TB-Profiler result

Run: ERR5917985
Summary

Run ID: ERR5917985

Sample name:

Date: 2024-10-04T19:16:53.896855

Number of reads: 1464871

Percentage reads mapped: 51.4

Median coverage: 45.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
rpoC p.Gly332Arg Uncertain significance Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine mmpR5 c.144dupC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid
delamanid
bedaquiline mmpR5 c.144dupC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.14 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.85 rifampicin Assoc w R
rpoC 764363 p.Gly332Arg missense_variant 1.0 rifampicin Uncertain significance Mutation from literature
mmpR5 779130 c.144dupC frameshift_variant 1.0 bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin Assoc w R
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.65 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.46 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 761111 c.1305C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761126 c.1320G>C synonymous_variant 0.14 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.15 rifampicin
rpoB 761159 c.1353G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761162 c.1356G>C synonymous_variant 0.14 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.17 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.16 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761196 p.Leu464Val missense_variant 0.17 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761243 c.1437G>C synonymous_variant 0.14 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>G synonymous_variant 0.16 rifampicin
rpoB 762180 p.Asp792Pro missense_variant 0.17 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.17 rifampicin
rpoB 762230 c.2424G>C synonymous_variant 0.17 rifampicin
rpoB 762231 p.Thr809Ser missense_variant 0.18 rifampicin
rpoB 762234 p.Pro810Ala missense_variant 0.18 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.19 rifampicin
rpoB 762264 p.Gly820Asn missense_variant 0.19 rifampicin
rpoB 762273 p.Ala823Ser missense_variant 0.18 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.18 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.18 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762965 c.-405T>G upstream_gene_variant 0.12 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.16 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.13 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.98 rifampicin Not assoc w R
rpoB 763070 c.3264T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763079 c.-291C>G upstream_gene_variant 0.14 rifampicin
rpoC 763589 p.Ile74Val missense_variant 0.4 rifampicin
rpoC 763614 c.246_251delGACCCG disruptive_inframe_deletion 0.37 rifampicin
rpoC 763622 p.Ala85Thr missense_variant 0.36 rifampicin Uncertain significance
rpoC 763627 c.258_259insTCGTCC conservative_inframe_insertion 0.34 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.23 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.23 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763727 p.Leu120Met missense_variant 0.15 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.2 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.23 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.31 rifampicin
rpoC 764632 c.1263T>A synonymous_variant 0.22 rifampicin
rpoC 764635 c.1266C>G synonymous_variant 0.21 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764660 p.Val431Ile missense_variant 0.2 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764690 p.Cys441Ala missense_variant 0.2 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.19 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764722 c.1353G>C synonymous_variant 0.18 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.13 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472256 n.411T>C non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.6 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472666 n.821G>T non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.51 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.52 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472694 n.849C>A non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.51 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.66 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472993 n.1148G>T non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473022 n.1177G>A non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.67 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474770 n.1113G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475068 n.1411A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475078 n.1421T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475084 n.1427G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476079 n.2422G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476080 n.2423T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476081 n.2424A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476544 n.2887T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476566 n.2909A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833668 p.Ile43Val missense_variant 0.27 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833677 p.Val46Ile missense_variant 0.25 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833704 p.Ile55Val missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1833709 c.168C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.29 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833745 c.204G>T synonymous_variant 0.3 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833782 p.Ser81Lys missense_variant 0.16 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833959 p.Leu140Val missense_variant 0.23 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833998 p.Val153Ile missense_variant 0.29 pyrazinamide
rpsA 1834004 p.Met155Leu missense_variant 0.3 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834025 p.Gln162Thr missense_variant 0.28 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834034 p.Ile165Leu missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834040 p.Lys167Gln missense_variant 0.28 pyrazinamide
rpsA 1834061 p.Ile174Leu missense_variant 0.28 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2103226 c.-184C>G upstream_gene_variant 1.0 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289042 p.Ser67Trp missense_variant 1.0 pyrazinamide Uncertain significance
ald 3086739 c.-81G>A upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
clpC1 4039966 p.Leu247Val missense_variant 0.2 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.18 pyrazinamide
clpC1 4039998 p.Gly236Asn missense_variant 0.18 pyrazinamide
clpC1 4040000 p.His235Lys missense_variant 0.18 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040307 p.Arg133Lys missense_variant 0.23 pyrazinamide
clpC1 4040310 p.Thr132Asn missense_variant 0.22 pyrazinamide
clpC1 4040312 c.393G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.21 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>G synonymous_variant 0.21 pyrazinamide
clpC1 4040432 p.Ser91Arg missense_variant 0.13 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R