TB-Profiler result

Run: ERR11465024
Summary

Run ID: ERR11465024

Sample name:

Date: 2024-03-27T02:46:02.652413

Number of reads: 1690026

Percentage reads mapped: 92.91

Median coverage: 49.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.1.3 Euro-American (X-type) RD193 0.97
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.16 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 4982 c.-258C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6508 c.-794A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6541 c.1302C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6542 c.1303_1305delATCinsCG frameshift_variant&missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6550 c.1311A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6551 c.1312T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6580 c.-722C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.26 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.15 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8324 c.1023T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8579 c.1278C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8891 c.1590G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.37 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
mshA 575566 c.219G>A synonymous_variant 0.99 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 0.93 ethionamide Uncertain significance
hadA 731732 c.-198G>A upstream_gene_variant 0.14 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.14 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.17 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.15 isoniazid
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.16 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.17 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.23 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.2 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.19 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.2 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.2 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.21 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Ile missense_variant 0.15 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.21 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.21 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.16 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.16 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.17 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.16 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.18 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.19 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.19 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.16 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.15 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.15 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.17 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.2 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.21 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.19 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.19 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761531 c.1725C>G synonymous_variant 0.14 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.19 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.22 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.2 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.32 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.37 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.35 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.3 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.34 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.31 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.31 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.28 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.32 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.26 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.18 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.15 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.15 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.16 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.14 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762788 c.2982G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.14 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.17 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.17 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.16 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.16 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.33 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.36 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.35 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.33 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.3 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.32 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.25 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.24 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.22 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.16 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.21 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.34 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.3 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.3 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.35 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.35 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.38 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.37 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.37 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.3 rifampicin
rpoC 764401 c.1032C>T synonymous_variant 0.13 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.15 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764452 c.1083T>C synonymous_variant 0.14 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.2 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.22 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.32 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.29 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.27 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.33 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.27 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765529 c.2160C>T synonymous_variant 0.22 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.24 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.24 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.26 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.24 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.2 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.18 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.19 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.22 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.22 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.22 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.22 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.3 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.26 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.22 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.24 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.24 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.25 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.26 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.19 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.2 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.21 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.24 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.27 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.26 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.29 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.31 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.41 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.35 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.42 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.4 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.39 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.4 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.37 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.15 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.15 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.16 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.25 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.21 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.25 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.22 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.23 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.22 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.25 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.26 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.25 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.23 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.22 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.18 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.19 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 0.91 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.16 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.16 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.17 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.18 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.17 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.25 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.28 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.31 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.3 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.28 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.31 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.28 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.28 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.31 linezolid
rplC 800814 c.6A>G synonymous_variant 0.32 linezolid
rplC 800817 c.9A>T synonymous_variant 0.32 linezolid
rplC 800844 c.36T>C synonymous_variant 0.26 linezolid
rplC 800865 c.57A>G synonymous_variant 0.26 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.25 linezolid
rplC 800874 c.66A>G synonymous_variant 0.24 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.24 linezolid
rplC 800880 c.72A>G synonymous_variant 0.23 linezolid
rplC 800889 c.81C>G synonymous_variant 0.26 linezolid
rplC 800892 c.84G>C synonymous_variant 0.26 linezolid
rplC 800907 c.99C>G synonymous_variant 0.25 linezolid
rplC 800916 c.108A>G synonymous_variant 0.22 linezolid
rplC 801321 c.513C>T synonymous_variant 0.14 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.15 linezolid
rplC 801348 c.540T>G synonymous_variant 0.14 linezolid
rplC 801423 c.615G>C synonymous_variant 0.16 linezolid
rplC 801426 c.618C>G synonymous_variant 0.16 linezolid
rplC 801427 p.Met207Val missense_variant 0.17 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.17 linezolid
atpE 1461197 c.153A>G synonymous_variant 0.18 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.18 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.17 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
inhA 1674486 c.285T>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.18 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.28 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.29 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.18 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.19 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.2 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1833595 c.54T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.35 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.32 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.27 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.23 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064942 c.-214G>A upstream_gene_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289987 c.-746C>T upstream_gene_variant 0.14 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.14 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.14 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.15 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.21 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.17 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.2 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.2 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.21 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.19 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.15 isoniazid
eis 2715620 c.-288C>T upstream_gene_variant 1.0 amikacin
kanamycin
ahpC 2726591 c.399C>G synonymous_variant 0.17 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.16 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.17 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.16 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.16 isoniazid
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3641298 c.-237G>A upstream_gene_variant 0.92 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.25 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.25 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.29 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.29 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.27 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.34 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.29 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.25 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.24 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.25 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.18 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.27 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.27 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.25 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.25 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.24 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.28 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.2 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878424 c.84G>C synonymous_variant 0.23 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.23 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.22 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.2 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.23 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.19 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.23 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.32 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.32 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.26 rifampicin
clpC1 4038671 c.2034T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.31 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.25 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.25 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.22 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039937 c.768G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.14 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.16 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044890 c.-609G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.23 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.22 pyrazinamide
panD 4044902 c.-623_-621delACGinsGC upstream_gene_variant 0.23 pyrazinamide
panD 4044908 c.-628_-627delCTinsTC upstream_gene_variant 0.23 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.27 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.26 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.27 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.3 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.32 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.29 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.27 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.26 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.24 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.25 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4245296 c.2064G>C synonymous_variant 0.13 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.13 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.14 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.14 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.15 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
embB 4245812 c.-702G>C upstream_gene_variant 0.16 ethambutol
embA 4245813 c.2581_2583delCCCinsGG frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.16 ethambutol
embB 4245824 c.-690G>C upstream_gene_variant 0.15 ethambutol
embB 4245833 c.-681G>C upstream_gene_variant 0.21 ethambutol
embB 4245842 c.-672G>C upstream_gene_variant 0.22 ethambutol
embB 4245845 c.-669T>C upstream_gene_variant 0.24 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.26 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.23 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.15 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.15 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.18 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.18 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.26 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.19 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.17 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.17 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.14 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.21 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.2 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.2 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.2 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.2 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.21 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.2 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.16 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.15 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.15 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.15 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.13 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.13 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.14 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4247914 c.1401G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.19 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.19 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.21 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.22 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.2 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.2 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.2 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.22 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.21 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.21 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.21 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.25 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.23 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.29 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.21 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.17 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.23 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.3 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.17 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.17 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.14 ethambutol
embB 4249408 c.2895G>A synonymous_variant 0.88 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin