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1475028 | n.1371G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1475201 | n.1544G>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475267 | n.1610G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475275 | n.1618C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1475409 | n.1752T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475659 | n.2002G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1476031 | n.2374C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1476032 | n.2375C>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1476033 | n.2376T>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476034 | n.2377C>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476047 | n.2390G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1476048 | n.2391G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476086 | n.2429G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476089 | n.2432T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476095 | n.2438C>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674324 | c.123C>T | synonymous_variant | 0.14 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
inhA | 1674870 | c.669T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
inhA | 1674879 | c.678T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
rpsA | 1833703 | c.162C>T | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833760 | c.219C>T | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833793 | c.252C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833811 | c.270G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833913 | c.372G>A | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833953 | c.412C>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833971 | c.430C>T | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834369 | c.828C>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834423 | c.882G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834435 | c.894G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834495 | c.954G>A | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834531 | c.990C>T | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.15 | pyrazinamide | |
tsnR | 1853360 | c.-246G>A | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853370 | c.-236_-234delGCAinsTG | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1853395 | c.-211T>C | upstream_gene_variant | 0.15 | linezolid | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
ndh | 2102275 | c.768C>T | synonymous_variant | 0.98 | ethionamide | Not assoc w R - Interim |
delamanid | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
pncA | 2289047 | c.195C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
pncA | 2289365 | c.-125delC | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2517917 | c.-198G>C | upstream_gene_variant | 0.17 | isoniazid | |
kasA | 2517965 | c.-150C>T | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518574 | c.460_462delATCinsGG | frameshift_variant&missense_variant | 0.16 | isoniazid | |
kasA | 2518579 | c.465T>C | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518591 | c.477G>T | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518606 | c.492G>C | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518609 | p.Met165Ile | missense_variant | 0.21 | isoniazid | |
kasA | 2518618 | c.504G>C | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518627 | c.513T>C | synonymous_variant | 0.23 | isoniazid | |
kasA | 2518636 | c.522C>T | synonymous_variant | 0.28 | isoniazid | |
kasA | 2518642 | c.528A>G | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518672 | c.558G>C | synonymous_variant | 0.33 | isoniazid | |
kasA | 2518678 | c.564C>T | synonymous_variant | 0.34 | isoniazid | |
kasA | 2518684 | c.570C>G | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518687 | c.573C>T | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518688 | p.Val192Phe | missense_variant | 0.32 | isoniazid | |
kasA | 2518705 | c.591T>G | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518711 | c.597A>G | synonymous_variant | 0.25 | isoniazid | |
kasA | 2518714 | c.600A>T | synonymous_variant | 0.25 | isoniazid | |
kasA | 2518717 | c.603C>T | synonymous_variant | 0.27 | isoniazid | |
kasA | 2518723 | c.609G>A | synonymous_variant | 0.27 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.26 | isoniazid | |
ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R |
folC | 2747053 | c.546C>T | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
folC | 2747792 | c.-194G>T | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
Rv2477c | 2782498 | c.1545C>T | synonymous_variant | 0.97 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 0.16 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2783044 | c.999G>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783059 | c.984T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783077 | c.966T>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783092 | c.951A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783095 | c.948C>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783098 | c.945C>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783116 | c.927T>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783140 | c.903C>G | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783158 | c.885A>C | synonymous_variant | 0.19 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783182 | c.861C>G | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783193 | p.Ser284Gly | missense_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783194 | c.849A>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783215 | c.828G>T | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783221 | c.822G>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783224 | c.819C>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783230 | c.813T>G | synonymous_variant | 0.17 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783235 | c.808T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783244 | p.Thr267Ala | missense_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783263 | c.780G>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783289 | p.Leu252Ile | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783299 | c.744A>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783332 | c.711T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783563 | c.480A>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783572 | c.471A>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783586 | p.Ala153Pro | missense_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783593 | c.450T>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783605 | c.438T>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783611 | c.432C>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783628 | p.Ala139Ser | missense_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783659 | c.384A>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783665 | c.378A>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783668 | c.375G>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783674 | c.369T>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783683 | c.360A>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783695 | c.348C>T | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783719 | c.324A>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783740 | c.303C>T | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783751 | p.Ile98Val | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783821 | p.Gln74Leu | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783833 | c.210G>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783839 | c.204C>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783843 | p.Gly67Asp | missense_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783846 | p.Thr66Asn | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783853 | c.190C>T | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783863 | c.180C>T | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
pepQ | 2859801 | c.618G>C | synonymous_variant | 0.16 | clofazimine | |
bedaquiline | ||||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3083 | 3449066 | c.565delG | frameshift_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3449260 | p.Lys253* | stop_gained | 1.0 | ethionamide | Uncertain significance |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3625465 | c.-555T>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625489 | c.-579A>C | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625510 | c.-600T>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625513 | c.-603G>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625518 | c.-608T>C | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625525 | c.-615G>C | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625528 | c.-618G>T | upstream_gene_variant | 0.23 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625537 | c.-627T>C | upstream_gene_variant | 0.23 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625543 | c.-633G>C | upstream_gene_variant | 0.25 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625569 | c.1045T>C | synonymous_variant | 0.27 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625572 | p.Thr348Ser | missense_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625579 | c.-669A>G | upstream_gene_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625587 | c.-677C>T | upstream_gene_variant | 0.29 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625592 | p.Ser341Asn | missense_variant | 0.29 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625594 | c.-684T>C | upstream_gene_variant | 0.29 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625602 | c.-692T>C | upstream_gene_variant | 0.28 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.25 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625616 | p.Arg333Ala | missense_variant | 0.25 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625624 | c.-714C>G | upstream_gene_variant | 0.26 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625630 | c.-720C>G | upstream_gene_variant | 0.28 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625636 | c.978C>G | synonymous_variant | 0.28 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625648 | c.-738T>C | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625657 | c.-747C>T | upstream_gene_variant | 0.25 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626627 | c.-14A>C | upstream_gene_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Uncertain significance | |||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627011 | c.-398T>G | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
rpoA | 3878163 | c.345C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878276 | c.232C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.21 | rifampicin | |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>T | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878307 | c.201C>G | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878364 | c.144A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878384 | c.124C>T | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878388 | c.120C>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878396 | c.112C>T | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878454 | c.54A>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878698 | c.-191A>G | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3878701 | c.-194C>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3878716 | c.-209C>G | upstream_gene_variant | 0.28 | rifampicin | |
rpoA | 3878725 | c.-218A>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878734 | c.-229_-227delATCinsGG | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878737 | c.-230G>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878742 | c.-235G>A | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 0.24 | rifampicin | Uncertain significance |
rpoA | 3878749 | c.-242G>T | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878761 | c.-254G>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878785 | c.-278T>A | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.21 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878824 | c.-317G>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878836 | c.-331_-329delAAGinsGGC | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.23 | rifampicin | Uncertain significance |
rpoA | 3878884 | c.-377C>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878909 | c.-402A>G | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.22 | rifampicin | Uncertain significance |
rpoA | 3878917 | c.-410G>A | upstream_gene_variant | 0.19 | rifampicin | Uncertain significance |
rpoA | 3878935 | c.-428C>T | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3878938 | c.-431T>G | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3878953 | c.-446C>T | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3878962 | c.-455G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 0.18 | rifampicin | Uncertain significance |
rpoA | 3878974 | c.-469_-467delATCinsGG | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 0.16 | rifampicin | Uncertain significance |
rpoA | 3879004 | c.-497G>C | upstream_gene_variant | 0.14 | rifampicin | Uncertain significance |
rpoA | 3879028 | c.-521C>T | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3879037 | c.-530G>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoA | 3879061 | c.-554C>T | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3879073 | c.-566A>G | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3879178 | c.-671T>C | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3879190 | c.-683C>G | upstream_gene_variant | 0.15 | rifampicin | |
clpC1 | 4038368 | c.2337T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038416 | c.2289C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038433 | c.2272C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038486 | p.Gly740Thr | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4038488 | c.2217C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038494 | c.2211G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038498 | p.Ser736Asn | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4038530 | p.Glu725Asp | missense_variant | 0.22 | pyrazinamide | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.26 | pyrazinamide | |
clpC1 | 4038653 | c.2052C>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038658 | p.Lys683Gln | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4038661 | p.Ser682Thr | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4038662 | c.2043T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038671 | c.2034T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038683 | c.2022T>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038701 | c.2004G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038707 | c.1998C>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038710 | c.1995G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038917 | c.1788C>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038923 | c.1780_1782delCTAinsTG | frameshift_variant&synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039186 | c.1519C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039208 | c.1497C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039484 | c.1221T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039556 | c.1149G>C | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039574 | p.Ala377Gly | missense_variant | 0.26 | pyrazinamide | |
clpC1 | 4039577 | c.1128T>C | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039592 | c.1113G>T | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039622 | c.1083C>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039652 | c.1053G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039661 | c.1044T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039673 | c.1032G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039760 | c.945T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039775 | c.930G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039790 | c.915C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039814 | c.891C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039817 | c.888A>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039820 | c.885T>C | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039831 | c.874T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039840 | c.865C>T | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039943 | c.762G>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039946 | c.759A>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039949 | c.756G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039955 | c.750G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039991 | c.714G>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039996 | p.Glu237Gln | missense_variant | 0.17 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040030 | c.675C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040042 | c.663C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040048 | c.657C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040144 | c.561G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040171 | c.534C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040180 | c.525C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040195 | c.510G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040200 | c.505T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040201 | c.504C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040204 | c.501G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040207 | c.498T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040213 | c.490_492delTCTinsAGC | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040222 | c.483G>A | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4040225 | c.480A>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040228 | c.477G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040237 | c.468C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040249 | c.456A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040252 | c.453C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040267 | c.438A>G | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040273 | c.432T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040277 | c.427_428delTCinsAG | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040279 | c.426C>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
panD | 4044291 | c.-10G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
panD | 4044872 | c.-591C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
glpK | 4138541 | c.1215C>T | synonymous_variant | 0.17 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | ||||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138547 | c.1209C>T | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138565 | c.1191G>A | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138568 | c.1188A>G | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138580 | c.1176C>T | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138583 | c.1173G>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138601 | c.1155G>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138606 | c.1150T>C | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138622 | c.1134C>T | synonymous_variant | 0.87 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
embC | 4240880 | p.Ala340Thr | missense_variant | 0.15 | ethambutol | Uncertain significance |
embC | 4240885 | c.1023T>C | synonymous_variant | 0.17 | ethambutol | |
embC | 4240897 | c.1035C>G | synonymous_variant | 0.17 | ethambutol | Not assoc w R |
embC | 4240898 | c.1036_1038delCTAinsTG | frameshift_variant&stop_gained | 0.16 | ethambutol | |
embC | 4240921 | c.1059C>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4240924 | c.1062C>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4240936 | c.1074A>G | synonymous_variant | 0.17 | ethambutol | |
embC | 4241008 | c.1146G>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4241017 | c.1155T>C | synonymous_variant | 0.17 | ethambutol | |
embC | 4241023 | c.1161T>G | synonymous_variant | 0.18 | ethambutol | |
embC | 4241026 | c.1164C>G | synonymous_variant | 0.17 | ethambutol | |
embC | 4241050 | c.1188T>G | synonymous_variant | 0.16 | ethambutol | |
embC | 4241053 | c.1191G>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4241071 | c.1209C>G | synonymous_variant | 0.16 | ethambutol | |
embC | 4242075 | p.Arg738Gln | missense_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4247395 | c.882C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4247401 | c.888T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247437 | c.924A>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247440 | c.927C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4247464 | c.951C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4247470 | c.957T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247485 | c.972C>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4247491 | c.978G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247800 | c.1287A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4247803 | c.1290G>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247806 | c.1293G>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247819 | c.1306_1308delGTTinsAC | frameshift_variant&missense_variant | 0.15 | ethambutol | |
embB | 4247875 | c.1362G>A | synonymous_variant | 0.15 | ethambutol | |
embB | 4247881 | c.1368G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247887 | c.1374C>T | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4247893 | c.1380C>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4247899 | p.Met462Ile | missense_variant | 0.16 | ethambutol | |
embB | 4247908 | c.1395C>T | synonymous_variant | 0.15 | ethambutol | |
embB | 4247915 | p.Arg468Lys | missense_variant | 0.16 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248130 | c.1617G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248133 | c.1620C>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248149 | p.Thr546Ala | missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4248163 | c.1650G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248175 | c.1662G>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4248206 | c.1693_1695delAGCinsGA | frameshift_variant&missense_variant | 0.16 | ethambutol | |
embB | 4248211 | c.1698G>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4248214 | c.1701C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4248226 | c.1713G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248232 | c.1719G>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248277 | c.1764G>C | synonymous_variant | 0.15 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |