TB-Profiler result

Run: ERR11466146
Summary

Run ID: ERR11466146

Sample name:

Date: 2024-04-14T06:42:15.004275

Number of reads: 3774078

Percentage reads mapped: 96.19

Median coverage: 113.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
La1.2.BCG M.bovis None 0.1
lineage4 Euro-American None 0.97
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.97
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 0.9
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6140 p.Val301Leu missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9200 c.1899A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9278 c.1977G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9300 p.Ala667Ser missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0565c 657264 c.207T>C synonymous_variant 0.15 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.2 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.15 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.15 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.19 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.19 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.18 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.19 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.24 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.22 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.24 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.25 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.15 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.13 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.14 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.15 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.17 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.24 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.22 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.21 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.22 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.22 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.25 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.28 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.26 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.31 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 760541 c.735G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.17 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.18 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.25 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.24 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.2 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.23 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.24 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.26 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.24 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.16 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.22 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.17 rifampicin
rpoB 761373 p.Val523Gln missense_variant 0.14 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.2 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.17 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.17 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.17 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.17 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.17 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.17 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.16 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.17 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.23 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.21 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.25 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.26 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.29 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.24 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.25 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761720 c.1914C>G synonymous_variant 0.14 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.14 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.22 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.22 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.23 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.22 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.22 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.2 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.24 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.3 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.28 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.27 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.28 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.28 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.28 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.25 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.17 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.18 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.2 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.29 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.3 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.27 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.28 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.25 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.28 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.27 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.32 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.3 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.34 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.31 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.21 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.22 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.24 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.2 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.19 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.19 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.21 rifampicin
rpoB 762729 p.Gln975Lys missense_variant 0.19 rifampicin
rpoB 762736 p.Ala977Glu missense_variant 0.17 rifampicin
rpoB 762744 p.Gln980Ala missense_variant 0.17 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.19 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.19 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.18 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.18 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.19 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.17 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.28 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.3 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.33 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.34 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.32 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.16 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.15 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.15 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.15 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.33 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.34 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.28 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.36 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.3 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.33 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.28 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.31 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.24 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.26 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.27 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.28 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.3 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.27 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.19 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.21 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.2 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.26 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.28 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.29 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.39 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.36 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.28 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.28 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.33 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.26 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.31 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.31 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.32 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.45 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.19 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.16 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.16 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.22 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.35 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.46 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.38 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.33 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.21 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.26 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.27 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.21 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.19 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.21 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.21 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.24 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.23 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.28 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.27 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.33 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.35 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.23 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.25 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.31 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.35 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.37 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.38 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.39 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.3 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.32 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.31 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.33 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.29 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.25 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.25 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.27 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.26 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.26 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.24 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.25 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.23 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.18 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.17 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.16 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.16 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.16 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.18 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.17 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.17 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.2 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.23 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.23 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.26 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.26 rifampicin
rpoC 766393 c.3024C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>G synonymous_variant 0.3 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.31 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.31 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.17 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.19 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.19 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.2 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.14 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.14 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.16 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.16 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.23 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.3 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767014 c.3645G>C synonymous_variant 0.14 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777176 p.Glu435Asp missense_variant 0.14 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.16 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.15 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.15 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.17 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.16 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.16 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.16 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.16 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.16 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.16 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.16 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.16 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.19 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.19 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.19 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.21 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.21 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.23 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.21 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.23 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.22 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.26 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.29 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.27 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.27 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.26 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.28 linezolid
rplC 800814 c.6A>G synonymous_variant 0.2 linezolid
rplC 800817 c.9A>T synonymous_variant 0.21 linezolid
rplC 800844 c.36T>C synonymous_variant 0.2 linezolid
rplC 800865 c.57A>G synonymous_variant 0.17 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.17 linezolid
rplC 800874 c.66A>G synonymous_variant 0.15 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.14 linezolid
rplC 800880 c.72A>G synonymous_variant 0.15 linezolid
rplC 800889 c.81C>G synonymous_variant 0.16 linezolid
rplC 800892 c.84G>C synonymous_variant 0.16 linezolid
rplC 800907 c.99C>G synonymous_variant 0.17 linezolid
rplC 801357 c.549T>C synonymous_variant 0.15 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.16 linezolid
rplC 801402 c.594T>C synonymous_variant 0.15 linezolid
rplC 801405 c.597T>C synonymous_variant 0.15 linezolid
rplC 801423 c.615G>C synonymous_variant 0.14 linezolid
rplC 801426 c.618C>G synonymous_variant 0.14 linezolid
rplC 801427 p.Met207Val missense_variant 0.14 linezolid
fbiC 1303641 c.711C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.15 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1673955 c.-247G>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.14 ethionamide
isoniazid Uncertain significance
inhA 1674042 c.-160G>T upstream_gene_variant 0.14 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.15 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834262 p.Ser241Thr missense_variant 0.14 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.25 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.27 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.24 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.17 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.17 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.18 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.18 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.22 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.17 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.17 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.17 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.18 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.17 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.19 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.18 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.18 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.16 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.16 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.16 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.17 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.19 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.18 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.27 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.26 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.17 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.17 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.15 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.16 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.16 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.15 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.15 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.15 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.17 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.17 isoniazid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782928 p.Thr372Lys missense_variant 0.14 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Not assoc w R
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Not assoc w R
amikacin Uncertain significance
Rv2477c 2782936 c.1107G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783309 p.Leu245Pro missense_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783401 c.642C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2752c 3064860 c.1332G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064863 c.1329G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066467 c.-276G>A upstream_gene_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067661 c.285C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.96 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625579 c.-669A>G upstream_gene_variant 0.14 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.16 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.14 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627917 c.-568G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627920 c.-571A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
fbiA 3641440 p.Gly300Arg missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
rpoA 3877553 p.Glu319Gln missense_variant 0.19 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.2 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.19 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878713 c.-206G>A upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.14 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.17 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.26 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.28 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.21 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878920 c.-413C>T upstream_gene_variant 0.15 rifampicin
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.18 rifampicin
rpoA 3878986 c.-479G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.16 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.98 pyrazinamide Not assoc w R
clpC1 4038368 c.2337T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.13 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.33 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.18 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.18 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.19 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.17 pyrazinamide
glpK 4139597 c.159C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4238953 c.-910G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240699 c.837C>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.17 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.16 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.17 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.17 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.17 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.17 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.15 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.17 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.15 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.15 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.14 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.15 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.16 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.96 ethambutol Not assoc w R
embA 4242754 c.-479G>C upstream_gene_variant 0.15 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.16 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.19 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.19 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.18 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.17 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.15 ethambutol
embA 4246080 c.2848_2850delCCTinsTC frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
embA 4246164 c.2932T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.17 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.2 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.19 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.17 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.17 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4246223 c.-291C>T upstream_gene_variant 0.15 ethambutol
embA 4246227 p.Ile999Val missense_variant 0.15 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Glu missense_variant 0.15 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.16 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.17 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.17 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.18 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.15 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.2 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.2 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.15 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.18 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.19 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.19 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.25 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.26 ethambutol
embB 4248111 p.Val533Ala missense_variant 0.19 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.18 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.18 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R