TB-Profiler result

Run: SRR1196677
Summary

Run ID: SRR1196677

Sample name:

Date: 2024-04-15T22:16:08.175990

Number of reads: 359775

Percentage reads mapped: 43.38

Median coverage: 7.0

Strain: lineage2.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
La1.2.BCG M.bovis None 0.06
lineage2.2 East-Asian (Beijing) RD105;RD207 0.49
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin tlyA c.4_6delGCAinsTT Assoc w R
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance Mutation from literature
tlyA 1917943 c.4_6delGCAinsTT frameshift_variant&missense_variant 0.54 capreomycin Assoc w R
embB 4247448 p.His312Arg missense_variant 0.7 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 771 c.771A>C synonymous_variant 0.41 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.41 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.41 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.37 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.44 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.44 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.5 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.55 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.5 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.5 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.46 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.5 isoniazid
gyrB 6115 c.876A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.46 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6787 c.-515G>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.56 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.6 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8111 c.810G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.57 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9200 c.1899A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.57 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
fgd1 491535 c.753G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.62 clofazimine
pretomanid
delamanid
mshA 575770 c.423G>A synonymous_variant 0.64 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.64 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.67 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.62 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.69 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.69 ethionamide
isoniazid
ccsA 620340 c.450C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.6 capreomycin
amikacin
kanamycin
hadA 731774 c.-156T>C upstream_gene_variant 0.79 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.86 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.86 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.77 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.64 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.67 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.69 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.69 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.71 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.67 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.62 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.71 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.68 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.7 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.71 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.8 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.74 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.75 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.67 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.73 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.73 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.73 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.73 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.73 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.92 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.92 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.71 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.79 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.58 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.62 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.83 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.72 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.72 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.73 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.63 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.63 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.63 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.53 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.56 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.75 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.86 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.92 rifampicin
rpoB 761373 p.Val523His missense_variant 0.91 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 1.0 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.83 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.87 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.54 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.54 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.5 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.47 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.47 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.67 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.67 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.67 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.62 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.62 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.57 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.53 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.64 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.65 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.61 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.65 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.62 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.57 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.57 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.57 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.55 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.65 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.67 rifampicin
rpoB 763034 c.3228C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.64 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.5 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.45 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.39 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.39 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.5 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.5 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.62 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.73 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.85 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.62 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.6 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.62 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.67 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.67 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.62 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.53 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.53 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.5 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.63 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.75 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.71 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.68 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.68 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.67 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.67 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.63 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.63 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.55 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.55 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.56 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.56 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.47 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.53 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.5 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.47 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.53 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.76 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.53 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.53 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.67 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.62 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.62 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.64 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.64 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.6 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.6 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.69 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.65 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.58 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.58 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.53 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.5 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.71 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.58 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.54 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.5 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.69 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.6 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.6 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.67 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.68 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.68 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.68 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.68 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.5 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.5 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.8 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.8 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.75 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.71 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.69 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.75 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.73 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.71 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.68 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.75 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.78 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.38 rifampicin
mmpL5 777158 c.1323C>G synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.67 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.67 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.67 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.47 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.47 clofazimine
bedaquiline
rpsL 781728 c.169T>C synonymous_variant 0.6 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.65 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.65 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.69 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.79 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.71 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.64 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.6 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.64 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.6 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.64 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.53 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.55 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.59 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.62 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.79 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.68 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.62 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.65 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.67 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.58 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.58 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.67 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.6 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.6 linezolid
rplC 800814 c.6A>G synonymous_variant 0.6 linezolid
rplC 800817 c.9A>T synonymous_variant 0.64 linezolid
rplC 800844 c.36T>C synonymous_variant 0.62 linezolid
rplC 801132 c.324T>C synonymous_variant 0.6 linezolid
rplC 801147 c.339T>C synonymous_variant 0.62 linezolid
rplC 801150 c.342G>C synonymous_variant 0.62 linezolid
rplC 801153 c.345G>C synonymous_variant 0.62 linezolid
rplC 801156 c.348T>A synonymous_variant 0.62 linezolid
rplC 801168 c.360C>G synonymous_variant 0.62 linezolid
rplC 801171 c.363A>G synonymous_variant 0.62 linezolid
rplC 801174 c.366T>C synonymous_variant 0.62 linezolid
rplC 801195 c.387G>C synonymous_variant 0.67 linezolid
rplC 801207 c.399C>T synonymous_variant 0.64 linezolid
fbiC 1304004 c.1074A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304891 p.Ile654Thr missense_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
atpE 1460840 c.-205A>G upstream_gene_variant 0.44 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.44 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.47 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.47 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.47 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.54 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.54 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.46 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474958 n.1301A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
inhA 1674555 c.354G>A synonymous_variant 0.7 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.73 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.58 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.64 ethionamide
isoniazid Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.58 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.55 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.47 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.82 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.79 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.77 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.92 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.8 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.77 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.79 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.71 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.67 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.57 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.83 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.8 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.81 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.84 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.86 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.69 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.69 pyrazinamide
tlyA 1917929 c.-11T>C upstream_gene_variant 0.58 capreomycin
tlyA 1917937 c.-3_-2insC upstream_gene_variant 0.54 capreomycin
tlyA 1917940 p.Val1Met missense_variant 0.54 capreomycin
tlyA 1917951 c.12T>C synonymous_variant 0.6 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.62 capreomycin
bacA 2063259 p.Glu490Asp missense_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063265 p.Gly488Asp missense_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063271 c.1458G>T synonymous_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063275 p.His485Cys missense_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063280 c.1449C>G synonymous_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063283 c.1446G>A synonymous_variant 0.62 streptomycin Not assoc w R - Interim
kanamycin
capreomycin
amikacin
bacA 2063289 c.1440A>C synonymous_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063303 c.1426C>T synonymous_variant 0.57 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin
amikacin Not assoc w R - Interim
bacA 2063307 c.1422G>C synonymous_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063313 c.1416T>C synonymous_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101939 c.1104A>G synonymous_variant 0.7 ethionamide
delamanid
isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.81 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.6 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.7 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.7 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.73 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.73 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.73 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.73 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.55 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.5 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.5 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.5 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.5 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.5 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.5 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.54 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.58 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.75 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.7 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.55 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.55 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.55 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.55 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.67 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.77 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.77 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.77 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.77 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.73 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.71 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.67 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.62 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.75 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.67 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.69 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.64 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.75 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.81 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.87 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.88 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.88 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.83 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.75 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.62 isoniazid
ahpC 2726216 c.24T>C synonymous_variant 0.6 isoniazid
ahpC 2726219 c.27A>G synonymous_variant 0.55 isoniazid
ahpC 2726232 p.Gln14Glu missense_variant 0.58 isoniazid
ahpC 2726243 c.51T>G synonymous_variant 0.58 isoniazid
ahpC 2726244 c.52_54delCTCinsTG frameshift_variant&missense_variant 0.58 isoniazid Uncertain significance
ahpC 2726251 p.Gly20Ala missense_variant 0.58 isoniazid Uncertain significance
ahpC 2726255 c.63T>C synonymous_variant 0.58 isoniazid Not assoc w R - Interim
ahpC 2726258 c.66C>T synonymous_variant 0.62 isoniazid Not assoc w R - Interim
ahpC 2726303 c.111T>C synonymous_variant 0.69 isoniazid
Rv2477c 2782936 c.1107G>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.67 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065901 c.291A>C synonymous_variant 0.7 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.64 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 p.Ala89Gly missense_variant 0.64 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.64 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.71 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.65 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065988 c.204A>G synonymous_variant 0.67 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.6 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066093 c.99T>C synonymous_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067685 c.261A>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.55 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625656 c.958T>C synonymous_variant 0.35 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.77 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.82 bedaquiline
rifampicin Uncertain significance
mtrB 3625797 p.Val273Met missense_variant 0.9 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625843 c.-933C>G upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.6 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626866 c.-253T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.74 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.63 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.54 bedaquiline
rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.64 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.65 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.61 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.65 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.75 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.83 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.71 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 1.0 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.8 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.8 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.73 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.73 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.73 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.73 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.73 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.67 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.6 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.7 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.73 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.83 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.85 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.85 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.85 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.92 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.86 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.88 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.88 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.83 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.6 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.59 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.62 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.62 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.62 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.62 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.67 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.67 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.55 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.64 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.6 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.58 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.55 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.68 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.63 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.67 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.67 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.65 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.56 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.53 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.73 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.69 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.73 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.77 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.62 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.62 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.64 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.6 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.62 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.63 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.63 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.57 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.57 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.8 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.45 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.58 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.54 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039898 c.807C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.71 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.67 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.62 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.5 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.43 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.56 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.61 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.59 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.53 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.53 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.59 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.56 pyrazinamide
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.6 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138718 c.1038T>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.64 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.62 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240819 c.957A>G synonymous_variant 0.58 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.6 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.8 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.8 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.8 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.8 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.71 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.71 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.77 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.8 ethambutol Not assoc w R - Interim
embA 4245060 c.1828T>C synonymous_variant 0.55 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.75 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.77 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.71 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.71 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.69 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.69 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.73 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.69 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.75 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.7 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.7 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.69 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.71 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.94 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.83 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.7 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.6 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.52 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.47 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.44 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.43 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.5 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.5 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.5 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.5 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.6 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.6 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.53 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.67 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.65 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.65 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.65 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.72 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.64 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.64 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.73 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.64 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.62 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.54 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.54 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.64 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.64 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.67 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.82 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.82 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.91 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.82 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.73 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.73 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.73 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.73 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.76 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.59 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.59 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.73 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.73 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.73 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.8 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.8 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.75 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.75 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.73 ethambutol