TB-Profiler result

Run: SRR7645928
Summary

Run ID: SRR7645928

Sample name:

Date: 04-04-2023 19:59:00

Number of reads: 750170

Percentage reads mapped: 41.49

Strain: lineage4.7

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761196 p.Leu464Met missense_variant 0.33 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.79 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.85 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.7 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6154 c.915C>G synonymous_variant 0.14
gyrB 6160 c.921C>T synonymous_variant 0.18
gyrB 6169 c.930C>G synonymous_variant 0.19
gyrB 6190 c.951A>G synonymous_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7832 c.531G>C synonymous_variant 0.33
gyrA 7835 c.534A>C synonymous_variant 0.33
gyrA 7837 p.Gly179Ala missense_variant 0.33
gyrA 7847 c.546G>C synonymous_variant 0.33
gyrA 7850 c.549C>G synonymous_variant 0.36
gyrA 7859 c.558A>C synonymous_variant 0.4
gyrA 7865 c.564T>C synonymous_variant 0.44
gyrA 7886 c.585T>C synonymous_variant 0.43
fgd1 490933 c.155delC frameshift_variant 0.15
ccsA 619969 p.Val27Ile missense_variant 0.15
rpoB 760991 c.1185G>C synonymous_variant 0.12
rpoB 760997 c.1191G>C synonymous_variant 0.26
rpoB 761015 c.1209G>C synonymous_variant 0.25
rpoB 761027 c.1221A>C synonymous_variant 0.39
rpoB 761036 c.1230G>C synonymous_variant 0.36
rpoB 761037 c.1231T>C synonymous_variant 0.36
rpoB 761051 c.1245G>C synonymous_variant 0.45
rpoB 761054 c.1248G>C synonymous_variant 0.45
rpoB 761060 c.1254C>G synonymous_variant 0.45
rpoB 761063 c.1257C>G synonymous_variant 0.45
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.56
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.4
rpoB 761102 c.1296A>G synonymous_variant 0.43
rpoB 761111 c.1305C>T synonymous_variant 0.4
rpoB 761147 c.1341C>T synonymous_variant 0.27
rpoB 761150 c.1344A>G synonymous_variant 0.25
rpoB 761156 c.1350G>C synonymous_variant 0.25
rpoB 761159 c.1353G>T synonymous_variant 0.23
rpoB 761165 c.1359G>C synonymous_variant 0.25
rpoB 761174 c.1368T>C synonymous_variant 0.25
rpoB 761180 c.1374A>C synonymous_variant 0.25
rpoB 761183 c.1377T>C synonymous_variant 0.27
rpoB 761186 p.Glu460Asp missense_variant 0.27
rpoB 761189 c.1383T>C synonymous_variant 0.27
rpoB 761195 c.1389G>C synonymous_variant 0.27
rpoB 761201 c.1395G>A synonymous_variant 0.33
rpoB 761213 c.1407G>C synonymous_variant 0.36
rpoB 761234 c.1428G>C synonymous_variant 0.33
rpoB 761249 c.1443A>G synonymous_variant 0.18
rpoB 761537 c.1731C>G synonymous_variant 0.25
rpoB 761558 c.1752C>G synonymous_variant 0.38
rpoB 761564 c.1758G>T synonymous_variant 0.38
rpoB 761565 p.Met587Leu missense_variant 0.43
rpoB 761570 c.1764T>C synonymous_variant 0.43
rpoB 761573 c.1767C>G synonymous_variant 0.38
rpoB 761575 p.Phe590Tyr missense_variant 0.38
rpoB 761579 c.1773G>C synonymous_variant 0.5
rpoB 761600 c.1794T>C synonymous_variant 0.55
rpoB 761603 c.1797C>G synonymous_variant 0.6
rpoB 761612 c.1806G>C synonymous_variant 0.4
rpoB 761615 c.1809A>C synonymous_variant 0.38
rpoB 761633 c.1827G>C synonymous_variant 0.33
rpoB 761643 p.Val613Leu missense_variant 0.22
rpoB 761961 p.Pro719Ser missense_variant 0.29
rpoB 761974 p.His723Leu missense_variant 0.44
rpoB 761990 c.2184G>C synonymous_variant 0.3
rpoB 762003 p.Asn733Gln missense_variant 0.27
rpoB 762008 c.2202C>G synonymous_variant 0.27
rpoB 762009 p.Leu735Met missense_variant 0.27
rpoB 762015 p.Glu737Ser missense_variant 0.21
rpoB 762020 p.Glu738Asp missense_variant 0.21
rpoB 762026 c.2220G>C synonymous_variant 0.23
rpoB 762029 c.2223C>G synonymous_variant 0.31
rpoB 762053 c.2247T>C synonymous_variant 0.26
rpoB 762065 c.2259T>C synonymous_variant 0.12
rpoB 762068 c.2262C>T synonymous_variant 0.18
rpoB 762080 c.2274G>C synonymous_variant 0.13
rpoB 762086 c.2280G>C synonymous_variant 0.13
rpoB 762098 c.2292C>G synonymous_variant 0.18
rpoB 762185 c.2379G>C synonymous_variant 0.31
rpoB 762209 c.2403C>G synonymous_variant 0.25
rpoB 762212 c.2406G>C synonymous_variant 0.25
rpoB 762218 c.2412T>C synonymous_variant 0.33
rpoB 762233 c.2427G>T synonymous_variant 0.38
rpoB 762245 c.2439G>C synonymous_variant 0.33
rpoB 762254 c.2448T>C synonymous_variant 0.33
rpoB 762257 c.2451C>G synonymous_variant 0.33
rpoB 762266 c.2460T>C synonymous_variant 0.33
rpoB 762273 p.Ala823Ser missense_variant 0.33
rpoB 762284 c.2478G>C synonymous_variant 0.29
rpoB 762293 c.2487T>C synonymous_variant 0.21
rpoB 762296 c.2490G>C synonymous_variant 0.23
rpoB 762308 c.2502G>C synonymous_variant 0.14
rpoB 762849 p.Tyr1015Asp missense_variant 0.25
rpoB 762855 p.Val1017Ile missense_variant 0.24
rpoB 762858 p.Thr1018Ser missense_variant 0.29
rpoC 762863 c.-507T>C upstream_gene_variant 0.31
rpoB 762870 p.Met1022Gln missense_variant 0.38
rpoB 762879 p.Met1025Leu missense_variant 0.67
rpoC 762923 c.-447C>G upstream_gene_variant 0.63
rpoC 762929 c.-441G>T upstream_gene_variant 0.63
rpoC 762947 c.-423C>G upstream_gene_variant 0.56
rpoC 762956 c.-414G>C upstream_gene_variant 0.51
rpoC 762971 c.-399G>C upstream_gene_variant 0.46
rpoC 762980 c.-390T>C upstream_gene_variant 0.35
rpoC 762989 c.-381G>C upstream_gene_variant 0.33
rpoC 762995 c.-375G>C upstream_gene_variant 0.27
rpoB 763005 p.Cys1067Val missense_variant 0.22
rpoC 763013 c.-357C>G upstream_gene_variant 0.24
rpoB 763014 p.Met1070Leu missense_variant 0.24
rpoB 763017 p.Gln1071Glu missense_variant 0.25
rpoC 763028 c.-342T>C upstream_gene_variant 0.27
rpoC 763031 c.-339T>C upstream_gene_variant 0.27
rpoC 763040 c.-330C>G upstream_gene_variant 0.25
rpoC 763088 c.-282C>G upstream_gene_variant 0.25
rpoC 763094 c.-276G>C upstream_gene_variant 0.22
rpoC 763115 c.-255T>C upstream_gene_variant 0.17
rpoC 763456 c.87A>G synonymous_variant 0.13
rpoC 763462 c.93G>C synonymous_variant 0.17
rpoC 763468 c.99G>C synonymous_variant 0.16
rpoC 763486 c.117T>C synonymous_variant 0.32
rpoC 763504 c.135C>G synonymous_variant 0.48
rpoC 763507 c.138G>C synonymous_variant 0.48
rpoC 763528 c.159G>C synonymous_variant 0.55
rpoC 763531 c.162G>C synonymous_variant 0.5
rpoC 763534 c.165T>C synonymous_variant 0.47
rpoC 763540 c.171C>T synonymous_variant 0.56
rpoC 763546 c.177A>G synonymous_variant 0.57
rpoC 763551 p.Tyr61Ser missense_variant 0.57
rpoC 763570 c.201G>C synonymous_variant 0.61
rpoC 763578 p.Phe70Tyr missense_variant 0.61
rpoC 763621 c.252C>T synonymous_variant 0.59
rpoC 763633 c.264T>C synonymous_variant 0.62
rpoC 763636 c.267T>C synonymous_variant 0.63
rpoC 763642 c.273G>C synonymous_variant 0.6
rpoC 763648 c.279C>G synonymous_variant 0.62
rpoC 763652 p.Ile95Leu missense_variant 0.55
rpoC 763660 c.291T>C synonymous_variant 0.53
rpoC 763666 c.297G>T synonymous_variant 0.56
rpoC 763669 c.300C>G synonymous_variant 0.56
rpoC 763672 c.303C>G synonymous_variant 0.58
rpoC 763696 c.327T>C synonymous_variant 0.56
rpoC 763705 c.336G>T synonymous_variant 0.43
rpoC 763708 c.339G>T synonymous_variant 0.4
rpoC 763714 c.345G>C synonymous_variant 0.37
rpoC 763717 c.348T>C synonymous_variant 0.34
rpoC 763732 c.363C>G synonymous_variant 0.33
rpoC 763735 c.366G>C synonymous_variant 0.3
rpoC 763751 p.Ile128Val missense_variant 0.33
rpoC 763765 c.396T>G synonymous_variant 0.36
rpoC 763772 p.Val135Met missense_variant 0.25
rpoC 764507 p.Ala380Ser missense_variant 0.22
rpoC 764521 c.1152T>C synonymous_variant 0.41
rpoC 764527 c.1158C>T synonymous_variant 0.41
rpoC 764536 c.1167G>T synonymous_variant 0.54
rpoC 764545 c.1176C>G synonymous_variant 0.69
rpoC 764548 c.1179G>C synonymous_variant 0.67
rpoC 764560 c.1191T>C synonymous_variant 0.59
rpoC 764561 p.Pro398Ala missense_variant 0.57
rpoC 764575 c.1206T>G synonymous_variant 0.56
rpoC 764578 c.1209C>G synonymous_variant 0.56
rpoC 764581 c.1212T>C synonymous_variant 0.56
rpoC 764582 p.Leu405Met missense_variant 0.58
rpoC 764605 c.1236G>C synonymous_variant 0.66
rpoC 764611 c.1242G>C synonymous_variant 0.71
rpoC 764632 c.1263T>C synonymous_variant 0.78
rpoC 764635 c.1266C>G synonymous_variant 0.81
rpoC 764650 c.1281G>C synonymous_variant 0.76
rpoC 764673 c.1305_1306insTTG conservative_inframe_insertion 0.72
rpoC 764676 p.Leu436Arg missense_variant 0.69
rpoC 764678 c.1310_1312delAGC disruptive_inframe_deletion 0.72
rpoC 764706 p.Leu446Gln missense_variant 0.7
rpoC 764713 c.1344G>A synonymous_variant 0.64
rpoC 764716 c.1347G>C synonymous_variant 0.61
rpoC 764746 c.1377G>C synonymous_variant 0.33
rpoC 764752 c.1383G>C synonymous_variant 0.32
rpoC 764755 c.1386C>T synonymous_variant 0.31
rpoC 764758 c.1389C>G synonymous_variant 0.31
rpoC 764764 c.1395T>C synonymous_variant 0.27
rpoC 764780 p.Ser471Cys missense_variant 0.15
rpoC 765886 c.2517C>G synonymous_variant 0.15
rpoC 765888 p.Phe840Tyr missense_variant 0.15
rpoC 765892 c.2523T>C synonymous_variant 0.15
rpoC 765904 c.2535C>G synonymous_variant 0.22
rpoC 765923 p.Asn852Ala missense_variant 0.3
rpoC 765937 c.2568T>C synonymous_variant 0.36
rpoC 765940 c.2571A>C synonymous_variant 0.36
rpoC 765947 c.2578T>C synonymous_variant 0.38
rpoC 765952 c.2583G>C synonymous_variant 0.42
rpoC 765962 c.2593T>C synonymous_variant 0.42
rpoC 765970 c.2601C>G synonymous_variant 0.36
rpoC 765973 c.2604C>G synonymous_variant 0.36
rpoC 765974 p.Asp869Asn missense_variant 0.36
rpoC 765994 c.2625A>T synonymous_variant 0.4
rpoC 766000 c.2631G>C synonymous_variant 0.32
rpoC 766003 c.2634G>C synonymous_variant 0.24
rpoC 766009 c.2640G>C synonymous_variant 0.15
rpoC 766582 c.3213C>T synonymous_variant 0.5
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775715 c.2766G>A synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781751 c.192G>T synonymous_variant 0.18
rpsL 781754 c.195G>C synonymous_variant 0.2
rpsL 781760 c.201T>C synonymous_variant 0.17
rpsL 781766 c.207C>T synonymous_variant 0.17
rpsL 781793 c.234G>C synonymous_variant 0.27
rpsL 781796 p.Met79Ile missense_variant 0.25
rpsL 781802 c.243G>C synonymous_variant 0.23
rpsL 781817 c.258G>A synonymous_variant 0.23
rpsL 781829 c.270G>C synonymous_variant 0.12
rplC 800648 c.-161A>G upstream_gene_variant 0.14
rplC 800693 c.-116A>G upstream_gene_variant 0.14
rplC 800702 c.-107G>C upstream_gene_variant 0.11
rplC 800703 c.-106T>C upstream_gene_variant 0.12
fbiC 1303929 c.999G>T synonymous_variant 0.15
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471961 n.116C>T non_coding_transcript_exon_variant 0.17
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.17
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.16
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.14
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.14
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.14
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.15
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.57
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.6
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.61
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.55
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.57
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.8
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.8
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.82
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.76
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.31
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.29
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.29
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.32
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.59
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.65
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.67
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.65
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.57
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.37
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.63
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.64
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.66
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.89
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.89
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.26
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.88
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.88
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.88
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.73
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.71
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.42
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.37
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.37
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.37
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.36
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.73
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.82
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.47
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.4
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.41
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.74
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.87
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.84
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.85
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.86
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.83
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.84
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.79
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.77
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.78
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.8
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.72
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.68
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.67
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.67
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.66
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.65
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.65
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.7
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.71
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.78
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.79
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.8
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.81
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.85
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.85
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.82
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.81
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.82
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.8
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.73
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.72
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.18
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.58
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.57
rrl 1473719 n.62G>C non_coding_transcript_exon_variant 0.6
rrl 1473721 n.64G>A non_coding_transcript_exon_variant 0.58
rrl 1473722 n.65G>T non_coding_transcript_exon_variant 0.58
rrl 1473744 n.87T>C non_coding_transcript_exon_variant 0.48
rrl 1473746 n.89T>A non_coding_transcript_exon_variant 0.46
rrl 1473747 n.90C>T non_coding_transcript_exon_variant 0.46
rrl 1473750 n.93C>G non_coding_transcript_exon_variant 0.46
rrl 1473753 n.96A>G non_coding_transcript_exon_variant 0.47
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.47
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.48
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.48
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.27
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.54
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.72
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.79
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.77
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.77
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.77
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.77
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.75
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.74
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.8
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.62
rrl 1473924 n.267A>T non_coding_transcript_exon_variant 0.54
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.42
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.66
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.61
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.62
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.63
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.63
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.65
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.65
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.66
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.64
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.66
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.53
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.5
rrl 1474284 n.631_633delCCT non_coding_transcript_exon_variant 0.38
rrl 1474293 n.637_651delCCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.43
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.41
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.57
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.61
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.6
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 0.6
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.62
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.48
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.48
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.41
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.5
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.72
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.81
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.85
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.86
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.87
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.85
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.84
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.84
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.83
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.84
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.67
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.41
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.4
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.38
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.37
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.38
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.38
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.38
rrl 1474641 n.984G>A non_coding_transcript_exon_variant 0.39
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.38
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.3
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.3
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.31
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.36
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.48
rrl 1474707 n.1051_1052delCG non_coding_transcript_exon_variant 0.32
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.24
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.3
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.57
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.58
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.6
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.6
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.61
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.75
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.74
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.79
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.82
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.85
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.85
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.85
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.85
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.86
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.7
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.67
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.6
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.25
rrl 1474948 n.1291C>T non_coding_transcript_exon_variant 0.21
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.22
rrl 1475093 n.1436C>T non_coding_transcript_exon_variant 0.21
rrl 1475104 n.1447T>G non_coding_transcript_exon_variant 0.21
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.18
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.2
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.2
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.21
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.21
rrl 1475124 n.1467A>C non_coding_transcript_exon_variant 0.29
rrl 1475515 n.1858G>A non_coding_transcript_exon_variant 0.5
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.57
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.61
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.64
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.56
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.53
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.53
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.15
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.32
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.58
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.59
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.59
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.59
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.62
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.63
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.73
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.88
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.89
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.46
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.93
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.9
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.89
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.89
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.85
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.86
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.87
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.85
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.85
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.83
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.82
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.82
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.81
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.83
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.83
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.81
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.77
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.54
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.54
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.73
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.75
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.79
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.79
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.8
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.73
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.72
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.73
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.72
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.6
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.54
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.48
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.49
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.47
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.47
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.51
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.4
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.26
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.26
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.31
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.76
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.89
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.9
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.85
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.88
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.88
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.81
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.75
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.68
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.67
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.62
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.6
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.6
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.6
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.6
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.59
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.26
rpsA 1833646 c.105T>C synonymous_variant 0.2
rpsA 1833653 p.Ile38Leu missense_variant 0.21
rpsA 1833658 c.117C>G synonymous_variant 0.2
rpsA 1833668 p.Ile43Val missense_variant 0.25
rpsA 1833676 c.135A>G synonymous_variant 0.2
rpsA 1833679 c.138G>C synonymous_variant 0.2
rpsA 1833682 c.141C>T synonymous_variant 0.23
rpsA 1833685 c.144G>T synonymous_variant 0.22
rpsA 1833694 c.153G>C synonymous_variant 0.28
rpsA 1833721 c.180A>G synonymous_variant 0.3
rpsA 1833727 c.186G>C synonymous_variant 0.28
rpsA 1833874 c.333T>C synonymous_variant 0.19
rpsA 1833884 p.Thr115Asp missense_variant 0.18
rpsA 1833893 p.Ala118Lys missense_variant 0.17
rpsA 1833896 p.Leu119Ile missense_variant 0.21
rpsA 1833905 p.Lys122Glu missense_variant 0.19
rpsA 1833912 p.Glu124Gly missense_variant 0.18
rpsA 1833915 p.Ala125Val missense_variant 0.19
rpsA 1833922 p.Lys127Asn missense_variant 0.26
rpsA 1833928 c.387G>C synonymous_variant 0.29
rpsA 1833949 c.408T>C synonymous_variant 0.24
rpsA 1833955 c.414G>C synonymous_variant 0.24
rpsA 1833970 c.429G>T synonymous_variant 0.14
rpsA 1833973 c.432G>T synonymous_variant 0.14
rpsA 1833979 c.438T>C synonymous_variant 0.14
rpsA 1833991 c.450C>G synonymous_variant 0.17
rpsA 1834000 c.459G>C synonymous_variant 0.12
rpsA 1834009 c.468C>T synonymous_variant 0.18
rpsA 1834213 c.672G>C synonymous_variant 0.2
rpsA 1834231 c.690T>C synonymous_variant 0.2
rpsA 1834234 c.693G>C synonymous_variant 0.15
rpsA 1834237 c.696C>T synonymous_variant 0.14
rpsA 1834240 c.699T>C synonymous_variant 0.13
rpsA 1834249 c.708T>C synonymous_variant 0.14
rpsA 1834255 c.714C>G synonymous_variant 0.17
rpsA 1834261 c.720A>G synonymous_variant 0.15
rpsA 1834264 c.723G>C synonymous_variant 0.13
rpsA 1834279 c.738C>T synonymous_variant 0.12
rpsA 1834427 p.Ile296Val missense_variant 0.12
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.19
rpsA 1834456 c.915T>C synonymous_variant 0.18
rpsA 1834459 c.918G>C synonymous_variant 0.2
rpsA 1834465 c.924T>C synonymous_variant 0.18
rpsA 1834468 c.927A>G synonymous_variant 0.19
rpsA 1834474 c.933C>G synonymous_variant 0.18
rpsA 1834486 p.Glu315Asp missense_variant 0.16
rpsA 1834489 c.948T>C synonymous_variant 0.16
tlyA 1917753 c.-187G>A upstream_gene_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101852 c.1191G>A synonymous_variant 0.15
PPE35 2169320 p.Leu431Phe missense_variant 0.3
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747208 p.Val131Leu missense_variant 0.12
ribD 2986749 c.-89delG upstream_gene_variant 0.14
fprA 3474363 c.357G>A synonymous_variant 0.4
whiB7 3568784 c.-105C>T upstream_gene_variant 0.25
Rv3236c 3612113 c.1003delG frameshift_variant 1.0
alr 3840459 p.Ser321Leu missense_variant 1.0
ddn 3986925 p.Met28Val missense_variant 0.13
ddn 3987018 p.Pro59Ser missense_variant 0.12
clpC1 4038826 p.Ile627Val missense_variant 0.12
clpC1 4038836 c.1869G>C synonymous_variant 0.18
clpC1 4038842 c.1863G>C synonymous_variant 0.2
clpC1 4038845 c.1860G>C synonymous_variant 0.21
clpC1 4038857 c.1848C>A synonymous_variant 0.18
clpC1 4038860 c.1845G>C synonymous_variant 0.38
clpC1 4038863 c.1842G>C synonymous_variant 0.38
clpC1 4038875 c.1830C>G synonymous_variant 0.22
clpC1 4038878 c.1827A>G synonymous_variant 0.25
clpC1 4038894 p.Tyr604Phe missense_variant 0.22
clpC1 4038899 c.1806C>G synonymous_variant 0.25
clpC1 4038905 c.1800A>C synonymous_variant 0.22
clpC1 4039850 c.855T>C synonymous_variant 0.25
clpC1 4039865 c.840T>C synonymous_variant 0.22
clpC1 4039873 p.Thr278Ser missense_variant 0.28
clpC1 4039874 p.Asn277Lys missense_variant 0.28
clpC1 4039904 c.801A>G synonymous_variant 0.21
clpC1 4039913 c.792C>T synonymous_variant 0.12
clpC1 4039916 c.789T>C synonymous_variant 0.13
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.13
clpC1 4039931 c.774T>C synonymous_variant 0.13
clpC1 4039934 c.771G>C synonymous_variant 0.12
clpC1 4039940 c.765G>C synonymous_variant 0.19
clpC1 4039946 c.759A>C synonymous_variant 0.12
clpC1 4039949 c.756G>C synonymous_variant 0.19
clpC1 4039952 c.753T>C synonymous_variant 0.24
clpC1 4039967 p.Gln246His missense_variant 0.54
clpC1 4039988 c.717C>G synonymous_variant 0.59
clpC1 4039991 c.714G>C synonymous_variant 0.61
clpC1 4039994 p.Glu237Asp missense_variant 0.56
clpC1 4040001 p.His235Arg missense_variant 0.59
clpC1 4040015 c.690G>C synonymous_variant 0.53
clpC1 4040021 c.684A>C synonymous_variant 0.56
clpC1 4040024 c.681A>G synonymous_variant 0.56
clpC1 4040030 c.675C>G synonymous_variant 0.47
clpC1 4040033 c.672G>C synonymous_variant 0.49
clpC1 4040051 c.654C>G synonymous_variant 0.44
clpC1 4040069 c.636G>C synonymous_variant 0.53
clpC1 4040090 c.615T>G synonymous_variant 0.5
clpC1 4040108 c.597G>C synonymous_variant 0.14
clpC1 4040114 p.Ile197Met missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249732 c.3219C>G synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407590 p.Ala205Thr missense_variant 1.0