TB-Profiler result

Run: SRR22175249
Summary

Run ID: SRR22175249

Sample name:

Date: 04-04-2023 04:02:54

Number of reads: 1015419

Percentage reads mapped: 45.11

Strain: lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Gly missense_variant 0.97 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 0.94 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.95 streptomycin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.63 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.66 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.53 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288766 p.Leu159Arg missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
ethA 4326922 c.549_551delTGG disruptive_inframe_deletion 1.0 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491290 p.Val170Met missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 760916 c.1110C>T synonymous_variant 0.14
rpoB 760920 p.Leu372Met missense_variant 0.14
rpoB 760925 c.1119T>C synonymous_variant 0.14
rpoB 760931 c.1125C>G synonymous_variant 0.18
rpoB 760944 p.Gln380Glu missense_variant 0.14
rpoB 760955 c.1151_1152insCACG frameshift_variant 0.2
rpoB 760961 c.1156_1159delGGCA frameshift_variant 0.24
rpoB 760970 c.1164G>C synonymous_variant 0.37
rpoB 760973 c.1167G>C synonymous_variant 0.36
rpoB 760982 c.1176G>C synonymous_variant 0.42
rpoB 760988 c.1182C>G synonymous_variant 0.48
rpoB 760991 c.1185G>C synonymous_variant 0.5
rpoB 760997 c.1191G>C synonymous_variant 0.12
rpoB 761015 c.1209G>C synonymous_variant 0.62
rpoB 761021 c.1215G>C synonymous_variant 0.13
rpoB 761027 c.1221A>G synonymous_variant 0.71
rpoB 761036 c.1230G>C synonymous_variant 0.9
rpoB 761037 c.1231T>C synonymous_variant 0.9
rpoB 761051 c.1245G>C synonymous_variant 0.7
rpoB 761057 c.1251G>C synonymous_variant 0.8
rpoB 761060 c.1254C>G synonymous_variant 0.7
rpoB 761066 c.1260G>C synonymous_variant 0.18
rpoB 761084 c.1278C>G synonymous_variant 0.42
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.42
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.33
rpoB 761102 c.1296A>G synonymous_variant 0.44
rpoB 761941 c.2137delC frameshift_variant 0.15
rpoB 761973 p.His723Tyr missense_variant 0.12
rpoB 761999 c.2193G>C synonymous_variant 0.11
rpoB 762003 p.Asn733Gln missense_variant 0.12
rpoB 762009 p.Leu735Ile missense_variant 0.12
rpoB 762014 c.2208C>G synonymous_variant 0.11
rpoB 762015 p.Glu737Gln missense_variant 0.11
rpoB 762020 p.Glu738Asp missense_variant 0.11
rpoB 762026 c.2220G>C synonymous_variant 0.14
rpoB 762030 p.Thr742Ser missense_variant 0.18
rpoB 762053 c.2247T>C synonymous_variant 0.25
rpoB 762057 p.Ile751Val missense_variant 0.28
rpoB 762062 c.2256T>C synonymous_variant 0.28
rpoB 762065 c.2259T>C synonymous_variant 0.28
rpoB 762083 c.2277T>C synonymous_variant 0.26
rpoB 762084 p.Ala760Pro missense_variant 0.27
rpoB 762110 c.2304G>C synonymous_variant 0.33
rpoB 762114 p.Ile770Val missense_variant 0.31
rpoB 762122 p.Asp772Glu missense_variant 0.34
rpoB 762128 c.2322G>C synonymous_variant 0.31
rpoB 762140 c.2334G>C synonymous_variant 0.26
rpoB 762143 c.2337T>C synonymous_variant 0.25
rpoB 762149 c.2343G>C synonymous_variant 0.36
rpoB 762152 c.2346C>G synonymous_variant 0.26
rpoB 762156 p.Val784Ile missense_variant 0.35
rpoB 762167 c.2361T>C synonymous_variant 0.28
rpoB 762176 c.2370T>G synonymous_variant 0.36
rpoB 762178 p.Arg791Gln missense_variant 0.14
rpoB 762181 p.Asp792Ala missense_variant 0.14
rpoB 762185 c.2379G>C synonymous_variant 0.44
rpoB 762189 p.Ile795Leu missense_variant 0.3
rpoB 762194 c.2388G>C synonymous_variant 0.45
rpoB 762197 c.2391C>G synonymous_variant 0.17
rpoB 762209 c.2403C>G synonymous_variant 0.38
rpoB 762212 c.2406G>C synonymous_variant 0.38
rpoB 762218 c.2412T>C synonymous_variant 0.14
rpoB 762233 c.2427G>C synonymous_variant 0.35
rpoB 762236 c.2430G>C synonymous_variant 0.21
rpoB 762245 c.2439G>C synonymous_variant 0.18
rpoB 762254 c.2448T>C synonymous_variant 0.29
rpoB 762257 c.2451C>G synonymous_variant 0.14
rpoB 762266 c.2460T>C synonymous_variant 0.12
rpoB 762273 p.Ala823Ser missense_variant 0.12
rpoB 762284 c.2478G>C synonymous_variant 0.17
rpoB 762293 c.2487T>C synonymous_variant 0.14
rpoB 762296 c.2490G>C synonymous_variant 0.13
rpoB 762299 c.2493G>C synonymous_variant 0.14
rpoC 762959 c.-411G>C upstream_gene_variant 0.13
rpoC 762962 c.-408C>T upstream_gene_variant 0.13
rpoC 762989 c.-381G>C upstream_gene_variant 0.22
rpoC 762995 c.-375G>C upstream_gene_variant 0.23
rpoB 763005 p.Cys1067Val missense_variant 0.21
rpoB 763014 p.Met1070Leu missense_variant 0.24
rpoB 763017 p.Gln1071Glu missense_variant 0.2
rpoC 763022 c.-348C>G upstream_gene_variant 0.2
rpoC 763028 c.-342T>C upstream_gene_variant 0.21
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoB 763038 p.Thr1078Ala missense_variant 0.16
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.13
rpoC 763070 c.-300T>C upstream_gene_variant 0.12
rpoB 763074 p.Thr1090Val missense_variant 0.12
rpoC 763486 c.117T>C synonymous_variant 0.13
rpoC 763492 c.123G>C synonymous_variant 0.14
rpoC 763528 c.159G>C synonymous_variant 0.11
rpoC 763531 c.162G>C synonymous_variant 0.2
rpoC 763534 c.165T>C synonymous_variant 0.23
rpoC 763537 c.168C>G synonymous_variant 0.24
rpoC 763546 c.177A>G synonymous_variant 0.25
rpoC 763558 c.189C>T synonymous_variant 0.13
rpoC 763570 c.201G>T synonymous_variant 0.18
rpoC 763573 c.204G>C synonymous_variant 0.13
rpoC 763578 p.Phe70Tyr missense_variant 0.19
rpoC 763609 c.240C>G synonymous_variant 0.24
rpoC 763615 c.246G>C synonymous_variant 0.33
rpoC 763618 c.249C>G synonymous_variant 0.32
rpoC 763660 c.291T>C synonymous_variant 0.38
rpoC 763666 c.297G>T synonymous_variant 0.33
rpoC 763672 c.303C>G synonymous_variant 0.27
rpoC 763696 c.327T>C synonymous_variant 0.22
rpoC 763708 c.339G>C synonymous_variant 0.21
rpoC 763709 c.340C>T synonymous_variant 0.21
rpoC 763717 c.348T>C synonymous_variant 0.24
rpoC 763729 c.360G>C synonymous_variant 0.19
rpoC 763744 c.375G>C synonymous_variant 0.13
rpoC 763751 p.Ile128Val missense_variant 0.12
rpoC 764377 c.1008C>G synonymous_variant 0.11
rpoC 764380 c.1011G>C synonymous_variant 0.11
rpoC 764389 p.Leu340Phe missense_variant 0.11
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.17
rpoC 764410 c.1041G>C synonymous_variant 0.13
rpoC 764428 c.1059G>C synonymous_variant 0.17
rpoC 764431 c.1062G>C synonymous_variant 0.16
rpoC 764434 c.1065A>G synonymous_variant 0.16
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.17
rpoC 764441 p.Ile358Leu missense_variant 0.17
rpoC 764446 c.1077T>C synonymous_variant 0.15
rpoC 764449 c.1080G>C synonymous_variant 0.14
rpoC 764458 c.1089G>C synonymous_variant 0.15
rpoC 764461 c.1092A>G synonymous_variant 0.15
rpoC 764485 c.1116G>C synonymous_variant 0.11
rpoC 764497 c.1128A>G synonymous_variant 0.26
rpoC 764498 p.Ser377Ala missense_variant 0.24
rpoC 764503 c.1134G>C synonymous_variant 0.17
rpoC 764521 c.1152T>C synonymous_variant 0.29
rpoC 764527 c.1158C>T synonymous_variant 0.23
rpoC 764533 c.1164C>T synonymous_variant 0.3
rpoC 764539 c.1170C>G synonymous_variant 0.31
rpoC 764542 c.1173C>G synonymous_variant 0.3
rpoC 764560 c.1191T>C synonymous_variant 0.26
rpoC 764566 c.1197C>G synonymous_variant 0.13
rpoC 764573 p.Leu402Ile missense_variant 0.26
rpoC 764581 c.1212T>C synonymous_variant 0.46
rpoC 764582 p.Leu405Met missense_variant 0.47
rpoC 764605 c.1236G>C synonymous_variant 0.22
rpoC 764611 c.1242G>T synonymous_variant 0.54
rpoC 764623 c.1254C>G synonymous_variant 0.22
rpoC 764632 c.1263T>C synonymous_variant 0.52
rpoC 764635 c.1266C>G synonymous_variant 0.2
rpoC 764641 c.1272C>T synonymous_variant 0.21
rpoC 764644 c.1275G>C synonymous_variant 0.54
rpoC 764647 c.1278C>T synonymous_variant 0.21
rpoC 764650 c.1281G>T synonymous_variant 0.53
rpoC 764653 c.1284G>C synonymous_variant 0.21
rpoC 764656 c.1287C>G synonymous_variant 0.21
rpoC 764662 c.1293G>C synonymous_variant 0.33
rpoC 764665 c.1296C>G synonymous_variant 0.23
rpoC 764671 c.1302G>C synonymous_variant 0.39
rpoC 764672 p.Gln435Thr missense_variant 0.3
rpoC 764677 c.1308C>G synonymous_variant 0.23
rpoC 764703 p.Lys445Arg missense_variant 0.45
rpoC 764706 p.Leu446Gln missense_variant 0.52
rpoC 764713 c.1344G>C synonymous_variant 0.29
rpoC 764714 c.1345C>T synonymous_variant 0.24
rpoC 764719 c.1350G>A synonymous_variant 0.27
rpoC 764722 c.1353G>C synonymous_variant 0.3
rpoC 764731 c.1362G>C synonymous_variant 0.11
rpoC 764746 c.1377G>C synonymous_variant 0.47
rpoC 764749 c.1380G>C synonymous_variant 0.46
rpoC 764752 c.1383G>C synonymous_variant 0.34
rpoC 764758 c.1389C>G synonymous_variant 0.12
rpoC 764759 p.Asn464Asp missense_variant 0.31
rpoC 764764 c.1395T>C synonymous_variant 0.41
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.35
rpoC 764797 c.1428G>C synonymous_variant 0.18
rpoC 764801 c.1433_1434insTG frameshift_variant 0.12
rpoC 764804 c.1436_1437delAG frameshift_variant 0.13
rpoC 764812 c.1443C>G synonymous_variant 0.24
rpoC 764815 c.1446A>G synonymous_variant 0.24
rpoC 764824 c.1455T>C synonymous_variant 0.25
rpoC 764833 c.1464A>G synonymous_variant 0.17
rpoC 764843 p.Ala492Thr missense_variant 0.29
rpoC 764858 c.1489T>C synonymous_variant 0.2
rpoC 764863 c.1494G>C synonymous_variant 0.15
rpoC 764869 c.1500C>T synonymous_variant 0.17
rpoC 764878 c.1509C>G synonymous_variant 0.15
rpoC 764887 c.1518G>T synonymous_variant 0.12
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.12
rpoC 764893 c.1524T>C synonymous_variant 0.12
rpoC 764911 c.1542A>G synonymous_variant 0.12
rpoC 764912 p.Met515Gln missense_variant 0.12
rpoC 764917 c.1548G>C synonymous_variant 0.12
rpoC 764920 c.1551G>C synonymous_variant 0.12
rpoC 764923 c.1554A>G synonymous_variant 0.13
rpoC 764935 c.1566T>C synonymous_variant 0.12
rpoC 764941 c.1572G>C synonymous_variant 0.11
rpoC 764948 c.1579T>C synonymous_variant 0.11
rpoC 764956 c.1587T>C synonymous_variant 0.1
rpoC 764958 p.Glu530Gly missense_variant 0.1
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775966 p.Ala839Thr missense_variant 0.12
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.11
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.13
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.39
rrs 1472107 n.262A>G non_coding_transcript_exon_variant 0.13
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.11
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.59
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.56
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.19
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.61
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.21
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.22
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.33
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.38
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.52
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.53
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.56
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.56
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.52
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.24
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.3
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.33
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.58
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.25
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.25
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.27
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.19
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.19
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.2
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.2
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.24
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.43
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.3
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.5
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.5
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.41
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.2
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.33
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.24
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.61
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.6
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.63
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.18
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.55
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.44
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.37
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.53
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.36
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.19
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.14
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.49
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.24
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.45
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.61
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.61
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.61
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.43
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.68
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.67
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.47
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.67
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.73
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.73
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.73
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.71
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.45
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.26
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.4
rrs 1473091 n.1246G>T non_coding_transcript_exon_variant 0.26
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.39
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.37
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.65
rrs 1473109 n.1264T>C non_coding_transcript_exon_variant 0.29
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.64
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.64
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.34
rrs 1473120 n.1275C>A non_coding_transcript_exon_variant 0.31
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.64
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.32
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.34
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.3
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.35
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.33
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.68
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.39
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.64
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.57
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.56
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.56
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.32
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.12
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.14
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.17
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.23
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.23
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.23
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.21
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.17
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.16
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.16
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.14
rrl 1473950 n.293G>T non_coding_transcript_exon_variant 0.14
rrl 1473957 n.300G>T non_coding_transcript_exon_variant 0.14
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.14
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.13
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.12
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.12
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.12
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.12
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.15
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.15
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.12
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.19
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.13
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.17
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.15
rrl 1474292 n.636_649delTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.18
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.15
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.15
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.16
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.17
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.17
rrl 1474353 n.696A>C non_coding_transcript_exon_variant 0.13
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.17
rrl 1474355 n.698A>T non_coding_transcript_exon_variant 0.13
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.18
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.13
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.18
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.27
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.29
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.33
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.42
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.67
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.6
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.6
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.72
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.55
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.55
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.69
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.52
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.52
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.63
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.41
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.63
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.63
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.22
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.64
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.62
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.23
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.52
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.22
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.44
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.44
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.57
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.39
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.55
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.36
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.57
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.17
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.39
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.59
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.56
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.54
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.35
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.19
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.63
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.12
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.56
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.55
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.42
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.12
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.32
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.32
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.17
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.16
rrl 1475697 n.2040C>A non_coding_transcript_exon_variant 0.17
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.43
rrl 1475702 n.2045G>T non_coding_transcript_exon_variant 0.17
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.17
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.31
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.19
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.21
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 0.33
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.21
rrl 1475756 n.2101dupA non_coding_transcript_exon_variant 0.41
rrl 1475765 n.2108A>C non_coding_transcript_exon_variant 0.45
rrl 1475768 n.2112dupT non_coding_transcript_exon_variant 0.45
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.21
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.21
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.21
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.36
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.39
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.52
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.58
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.32
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.33
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.71
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.71
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.55
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.5
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.42
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.72
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.3
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.69
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.38
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.59
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.59
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.58
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.39
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.58
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.42
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.42
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.55
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.25
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.19
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.35
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.32
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.33
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.36
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.36
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.58
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.65
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.43
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.24
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.66
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.24
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.63
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.4
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.63
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.62
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.33
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.22
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.48
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.52
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.44
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.76
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.67
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.61
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.62
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.68
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.4
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.54
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.17
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.48
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.13
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.32
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.4
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.4
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.12
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.28
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.28
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.12
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.37
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.37
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.27
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.12
rpsA 1833727 c.186G>C synonymous_variant 0.15
rpsA 1833734 p.Ala65Ser missense_variant 0.17
rpsA 1833742 c.201A>G synonymous_variant 0.19
rpsA 1833745 c.204G>C synonymous_variant 0.14
rpsA 1833781 c.240T>C synonymous_variant 0.17
rpsA 1833782 p.Ser81Gly missense_variant 0.2
rpsA 1833790 c.249T>C synonymous_variant 0.16
rpsA 1833802 c.261A>G synonymous_variant 0.19
rpsA 1833811 c.270G>C synonymous_variant 0.14
rpsA 1833815 p.Thr92His missense_variant 0.11
rpsA 1833835 c.294C>T synonymous_variant 0.17
rpsA 1833841 c.300C>G synonymous_variant 0.23
rpsA 1833847 c.306C>G synonymous_variant 0.16
rpsA 1833856 c.315A>G synonymous_variant 0.23
rpsA 1833862 c.321G>C synonymous_variant 0.19
rpsA 1833874 c.333T>C synonymous_variant 0.33
rpsA 1833877 c.336C>G synonymous_variant 0.14
rpsA 1833884 p.Thr115Asp missense_variant 0.18
rpsA 1833893 p.Ala118Lys missense_variant 0.3
rpsA 1833896 p.Leu119Val missense_variant 0.3
rpsA 1833905 p.Lys122Glu missense_variant 0.29
rpsA 1833912 p.Glu124Gly missense_variant 0.3
rpsA 1833915 p.Ala125Val missense_variant 0.3
rpsA 1833921 p.Lys127Thr missense_variant 0.34
rpsA 1833928 c.387G>C synonymous_variant 0.32
rpsA 1833949 c.408T>C synonymous_variant 0.38
rpsA 1833955 c.414G>C synonymous_variant 0.42
rpsA 1833961 c.420C>G synonymous_variant 0.23
rpsA 1833970 c.429G>C synonymous_variant 0.36
rpsA 1833976 c.435C>T synonymous_variant 0.16
rpsA 1833979 c.438T>C synonymous_variant 0.34
rpsA 1833988 c.447C>G synonymous_variant 0.13
rpsA 1833994 c.453G>C synonymous_variant 0.24
rpsA 1833997 c.456G>C synonymous_variant 0.32
rpsA 1834000 c.459G>C synonymous_variant 0.11
rpsA 1834012 c.471G>C synonymous_variant 0.19
rpsA 1834015 c.474G>C synonymous_variant 0.16
rpsA 1834024 c.483G>C synonymous_variant 0.19
rpsA 1834025 p.Gln162Ala missense_variant 0.17
rpsA 1834030 c.489C>G synonymous_variant 0.2
rpsA 1834039 c.498C>T synonymous_variant 0.16
rpsA 1834040 p.Lys167Gln missense_variant 0.25
rpsA 1834043 p.Glu168Gln missense_variant 0.16
rpsA 1834046 p.Ile169Leu missense_variant 0.17
rpsA 1834069 c.528G>C synonymous_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834222 c.681T>C synonymous_variant 0.11
rpsA 1834234 c.693G>C synonymous_variant 0.14
rpsA 1834243 c.702G>C synonymous_variant 0.15
rpsA 1834246 c.705G>C synonymous_variant 0.15
rpsA 1834249 c.708T>C synonymous_variant 0.15
rpsA 1834261 c.720A>C synonymous_variant 0.15
rpsA 1834285 c.744G>C synonymous_variant 0.33
rpsA 1834294 c.753G>C synonymous_variant 0.4
rpsA 1834298 p.Gln253Glu missense_variant 0.4
rpsA 1834303 c.762T>C synonymous_variant 0.39
rpsA 1834307 p.Asp256Gln missense_variant 0.38
rpsA 1834310 p.Glu257Lys missense_variant 0.25
rpsA 1834327 c.786G>C synonymous_variant 0.32
rpsA 1834330 c.789C>G synonymous_variant 0.13
rpsA 1834336 c.795C>G synonymous_variant 0.14
rpsA 1834345 c.804C>T synonymous_variant 0.15
rpsA 1834348 c.807T>C synonymous_variant 0.37
rpsA 1834354 c.813G>T synonymous_variant 0.3
rpsA 1834357 c.816T>C synonymous_variant 0.22
rpsA 1834360 c.819G>C synonymous_variant 0.19
rpsA 1834361 c.820T>C synonymous_variant 0.29
rpsA 1834366 c.825A>G synonymous_variant 0.29
rpsA 1834378 c.837T>G synonymous_variant 0.19
rpsA 1834384 c.843A>G synonymous_variant 0.19
rpsA 1834395 p.Arg285Gln missense_variant 0.26
rpsA 1834411 c.870T>C synonymous_variant 0.28
rpsA 1834417 c.876G>C synonymous_variant 0.23
rpsA 1834423 c.882G>C synonymous_variant 0.23
rpsA 1834427 p.Ile296Val missense_variant 0.22
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.19
rpsA 1834456 c.915T>C synonymous_variant 0.19
rpsA 1834468 c.927A>G synonymous_variant 0.19
rpsA 1834474 c.933C>G synonymous_variant 0.17
rpsA 1834483 p.Glu314Asp missense_variant 0.12
rpsA 1834486 p.Glu315Asp missense_variant 0.12
rpsA 1834498 c.957C>T synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154069 c.2043G>A synonymous_variant 0.14
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3642549 p.Gln339Lys missense_variant 0.13
clpC1 4038878 c.1827A>G synonymous_variant 0.12
clpC1 4038881 c.1824C>T synonymous_variant 0.12
clpC1 4039850 c.855T>C synonymous_variant 0.15
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.19
clpC1 4039934 c.771G>C synonymous_variant 0.18
clpC1 4039940 c.765G>C synonymous_variant 0.19
clpC1 4039952 c.753T>C synonymous_variant 0.18
clpC1 4039991 c.714G>C synonymous_variant 0.17
clpC1 4039994 p.Glu237Asp missense_variant 0.15
clpC1 4039997 c.708C>G synonymous_variant 0.16
clpC1 4040001 p.His235Arg missense_variant 0.15
clpC1 4040009 c.696C>G synonymous_variant 0.18
clpC1 4040015 c.690G>C synonymous_variant 0.16
clpC1 4040021 c.684A>C synonymous_variant 0.18
clpC1 4040024 c.681A>G synonymous_variant 0.26
clpC1 4040027 c.678C>G synonymous_variant 0.16
clpC1 4040042 c.663C>T synonymous_variant 0.13
clpC1 4040108 c.597G>C synonymous_variant 0.11
embC 4241022 p.Ala387Val missense_variant 0.96
embC 4241443 c.1581C>T synonymous_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243190 c.-43G>C upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407620 p.Tyr195His missense_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0
gid 4408382 c.-180A>G upstream_gene_variant 0.11