TB-Profiler result

Run: ERR9786421
Summary

Run ID: ERR9786421

Sample name:

Date: 2024-04-13T21:51:34.042225

Number of reads: 814148

Percentage reads mapped: 69.99

Median coverage: 35.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.9
lineage4.1.2 Euro-American None 0.98
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
La1.2.BCG M.bovis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1078_1080delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.21 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.29 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304008 c.1078_1080delTTGinsCC frameshift_variant&missense_variant 0.36 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.3 ethambutol Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.2 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.24 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.19 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.19 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.21 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.21 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.18 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 996 c.996A>G synonymous_variant 0.19 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6440 c.1201_1203delACCinsGG frameshift_variant&missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6448 c.-854G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6451 c.-851A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6454 c.-848C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6457 c.-845T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6460 c.-842G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.24 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.21 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6952 c.1713C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7406 c.105G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7793 c.492G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.22 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8740 p.Arg480His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9176 c.1875G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9224 c.1923C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490827 c.45C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491077 p.Asn99Gly missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491256 p.Lys158Asn missense_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.77 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575623 c.276C>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575632 c.285G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.33 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.29 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575665 c.318G>A synonymous_variant 0.31 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575679 p.Asn111Ser missense_variant 0.64 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.3 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.27 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.33 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575875 c.528C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.24 ethionamide
isoniazid
ccsA 619543 c.-348C>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
Rv0565c 657269 p.Ser68Pro missense_variant 0.72 ethionamide Uncertain significance
hadA 731732 c.-198G>A upstream_gene_variant 0.21 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.45 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.45 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.45 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.45 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.45 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.45 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.52 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.48 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.48 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.31 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.29 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.32 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.37 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.38 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.39 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.39 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.4 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.41 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.29 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.27 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.29 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.39 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.61 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.47 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.43 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.62 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.51 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.51 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.51 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.51 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.46 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.46 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.44 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.5 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.52 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.5 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.49 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.51 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.5 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.47 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.42 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.42 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.33 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.3 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.29 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.19 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.23 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.28 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.36 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.57 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.6 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.62 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.6 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.45 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.46 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.49 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.46 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.42 rifampicin
rpoB 761373 p.Val523His missense_variant 0.37 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.4 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.36 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.35 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.35 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.34 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.34 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.33 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.33 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.32 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.35 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.31 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.3 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.29 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.25 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.24 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.24 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.24 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.26 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.26 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.24 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.26 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.25 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.3 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.3 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.4 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.45 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.45 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.48 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.53 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.53 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.49 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.49 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.49 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.49 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.49 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.5 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.4 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.44 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.43 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.43 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.46 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.47 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.49 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.49 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.54 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.5 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.44 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.42 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.44 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.44 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.42 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.4 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.38 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.37 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.41 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.36 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.28 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.29 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.29 rifampicin
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.28 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.31 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.6 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.56 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.65 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.6 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.56 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.44 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.44 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.44 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.45 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.39 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.36 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.29 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.31 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.3 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.35 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.45 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.5 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.37 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.42 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.43 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.39 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.4 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.38 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.41 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.41 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.41 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.43 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.39 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.39 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.44 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.43 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.43 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.41 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.42 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.42 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.42 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.46 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.42 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.4 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.42 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.45 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.38 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.38 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.44 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.4 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.36 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.36 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.41 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.42 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.41 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.4 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.43 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.43 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.42 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.33 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.32 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.33 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.31 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.38 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.39 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.4 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.38 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.33 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.33 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.35 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.45 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.42 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.36 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.39 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.31 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.27 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.34 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 0.84 rifampicin Not assoc w R
rpoC 765319 c.1950A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.21 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.22 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.4 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.38 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.53 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.47 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.43 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.44 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.44 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.47 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.44 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.43 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.4 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.4 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.44 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.42 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.42 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.42 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.24 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.25 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.24 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.23 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.22 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.27 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.27 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.26 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766258 c.2889T>C synonymous_variant 0.3 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.31 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.31 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.34 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.35 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.48 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.53 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.51 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.5 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.47 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.53 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.54 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.54 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.54 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.56 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.5 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.52 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.48 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.51 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.47 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.46 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.46 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.42 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.38 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.38 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.36 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.35 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.35 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.38 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.39 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.41 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.37 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.37 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.32 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.36 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.36 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.45 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.47 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.5 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.55 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.53 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.55 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.57 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.54 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.45 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.38 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.35 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.37 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.29 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.29 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.29 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.27 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.28 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.31 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.29 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.31 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.3 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.36 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.36 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.38 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.41 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.38 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.4 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.4 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.4 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.4 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.42 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.45 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.38 streptomycin Uncertain significance
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.21 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.23 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.24 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.24 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800817 c.9A>T synonymous_variant 0.27 linezolid
rplC 800844 c.36T>C synonymous_variant 0.28 linezolid
rplC 800967 c.159C>G synonymous_variant 0.24 linezolid
rplC 800970 c.162T>C synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801195 c.387G>C synonymous_variant 0.27 linezolid
rplC 801207 c.399C>T synonymous_variant 0.28 linezolid
rplC 801246 c.438C>T synonymous_variant 0.36 linezolid
rplC 801249 c.441T>C synonymous_variant 0.35 linezolid
rplC 801255 c.447C>T synonymous_variant 0.35 linezolid
rplC 801264 c.456C>T synonymous_variant 0.34 linezolid
rplC 801267 c.459A>T synonymous_variant 0.34 linezolid
rplC 801270 c.462T>C synonymous_variant 0.33 linezolid
rplC 801276 c.468G>C synonymous_variant 0.33 linezolid
rplC 801279 c.471G>C synonymous_variant 0.33 linezolid
rplC 801282 c.474G>C synonymous_variant 0.34 linezolid
rplC 801285 c.477G>C synonymous_variant 0.33 linezolid
rplC 801300 c.492C>G synonymous_variant 0.33 linezolid
rplC 801309 c.501C>G synonymous_variant 0.31 linezolid
rplC 801312 c.504G>C synonymous_variant 0.31 linezolid
rplC 801321 c.513C>T synonymous_variant 0.31 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.36 linezolid
rplC 801339 c.531T>C synonymous_variant 0.32 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.32 linezolid
rplC 801348 c.540T>G synonymous_variant 0.35 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.38 linezolid
rplC 801402 c.594T>C synonymous_variant 0.36 linezolid
rplC 801405 c.597T>C synonymous_variant 0.36 linezolid
rplC 801423 c.615G>C synonymous_variant 0.24 linezolid
rplC 801426 c.618C>G synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.23 linezolid
rplC 801438 c.630T>C synonymous_variant 0.29 linezolid
rplC 801442 p.Ile212Val missense_variant 0.29 linezolid
fbiC 1303512 c.582T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303977 c.1047C>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
Rv1258c 1406341 p.Tyr334His missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsATTGGG non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673568 c.-634C>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673580 c.-622T>G upstream_gene_variant 0.26 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673591 c.-611C>T upstream_gene_variant 0.23 ethionamide
isoniazid Uncertain significance
inhA 1673595 c.-607A>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.24 ethionamide
isoniazid
inhA 1673602 c.-600C>T upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.23 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.23 ethionamide
isoniazid
fabG1 1673637 p.Asp66Glu missense_variant 0.24 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.24 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.24 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.22 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.18 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.21 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.29 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.38 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.6 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.57 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.49 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.44 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.44 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.37 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.39 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.33 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.34 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.33 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064936 c.-208C>G upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101808 p.Thr412Ser missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101837 p.Ala402Val missense_variant 0.21 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101894 c.1149T>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.19 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.31 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.23 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.24 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.32 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.38 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.44 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.46 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.43 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.4 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.4 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.38 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.35 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.35 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.34 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.32 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.3 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.3 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.32 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.32 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.32 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.38 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.42 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.42 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.41 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.41 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.41 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.49 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.38 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.31 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.33 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.33 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.36 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.36 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.38 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.39 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.38 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.38 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.42 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.41 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.44 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.36 isoniazid
ahpC 2726486 c.294A>G synonymous_variant 0.21 isoniazid
ahpC 2726493 c.301_303delAACinsGG frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
ahpC 2726506 p.Thr105Lys missense_variant 0.27 isoniazid Uncertain significance
ahpC 2726508 c.316_318delTTAinsCG frameshift_variant&missense_variant 0.25 isoniazid Uncertain significance
ahpC 2726528 c.336C>G synonymous_variant 0.29 isoniazid
ahpC 2726540 c.348C>G synonymous_variant 0.27 isoniazid
ahpC 2726543 c.351A>G synonymous_variant 0.28 isoniazid
ahpC 2726546 c.354C>G synonymous_variant 0.26 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.26 isoniazid
ahpC 2726556 c.364_366delGCAinsAC frameshift_variant&missense_variant 0.25 isoniazid Uncertain significance
ahpC 2726564 c.372C>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.24 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.2 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.2 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.2 isoniazid
Rv2477c 2782695 c.1348A>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782711 c.1332C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782741 c.1302G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.48 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.53 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.55 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.57 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783428 c.615C>T synonymous_variant 0.31 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783431 c.610_612delAGCinsTCG synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.53 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3064876 p.Ser439Phe missense_variant 0.86 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064914 c.1278T>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064926 c.1264_1266delTTGinsCC frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064932 c.1260T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064947 c.1245A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065007 c.1185G>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 c.1170G>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>T synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.62 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.58 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065115 c.1077C>A synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065126 p.Ser356Ala missense_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065127 c.1065G>C synonymous_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 p.Ala354Glu missense_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065151 c.1041G>C synonymous_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065183 p.Ser337Ala missense_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065186 c.1006T>C synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065190 c.1000_1002delATCinsGG frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065196 c.996T>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065202 c.990T>G synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065210 c.982T>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065232 c.960T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065241 c.951A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067349 c.597G>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.43 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.41 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.44 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.46 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.44 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.43 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.41 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.43 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.43 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.43 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073791 c.681T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073794 c.678A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073815 c.657G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.28 para-aminosalicylic_acid
thyA 3074055 p.Glu139Pro missense_variant 0.28 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.3 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074244 c.228A>G synonymous_variant 0.25 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3623531 c.1380T>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3623549 c.1362C>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.21 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623575 p.Leu446Phe missense_variant 0.18 bedaquiline
rifampicin Uncertain significance
lpqB 3623580 p.Asn444Thr missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623601 p.Ser437Thr missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623612 p.Thr433Val missense_variant 0.22 bedaquiline
rifampicin
lpqB 3623630 c.1281G>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.27 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625195 c.-285A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.32 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.42 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.43 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.48 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.51 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.42 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.4 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.22 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626158 c.456C>T synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3626161 c.453C>A synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3626179 c.435A>T synonymous_variant 0.31 bedaquiline
rifampicin
mtrB 3626185 c.429T>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626188 c.424_426delTCTinsAC frameshift_variant&missense_variant 0.31 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626191 c.423C>G synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3626194 c.420T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626203 c.411G>A synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3626206 c.408T>C synonymous_variant 0.35 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626209 c.405T>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626230 c.384T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626236 c.378G>C synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3626239 c.375T>C synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3626245 c.367_369delCTCinsAG frameshift_variant&missense_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626248 c.366C>G synonymous_variant 0.23 bedaquiline
rifampicin
mtrB 3626251 c.363T>G synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626254 c.360G>C synonymous_variant 0.23 bedaquiline
rifampicin
mtrB 3626257 c.357G>C synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626260 c.354T>C synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626263 p.Pro117Gln missense_variant 0.24 bedaquiline
rifampicin
mtrB 3626272 c.342A>G synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626275 c.339G>C synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626284 c.330T>G synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626293 c.321G>C synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626296 c.318T>G synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626308 c.306T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626317 c.297A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626325 p.Thr97Ala missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626332 c.282T>C synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3626338 c.276C>G synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627299 c.51G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3640899 c.-636G>C upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.27 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.25 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.26 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.27 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.26 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.31 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.3 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.34 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.35 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877748 c.760C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.31 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.54 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.53 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.54 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.54 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.52 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.52 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.52 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.49 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.55 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.57 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.59 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.63 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.63 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.63 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.61 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.63 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.58 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.59 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.61 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.6 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.5 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.47 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.48 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.39 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.41 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.4 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.4 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.42 rifampicin
rpoA 3878187 c.321C>A synonymous_variant 0.4 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.55 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.56 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.59 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.6 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.56 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.56 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.63 rifampicin
rpoA 3878352 c.156C>G synonymous_variant 0.63 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.64 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.64 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.66 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.62 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.66 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.64 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.61 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.61 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.6 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.59 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.53 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.54 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.54 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.52 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.48 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.48 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.47 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.5 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.5 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.5 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.5 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.48 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.54 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.54 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.54 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.56 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.56 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.52 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.68 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.66 rifampicin Uncertain significance
rpoA 3878881 c.-374C>T upstream_gene_variant 0.64 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.59 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.52 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.52 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.48 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.5 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.48 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.57 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.55 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.54 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.54 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.56 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.56 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.56 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.57 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.59 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.44 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.45 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.39 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.35 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.25 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.28 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.3 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.27 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.25 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.25 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.25 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.37 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.35 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.41 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.41 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.37 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.38 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.39 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.39 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.37 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.35 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.33 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.27 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.3 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.35 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040278 p.Ser143Thr missense_variant 0.2 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.25 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
panD 4044812 c.-531A>C upstream_gene_variant 0.25 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.24 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.25 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.23 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.19 pyrazinamide
panD 4044909 c.-628C>T upstream_gene_variant 0.17 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.17 pyrazinamide
panD 4044936 c.-655A>T upstream_gene_variant 0.16 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.2 pyrazinamide
panD 4044959 c.-678C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.18 pyrazinamide
glpK 4138460 c.1296C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138604 c.1150_1152delTTGinsCA frameshift_variant&missense_variant 0.45 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138610 c.1146C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139417 c.339A>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139420 c.336T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139537 c.219G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139541 p.Ile72Thr missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139545 c.211T>C synonymous_variant 0.38 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.202_204delGCGinsTC frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139561 c.195G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4239298 c.-565C>T upstream_gene_variant 0.97 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.26 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.25 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.26 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.26 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.21 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.19 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.18 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.19 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.21 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.21 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.2 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.22 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.26 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.28 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.38 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.36 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.35 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.35 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.29 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.29 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.27 ethambutol
embC 4242803 p.Val981Leu missense_variant 0.74 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.26 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.26 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.29 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.27 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.28 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.28 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.24 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.24 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.23 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embA 4245083 c.1851A>C synonymous_variant 0.31 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.31 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.29 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.27 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.29 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.32 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.38 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.36 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.36 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.38 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.37 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.45 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.45 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.29 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.29 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.3 ethambutol
embB 4247413 c.900C>T synonymous_variant 0.24 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.25 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.3 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.3 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.3 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.33 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.34 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.3 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.29 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.25 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.27 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.23 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.25 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.25 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.23 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.23 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.23 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.28 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.27 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.25 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.22 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.2 ethambutol Not assoc w R
embB 4247656 c.1143A>G synonymous_variant 0.2 ethambutol
embB 4247659 c.1146C>G synonymous_variant 0.2 ethambutol
embB 4247662 c.1149C>G synonymous_variant 0.2 ethambutol
embB 4247683 c.1170C>G synonymous_variant 0.23 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.2 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.17 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.22 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.31 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.31 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.31 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.31 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.37 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.4 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.4 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.33 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.33 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.33 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.33 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.33 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.33 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.33 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.3 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.3 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.3 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.21 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.3 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.29 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.3 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.3 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.3 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.29 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.29 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.29 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.29 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.29 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.29 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.27 ethambutol
aftB 4268236 p.Leu201Met missense_variant 0.26 ethambutol
ubiA 4269075 c.757_759delATTinsGC frameshift_variant&missense_variant 0.38 ethambutol
aftB 4269081 c.-245G>C upstream_gene_variant 0.33 ethambutol
aftB 4269084 c.-248G>C upstream_gene_variant 0.33 ethambutol
ubiA 4269102 c.731_732delGCinsCCATTCG frameshift_variant&missense_variant 0.3 ethambutol
ubiA 4269105 c.724_728delGGCTA frameshift_variant 0.3 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.3 ethambutol
ubiA 4269131 c.703C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
aftB 4269132 c.-296G>C upstream_gene_variant 0.28 ethambutol
aftB 4269138 c.-302C>T upstream_gene_variant 0.27 ethambutol
ubiA 4269141 c.691_693delTTGinsGC frameshift_variant&missense_variant 0.27 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
aftB 4269159 c.-323G>C upstream_gene_variant 0.29 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.29 ethambutol
aftB 4269165 c.-329G>C upstream_gene_variant 0.27 ethambutol
aftB 4269179 c.-343C>A upstream_gene_variant 0.25 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.27 ethambutol
aftB 4269186 c.-350C>G upstream_gene_variant 0.27 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.32 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.26 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.31 ethambutol
aftB 4269242 c.-406C>T upstream_gene_variant 0.31 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.3 ethambutol
aftB 4269249 c.-413G>A upstream_gene_variant 0.31 ethambutol
aftB 4269258 c.-422C>T upstream_gene_variant 0.27 ethambutol
ethA 4326644 p.Asp277Gly missense_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin