TB-Profiler result

Run: ERR245758
Summary

Run ID: ERR245758

Sample name:

Date: 2024-04-15T04:13:42.968425

Number of reads: 9797143

Percentage reads mapped: 82.53

Median coverage: 163.0

Strain: lineage4.9.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.9.1 Euro-American (H37Rv-like) None 0.96
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6917 p.His560Tyr missense_variant 0.99 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7821 c.520C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8706 c.1405C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.13 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9182 c.1881T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.12 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
ccsA 619630 c.-261C>G upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>G upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>C upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
Rv0565c 656307 c.1164G>C synonymous_variant 0.13 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.12 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.18 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.16 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.17 isoniazid
hadA 731816 c.-114G>C upstream_gene_variant 0.15 isoniazid
hadA 731817 c.-113C>A upstream_gene_variant 0.16 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.15 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.14 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.14 isoniazid
rpoB 759606 c.-201T>C upstream_gene_variant 0.15 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.14 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760259 c.453C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.16 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.14 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.14 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.14 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.15 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>G synonymous_variant 0.15 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.15 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.15 rifampicin
rpoB 760938 c.1132C>T synonymous_variant 0.13 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.19 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.16 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.19 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.21 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761690 c.1884G>C synonymous_variant 0.13 rifampicin
rpoB 761972 c.2166C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.18 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.13 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.14 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>G synonymous_variant 0.13 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.16 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.14 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.14 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.16 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.15 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.15 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.14 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.32 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762868 p.Tyr1021Phe missense_variant 0.2 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.2 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763181 c.-189G>C upstream_gene_variant 0.15 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.15 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763250 c.-120C>T upstream_gene_variant 0.14 rifampicin
rpoC 763253 c.-117G>C upstream_gene_variant 0.13 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.17 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.16 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.2 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.21 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.16 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.16 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763765 c.396T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.14 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.18 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.19 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.2 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.22 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.22 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.22 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.21 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.2 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.18 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.19 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.17 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.15 rifampicin
rpoC 763948 c.579G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763951 c.582G>A synonymous_variant 0.14 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.19 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.19 rifampicin
rpoC 764002 c.633C>T synonymous_variant 0.17 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.18 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.17 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.2 rifampicin
rpoC 764077 c.708C>G synonymous_variant 0.21 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.24 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764218 c.849C>T synonymous_variant 0.19 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.2 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.15 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.18 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.16 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>T synonymous_variant 0.21 rifampicin
rpoC 764761 c.1392C>T synonymous_variant 0.23 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.19 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.19 rifampicin
rpoC 765079 c.1710T>C synonymous_variant 0.19 rifampicin
rpoC 765082 c.1713G>T synonymous_variant 0.18 rifampicin
rpoC 765100 c.1731G>C synonymous_variant 0.14 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.12 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.21 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.2 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.2 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765553 c.2184C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.2 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.23 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765655 c.2286T>A synonymous_variant 0.23 rifampicin
rpoC 765688 c.2319G>A synonymous_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765752 p.Asp795Ser missense_variant 0.14 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.12 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.23 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.23 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.14 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.12 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.13 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.16 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.15 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.17 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.17 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.15 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.14 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.14 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.18 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.16 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.19 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.15 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.14 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.14 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.16 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.14 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.21 rifampicin
rpoC 767149 c.3780C>G synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.15 streptomycin
rpsL 781703 c.144G>C synonymous_variant 0.15 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.16 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.15 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.16 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.14 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.14 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.13 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781832 c.273T>C synonymous_variant 0.14 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.17 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.16 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.14 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.15 linezolid
rplC 800546 c.-263T>A upstream_gene_variant 0.15 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.16 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.16 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.16 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.16 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.17 linezolid
sigE 1365003 c.591T>C synonymous_variant 0.13 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.14 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.16 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.15 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.14 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.12 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474071 n.414G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474102 n.445T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674618 c.417C>T synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.13 ethionamide
isoniazid
inhA 1674663 c.462G>C synonymous_variant 0.14 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.14 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1833771 p.Asn77Ser missense_variant 0.15 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.13 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.13 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.13 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834288 c.747C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.13 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289138 p.Leu35Arg missense_variant 0.99 pyrazinamide Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.13 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.14 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.16 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.17 isoniazid
kasA 2518217 p.Gly35Ser missense_variant 0.16 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.17 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.15 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.13 isoniazid
kasA 2518510 c.396C>T synonymous_variant 0.14 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.16 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.15 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.15 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.15 isoniazid
kasA 2518765 c.651G>C synonymous_variant 0.23 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.15 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.15 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.14 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.14 isoniazid
Rv2477c 2783140 c.903C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067355 c.591A>C synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.14 para-aminosalicylic_acid
fbiD 3339385 p.Asp90Asn missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
mtrB 3625569 c.1045T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.13 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877575 c.933C>T synonymous_variant 0.12 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.17 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.16 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.17 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.27 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.26 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.2 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.22 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.21 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.2 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.14 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.15 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.15 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878385 c.123C>G synonymous_variant 0.17 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.17 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.18 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.17 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.15 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.14 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.13 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.15 rifampicin
rpoA 3878758 c.-251G>C upstream_gene_variant 0.13 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.15 rifampicin
rpoA 3878884 c.-377C>G upstream_gene_variant 0.13 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.15 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.13 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.13 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.13 rifampicin
clpC1 4038536 c.2169C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.13 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.13 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039205 c.1500C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039556 c.1149G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039582 p.Thr375Ser missense_variant 0.17 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.13 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.14 pyrazinamide
glpK 4138601 c.1155G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139642 c.114G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139648 c.108T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139653 p.His35Asn missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241107 c.1245G>C synonymous_variant 0.14 ethambutol
embC 4241426 c.1564C>T synonymous_variant 0.14 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.14 ethambutol Uncertain significance
embB 4247845 c.1332G>C synonymous_variant 0.13 ethambutol
embB 4247857 c.1344C>A synonymous_variant 0.16 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.14 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247956 c.1443G>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4247968 c.1455C>G synonymous_variant 0.15 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.16 ethambutol
embB 4247983 c.1470G>C synonymous_variant 0.15 ethambutol
embB 4247986 c.1473C>G synonymous_variant 0.14 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.15 ethambutol
embB 4248163 c.1650G>C synonymous_variant 0.14 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.14 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.14 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.19 ethambutol Uncertain significance
embB 4248211 c.1698G>C synonymous_variant 0.2 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.23 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.22 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.25 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.25 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.21 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.19 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R