TB-Profiler result

Run: ERR7801175
Summary

Run ID: ERR7801175

Sample name:

Date: 2024-04-16T10:13:59.543485

Number of reads: 1407817

Percentage reads mapped: 37.31

Median coverage: 35.0

Strain: lineage4.6.5

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6.5 Euro-American None 1.0
lineage4.6 Euro-American None 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.343_345delATCinsGG Assoc w R High-level resistance
c.304_306delTTTinsAG Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rrs n.628G>C Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
tlyA p.Asn236Lys Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472473 n.628G>C non_coding_transcript_exon_variant 0.28 streptomycin Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.26 amikacin Assoc w R
kanamycin Assoc w R
capreomycin Assoc w R
tlyA 1918647 p.Asn236Lys missense_variant 1.0 capreomycin Assoc w R
katG 2155767 c.343_345delATCinsGG frameshift_variant&missense_variant 0.26 isoniazid Assoc w R High-level resistance
katG 2155806 c.304_306delTTTinsAG frameshift_variant&stop_gained 0.28 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1186 p.Glu396Lys missense_variant 1.0 isoniazid Uncertain significance
dnaA 1326 p.Gln442His missense_variant 1.0 isoniazid Uncertain significance
gyrB 5489 p.Ile84Val missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490756 c.-27T>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
rpoB 761051 c.1245G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>T synonymous_variant 0.18 rifampicin
rpoB 761067 c.1261_1263delATCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.18 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.18 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.19 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761565 p.Met587Leu missense_variant 0.18 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Phe missense_variant 0.14 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 762008 c.2202C>A synonymous_variant 0.39 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762015 c.2209_2211delGAAinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.36 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.54 rifampicin Uncertain significance
rpoB 762065 c.2259T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.49 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>C synonymous_variant 0.49 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.51 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.53 rifampicin
rpoB 762126 p.Val774Met missense_variant 0.54 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.55 rifampicin
rpoB 762135 p.Asp777Asn missense_variant 0.57 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.57 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.57 rifampicin
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.57 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Gly missense_variant 0.46 rifampicin
rpoB 762180 p.Asp792Thr missense_variant 0.46 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.46 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762249 c.2443C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.32 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.29 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762297 p.Leu831Met missense_variant 0.25 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762318 p.Ser838Ala missense_variant 0.18 rifampicin
rpoB 762325 p.Lys840Thr missense_variant 0.16 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.3 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.33 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.41 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.42 rifampicin
rpoB 762474 p.Gly890Ser missense_variant 0.46 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.2 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762902 c.-468C>T upstream_gene_variant 0.31 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.34 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.28 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.22 rifampicin
rpoB 763014 c.3208_3210delATGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.18 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.16 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.16 rifampicin Not assoc w R
rpoB 763036 p.Tyr1077Trp missense_variant 0.15 rifampicin
rpoB 763038 p.Thr1078Ala missense_variant 0.15 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.18 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.32 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763496 p.Lys43Arg missense_variant 0.42 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.48 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.47 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.47 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.48 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.55 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.38 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.38 rifampicin Uncertain significance
rpoC 763625 p.Lys86Gly missense_variant 0.38 rifampicin
rpoC 763630 c.261G>C synonymous_variant 0.39 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.43 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.44 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.41 rifampicin
rpoC 763705 c.336G>C synonymous_variant 0.42 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.41 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763727 c.358_360delCTGinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.3 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.23 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.24 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.37 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.46 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.47 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.49 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.41 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.45 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.38 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.37 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsAC frameshift_variant&missense_variant 0.37 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.37 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.38 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.38 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.37 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Ala missense_variant 0.52 rifampicin
rpoC 764751 p.Val461Asp missense_variant 0.53 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.47 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.42 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.38 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.32 rifampicin
rpoC 764813 p.Gln482Val missense_variant 0.32 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Ser missense_variant 0.28 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777974 c.507C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781706 c.147T>G synonymous_variant 0.13 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.13 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.14 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.15 streptomycin
rpsL 781731 p.Thr58Ser missense_variant 0.15 streptomycin
rpsL 781733 c.174_176delGAGinsC frameshift_variant&synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781738 p.Gln60Pro missense_variant 0.16 streptomycin
rpsL 781739 c.181_182dupGT frameshift_variant 0.16 streptomycin Uncertain significance
rpsL 781748 c.189C>G synonymous_variant 0.2 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.23 streptomycin
rpsL 781768 p.Glu70Val missense_variant 0.31 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.42 streptomycin
rpsL 781805 c.246G>T synonymous_variant 0.44 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.46 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.42 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.39 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.4 streptomycin
rpsL 781863 c.304C>T synonymous_variant 0.41 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.33 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.31 streptomycin
rpsL 781906 p.Arg116Leu missense_variant 0.22 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.2 streptomycin
rplC 800632 c.-177_-176delATinsTC upstream_gene_variant 0.19 linezolid
rplC 800639 c.-170C>G upstream_gene_variant 0.2 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.21 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.24 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.24 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800726 c.-83G>C upstream_gene_variant 0.21 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472368 n.523A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472439 n.594C>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472472 n.627G>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472522 n.677T>G non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472971 n.1126G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473029 n.1184C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474264 n.607T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474587 n.930G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474801 n.1144G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474802 n.1145T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474853 n.1196A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474917 n.1260G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475880 n.2223C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475892 n.2235A>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476213 n.2556G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476363 n.2706A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476366 n.2709A>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476374 n.2717T>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476572 n.2915G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rpsA 1833952 c.411C>T synonymous_variant 0.52 pyrazinamide
rpsA 1833959 p.Leu140Ile missense_variant 0.44 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.49 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.47 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.46 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834287 p.Ser249Cys missense_variant 0.15 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155716 c.396T>G synonymous_variant 0.29 isoniazid
katG 2155728 c.384G>T synonymous_variant 0.29 isoniazid
katG 2155735 p.Met126Gln missense_variant 0.28 isoniazid
katG 2155741 p.Gly124Thr missense_variant 0.3 isoniazid
katG 2155743 c.369G>T synonymous_variant 0.3 isoniazid
katG 2155764 p.His116Gln missense_variant 0.26 isoniazid
katG 2155770 c.342C>G synonymous_variant 0.26 isoniazid
katG 2155773 c.339C>T synonymous_variant 0.27 isoniazid Not assoc w R - Interim
katG 2155785 c.327T>G synonymous_variant 0.27 isoniazid
katG 2155788 c.324C>T synonymous_variant 0.3 isoniazid
katG 2155794 c.318G>C synonymous_variant 0.29 isoniazid
katG 2155815 c.297G>C synonymous_variant 0.27 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
folC 2746995 p.Val202Ile missense_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782475 p.Phe523Tyr missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782488 p.Glu519Gln missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782492 p.Asp517Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782526 c.1517delGinsCGC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782537 c.1506T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
fbiA 3640346 c.-196delA upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
clpC1 4038332 c.2373C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038836 c.1869G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038839 c.1864_1866delGTGinsAC frameshift_variant&missense_variant 0.71 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.75 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>T synonymous_variant 0.64 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.55 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.31 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039477 p.Met410Leu missense_variant 0.28 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039532 c.1171_1173delAACinsCG frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.22 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.5 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.48 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.5 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.49 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.43 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039874 p.Asn277Lys missense_variant 0.23 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin