TB-Profiler result

Run: ERR4816113
Summary

Run ID: ERR4816113

Sample name:

Date: 2024-04-16T09:55:27.620256

Number of reads: 1374700

Percentage reads mapped: 69.45

Median coverage: 45.0

Strain: lineage4.1.1.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.99
lineage4.1.1.1 Euro-American (X-type) RD183 0.89
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6610 c.-692C>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6631 c.-671C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6697 c.1458C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.27 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6727 c.-575G>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6764 c.-538C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6796 c.-506C>T upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.13 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7072 c.-230G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7159 c.1920C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7162 c.-140C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7469 c.168C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8915 c.1614A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9026 c.1725G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490661 c.-122_-121insGCGAGC upstream_gene_variant 0.98 clofazimine
pretomanid
delamanid
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.13 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.18 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.14 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.13 rifampicin
rpoB 760319 p.Ser171Arg missense_variant 0.12 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.12 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.12 rifampicin
rpoB 760370 c.564C>G synonymous_variant 0.14 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.14 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.17 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.14 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.18 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>T synonymous_variant 0.16 rifampicin
rpoB 760561 c.757_758delCG frameshift_variant 0.15 rifampicin
rpoB 760567 c.761delCinsGGG frameshift_variant&missense_variant 0.15 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.15 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.18 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.18 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.19 rifampicin
rpoB 760607 c.801G>C synonymous_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.16 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.24 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Leu missense_variant 0.22 rifampicin
rpoB 760877 c.1071G>C synonymous_variant 0.22 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.22 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.22 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.29 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760973 c.1167G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.23 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.21 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.2 rifampicin
rpoB 761126 c.1320G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>T synonymous_variant 0.16 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.17 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.18 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.17 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.17 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.17 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.16 rifampicin
rpoB 761717 c.1911C>T synonymous_variant 0.14 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.15 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.15 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.15 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761741 c.1935G>A synonymous_variant 0.15 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.15 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.13 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.12 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>T synonymous_variant 0.17 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.18 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.16 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.19 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.18 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.18 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.17 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.14 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.14 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.14 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.15 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.15 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.15 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.15 rifampicin
rpoC 763781 c.412_414delTCGinsGC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.14 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.13 rifampicin
rpoC 763801 c.432C>T synonymous_variant 0.13 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.13 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.32 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.35 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.39 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.4 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.4 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.37 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764810 c.1441_1443delCCCinsGT frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.16 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764912 p.Met515Gln missense_variant 0.12 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765478 c.2109T>G synonymous_variant 0.12 rifampicin
rpoC 765861 p.Phe831Tyr missense_variant 0.16 rifampicin Uncertain significance
rpoC 765868 c.2499G>A synonymous_variant 0.16 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.29 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.31 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>T synonymous_variant 0.13 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767128 c.3759C>T synonymous_variant 0.24 rifampicin
rpoC 767134 c.3765C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.28 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.29 rifampicin Uncertain significance
rpoC 767188 c.3819G>A synonymous_variant 0.27 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.26 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.22 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>T synonymous_variant 0.22 rifampicin
rpoC 767233 c.3864T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767264 c.3895_3897delGCGinsTC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 767267 p.Ala1300Asn missense_variant 0.17 rifampicin Uncertain significance
rpoC 767281 c.3912C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.97 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.13 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.14 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.14 streptomycin
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
fbiC 1303367 p.Thr146Ile missense_variant 1.0 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833604 c.63C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.13 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.12 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.12 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.12 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.12 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.16 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.15 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.17 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.15 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.12 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.31 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.27 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.3 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.3 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.31 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.33 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
eis 2715349 c.-17T>C upstream_gene_variant 1.0 amikacin
kanamycin
ahpC 2726210 c.18T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv2477c 2783317 c.726G>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783341 c.702C>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627056 c.294C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627083 c.-470G>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627133 p.Ala73Ser missense_variant 0.17 bedaquiline
rifampicin
mtrB 3627134 c.-521C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627149 c.-536G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
fbiA 3641447 p.Thr302Met missense_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
rpoA 3877553 p.Glu319Lys missense_variant 0.97 rifampicin Not assoc w R
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.17 rifampicin
rpoA 3877602 c.906C>T synonymous_variant 0.17 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.19 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.19 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>T synonymous_variant 0.19 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877983 c.525C>G synonymous_variant 0.15 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.15 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.22 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.27 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.25 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.33 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.22 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.2 rifampicin
clpC1 4038767 c.1938G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.14 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038818 c.1887G>A synonymous_variant 0.13 pyrazinamide
clpC1 4038847 p.Ser620Thr missense_variant 0.12 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.21 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.21 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039336 c.1369C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039338 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039346 p.Arg453Ser missense_variant 0.17 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.22 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.37 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.3 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039484 c.1221T>A synonymous_variant 0.28 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039745 c.960C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039874 c.831C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040000 c.705C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040510 c.195G>A synonymous_variant 0.13 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040543 c.162C>T synonymous_variant 0.16 pyrazinamide
clpC1 4040546 c.159G>T synonymous_variant 0.16 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.16 pyrazinamide
embC 4240897 c.1035C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338498 p.Glu8Asp missense_variant 0.98 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin