TB-Profiler result

Run: SRR1162740
Summary

Run ID: SRR1162740

Sample name:

Date: 2024-04-14T21:56:09.751465

Number of reads: 1499471

Percentage reads mapped: 77.1

Median coverage: 33.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.96
lineage4.1.2 Euro-American None 0.98
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.95
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.25 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.27 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 534 c.534T>G synonymous_variant 0.17 isoniazid
dnaA 540 c.540C>G synonymous_variant 0.19 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.21 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.28 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.26 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.26 isoniazid
gyrB 6169 c.930C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7760 c.459C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7970 c.669T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7979 c.678G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490851 c.69A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.91 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575648 p.Val101Gln missense_variant 0.2 ethionamide
isoniazid
mshA 575658 p.Ala104Val missense_variant 0.19 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575669 p.Leu108Val missense_variant 0.19 ethionamide
isoniazid
mshA 575679 p.Asn111Ser missense_variant 0.86 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575821 c.474G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.21 ethionamide
isoniazid
ccsA 619579 c.-312G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619655 c.-236A>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.19 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.21 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.22 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.21 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.21 ethionamide
Rv0565c 657267 c.202_204delTCGinsCC frameshift_variant&synonymous_variant 0.21 ethionamide Uncertain significance
Rv0565c 657291 c.180C>G synonymous_variant 0.2 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.2 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.24 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.21 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.24 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.26 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.16 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.15 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.17 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.18 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.18 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.18 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.19 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.24 isoniazid Uncertain significance
nusG 734078 c.-176C>A upstream_gene_variant 0.15 rifampicin
nusG 734093 c.-161A>C upstream_gene_variant 0.16 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.16 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.16 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.16 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
nusG 734129 c.-125G>C upstream_gene_variant 0.19 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.19 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.19 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.17 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.18 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.19 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.18 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.18 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.19 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.21 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.23 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.24 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.29 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.26 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.25 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.24 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.24 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.25 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.24 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.74 rifampicin Not assoc w R
rpoB 760118 c.312T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.24 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.26 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.2 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.19 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.3 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.38 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.33 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.27 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.24 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.21 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.24 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.22 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.2 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.26 rifampicin
rpoB 761051 c.1245G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.16 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761222 c.1416G>C synonymous_variant 0.23 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.18 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.17 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.29 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.26 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.16 rifampicin
rpoC 762443 c.-927G>T upstream_gene_variant 0.2 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.18 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.21 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.15 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.27 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.3 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.28 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.28 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.28 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.34 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.33 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.34 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.35 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.31 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765300 p.Val644Ala missense_variant 0.15 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765325 c.1956C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.18 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.18 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.16 rifampicin Uncertain significance
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.26 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.24 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.26 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.28 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.34 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.29 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.29 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.27 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.33 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.33 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.24 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Glu missense_variant 0.22 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.24 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.26 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.23 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.18 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.27 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.21 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.21 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.16 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.25 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.29 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.25 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.21 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.25 streptomycin Uncertain significance
rplC 800540 c.-269T>C upstream_gene_variant 0.24 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.26 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.28 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.27 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.23 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.26 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.17 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.15 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.17 linezolid
rplC 800814 c.6A>G synonymous_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.17 linezolid
rplC 801171 c.363A>G synonymous_variant 0.22 linezolid
rplC 801174 c.366T>C synonymous_variant 0.22 linezolid
rplC 801222 c.414T>C synonymous_variant 0.19 linezolid
rplC 801228 c.420T>C synonymous_variant 0.21 linezolid
fbiC 1303509 c.579G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304523 c.1593G>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
atpE 1461159 p.Val39Ile missense_variant 0.24 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.2 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.2 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.19 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.18 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673535 c.-667A>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.3 ethionamide
isoniazid Uncertain significance
inhA 1674561 c.360C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.26 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.24 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.22 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.21 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.23 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.21 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.25 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.25 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.35 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.34 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.26 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917934 c.-6T>C upstream_gene_variant 1.0 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101972 c.1071G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101988 p.Ala352Gly missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>T synonymous_variant 0.21 ethionamide
delamanid
isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.28 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.28 isoniazid Uncertain significance
katG 2155691 c.421T>C synonymous_variant 0.34 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.3 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.32 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.32 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.26 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.29 isoniazid
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289994 c.-753A>G upstream_gene_variant 0.27 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.26 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.23 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.21 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.22 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.21 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.2 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.17 isoniazid
kasA 2518034 c.-81T>C upstream_gene_variant 0.17 isoniazid
kasA 2518035 c.-80C>G upstream_gene_variant 0.17 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.21 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.17 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.19 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.26 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.29 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.31 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.34 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.33 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.29 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.28 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.28 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.29 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.27 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.22 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.21 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.17 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.18 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.17 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.23 isoniazid
kasA 2519098 c.984C>G synonymous_variant 0.22 isoniazid
kasA 2519104 c.990T>A synonymous_variant 0.23 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.23 isoniazid
kasA 2519111 p.Gln333Glu missense_variant 0.24 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.24 isoniazid
kasA 2519125 c.1011C>T synonymous_variant 0.31 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.27 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.27 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.31 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.26 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.27 isoniazid
ahpC 2726594 c.402G>C synonymous_variant 0.17 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.2 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.25 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.29 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.31 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.26 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
folC 2747275 c.324T>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.27 para-aminosalicylic_acid
folC 2747290 c.309A>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.27 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783755 c.288C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.3 capreomycin Uncertain significance
Rv2752c 3065687 p.Gly169Ser missense_variant 0.94 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.2 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.94 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624389 c.522C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625327 c.-417A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625357 c.-447T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.18 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625714 c.-804C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.17 bedaquiline
rifampicin Uncertain significance
fbiB 3642593 c.1059G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
rpoA 3877507 p.Gly334Ala missense_variant 0.15 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.18 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.24 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.25 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.21 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.33 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.37 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.33 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.26 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.33 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.18 delamanid
pretomanid
clpC1 4038317 c.2388G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.21 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.21 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.53 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.36 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.24 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.22 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.23 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.25 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.26 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.17 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040662 c.43C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040699 c.6C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.16 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.16 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.18 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.18 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.21 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.17 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.17 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.15 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.16 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.15 pyrazinamide
glpK 4138681 p.Met359Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 0.91 ethambutol Not assoc w R
embC 4240632 p.Met257Thr missense_variant 0.28 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.27 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.24 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.29 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.26 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.26 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.22 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.21 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.25 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.19 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.22 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.23 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.21 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.97 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.16 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.32 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.31 ethambutol Uncertain significance
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.33 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.31 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.34 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.35 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.33 ethambutol
embA 4246329 p.Thr1033Leu missense_variant 0.18 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.16 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.2 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.2 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.19 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.26 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.27 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.31 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.23 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.26 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.29 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.3 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.3 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.27 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.3 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.36 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.28 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.22 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.23 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.22 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.21 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.2 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.2 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.15 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin