TB-Profiler result

Run: ERR7821163
Summary

Run ID: ERR7821163

Sample name:

Date: 2024-04-16T12:52:26.065590

Number of reads: 1551336

Percentage reads mapped: 75.74

Median coverage: 40.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.27 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1188 c.1188G>A synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.19 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.3 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.28 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.33 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.28 isoniazid
dnaA 1278 c.1278T>G synonymous_variant 0.27 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.26 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.26 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.26 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.26 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>A synonymous_variant 0.27 isoniazid Not assoc w R
dnaA 1329 c.1329A>G synonymous_variant 0.19 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1341 c.1341G>C synonymous_variant 0.19 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.18 isoniazid
dnaA 1413 c.1413A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1425 c.1425C>T synonymous_variant 0.16 isoniazid
gyrB 6184 c.945C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7505 c.204C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7514 c.213C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8121 c.820T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8126 c.825G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8442 c.1141C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8570 p.Glu423Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9329 c.2028C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490998 c.216T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491010 c.228C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491058 c.276C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491083 p.Val101Ile missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491110 p.Ala110Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620748 c.858T>A synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656478 c.993C>G synonymous_variant 0.17 ethionamide
Rv0565c 656481 c.990A>G synonymous_variant 0.16 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.16 ethionamide
Rv0565c 656490 c.981C>G synonymous_variant 0.16 ethionamide
Rv0565c 656493 c.978C>G synonymous_variant 0.17 ethionamide
Rv0565c 656505 c.966C>T synonymous_variant 0.18 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
Rv0565c 656514 c.957C>T synonymous_variant 0.16 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.97 ethionamide Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.18 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.22 isoniazid
hadA 732370 c.441C>T synonymous_variant 0.22 isoniazid
nusG 734205 c.-49A>C upstream_gene_variant 0.18 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.18 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.22 rifampicin
nusG 734514 c.261A>G synonymous_variant 0.24 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734771 p.Ala173Val missense_variant 0.18 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.21 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.21 rifampicin
nusG 734787 c.534T>G synonymous_variant 0.3 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.23 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.22 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.3 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.3 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.23 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.24 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.24 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.24 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.23 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.27 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.25 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760346 c.540C>T synonymous_variant 0.22 rifampicin
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.2 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.26 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.25 rifampicin
rpoB 760758 p.Val318Thr missense_variant 0.26 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.28 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.27 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.17 rifampicin
rpoB 760845 p.Thr347Ala missense_variant 0.17 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.18 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.19 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760968 p.Ser388Thr missense_variant 0.16 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.16 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.28 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.22 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.23 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761324 c.1518C>T synonymous_variant 0.17 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.18 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.27 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>C synonymous_variant 0.31 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.32 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761604 c.1798_1800delCTCinsTG frameshift_variant&missense_variant 0.27 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>T synonymous_variant 0.26 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.3 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.31 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.24 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.21 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.19 rifampicin Not assoc w R
rpoB 761724 p.Glu640Lys missense_variant 0.19 rifampicin
rpoB 761727 p.Ser641Ala missense_variant 0.18 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.18 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.19 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.19 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.15 rifampicin
rpoB 761831 c.2025C>A synonymous_variant 0.15 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.34 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.35 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762095 c.2289C>A synonymous_variant 0.43 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.46 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.49 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.47 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.43 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.38 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.35 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.3 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.3 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.29 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.19 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.2 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.26 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.29 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.32 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.69 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.33 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.29 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.27 rifampicin
rpoC 763181 c.-189G>C upstream_gene_variant 0.3 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.18 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763567 c.198G>A synonymous_variant 0.26 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.32 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>G synonymous_variant 0.33 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.33 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.29 rifampicin
rpoC 763756 c.387C>T synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.32 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.29 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.27 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.28 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.26 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.21 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.29 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.3 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.29 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.31 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.2 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.21 rifampicin Uncertain significance
rpoC 764245 c.876C>G synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.26 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.4 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.42 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.33 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.34 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.36 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.37 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.38 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.4 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.44 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.43 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.44 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.46 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764659 c.1290C>T synonymous_variant 0.34 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764689 c.1320G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.22 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>A synonymous_variant 0.16 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.17 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.22 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.19 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.2 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.21 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.26 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.3 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.27 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.23 rifampicin
rpoC 766087 c.2718C>G synonymous_variant 0.24 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.23 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.23 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.23 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.26 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.25 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.24 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.24 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.24 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.27 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.25 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.33 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.21 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.23 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.17 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.29 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.26 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.27 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.26 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.28 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.28 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.24 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.31 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.36 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.37 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.41 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.59 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.44 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.46 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.4 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.26 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.3 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.28 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.28 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.26 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.27 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.28 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.3 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.27 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.25 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.27 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.22 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.22 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.24 streptomycin
rpsL 781859 c.300T>A synonymous_variant 0.23 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800648 c.-161A>T upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.2 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.17 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303761 c.831T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303800 c.870G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304199 c.1269C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
sigE 1364709 c.297T>C synonymous_variant 0.17 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.17 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.18 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.18 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.2 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.22 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.2 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.2 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.18 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.16 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473981 n.324_325insT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
fabG1 1674079 p.Pro214Ala missense_variant 0.19 ethionamide
isoniazid
inhA 1674084 c.-118C>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1674096 c.-106G>T upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1674099 c.-103G>A upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.24 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674993 c.792G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674994 p.His265Ser missense_variant 0.19 ethionamide
isoniazid
rpsA 1833254 c.-288G>C upstream_gene_variant 0.88 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833772 c.231C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834057 c.516G>A synonymous_variant 0.25 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834636 c.1095C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834693 c.1152C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834723 c.1182G>A synonymous_variant 0.31 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.31 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.29 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.26 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.2 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.2 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.23 linezolid
tsnR 1853384 c.-222G>T upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.24 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.24 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.22 linezolid
tsnR 1853399 c.-207C>T upstream_gene_variant 0.22 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.23 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.23 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.2 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.2 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.98 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2065005 c.-277C>T upstream_gene_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101939 c.1104A>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Gly missense_variant 0.24 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid
folC 2746915 c.684G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746921 c.678T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747026 c.573C>A synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.18 para-aminosalicylic_acid
folC 2747347 c.252G>A synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747350 c.249C>T synonymous_variant 0.16 para-aminosalicylic_acid
Rv2477c 2783116 c.927T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.21 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783167 c.876G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067739 c.207T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067838 c.108C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067849 p.Pro33Ala missense_variant 0.25 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067869 p.Thr26Asp missense_variant 0.23 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339117 c.-1C>A upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3623417 c.1494A>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623519 c.1392C>T synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623552 c.1359G>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623557 p.Gly452Arg missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625675 c.-765G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625683 c.-773C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625714 c.-804C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.32 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626840 c.-227C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626891 c.-278G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626921 c.-308C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626948 c.-335C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627092 c.-479C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627137 c.211_213delTTGinsCA frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.17 bedaquiline
rifampicin
fbiA 3641332 p.Gly264Arg missense_variant 0.98 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
alr 3840987 p.Val145Ala missense_variant 0.15 cycloserine
alr 3841017 p.Leu135Glu missense_variant 0.16 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.16 cycloserine
alr 3841037 c.382_384delGTGinsAT frameshift_variant&missense_variant 0.17 cycloserine
alr 3841043 c.378C>T synonymous_variant 0.18 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.37 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.33 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.29 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.27 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877761 c.747G>C synonymous_variant 0.29 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.23 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.32 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.26 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.28 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.28 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.29 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.29 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.29 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.28 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.22 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.22 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.21 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.23 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.24 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.36 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.41 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.43 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.37 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.38 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.38 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.39 rifampicin
rpoA 3878352 c.156C>T synonymous_variant 0.36 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.38 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.36 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.33 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.36 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.35 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.37 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.34 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.37 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.44 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.44 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.42 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.48 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.48 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.47 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878794 c.-287G>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.48 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.48 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.4 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.37 rifampicin
rpoA 3878836 c.-330_-329delAGinsGC upstream_gene_variant 0.34 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.38 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.34 rifampicin
rpoA 3878862 c.-355T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.19 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878953 c.-446C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878962 c.-455G>T upstream_gene_variant 0.25 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.2 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879016 c.-509A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.25 rifampicin
rpoA 3879067 c.-560G>A upstream_gene_variant 0.23 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>G upstream_gene_variant 0.27 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.23 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879238 c.-731C>T upstream_gene_variant 0.19 rifampicin
clpC1 4038359 c.2346A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038433 c.2272C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.2 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.19 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038486 p.Gly740Ala missense_variant 0.16 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.2 pyrazinamide
clpC1 4038506 c.2199G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.24 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.24 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.28 pyrazinamide
clpC1 4038692 c.2013C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038815 c.1890G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1704C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.21 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039338 p.Thr456Lys missense_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039466 c.1239T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039556 c.1149G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039570 c.1134_1135insCA frameshift_variant 0.19 pyrazinamide
clpC1 4039575 c.1128_1129delTG frameshift_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040246 c.459C>A synonymous_variant 0.18 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.18 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.22 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040309 c.396C>T synonymous_variant 0.21 pyrazinamide
panD 4044890 c.-609G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.19 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.19 pyrazinamide
panD 4044902 c.-621G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044909 c.-628C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044923 c.-642A>C upstream_gene_variant 0.19 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.17 pyrazinamide
panD 4044938 c.-657G>C upstream_gene_variant 0.17 pyrazinamide
panD 4044941 c.-662_-660delCTGinsGC upstream_gene_variant 0.17 pyrazinamide
panD 4044954 c.-673C>T upstream_gene_variant 0.2 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.25 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044986 c.-705C>G upstream_gene_variant 0.22 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.22 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.23 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.16 pyrazinamide
embC 4240726 c.864G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4240738 c.876C>A synonymous_variant 0.2 ethambutol
embC 4240771 c.909G>A synonymous_variant 0.25 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.27 ethambutol
embC 4240786 c.924C>T synonymous_variant 0.22 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.17 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.15 ethambutol
embC 4241056 c.1194C>G synonymous_variant 0.18 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.21 ethambutol
embC 4241116 c.1254C>G synonymous_variant 0.24 ethambutol
embC 4241126 c.1264C>T synonymous_variant 0.2 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.19 ethambutol
embC 4241176 c.1314C>G synonymous_variant 0.23 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.25 ethambutol
embC 4241224 c.1362G>A synonymous_variant 0.25 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.21 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245074 c.1842G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4245078 p.Trp616Gly missense_variant 0.17 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4245089 c.1857G>C synonymous_variant 0.19 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.19 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.19 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.21 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.23 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.23 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.23 ethambutol
embB 4247404 c.891G>C synonymous_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.27 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.26 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.22 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.23 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.22 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.17 ethambutol
embB 4249640 c.3127T>C synonymous_variant 0.93 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4268991 c.-155C>T upstream_gene_variant 0.21 ethambutol
aftB 4268994 c.-158T>G upstream_gene_variant 0.21 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.21 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.22 ethambutol
ubiA 4269015 c.819G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
aftB 4269018 c.-182G>C upstream_gene_variant 0.2 ethambutol
aftB 4269027 c.-191C>A upstream_gene_variant 0.2 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.21 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.22 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.23 ethambutol
aftB 4269048 c.-212C>T upstream_gene_variant 0.24 ethambutol
ubiA 4269051 c.783C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
ubiA 4269075 c.757_759delATTinsGG frameshift_variant&missense_variant 0.25 ethambutol
aftB 4269081 c.-245G>C upstream_gene_variant 0.2 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R