TB-Profiler result

Run: ERR2509673
Summary

Run ID: ERR2509673

Sample name:

Date: 2024-03-27T05:42:35.893396

Number of reads: 5681854

Percentage reads mapped: 82.65

Median coverage: 125.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.18 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1104 c.1104T>C synonymous_variant 0.14 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.16 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.16 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.16 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.16 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.16 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1177 p.Ala393Ser missense_variant 0.14 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.16 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.16 isoniazid
gyrB 6209 c.970C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7451 c.150C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9311 c.2010C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9677 c.2376C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490827 c.45C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490833 c.51G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491502 c.720G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491532 c.750G>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.99 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619574 c.-317G>A upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.22 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>T synonymous_variant 0.13 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620619 c.729G>C synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.99 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656670 c.801G>T synonymous_variant 1.0 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.95 ethionamide Uncertain significance
nusG 734373 c.120G>C synonymous_variant 0.16 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.17 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.19 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.2 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.22 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.2 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.21 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.19 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.15 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.19 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.2 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760564 p.Arg253Leu missense_variant 0.14 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.14 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.17 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.14 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.16 rifampicin Uncertain significance
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.17 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.15 rifampicin
rpoB 761021 c.1215G>C synonymous_variant 0.15 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.14 rifampicin
rpoB 761060 c.1254C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.15 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.17 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.15 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.17 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.24 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.16 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.16 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.25 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.23 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.17 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.13 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.14 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.16 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.17 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.15 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.16 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.17 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.17 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.17 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.17 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.17 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.25 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.26 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.17 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.26 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.23 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763070 c.3264T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.15 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.17 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.16 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.19 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763919 c.550C>T synonymous_variant 0.14 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.14 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.14 rifampicin
rpoC 764714 c.1345C>T synonymous_variant 0.18 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.17 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.15 rifampicin
rpoC 764830 c.1461C>G synonymous_variant 0.17 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.17 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.22 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.23 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.23 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.16 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.16 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.15 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.14 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.15 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.23 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.21 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766069 c.2700G>A synonymous_variant 0.14 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.15 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.17 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.18 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.17 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766142 c.2773C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.15 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.21 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.17 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.19 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.2 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.22 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.21 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.15 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766609 p.Ile1080Met missense_variant 0.15 rifampicin Uncertain significance
rpoC 766630 c.3261G>C synonymous_variant 0.18 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.22 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.25 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.25 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.31 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.3 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.24 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.24 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766972 c.3603G>C synonymous_variant 0.15 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767009 p.Ser1214Thr missense_variant 0.14 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.14 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.28 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.29 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.26 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.98 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781751 c.192G>C synonymous_variant 0.15 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.17 streptomycin
rplC 800537 c.-272C>T upstream_gene_variant 0.17 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.17 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.2 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.26 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.22 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.19 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.18 linezolid
rplC 800877 c.69A>C synonymous_variant 0.15 linezolid
rplC 800880 c.72A>G synonymous_variant 0.15 linezolid
rplC 800889 c.81C>G synonymous_variant 0.18 linezolid
rplC 800907 c.99C>G synonymous_variant 0.22 linezolid
rplC 800916 c.108A>G synonymous_variant 0.23 linezolid
rplC 800937 c.129A>G synonymous_variant 0.17 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.15 linezolid
rplC 800955 c.147C>G synonymous_variant 0.15 linezolid
rplC 800967 c.159C>G synonymous_variant 0.16 linezolid
rplC 800970 c.162T>C synonymous_variant 0.15 linezolid Not assoc w R - Interim
rplC 801174 c.366T>C synonymous_variant 0.16 linezolid
rplC 801222 c.414T>C synonymous_variant 0.16 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.14 linezolid
Rv1129c 1254057 p.Asp160Asn missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.99 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303509 c.579G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.17 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304961 c.2031C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.15 pyrazinamide Uncertain significance
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.16 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833254 c.-288G>C upstream_gene_variant 1.0 pyrazinamide
rpsA 1833589 c.48A>T synonymous_variant 0.14 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.22 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834201 c.660C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.2 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102065 c.978G>C synonymous_variant 0.15 ethionamide
delamanid
isoniazid
ndh 2102242 c.801G>A synonymous_variant 0.14 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.21 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.18 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.15 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.15 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.15 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.15 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.19 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.19 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.23 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.23 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.24 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.21 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.2 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.17 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.17 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.17 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.15 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.16 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.15 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.16 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.17 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.19 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.2 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.18 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.18 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.15 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.15 isoniazid
folC 2747065 c.534C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.14 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.16 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.15 para-aminosalicylic_acid
Rv2477c 2783002 c.1041T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783110 c.933C>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3064980 c.1212C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3064998 c.1194A>G synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1164G>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065031 c.1161G>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>G synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067850 c.96A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073824 c.648A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.31 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624680 c.231T>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.16 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625543 c.-633G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.18 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.23 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.22 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625714 c.-804C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625882 c.732G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626840 c.-227C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
fbiA 3640323 c.-220A>C upstream_gene_variant 0.97 clofazimine
pretomanid
delamanid
fbiA 3641332 p.Gly264Arg missense_variant 0.97 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
rpoA 3877553 p.Glu319Gln missense_variant 0.16 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.18 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.15 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.16 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.16 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.19 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.16 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin
rpoA 3878331 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.17 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.14 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.15 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.15 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878853 c.-346G>A upstream_gene_variant 0.14 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.16 rifampicin
rpoA 3878924 c.-417G>C upstream_gene_variant 0.15 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.15 rifampicin
rpoA 3878989 c.-482G>C upstream_gene_variant 0.14 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.16 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.21 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.21 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.14 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.16 delamanid
pretomanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.15 delamanid
pretomanid
clpC1 4038244 p.Thr821Ala missense_variant 0.15 pyrazinamide
clpC1 4038310 p.Val799Met missense_variant 0.14 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038434 c.2271G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.13 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.15 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.18 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.14 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.2 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.27 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.23 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.18 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
panD 4044752 c.-471T>C upstream_gene_variant 0.25 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.25 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.25 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044809 c.-528C>G upstream_gene_variant 0.15 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.15 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.15 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.16 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.16 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.16 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.16 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138594 p.Asn388Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138718 c.1038T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.572dupG frameshift_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139581 p.Asn59Asp missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 p.His35Gln missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240183 c.321A>G synonymous_variant 0.15 ethambutol
embC 4240210 c.348C>G synonymous_variant 0.15 ethambutol
embC 4240514 p.Val218Met missense_variant 0.14 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.18 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.15 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.18 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.13 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.19 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.19 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.2 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.21 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.25 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.27 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.24 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.24 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.23 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.21 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.22 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.22 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.21 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.21 ethambutol
embC 4240919 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.16 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.17 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.16 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.17 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.18 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.17 ethambutol
embC 4241443 c.1581C>G synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.14 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.15 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.18 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.22 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.23 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.16 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.13 ethambutol
embA 4246329 p.Thr1033Leu missense_variant 0.18 ethambutol
embB 4246355 c.-159G>C upstream_gene_variant 0.24 ethambutol
embA 4246359 c.3127_3129delGCCinsCG frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
embB 4246364 c.-150G>C upstream_gene_variant 0.21 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.2 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.2 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.21 ethambutol
embB 4247348 p.Thr279Ala missense_variant 0.14 ethambutol
embB 4247355 p.Ala281Val missense_variant 0.15 ethambutol Uncertain significance
embB 4247358 p.Val282Ala missense_variant 0.16 ethambutol Uncertain significance
embB 4247365 c.852A>C synonymous_variant 0.18 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.19 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.2 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.22 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.25 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.27 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.24 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.21 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.18 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.16 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.16 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.16 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.16 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.18 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.17 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.23 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.32 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.24 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.24 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.15 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.15 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.89 ethambutol Not assoc w R
ubiA 4269001 p.Ala278Val missense_variant 0.17 ethambutol Uncertain significance
aftB 4269006 c.-170T>C upstream_gene_variant 0.16 ethambutol
aftB 4269009 c.-173A>G upstream_gene_variant 0.16 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.16 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.18 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.18 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.18 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.22 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.22 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.22 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.2 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.19 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.19 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.19 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.18 ethambutol
whiB6 4338596 c.-76_-75delAGinsC upstream_gene_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R