TB-Profiler result

Run: ERR245675
Summary

Run ID: ERR245675

Sample name:

Date: 2024-10-05T09:46:09.493376

Number of reads: 10657231

Percentage reads mapped: 74.7

Median coverage: 175.0

Strain: lineage1.1.2

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.99
lineage1.1 Indo-Oceanic RD239 1.0
lineage1 Indo-Oceanic RD239 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6775 c.1536G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 6823 c.-479G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6844 c.-458T>G upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8452 p.Ala384Val missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491310 c.528C>G synonymous_variant 0.13 pretomanid
delamanid
clofazimine
fgd1 491316 c.534C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575821 c.474G>C synonymous_variant 0.15 isoniazid
ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.14 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.2 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.2 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.14 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.19 rifampicin Uncertain significance
rpoB 762923 c.3117C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.14 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.99 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.13 rifampicin
rpoC 763076 c.-294C>G upstream_gene_variant 0.13 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.12 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.16 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.14 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.14 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.14 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.16 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.15 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.12 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.9 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.9 rifampicin Not assoc w R
rpoC 764353 c.984G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764584 c.1215G>A synonymous_variant 0.16 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.18 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.14 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.13 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765419 p.Val684Ile missense_variant 0.14 rifampicin Uncertain significance
rpoC 765425 p.Lys686Glu missense_variant 0.13 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.13 rifampicin
rpoC 765988 c.2619G>A synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.14 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.13 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.13 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.13 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.12 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.13 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.14 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.13 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.13 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.14 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.12 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.14 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.12 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.13 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.17 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.18 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.13 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.13 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.13 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.17 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.13 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.13 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.14 streptomycin
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303587 c.657G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303596 c.666G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.12 pretomanid
delamanid
clofazimine
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1461071 c.27C>G synonymous_variant 0.14 bedaquiline
atpE 1461080 c.36C>T synonymous_variant 0.17 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.14 bedaquiline
atpE 1461116 c.72C>G synonymous_variant 0.12 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.12 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1474708 n.1052_1053insACAAG non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474711 n.1055_1058delGTGT non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475220 n.1563G>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036delGinsAA non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
inhA 1674656 p.Ser152Thr missense_variant 0.13 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.14 isoniazid
ethionamide
inhA 1674687 c.486G>C synonymous_variant 0.13 isoniazid
ethionamide
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.17 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.15 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.11 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.12 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.16 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.16 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.2 pyrazinamide
rpsA 1833907 c.366G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834234 c.693G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.14 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834678 c.1137C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.15 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 0.99 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223550 c.-386C>T upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
kasA 2517941 c.-174C>G upstream_gene_variant 0.12 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.13 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
ahpC 2726468 c.276G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv2681 2996912 c.174C>T synonymous_variant 1.0 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
thyX 3067355 c.591A>G synonymous_variant 0.12 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067385 c.561C>G synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067491 p.Ala152Val missense_variant 0.99 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
fbiA 3640446 c.-97A>T upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
rpoA 3877656 c.852T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.14 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.12 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.14 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>C synonymous_variant 0.12 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.17 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3878143 p.Gly122Asp missense_variant 0.12 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.16 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
clpC1 4038551 c.2154C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.12 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.12 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.12 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.11 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039010 c.1695G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.14 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.13 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039931 p.Gly258Val missense_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.92 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240819 c.957A>G synonymous_variant 0.12 ethambutol
embC 4241042 p.Asn394Asp missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326851 p.Ser208Leu missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.99 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R