TB-Profiler result

Run: ERR5311077
Summary

Run ID: ERR5311077

Sample name:

Date: 01-04-2023 22:30:31

Number of reads: 1486757

Percentage reads mapped: 50.58

Strain: La1.8.1

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
La1 M.bovis None None 1.0
La1.8 M.bovis None None 1.0
La1.8.1 M.bovis None None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761196 p.Leu464Met missense_variant 0.19 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.94 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.97 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.89 kanamycin, capreomycin, aminoglycosides, amikacin
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5752 c.513G>A synonymous_variant 1.0
gyrA 6406 c.-896C>T upstream_gene_variant 1.0
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8032 p.Tyr244Ser missense_variant 0.17
gyrA 8285 c.984C>T synonymous_variant 1.0
gyrA 8741 c.1440C>T synonymous_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9217 p.Asp639Ala missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 760925 c.1119T>C synonymous_variant 0.12
rpoB 760940 c.1134G>C synonymous_variant 0.13
rpoB 760944 p.Gln380Glu missense_variant 0.14
rpoB 760953 p.Ile383Val missense_variant 0.13
rpoB 760958 c.1152G>C synonymous_variant 0.13
rpoB 760960 p.Val385Ala missense_variant 0.13
rpoB 760965 p.Met387Leu missense_variant 0.13
rpoB 760970 c.1164G>C synonymous_variant 0.13
rpoB 760982 c.1176G>C synonymous_variant 0.17
rpoB 760985 c.1179G>C synonymous_variant 0.17
rpoB 760991 c.1185G>C synonymous_variant 0.22
rpoB 760997 c.1191G>T synonymous_variant 0.32
rpoB 761003 c.1197C>G synonymous_variant 0.38
rpoB 761015 c.1209G>C synonymous_variant 0.48
rpoB 761021 c.1215G>C synonymous_variant 0.44
rpoB 761027 c.1221A>G synonymous_variant 0.42
rpoB 761036 c.1230G>C synonymous_variant 0.38
rpoB 761037 c.1231T>C synonymous_variant 0.39
rpoB 761051 c.1245G>C synonymous_variant 0.41
rpoB 761054 c.1248G>C synonymous_variant 0.4
rpoB 761057 c.1251G>C synonymous_variant 0.4
rpoB 761060 c.1254C>G synonymous_variant 0.41
rpoB 761063 c.1257C>A synonymous_variant 0.45
rpoB 761084 c.1278C>A synonymous_variant 0.46
rpoB 761087 c.1281C>G synonymous_variant 0.46
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.46
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.46
rpoB 761102 c.1296A>G synonymous_variant 0.5
rpoB 761132 c.1326G>T synonymous_variant 0.52
rpoB 761133 c.1327T>C synonymous_variant 0.52
rpoB 761150 c.1344A>C synonymous_variant 0.39
rpoB 761159 c.1353G>T synonymous_variant 0.25
rpoB 761162 c.1356G>T synonymous_variant 0.18
rpoB 761165 c.1359G>C synonymous_variant 0.18
rpoB 761168 c.1362C>G synonymous_variant 0.19
rpoB 761171 c.1365C>T synonymous_variant 0.2
rpoB 761180 c.1374A>C synonymous_variant 0.21
rpoB 761186 p.Glu460Asp missense_variant 0.21
rpoB 761189 c.1383T>C synonymous_variant 0.21
rpoB 761192 c.1386C>A synonymous_variant 0.21
rpoB 761195 c.1389G>C synonymous_variant 0.2
rpoB 761201 c.1395G>A synonymous_variant 0.19
rpoB 761207 c.1401C>A synonymous_variant 0.18
rpoB 761213 c.1407G>T synonymous_variant 0.18
rpoB 761222 c.1416G>C synonymous_variant 0.17
rpoB 761231 c.1425C>A synonymous_variant 0.17
rpoB 761234 c.1428G>T synonymous_variant 0.16
rpoB 761243 c.1437G>C synonymous_variant 0.17
rpoB 762849 p.Tyr1015Asp missense_variant 0.18
rpoB 762855 p.Val1017Ile missense_variant 0.18
rpoB 762858 p.Thr1018Ser missense_variant 0.17
rpoC 762863 c.-507T>C upstream_gene_variant 0.17
rpoB 762879 p.Met1025Leu missense_variant 0.18
rpoC 762887 c.-483G>C upstream_gene_variant 0.18
rpoC 762914 c.-456C>T upstream_gene_variant 0.17
rpoC 762917 c.-453C>G upstream_gene_variant 0.17
rpoC 762929 c.-441G>C upstream_gene_variant 0.17
rpoC 762938 c.-432G>C upstream_gene_variant 0.15
rpoC 762947 c.-423C>G upstream_gene_variant 0.16
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763453 c.84C>T synonymous_variant 0.19
rpoC 763456 c.87A>G synonymous_variant 0.29
rpoC 763465 c.96G>A synonymous_variant 0.36
rpoC 763468 c.99G>C synonymous_variant 0.41
rpoC 763486 c.117T>C synonymous_variant 0.48
rpoC 763492 c.123G>T synonymous_variant 0.49
rpoC 763507 c.138G>C synonymous_variant 0.57
rpoC 763528 c.159G>C synonymous_variant 0.67
rpoC 763532 p.Thr55Ser missense_variant 0.65
rpoC 763546 c.177A>G synonymous_variant 0.68
rpoC 763558 c.189C>T synonymous_variant 0.67
rpoC 763570 c.201G>C synonymous_variant 0.65
rpoC 763594 c.225C>T synonymous_variant 0.64
rpoC 763600 c.231C>G synonymous_variant 0.62
rpoC 763603 c.234C>T synonymous_variant 0.6
rpoC 763609 c.240C>T synonymous_variant 0.57
rpoC 763615 c.246G>C synonymous_variant 0.55
rpoC 763624 c.255C>A synonymous_variant 0.52
rpoC 763630 c.261G>C synonymous_variant 0.51
rpoC 763633 c.264T>C synonymous_variant 0.52
rpoC 763642 c.273G>C synonymous_variant 0.53
rpoC 763660 c.291T>G synonymous_variant 0.42
rpoC 763666 c.297G>C synonymous_variant 0.38
rpoC 763669 c.300C>G synonymous_variant 0.36
rpoC 763675 c.306C>G synonymous_variant 0.34
rpoC 763699 c.330G>T synonymous_variant 0.29
rpoC 763702 c.333C>G synonymous_variant 0.27
rpoC 763705 c.336G>C synonymous_variant 0.29
rpoC 763708 c.339G>C synonymous_variant 0.3
rpoC 763714 c.345G>C synonymous_variant 0.31
rpoC 763717 c.348T>C synonymous_variant 0.31
rpoC 763720 c.351G>C synonymous_variant 0.31
rpoC 763723 c.354G>T synonymous_variant 0.31
rpoC 763732 c.363C>A synonymous_variant 0.3
rpoC 763744 c.375G>C synonymous_variant 0.3
rpoC 763747 c.378G>A synonymous_variant 0.28
rpoC 763751 p.Ile128Val missense_variant 0.25
rpoC 763756 c.387C>T synonymous_variant 0.24
rpoC 763765 c.396T>C synonymous_variant 0.15
rpoC 764353 c.984G>C synonymous_variant 0.21
rpoC 764359 c.990C>G synonymous_variant 0.19
rpoC 764365 c.996C>T synonymous_variant 0.21
rpoC 764371 c.1002G>C synonymous_variant 0.23
rpoC 764377 c.1008C>G synonymous_variant 0.22
rpoC 764380 c.1011G>C synonymous_variant 0.22
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.23
rpoC 764398 c.1029G>C synonymous_variant 0.23
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.24
rpoC 764428 c.1059G>C synonymous_variant 0.19
rpoC 764431 c.1062G>C synonymous_variant 0.19
rpoC 764434 c.1065A>G synonymous_variant 0.19
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.19
rpoC 764441 p.Ile358Leu missense_variant 0.19
rpoC 764449 c.1080G>C synonymous_variant 0.2
rpoC 764455 c.1086G>C synonymous_variant 0.28
rpoC 764461 c.1092A>G synonymous_variant 0.26
rpoC 764485 c.1116G>C synonymous_variant 0.24
rpoC 764491 c.1122G>T synonymous_variant 0.19
rpoC 764498 p.Ser377Ala missense_variant 0.19
rpoC 764503 c.1134G>T synonymous_variant 0.19
rpoC 764507 p.Ala380Ser missense_variant 0.18
rpoC 764512 c.1143G>C synonymous_variant 0.18
rpoC 764521 c.1152T>C synonymous_variant 0.22
rpoC 764536 c.1167G>T synonymous_variant 0.28
rpoC 764539 c.1170C>G synonymous_variant 0.31
rpoC 764548 c.1179G>A synonymous_variant 0.33
rpoC 764566 c.1197C>G synonymous_variant 0.31
rpoC 764572 c.1203G>C synonymous_variant 0.28
rpoC 764575 c.1206T>G synonymous_variant 0.28
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.28
rpoC 764581 c.1212T>C synonymous_variant 0.28
rpoC 764582 p.Leu405Met missense_variant 0.28
rpoC 764602 c.1233C>T synonymous_variant 0.37
rpoC 764605 c.1236G>T synonymous_variant 0.41
rpoC 764611 c.1242G>C synonymous_variant 0.4
rpoC 764620 c.1251G>C synonymous_variant 0.46
rpoC 764623 c.1254C>G synonymous_variant 0.49
rpoC 764626 c.1257C>T synonymous_variant 0.52
rpoC 764632 c.1263T>C synonymous_variant 0.51
rpoC 764635 c.1266C>T synonymous_variant 0.51
rpoC 764644 c.1275G>C synonymous_variant 0.5
rpoC 764650 c.1281G>T synonymous_variant 0.52
rpoC 764653 c.1284G>T synonymous_variant 0.52
rpoC 764656 c.1287C>G synonymous_variant 0.51
rpoC 764677 c.1308C>G synonymous_variant 0.42
rpoC 764692 c.1323C>T synonymous_variant 0.4
rpoC 764695 c.1326T>C synonymous_variant 0.39
rpoC 764701 c.1332C>G synonymous_variant 0.41
rpoC 764706 p.Leu446Gln missense_variant 0.44
rpoC 764722 c.1353G>C synonymous_variant 0.49
rpoC 764746 c.1377G>C synonymous_variant 0.46
rpoC 764752 c.1383G>T synonymous_variant 0.43
rpoC 764761 c.1392C>T synonymous_variant 0.28
rpoC 764764 c.1395T>C synonymous_variant 0.24
rpoC 764767 c.1398G>C synonymous_variant 0.23
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.14
rpoC 764788 c.1419G>A synonymous_variant 0.15
rpoC 764791 c.1422C>G synonymous_variant 0.14
rpoC 764797 c.1428G>C synonymous_variant 0.14
rpoC 764806 p.Gln479His missense_variant 0.14
rpoC 764812 c.1443C>G synonymous_variant 0.15
rpoC 764815 c.1446A>G synonymous_variant 0.15
rpoC 764818 c.1449G>C synonymous_variant 0.15
rpoC 764827 c.1458G>C synonymous_variant 0.18
rpoC 764837 p.Val490Ile missense_variant 0.17
rpoC 764843 p.Ala492Thr missense_variant 0.17
rpoC 764858 c.1489T>C synonymous_variant 0.12
rpoC 764932 c.1563C>A synonymous_variant 0.13
rpoC 764935 c.1566T>C synonymous_variant 0.12
rpoC 764948 c.1579T>C synonymous_variant 0.12
rpoC 764953 c.1584G>T synonymous_variant 0.13
rpoC 764958 p.Glu530Gly missense_variant 0.14
rpoC 764962 c.1593G>C synonymous_variant 0.2
rpoC 764968 c.1599T>C synonymous_variant 0.2
rpoC 764971 c.1602C>T synonymous_variant 0.2
rpoC 764983 c.1614T>C synonymous_variant 0.19
rpoC 764995 c.1626C>A synonymous_variant 0.16
rpoC 764998 c.1629G>C synonymous_variant 0.15
rpoC 765007 c.1638T>G synonymous_variant 0.15
rpoC 765008 c.1639T>C synonymous_variant 0.15
rpoC 765014 p.Ala549Pro missense_variant 0.14
rpoC 765034 c.1665T>C synonymous_variant 0.16
rpoC 765040 c.1671T>C synonymous_variant 0.15
rpoC 765041 c.1672T>C synonymous_variant 0.15
rpoC 765047 c.1678T>C synonymous_variant 0.15
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781851 p.Ile98Val missense_variant 0.14
rpsL 781892 c.333A>G synonymous_variant 0.15
rpsL 781901 c.342C>T synonymous_variant 0.16
rpsL 781907 c.348T>C synonymous_variant 0.15
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.18
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.75
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.75
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.75
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.75
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.75
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.89
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.88
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.9
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.86
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.25
rrs 1472340 n.495C>T non_coding_transcript_exon_variant 0.25
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.22
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.25
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.25
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.25
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.38
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.79
rrs 1472495 n.650C>A non_coding_transcript_exon_variant 0.79
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.8
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.91
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.91
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.92
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.94
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.94
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.94
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.94
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.91
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.91
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.92
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.91
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.91
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.93
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.43
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.4
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.86
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.92
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.92
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.93
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.93
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.93
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.91
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.76
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.93
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.93
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.94
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.94
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.96
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.97
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.96
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.95
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.97
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.98
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.98
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.98
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.98
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.97
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.97
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.97
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.97
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.97
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.97
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.96
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.96
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.93
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.93
rrl 1473393 n.-265A>T upstream_gene_variant 0.12
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.25
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.47
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.5
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.44
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.4
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.33
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.17
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.25
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.25
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.33
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.5
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.55
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.55
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.55
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.55
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.71
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.64
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.8
rrl 1474249 n.592G>C non_coding_transcript_exon_variant 0.92
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.91
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.91
rrl 1474286 n.629_630insAG non_coding_transcript_exon_variant 0.9
rrl 1474289 n.632C>T non_coding_transcript_exon_variant 0.9
rrl 1474290 n.633T>G non_coding_transcript_exon_variant 0.9
rrl 1474291 n.634T>A non_coding_transcript_exon_variant 0.9
rrl 1474294 n.638_652delCTCTCCGGAGGAGGG non_coding_transcript_exon_variant 0.93
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.9
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.84
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.84
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 0.84
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.84
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.85
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.87
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.85
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.83
rrl 1474413 n.756A>T non_coding_transcript_exon_variant 0.64
rrl 1474414 n.757C>T non_coding_transcript_exon_variant 0.64
rrl 1474415 n.758C>G non_coding_transcript_exon_variant 0.64
rrl 1474416 n.761_784delCACGCGCATACGCGCGTGTGAATA non_coding_transcript_exon_variant 0.64
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.86
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.88
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.91
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.95
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.95
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.95
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.95
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.95
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.94
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.94
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.94
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.93
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.93
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.93
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.94
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.94
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.93
rrl 1474664 n.1007G>A non_coding_transcript_exon_variant 0.93
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.95
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.9
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.9
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.9
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.9
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.92
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.92
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.91
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.91
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.92
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.94
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.93
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.92
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.92
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.92
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.93
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.91
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.9
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.89
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.9
rrl 1474869 n.1212G>A non_coding_transcript_exon_variant 0.88
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.84
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.83
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.8
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.72
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.2
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.84
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.84
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.84
rrl 1475068 n.1411A>G non_coding_transcript_exon_variant 0.84
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.84
rrl 1475078 n.1421T>C non_coding_transcript_exon_variant 0.88
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.88
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.88
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.91
rrl 1475093 n.1436C>T non_coding_transcript_exon_variant 0.91
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.91
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.91
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.91
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.91
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.91
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.91
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.91
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.91
rrl 1475515 n.1858G>A non_coding_transcript_exon_variant 0.44
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.5
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.5
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.5
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.5
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.5
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.5
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.4
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.33
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.3
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.3
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.5
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.91
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.94
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.94
rrl 1475783 n.2126T>C non_coding_transcript_exon_variant 0.95
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.97
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.98
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.98
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.98
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.97
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.96
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.93
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.91
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.91
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.9
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.85
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.85
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.85
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.84
rrl 1475996 n.2339T>A non_coding_transcript_exon_variant 0.79
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.79
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.79
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.8
rrl 1476024 n.2367T>G non_coding_transcript_exon_variant 0.76
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.76
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.76
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.73
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.75
rrl 1476045 n.2388G>C non_coding_transcript_exon_variant 0.76
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.76
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.74
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.77
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.65
rrl 1476079 n.2422G>A non_coding_transcript_exon_variant 0.5
rrl 1476080 n.2423T>C non_coding_transcript_exon_variant 0.5
rrl 1476081 n.2424A>T non_coding_transcript_exon_variant 0.47
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.41
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.47
rrl 1476104 n.2447T>G non_coding_transcript_exon_variant 0.47
rrl 1476105 n.2448G>T non_coding_transcript_exon_variant 0.47
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.47
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.44
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.5
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.61
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.63
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.82
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.84
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.84
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.84
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.88
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.89
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.9
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.92
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.92
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.9
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.93
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.93
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.93
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.93
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.83
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.83
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.85
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.92
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.95
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.95
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.95
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.96
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.93
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.91
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.86
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.86
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.86
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.86
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.86
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.86
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.86
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.85
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.86
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.5
rrl 1476586 n.2929C>T non_coding_transcript_exon_variant 0.5
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.4
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.4
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.4
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.4
rrl 1476613 n.2956G>A non_coding_transcript_exon_variant 0.4
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.4
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.4
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.4
rrl 1476629 n.2972C>T non_coding_transcript_exon_variant 0.4
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.4
rpsA 1833970 c.429G>T synonymous_variant 0.18
rpsA 1833979 c.438T>C synonymous_variant 0.21
rpsA 1833991 c.450C>A synonymous_variant 0.28
rpsA 1833994 c.453G>C synonymous_variant 0.28
rpsA 1833997 c.456G>C synonymous_variant 0.28
rpsA 1834000 c.459G>C synonymous_variant 0.28
rpsA 1834012 c.471G>T synonymous_variant 0.28
rpsA 1834024 c.483G>C synonymous_variant 0.3
rpsA 1834025 p.Gln162Ala missense_variant 0.32
rpsA 1834030 c.489C>G synonymous_variant 0.29
rpsA 1834039 c.498C>T synonymous_variant 0.3
rpsA 1834040 p.Lys167Gln missense_variant 0.3
rpsA 1834043 p.Glu168Lys missense_variant 0.3
rpsA 1834051 c.510G>A synonymous_variant 0.35
rpsA 1834057 c.516G>A synonymous_variant 0.36
rpsA 1834090 c.549G>T synonymous_variant 0.33
rpsA 1834102 c.561T>C synonymous_variant 0.26
rpsA 1834105 c.564C>T synonymous_variant 0.19
rpsA 1834114 c.573G>C synonymous_variant 0.15
rpsA 1834261 c.720A>G synonymous_variant 0.12
rpsA 1834264 c.723G>C synonymous_variant 0.12
rpsA 1834294 c.753G>T synonymous_variant 0.17
rpsA 1834298 p.Gln253Glu missense_variant 0.17
rpsA 1834306 c.765T>C synonymous_variant 0.19
rpsA 1834307 p.Asp256Gln missense_variant 0.19
rpsA 1834312 c.771G>A synonymous_variant 0.19
rpsA 1834327 c.786G>T synonymous_variant 0.26
rpsA 1834333 p.Asp264Glu missense_variant 0.27
rpsA 1834340 p.Met267Leu missense_variant 0.24
rpsA 1834348 c.807T>C synonymous_variant 0.25
rpsA 1834354 c.813G>T synonymous_variant 0.22
rpsA 1834360 c.819G>C synonymous_variant 0.23
rpsA 1834361 c.820T>C synonymous_variant 0.23
rpsA 1834366 c.825A>G synonymous_variant 0.21
rpsA 1834375 c.834G>T synonymous_variant 0.26
rpsA 1834378 c.837T>G synonymous_variant 0.26
rpsA 1834387 c.846C>T synonymous_variant 0.23
rpsA 1834395 p.Arg285Gln missense_variant 0.21
rpsA 1834397 p.His286Thr missense_variant 0.21
rpsA 1834411 c.870T>C synonymous_variant 0.24
rpsA 1834417 c.876G>C synonymous_variant 0.17
rpsA 1834427 p.Ile296Val missense_variant 0.19
rpsA 1834438 c.897C>T synonymous_variant 0.22
rpsA 1834451 c.910T>C synonymous_variant 0.22
rpsA 1834859 p.Ala440Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102193 p.Arg284Trp missense_variant 1.0
ndh 2103173 c.-132delG upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
katG 2156025 c.87C>A synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168011 p.Ser868Arg missense_variant 1.0
PPE35 2168319 p.Thr765Ile missense_variant 1.0
PPE35 2168814 c.1798dupA frameshift_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
eis 2715125 p.Thr70Ala missense_variant 1.0
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
Rv3083 3448783 p.Val94Ile missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474427 p.Val141Ile missense_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
Rv3236c 3613251 c.-135C>T upstream_gene_variant 1.0
rpoA 3878630 c.-124delC upstream_gene_variant 1.0
clpC1 4038403 c.2302T>C synonymous_variant 1.0
clpC1 4040273 c.432T>C synonymous_variant 0.13
clpC1 4040276 c.429C>G synonymous_variant 0.15
clpC1 4040291 c.414G>C synonymous_variant 0.18
clpC1 4040303 c.402G>C synonymous_variant 0.18
clpC1 4040306 c.399G>T synonymous_variant 0.17
clpC1 4040310 p.Thr132Asn missense_variant 0.17
clpC1 4040312 c.393G>T synonymous_variant 0.17
clpC1 4040315 p.Glu130Asp missense_variant 0.17
clpC1 4040318 c.387C>G synonymous_variant 0.17
clpC1 4040324 c.381G>C synonymous_variant 0.17
clpC1 4040348 c.357G>A synonymous_variant 0.17
clpC1 4040351 c.354C>T synonymous_variant 0.17
clpC1 4040363 c.342A>C synonymous_variant 0.17
clpC1 4040375 c.330G>C synonymous_variant 0.17
clpC1 4040380 c.325T>C synonymous_variant 0.16
clpC1 4040381 c.324T>C synonymous_variant 0.16
clpC1 4040387 c.318A>G synonymous_variant 0.17
clpC1 4040390 c.315C>G synonymous_variant 0.17
clpC1 4040393 c.312G>C synonymous_variant 0.19
clpC1 4040408 c.297C>A synonymous_variant 0.13
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242970 c.-263C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embB 4246551 p.Asn13Ser missense_variant 1.0
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
aftB 4267858 p.Ile327Val missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0