Run ID: ERR7801175
Sample name:
Date: 2024-04-16T10:13:59.543485
Number of reads: 1407817
Percentage reads mapped: 37.31
Median coverage: 35.0
Strain: lineage4.6.5
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.6.5 | Euro-American | None | 1.0 |
lineage4.6 | Euro-American | None | 1.0 |
lineage4 | Euro-American | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | c.343_345delATCinsGG | Assoc w R | High-level resistance |
c.304_306delTTTinsAG | Assoc w R | High-level resistance | ||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | rrs | n.628G>C | Mutation from literature | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
capreomycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
tlyA | p.Asn236Lys | Assoc w R | ||
kanamycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
n.1484G>T | Assoc w R | |||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1472473 | n.628G>C | non_coding_transcript_exon_variant | 0.28 | streptomycin | Mutation from literature | |
rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance | Mutation from literature |
amikacin | Uncertain significance | Mutation from literature | |||||
kanamycin | Uncertain significance | Mutation from literature | |||||
rrs | 1473329 | n.1484G>T | non_coding_transcript_exon_variant | 0.26 | amikacin | Assoc w R | |
kanamycin | Assoc w R | ||||||
capreomycin | Assoc w R | ||||||
tlyA | 1918647 | p.Asn236Lys | missense_variant | 1.0 | capreomycin | Assoc w R | |
katG | 2155767 | c.343_345delATCinsGG | frameshift_variant&missense_variant | 0.26 | isoniazid | Assoc w R | High-level resistance |
katG | 2155806 | c.304_306delTTTinsAG | frameshift_variant&stop_gained | 0.28 | isoniazid | Assoc w R | High-level resistance |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 1186 | p.Glu396Lys | missense_variant | 1.0 | isoniazid | Uncertain significance |
dnaA | 1326 | p.Gln442His | missense_variant | 1.0 | isoniazid | Uncertain significance |
gyrB | 5489 | p.Ile84Val | missense_variant | 1.0 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 490756 | c.-27T>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
rpoB | 761051 | c.1245G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761060 | c.1254C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761063 | c.1257C>T | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761067 | c.1261_1263delATCinsCG | frameshift_variant&missense_variant | 0.18 | rifampicin | |
rpoB | 761088 | c.1282_1284delAGCinsTCG | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761097 | c.1291_1292delAGinsTC | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761537 | c.1731C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761558 | c.1752C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761565 | p.Met587Leu | missense_variant | 0.18 | rifampicin | |
rpoB | 761570 | c.1764T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761955 | p.Ile717Phe | missense_variant | 0.14 | rifampicin | |
rpoB | 762003 | c.2197_2199delAACinsCG | frameshift_variant&missense_variant | 0.38 | rifampicin | |
rpoB | 762008 | c.2202C>A | synonymous_variant | 0.39 | rifampicin | |
rpoB | 762014 | c.2208C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 762015 | c.2209_2211delGAAinsCG | frameshift_variant&missense_variant | 0.38 | rifampicin | |
rpoB | 762020 | p.Glu738Asp | missense_variant | 0.36 | rifampicin | |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoB | 762057 | p.Ile751Val | missense_variant | 0.54 | rifampicin | Uncertain significance |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoB | 762080 | c.2274G>C | synonymous_variant | 0.49 | rifampicin | |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 762110 | c.2304G>C | synonymous_variant | 0.49 | rifampicin | |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.51 | rifampicin | Uncertain significance |
rpoB | 762122 | p.Asp772Glu | missense_variant | 0.53 | rifampicin | |
rpoB | 762126 | p.Val774Met | missense_variant | 0.54 | rifampicin | |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.55 | rifampicin | |
rpoB | 762135 | p.Asp777Asn | missense_variant | 0.57 | rifampicin | Uncertain significance |
rpoB | 762140 | c.2334G>C | synonymous_variant | 0.57 | rifampicin | |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.57 | rifampicin | |
rpoB | 762156 | c.2350_2352delGTGinsAC | frameshift_variant&missense_variant | 0.57 | rifampicin | |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 762177 | p.Arg791Gly | missense_variant | 0.46 | rifampicin | |
rpoB | 762180 | p.Asp792Thr | missense_variant | 0.46 | rifampicin | |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 762218 | c.2412T>C | synonymous_variant | 0.46 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762249 | c.2443C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 762254 | c.2448T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.32 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.29 | rifampicin | |
rpoB | 762275 | c.2469C>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762297 | p.Leu831Met | missense_variant | 0.25 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762318 | p.Ser838Ala | missense_variant | 0.18 | rifampicin | |
rpoB | 762325 | p.Lys840Thr | missense_variant | 0.16 | rifampicin | |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoB | 762416 | c.2610A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 762419 | c.-951C>G | upstream_gene_variant | 0.33 | rifampicin | |
rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.41 | rifampicin | |
rpoC | 762443 | c.-927G>C | upstream_gene_variant | 0.42 | rifampicin | |
rpoB | 762474 | p.Gly890Ser | missense_variant | 0.46 | rifampicin | |
rpoB | 762488 | c.2682G>C | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoB | 762491 | c.2685T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 762509 | c.-861T>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoB | 762899 | c.3093G>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 762902 | c.-468C>T | upstream_gene_variant | 0.31 | rifampicin | |
rpoB | 762929 | c.3123G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 762938 | c.-432G>C | upstream_gene_variant | 0.34 | rifampicin | |
rpoB | 762995 | c.3189G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 763005 | p.Cys1067Val | missense_variant | 0.28 | rifampicin | |
rpoC | 763013 | c.-357C>A | upstream_gene_variant | 0.22 | rifampicin | |
rpoB | 763014 | c.3208_3210delATGinsCC | frameshift_variant&missense_variant | 0.17 | rifampicin | |
rpoB | 763017 | p.Gln1071Glu | missense_variant | 0.18 | rifampicin | |
rpoC | 763022 | c.-348C>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R |
rpoB | 763036 | p.Tyr1077Trp | missense_variant | 0.15 | rifampicin | |
rpoB | 763038 | p.Thr1078Ala | missense_variant | 0.15 | rifampicin | |
rpoB | 763053 | c.3247T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763094 | c.3288G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763142 | c.-228C>G | upstream_gene_variant | 0.18 | rifampicin | |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763462 | c.93G>C | synonymous_variant | 0.32 | rifampicin | |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 763496 | p.Lys43Arg | missense_variant | 0.42 | rifampicin | |
rpoC | 763528 | c.159G>T | synonymous_variant | 0.48 | rifampicin | |
rpoC | 763531 | c.162G>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R |
rpoC | 763534 | c.165T>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 763537 | c.168C>G | synonymous_variant | 0.48 | rifampicin | |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoC | 763576 | c.207C>G | synonymous_variant | 0.55 | rifampicin | |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 763622 | p.Ala85Ser | missense_variant | 0.38 | rifampicin | Uncertain significance |
rpoC | 763625 | p.Lys86Gly | missense_variant | 0.38 | rifampicin | |
rpoC | 763630 | c.261G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 763633 | c.264T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 763636 | c.267T>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 763648 | c.279C>T | synonymous_variant | 0.44 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 763666 | c.297G>C | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 763669 | c.300C>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 763696 | c.327T>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763699 | c.330G>T | synonymous_variant | 0.41 | rifampicin | |
rpoC | 763705 | c.336G>C | synonymous_variant | 0.42 | rifampicin | |
rpoC | 763708 | c.339G>C | synonymous_variant | 0.41 | rifampicin | |
rpoC | 763714 | c.345G>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763717 | c.348T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 763727 | c.358_360delCTGinsAC | frameshift_variant&missense_variant | 0.34 | rifampicin | |
rpoC | 763751 | p.Ile128Val | missense_variant | 0.3 | rifampicin | |
rpoC | 763765 | c.396T>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763768 | c.399C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 763772 | p.Val135Met | missense_variant | 0.24 | rifampicin | |
rpoC | 764377 | c.1008C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764387 | c.1018T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764398 | c.1029G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764405 | c.1036_1038delAGGinsCC | frameshift_variant&missense_variant | 0.4 | rifampicin | |
rpoC | 764419 | c.1050C>G | synonymous_variant | 0.46 | rifampicin | |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 764435 | c.1066_1068delAGGinsCA | frameshift_variant&missense_variant | 0.44 | rifampicin | |
rpoC | 764441 | p.Ile358Leu | missense_variant | 0.47 | rifampicin | |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.49 | rifampicin | |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764498 | p.Ser377Ala | missense_variant | 0.41 | rifampicin | |
rpoC | 764507 | p.Ala380Ser | missense_variant | 0.45 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 764530 | c.1161C>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 764542 | c.1173C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764548 | c.1179G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 764573 | c.1204_1206delCTTinsAC | frameshift_variant&missense_variant | 0.37 | rifampicin | |
rpoC | 764578 | c.1209C>G | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764582 | p.Leu405Met | missense_variant | 0.38 | rifampicin | |
rpoC | 764587 | c.1218C>G | synonymous_variant | 0.37 | rifampicin | |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.51 | rifampicin | Not assoc w R - Interim |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764644 | c.1275G>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 764705 | p.Leu446Ala | missense_variant | 0.52 | rifampicin | |
rpoC | 764751 | p.Val461Asp | missense_variant | 0.53 | rifampicin | |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 764767 | c.1398G>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 764780 | c.1411_1412delAGinsTC | synonymous_variant | 0.42 | rifampicin | |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.32 | rifampicin | |
rpoC | 764813 | p.Gln482Val | missense_variant | 0.32 | rifampicin | |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 764843 | p.Ala492Ser | missense_variant | 0.28 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 777974 | c.507C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781706 | c.147T>G | synonymous_variant | 0.13 | streptomycin | |
rpsL | 781709 | c.150G>C | synonymous_variant | 0.13 | streptomycin | Not assoc w R - Interim |
rpsL | 781715 | c.156T>G | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.15 | streptomycin | |
rpsL | 781731 | p.Thr58Ser | missense_variant | 0.15 | streptomycin | |
rpsL | 781733 | c.174_176delGAGinsC | frameshift_variant&synonymous_variant | 0.15 | streptomycin | Uncertain significance |
rpsL | 781738 | p.Gln60Pro | missense_variant | 0.16 | streptomycin | |
rpsL | 781739 | c.181_182dupGT | frameshift_variant | 0.16 | streptomycin | Uncertain significance |
rpsL | 781748 | c.189C>G | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781768 | p.Glu70Val | missense_variant | 0.31 | streptomycin | |
rpsL | 781772 | c.213C>T | synonymous_variant | 0.32 | streptomycin | Not assoc w R - Interim |
rpsL | 781802 | c.243G>C | synonymous_variant | 0.42 | streptomycin | |
rpsL | 781805 | c.246G>T | synonymous_variant | 0.44 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.46 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.42 | streptomycin | |
rpsL | 781832 | c.273T>G | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781835 | c.276T>C | synonymous_variant | 0.39 | streptomycin | Not assoc w R - Interim |
rpsL | 781838 | c.279G>C | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781863 | c.304C>T | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.37 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.33 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781906 | p.Arg116Leu | missense_variant | 0.22 | streptomycin | |
rpsL | 781916 | c.357T>G | synonymous_variant | 0.2 | streptomycin | |
rplC | 800632 | c.-177_-176delATinsTC | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800639 | c.-170C>G | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800645 | c.-164C>T | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800648 | c.-161A>G | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800667 | c.-142_-140delTCGinsAGC | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800672 | c.-137G>C | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800693 | c.-116A>C | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.25 | linezolid | |
rplC | 800726 | c.-83G>C | upstream_gene_variant | 0.21 | linezolid | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472112 | n.267C>T | non_coding_transcript_exon_variant | 0.15 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472113 | n.268T>C | non_coding_transcript_exon_variant | 0.21 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472122 | n.277G>T | non_coding_transcript_exon_variant | 0.22 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472123 | n.278A>T | non_coding_transcript_exon_variant | 0.23 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472148 | n.303T>C | non_coding_transcript_exon_variant | 0.33 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.33 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472240 | n.395G>A | non_coding_transcript_exon_variant | 0.32 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472251 | n.406G>C | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472279 | n.434T>G | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472286 | n.441C>G | non_coding_transcript_exon_variant | 0.21 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472289 | n.444T>C | non_coding_transcript_exon_variant | 0.19 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472297 | n.453_465delGTCCGGGTTCTCT | non_coding_transcript_exon_variant | 0.17 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472313 | n.468delGinsAA | non_coding_transcript_exon_variant | 0.15 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472315 | n.470T>G | non_coding_transcript_exon_variant | 0.15 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472328 | n.483G>C | non_coding_transcript_exon_variant | 0.16 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472337 | n.492C>G | non_coding_transcript_exon_variant | 0.21 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472368 | n.523A>G | non_coding_transcript_exon_variant | 0.27 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472380 | n.535G>C | non_coding_transcript_exon_variant | 0.32 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472400 | n.555C>T | non_coding_transcript_exon_variant | 0.31 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472422 | n.577T>C | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Uncertain significance | |||||
rrs | 1472435 | n.590T>C | non_coding_transcript_exon_variant | 0.25 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472437 | n.592T>G | non_coding_transcript_exon_variant | 0.25 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472438 | n.593T>A | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472439 | n.594C>A | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472446 | n.601T>A | non_coding_transcript_exon_variant | 0.26 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472451 | n.606C>G | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472461 | n.616G>C | non_coding_transcript_exon_variant | 0.28 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472467 | n.622G>C | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472471 | n.626G>T | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472472 | n.627G>T | non_coding_transcript_exon_variant | 0.28 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472493 | n.648T>G | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472522 | n.677T>G | non_coding_transcript_exon_variant | 0.15 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472571 | n.726G>T | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472580 | n.735C>A | non_coding_transcript_exon_variant | 0.28 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472581 | n.736A>C | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472582 | n.737G>T | non_coding_transcript_exon_variant | 0.29 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472584 | n.739A>T | non_coding_transcript_exon_variant | 0.3 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472585 | n.740A>C | non_coding_transcript_exon_variant | 0.3 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472616 | n.771G>A | non_coding_transcript_exon_variant | 0.41 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472623 | n.778A>C | non_coding_transcript_exon_variant | 0.43 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472660 | n.815T>C | non_coding_transcript_exon_variant | 0.49 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472674 | n.829T>C | non_coding_transcript_exon_variant | 0.45 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472675 | n.830T>A | non_coding_transcript_exon_variant | 0.44 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472677 | n.832C>A | non_coding_transcript_exon_variant | 0.46 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472682 | n.837T>A | non_coding_transcript_exon_variant | 0.45 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472683 | n.838T>C | non_coding_transcript_exon_variant | 0.45 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472685 | n.840G>T | non_coding_transcript_exon_variant | 0.45 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472714 | n.869A>G | non_coding_transcript_exon_variant | 0.46 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472790 | n.945T>C | non_coding_transcript_exon_variant | 0.28 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472952 | n.1107T>C | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472956 | n.1111T>C | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.19 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.22 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.21 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472971 | n.1126G>A | non_coding_transcript_exon_variant | 0.22 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.22 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.24 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472987 | n.1142G>A | non_coding_transcript_exon_variant | 0.21 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472989 | n.1144G>A | non_coding_transcript_exon_variant | 0.22 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472990 | n.1145A>G | non_coding_transcript_exon_variant | 0.22 | streptomycin | Uncertain significance |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1473029 | n.1184C>G | non_coding_transcript_exon_variant | 0.31 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473066 | n.1221A>G | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473081 | n.1236C>T | non_coding_transcript_exon_variant | 0.38 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473099 | n.1254T>A | non_coding_transcript_exon_variant | 0.5 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.5 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.52 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>T | non_coding_transcript_exon_variant | 0.54 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473121 | n.1276T>C | non_coding_transcript_exon_variant | 0.5 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1473122 | n.1277T>A | non_coding_transcript_exon_variant | 0.5 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1473130 | n.1285G>A | non_coding_transcript_exon_variant | 0.54 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.59 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.63 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473262 | n.1417T>C | non_coding_transcript_exon_variant | 0.5 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.47 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473283 | n.1438T>C | non_coding_transcript_exon_variant | 0.43 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473288 | n.1443C>T | non_coding_transcript_exon_variant | 0.41 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.38 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446G>T | non_coding_transcript_exon_variant | 0.38 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.36 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473314 | n.1469A>G | non_coding_transcript_exon_variant | 0.27 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473315 | n.1470T>C | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473316 | n.1471C>T | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473319 | n.1474C>T | non_coding_transcript_exon_variant | 0.27 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473320 | n.1475G>A | non_coding_transcript_exon_variant | 0.27 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473324 | n.1479G>A | non_coding_transcript_exon_variant | 0.25 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | ||||||
rrl | 1474218 | n.561T>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474264 | n.607T>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474265 | n.608G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474476 | n.819C>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1474488 | n.831G>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474496 | n.839C>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474497 | n.840G>C | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474506 | n.849C>G | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474507 | n.850G>T | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474516 | n.859C>A | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474527 | n.870T>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1474537 | n.880G>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474542 | n.885A>G | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1474558 | n.901G>A | non_coding_transcript_exon_variant | 0.49 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474587 | n.930G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1474779 | n.1122G>A | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474782 | n.1125G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1474783 | n.1126G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474800 | n.1143T>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1474801 | n.1144G>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1474802 | n.1145T>A | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474827 | n.1170C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>C | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474853 | n.1196A>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1474904 | n.1247G>C | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474905 | n.1248T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474913 | n.1256T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474917 | n.1260G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1475722 | n.2065G>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475747 | n.2090A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475869 | n.2212C>A | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1475880 | n.2223C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1475883 | n.2226A>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475892 | n.2235A>C | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1475897 | n.2240T>C | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475898 | n.2241A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475899 | n.2242G>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475943 | n.2286G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475952 | n.2295A>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476130 | n.2473G>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476141 | n.2484A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476153 | n.2496T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476160 | n.2503T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476165 | n.2508T>G | non_coding_transcript_exon_variant | 0.28 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476194 | n.2537A>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476200 | n.2543A>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476201 | n.2544C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476213 | n.2556G>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476245 | n.2588C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476250 | n.2593C>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476252 | n.2595T>G | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476256 | n.2599A>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476257 | n.2600G>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476363 | n.2706A>G | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1476366 | n.2709A>C | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1476374 | n.2717T>G | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.56 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.55 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.57 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476515 | n.2858C>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476524 | n.2867C>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476525 | n.2868A>G | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476528 | n.2871A>G | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476529 | n.2872A>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476536 | n.2879G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476538 | n.2881A>G | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476540 | n.2883C>G | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476547 | n.2890C>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476572 | n.2915G>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | |
linezolid | ||||||
rpsA | 1833952 | c.411C>T | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833959 | p.Leu140Ile | missense_variant | 0.44 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834034 | p.Ile165Val | missense_variant | 0.49 | pyrazinamide | |
rpsA | 1834040 | p.Lys167Gln | missense_variant | 0.47 | pyrazinamide | |
rpsA | 1834046 | p.Ile169Leu | missense_variant | 0.46 | pyrazinamide | |
rpsA | 1834054 | c.513C>G | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834102 | c.561T>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834105 | c.564C>T | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834108 | c.567C>G | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1834114 | c.573G>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834287 | p.Ser249Cys | missense_variant | 0.15 | pyrazinamide | |
rpsA | 1834294 | c.753G>C | synonymous_variant | 0.17 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2155716 | c.396T>G | synonymous_variant | 0.29 | isoniazid | |
katG | 2155728 | c.384G>T | synonymous_variant | 0.29 | isoniazid | |
katG | 2155735 | p.Met126Gln | missense_variant | 0.28 | isoniazid | |
katG | 2155741 | p.Gly124Thr | missense_variant | 0.3 | isoniazid | |
katG | 2155743 | c.369G>T | synonymous_variant | 0.3 | isoniazid | |
katG | 2155764 | p.His116Gln | missense_variant | 0.26 | isoniazid | |
katG | 2155770 | c.342C>G | synonymous_variant | 0.26 | isoniazid | |
katG | 2155773 | c.339C>T | synonymous_variant | 0.27 | isoniazid | Not assoc w R - Interim |
katG | 2155785 | c.327T>G | synonymous_variant | 0.27 | isoniazid | |
katG | 2155788 | c.324C>T | synonymous_variant | 0.3 | isoniazid | |
katG | 2155794 | c.318G>C | synonymous_variant | 0.29 | isoniazid | |
katG | 2155815 | c.297G>C | synonymous_variant | 0.27 | isoniazid | |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
folC | 2746995 | p.Val202Ile | missense_variant | 1.0 | para-aminosalicylic_acid | |
Rv2477c | 2782475 | p.Phe523Tyr | missense_variant | 0.22 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782483 | c.1560G>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782488 | p.Glu519Gln | missense_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782492 | p.Asp517Glu | missense_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782510 | c.1533G>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782522 | c.1521G>C | synonymous_variant | 0.21 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782526 | c.1517delGinsCGC | frameshift_variant&missense_variant | 0.21 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2782537 | c.1506T>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782540 | c.1503T>C | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782555 | c.1488G>C | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782558 | c.1485T>C | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
fbiA | 3640346 | c.-196delA | upstream_gene_variant | 1.0 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
clpC1 | 4038332 | c.2373C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038836 | c.1869G>C | synonymous_variant | 0.71 | pyrazinamide | |
clpC1 | 4038839 | c.1864_1866delGTGinsAC | frameshift_variant&missense_variant | 0.71 | pyrazinamide | |
clpC1 | 4038875 | c.1830C>G | synonymous_variant | 0.75 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.75 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038896 | c.1809C>T | synonymous_variant | 0.64 | pyrazinamide | |
clpC1 | 4038905 | c.1800A>C | synonymous_variant | 0.55 | pyrazinamide | |
clpC1 | 4038911 | c.1794G>C | synonymous_variant | 0.55 | pyrazinamide | |
clpC1 | 4039454 | c.1251A>T | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039463 | c.1242C>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039477 | p.Met410Leu | missense_variant | 0.28 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039487 | c.1218G>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039526 | c.1179G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039532 | c.1171_1173delAACinsCG | frameshift_variant&missense_variant | 0.23 | pyrazinamide | |
clpC1 | 4039714 | p.Tyr331His | missense_variant | 0.22 | pyrazinamide | |
clpC1 | 4039727 | c.978C>T | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039733 | c.972G>C | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.51 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.51 | pyrazinamide | |
clpC1 | 4039773 | p.Lys311Met | missense_variant | 0.5 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.49 | pyrazinamide | |
clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4039796 | c.909C>T | synonymous_variant | 0.51 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039817 | c.888A>T | synonymous_variant | 0.5 | pyrazinamide | |
clpC1 | 4039820 | c.885T>G | synonymous_variant | 0.49 | pyrazinamide | |
clpC1 | 4039831 | c.874T>C | synonymous_variant | 0.5 | pyrazinamide | |
clpC1 | 4039838 | c.865_867delCTGinsAC | frameshift_variant&missense_variant | 0.43 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039855 | c.850C>T | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039874 | p.Asn277Lys | missense_variant | 0.23 | pyrazinamide | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin |