TB-Profiler result

Run: ERR5917985
Summary

Run ID: ERR5917985

Sample name:

Date: 02-04-2023 01:00:05

Number of reads: 1464871

Percentage reads mapped: 51.4

Strain: lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.14 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 0.85 rifampicin
rpoC 764363 p.Gly332Arg missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.65 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.46 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 761111 c.1305C>T synonymous_variant 0.15
rpoB 761126 c.1320G>C synonymous_variant 0.14
rpoB 761132 c.1326G>T synonymous_variant 0.15
rpoB 761133 c.1327T>C synonymous_variant 0.13
rpoB 761147 c.1341C>T synonymous_variant 0.15
rpoB 761150 c.1344A>C synonymous_variant 0.15
rpoB 761153 c.1347G>C synonymous_variant 0.15
rpoB 761159 c.1353G>C synonymous_variant 0.15
rpoB 761162 c.1356G>C synonymous_variant 0.14
rpoB 761165 c.1359G>C synonymous_variant 0.15
rpoB 761180 c.1374A>G synonymous_variant 0.17
rpoB 761189 c.1383T>C synonymous_variant 0.16
rpoB 761192 c.1386C>G synonymous_variant 0.16
rpoB 761195 c.1389G>C synonymous_variant 0.16
rpoB 761196 p.Leu464Val missense_variant 0.17
rpoB 761207 c.1401C>T synonymous_variant 0.16
rpoB 761234 c.1428G>C synonymous_variant 0.15
rpoB 761243 c.1437G>C synonymous_variant 0.14
rpoB 762167 c.2361T>C synonymous_variant 0.12
rpoB 762176 c.2370T>G synonymous_variant 0.16
rpoB 762180 p.Asp792Pro missense_variant 0.17
rpoB 762185 c.2379G>C synonymous_variant 0.18
rpoB 762194 c.2388G>C synonymous_variant 0.18
rpoB 762218 c.2412T>C synonymous_variant 0.17
rpoB 762230 c.2424G>C synonymous_variant 0.17
rpoB 762231 p.Thr809Ser missense_variant 0.18
rpoB 762234 p.Pro810Ala missense_variant 0.18
rpoB 762245 c.2439G>C synonymous_variant 0.18
rpoB 762254 c.2448T>C synonymous_variant 0.18
rpoB 762257 c.2451C>G synonymous_variant 0.19
rpoB 762264 p.Gly820Asn missense_variant 0.19
rpoB 762273 p.Ala823Ser missense_variant 0.18
rpoB 762281 c.2475G>A synonymous_variant 0.18
rpoB 762284 c.2478G>C synonymous_variant 0.17
rpoB 762293 c.2487T>G synonymous_variant 0.18
rpoC 762959 c.-411G>C upstream_gene_variant 0.14
rpoC 762965 c.-405T>G upstream_gene_variant 0.12
rpoC 762980 c.-390T>C upstream_gene_variant 0.16
rpoC 762989 c.-381G>C upstream_gene_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 0.98
rpoC 763070 c.-300T>C upstream_gene_variant 0.12
rpoC 763079 c.-291C>G upstream_gene_variant 0.14
rpoC 763094 c.-276G>C upstream_gene_variant 0.14
rpoC 763115 c.-255T>C upstream_gene_variant 0.13
rpoC 763468 c.99G>C synonymous_variant 0.22
rpoC 763483 c.114G>C synonymous_variant 0.22
rpoC 763486 c.117T>G synonymous_variant 0.22
rpoC 763492 c.123G>C synonymous_variant 0.25
rpoC 763504 c.135C>T synonymous_variant 0.21
rpoC 763511 p.Cys48Gly missense_variant 0.21
rpoC 763517 p.Lys50Gln missense_variant 0.2
rpoC 763528 c.159G>C synonymous_variant 0.24
rpoC 763531 c.162G>C synonymous_variant 0.23
rpoC 763532 p.Thr55Ser missense_variant 0.23
rpoC 763546 c.177A>G synonymous_variant 0.26
rpoC 763550 p.Tyr61Ala missense_variant 0.27
rpoC 763570 c.201G>C synonymous_variant 0.31
rpoC 763589 p.Ile74Val missense_variant 0.4
rpoC 763614 c.246_251delGACCCG disruptive_inframe_deletion 0.37
rpoC 763622 p.Ala85Thr missense_variant 0.36
rpoC 763627 c.258_259insTCGTCC conservative_inframe_insertion 0.34
rpoC 763633 c.264T>C synonymous_variant 0.34
rpoC 763642 c.273G>C synonymous_variant 0.35
rpoC 763660 c.291T>C synonymous_variant 0.36
rpoC 763675 c.306C>G synonymous_variant 0.32
rpoC 763696 c.327T>C synonymous_variant 0.28
rpoC 763708 c.339G>C synonymous_variant 0.23
rpoC 763711 c.342G>C synonymous_variant 0.23
rpoC 763717 c.348T>C synonymous_variant 0.21
rpoC 763723 c.354G>C synonymous_variant 0.19
rpoC 763727 p.Leu120Met missense_variant 0.15
rpoC 764485 c.1116G>C synonymous_variant 0.17
rpoC 764497 c.1128A>G synonymous_variant 0.2
rpoC 764498 p.Ser377Ala missense_variant 0.2
rpoC 764503 c.1134G>C synonymous_variant 0.19
rpoC 764521 c.1152T>C synonymous_variant 0.2
rpoC 764524 c.1155C>T synonymous_variant 0.2
rpoC 764533 c.1164C>T synonymous_variant 0.2
rpoC 764539 c.1170C>G synonymous_variant 0.19
rpoC 764542 c.1173C>G synonymous_variant 0.19
rpoC 764545 c.1176C>G synonymous_variant 0.2
rpoC 764548 c.1179G>C synonymous_variant 0.21
rpoC 764549 p.Pro394Thr missense_variant 0.2
rpoC 764560 c.1191T>C synonymous_variant 0.19
rpoC 764561 p.Pro398Ala missense_variant 0.19
rpoC 764566 c.1197C>G synonymous_variant 0.19
rpoC 764572 c.1203G>C synonymous_variant 0.19
rpoC 764575 c.1206T>C synonymous_variant 0.19
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.2
rpoC 764581 c.1212T>C synonymous_variant 0.19
rpoC 764582 p.Leu405Met missense_variant 0.2
rpoC 764587 c.1218C>G synonymous_variant 0.23
rpoC 764611 c.1242G>C synonymous_variant 0.31
rpoC 764632 c.1263T>A synonymous_variant 0.22
rpoC 764635 c.1266C>G synonymous_variant 0.21
rpoC 764650 c.1281G>T synonymous_variant 0.22
rpoC 764660 p.Val431Ile missense_variant 0.2
rpoC 764668 c.1299C>T synonymous_variant 0.22
rpoC 764677 c.1308C>G synonymous_variant 0.21
rpoC 764690 p.Cys441Ala missense_variant 0.2
rpoC 764701 c.1332C>G synonymous_variant 0.19
rpoC 764706 p.Leu446Gln missense_variant 0.19
rpoC 764716 c.1347G>C synonymous_variant 0.2
rpoC 764722 c.1353G>C synonymous_variant 0.18
rpoC 764737 c.1368G>C synonymous_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpR5 779130 c.144dupC frameshift_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.26
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.38
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.4
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.43
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.43
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.54
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.62
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.6
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.52
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.46
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.42
rrs 1472256 n.411T>C non_coding_transcript_exon_variant 0.41
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.26
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.43
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.44
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.45
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.47
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.55
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.58
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.59
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.6
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.57
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.57
rrs 1472666 n.821G>T non_coding_transcript_exon_variant 0.54
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.51
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.51
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.52
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.53
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.53
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.52
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.52
rrs 1472694 n.849C>A non_coding_transcript_exon_variant 0.54
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.54
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.51
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.23
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.32
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.58
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.58
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.58
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.59
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.64
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.64
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.66
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.66
rrs 1472993 n.1148G>T non_coding_transcript_exon_variant 0.66
rrs 1473022 n.1177G>A non_coding_transcript_exon_variant 0.33
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.76
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.72
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.72
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.75
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.42
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.72
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.73
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.72
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.69
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.7
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.7
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.73
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.71
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.72
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.67
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.68
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.69
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.62
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.61
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.59
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.57
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.56
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.57
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.47
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.47
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.46
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.13
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.15
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.19
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.25
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.29
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.3
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.3
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.33
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.33
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.41
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.51
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.58
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.62
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.62
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.57
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.57
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.57
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.58
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.58
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.51
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.15
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.16
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.16
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.22
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.24
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.25
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.24
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.24
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.26
rrl 1474770 n.1113G>A non_coding_transcript_exon_variant 0.3
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.32
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.31
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.31
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.31
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.43
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.44
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.48
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.38
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.38
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.37
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.38
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.38
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.28
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.28
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.25
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.26
rrl 1474935 n.1278A>G non_coding_transcript_exon_variant 0.13
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.28
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.25
rrl 1475068 n.1411A>T non_coding_transcript_exon_variant 0.25
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.23
rrl 1475078 n.1421T>A non_coding_transcript_exon_variant 0.24
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.25
rrl 1475084 n.1427G>T non_coding_transcript_exon_variant 0.27
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.25
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.25
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.23
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.22
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.23
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.24
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.24
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.24
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.25
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.39
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.53
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.72
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.72
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.73
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.67
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.67
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.66
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.67
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.66
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.63
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.59
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.57
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.56
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.56
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.42
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.38
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.36
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.24
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.26
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.29
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.29
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.29
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.28
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 0.29
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.28
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.31
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.26
rrl 1476079 n.2422G>A non_coding_transcript_exon_variant 0.26
rrl 1476080 n.2423T>C non_coding_transcript_exon_variant 0.26
rrl 1476081 n.2424A>T non_coding_transcript_exon_variant 0.26
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.26
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.26
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.28
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.35
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.36
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.36
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.4
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.38
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.41
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.39
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.39
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.49
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.51
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.46
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.47
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.48
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.46
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.45
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.41
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.41
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.4
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.41
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.42
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.42
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.45
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.48
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.59
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.65
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.67
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.66
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.66
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.49
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.49
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.38
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.38
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.35
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.36
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.36
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.36
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.36
rrl 1476544 n.2887T>A non_coding_transcript_exon_variant 0.37
rrl 1476566 n.2909A>T non_coding_transcript_exon_variant 0.36
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.34
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.27
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.23
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.23
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.19
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.21
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.2
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.17
rpsA 1833636 p.Tyr32Phe missense_variant 0.16
rpsA 1833646 c.105T>C synonymous_variant 0.18
rpsA 1833649 c.108C>A synonymous_variant 0.17
rpsA 1833653 p.Ile38Leu missense_variant 0.16
rpsA 1833656 p.Val39Ile missense_variant 0.16
rpsA 1833668 p.Ile43Val missense_variant 0.27
rpsA 1833676 c.135A>G synonymous_variant 0.26
rpsA 1833677 p.Val46Ile missense_variant 0.25
rpsA 1833685 c.144G>C synonymous_variant 0.23
rpsA 1833694 c.153G>C synonymous_variant 0.25
rpsA 1833704 p.Ile55Val missense_variant 0.27
rpsA 1833709 c.168C>T synonymous_variant 0.27
rpsA 1833721 c.180A>G synonymous_variant 0.26
rpsA 1833727 c.186G>C synonymous_variant 0.27
rpsA 1833734 p.Ala65Ser missense_variant 0.29
rpsA 1833742 c.201A>G synonymous_variant 0.3
rpsA 1833745 c.204G>T synonymous_variant 0.3
rpsA 1833748 c.207C>G synonymous_variant 0.29
rpsA 1833781 c.240T>C synonymous_variant 0.17
rpsA 1833782 p.Ser81Lys missense_variant 0.16
rpsA 1833790 c.249T>C synonymous_variant 0.16
rpsA 1833802 c.261A>G synonymous_variant 0.15
rpsA 1833955 c.414G>C synonymous_variant 0.23
rpsA 1833959 p.Leu140Val missense_variant 0.23
rpsA 1833970 c.429G>C synonymous_variant 0.25
rpsA 1833979 c.438T>C synonymous_variant 0.26
rpsA 1833985 c.444G>C synonymous_variant 0.28
rpsA 1833997 c.456G>C synonymous_variant 0.29
rpsA 1833998 p.Val153Ile missense_variant 0.29
rpsA 1834004 p.Met155Leu missense_variant 0.3
rpsA 1834009 c.468C>T synonymous_variant 0.29
rpsA 1834012 c.471G>C synonymous_variant 0.3
rpsA 1834015 c.474G>C synonymous_variant 0.3
rpsA 1834024 c.483G>C synonymous_variant 0.29
rpsA 1834025 p.Gln162Thr missense_variant 0.28
rpsA 1834030 c.489C>G synonymous_variant 0.28
rpsA 1834034 p.Ile165Leu missense_variant 0.28
rpsA 1834040 p.Lys167Gln missense_variant 0.28
rpsA 1834061 p.Ile174Leu missense_variant 0.28
rpsA 1834069 c.528G>C synonymous_variant 0.28
rpsA 1834090 c.549G>C synonymous_variant 0.14
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103226 c.-184C>G upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289042 p.Ser67Trp missense_variant 1.0
ald 3086739 c.-81G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
clpC1 4039901 c.804C>A synonymous_variant 0.13
clpC1 4039904 c.801A>G synonymous_variant 0.13
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.16
clpC1 4039934 c.771G>C synonymous_variant 0.16
clpC1 4039937 p.Val256Ile missense_variant 0.17
clpC1 4039946 c.759A>C synonymous_variant 0.16
clpC1 4039949 c.756G>C synonymous_variant 0.16
clpC1 4039952 c.753T>C synonymous_variant 0.16
clpC1 4039955 c.750G>C synonymous_variant 0.16
clpC1 4039960 p.Thr249Ser missense_variant 0.17
clpC1 4039966 p.Leu247Val missense_variant 0.2
clpC1 4039979 c.726C>G synonymous_variant 0.21
clpC1 4039991 c.714G>C synonymous_variant 0.2
clpC1 4039994 p.Glu237Asp missense_variant 0.18
clpC1 4039998 p.Gly236Asn missense_variant 0.18
clpC1 4040000 p.His235Lys missense_variant 0.18
clpC1 4040009 c.696C>G synonymous_variant 0.24
clpC1 4040018 c.687G>C synonymous_variant 0.26
clpC1 4040021 c.684A>C synonymous_variant 0.26
clpC1 4040024 c.681A>G synonymous_variant 0.26
clpC1 4040033 c.672G>C synonymous_variant 0.29
clpC1 4040063 c.642G>C synonymous_variant 0.14
clpC1 4040066 c.639G>C synonymous_variant 0.15
clpC1 4040069 c.636G>C synonymous_variant 0.14
clpC1 4040081 c.624C>G synonymous_variant 0.12
clpC1 4040087 c.618G>C synonymous_variant 0.12
clpC1 4040090 c.615T>G synonymous_variant 0.12
clpC1 4040093 c.612C>G synonymous_variant 0.12
clpC1 4040096 c.609G>C synonymous_variant 0.12
clpC1 4040105 c.600C>G synonymous_variant 0.12
clpC1 4040108 c.597G>C synonymous_variant 0.12
clpC1 4040117 c.588A>G synonymous_variant 0.12
clpC1 4040129 c.576C>G synonymous_variant 0.12
clpC1 4040138 c.567G>C synonymous_variant 0.13
clpC1 4040291 c.414G>C synonymous_variant 0.18
clpC1 4040307 p.Arg133Lys missense_variant 0.23
clpC1 4040310 p.Thr132Asn missense_variant 0.22
clpC1 4040312 c.393G>C synonymous_variant 0.22
clpC1 4040315 p.Glu130Asp missense_variant 0.21
clpC1 4040324 c.381G>C synonymous_variant 0.21
clpC1 4040333 c.372G>C synonymous_variant 0.21
clpC1 4040342 c.363C>G synonymous_variant 0.2
clpC1 4040348 c.357G>C synonymous_variant 0.2
clpC1 4040354 c.351A>G synonymous_variant 0.2
clpC1 4040357 c.348T>C synonymous_variant 0.2
clpC1 4040363 c.342A>C synonymous_variant 0.21
clpC1 4040375 c.330G>C synonymous_variant 0.23
clpC1 4040380 c.325T>C synonymous_variant 0.23
clpC1 4040381 c.324T>C synonymous_variant 0.23
clpC1 4040387 c.318A>G synonymous_variant 0.24
clpC1 4040393 c.312G>C synonymous_variant 0.24
clpC1 4040411 c.294T>G synonymous_variant 0.21
clpC1 4040432 p.Ser91Arg missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0