TB-Profiler result

Run: ERR7801175
Summary

Run ID: ERR7801175

Sample name:

Date: 02-04-2023 05:57:57

Number of reads: 1407817

Percentage reads mapped: 37.31

Strain: lineage4.6.5

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.5 Euro-American T;LAM None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.16 rifampicin
rrs 1472473 n.628G>C non_coding_transcript_exon_variant 0.28 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.53 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.26 kanamycin, capreomycin, aminoglycosides, amikacin
tlyA 1918647 p.Asn236Lys missense_variant 1.0 capreomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5489 p.Ile84Val missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7962 p.Gly221Trp missense_variant 0.2
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490756 c.-27T>G upstream_gene_variant 1.0
rpoB 760408 p.Ser201Thr missense_variant 0.15
rpoB 760415 c.609C>T synonymous_variant 0.14
rpoB 760418 c.612G>C synonymous_variant 0.15
rpoB 760430 c.624T>C synonymous_variant 0.14
rpoB 760433 p.Asp209Glu missense_variant 0.12
rpoB 760451 c.645C>G synonymous_variant 0.14
rpoB 760460 c.654G>A synonymous_variant 0.14
rpoB 760464 p.Ile220Leu missense_variant 0.13
rpoB 760475 c.669A>G synonymous_variant 0.12
rpoB 761051 c.1245G>T synonymous_variant 0.14
rpoB 761060 c.1254C>G synonymous_variant 0.18
rpoB 761063 c.1257C>T synonymous_variant 0.18
rpoB 761067 p.Ile421Leu missense_variant 0.18
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.18
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.18
rpoB 761102 c.1296A>G synonymous_variant 0.19
rpoB 761126 c.1320G>C synonymous_variant 0.16
rpoB 761132 c.1326G>T synonymous_variant 0.17
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.17
rpoB 761150 c.1344A>C synonymous_variant 0.19
rpoB 761153 c.1347G>C synonymous_variant 0.2
rpoB 761165 c.1359G>C synonymous_variant 0.19
rpoB 761168 c.1362C>G synonymous_variant 0.15
rpoB 761189 c.1383T>C synonymous_variant 0.12
rpoB 761192 c.1386C>G synonymous_variant 0.12
rpoB 761207 c.1401C>T synonymous_variant 0.17
rpoB 761219 c.1413G>C synonymous_variant 0.17
rpoB 761537 c.1731C>G synonymous_variant 0.23
rpoB 761558 c.1752C>G synonymous_variant 0.2
rpoB 761565 p.Met587Leu missense_variant 0.18
rpoB 761570 c.1764T>C synonymous_variant 0.17
rpoB 761573 c.1767C>G synonymous_variant 0.17
rpoB 761579 c.1773G>C synonymous_variant 0.14
rpoB 761954 c.2148C>G synonymous_variant 0.13
rpoB 761955 p.Ile717Phe missense_variant 0.14
rpoB 762003 p.Asn733Gln missense_variant 0.38
rpoB 762008 c.2202C>A synonymous_variant 0.39
rpoB 762014 c.2208C>G synonymous_variant 0.38
rpoB 762015 p.Glu737Gln missense_variant 0.38
rpoB 762020 p.Glu738Asp missense_variant 0.36
rpoB 762053 c.2247T>C synonymous_variant 0.54
rpoB 762057 p.Ile751Val missense_variant 0.54
rpoB 762065 c.2259T>C synonymous_variant 0.55
rpoB 762080 c.2274G>C synonymous_variant 0.49
rpoB 762086 c.2280G>C synonymous_variant 0.48
rpoB 762110 c.2304G>C synonymous_variant 0.49
rpoB 762114 p.Ile770Val missense_variant 0.51
rpoB 762122 p.Asp772Glu missense_variant 0.53
rpoB 762126 p.Val774Met missense_variant 0.54
rpoB 762131 c.2325C>G synonymous_variant 0.55
rpoB 762135 p.Asp777Asn missense_variant 0.57
rpoB 762140 c.2334G>C synonymous_variant 0.57
rpoB 762143 c.2337T>C synonymous_variant 0.57
rpoB 762156 p.Val784Ile missense_variant 0.57
rpoB 762176 c.2370T>C synonymous_variant 0.47
rpoB 762177 p.Arg791Gly missense_variant 0.46
rpoB 762180 p.Asp792Thr missense_variant 0.46
rpoB 762185 c.2379G>C synonymous_variant 0.48
rpoB 762218 c.2412T>C synonymous_variant 0.46
rpoB 762233 c.2427G>C synonymous_variant 0.4
rpoB 762249 c.2443C>T synonymous_variant 0.32
rpoB 762254 c.2448T>C synonymous_variant 0.32
rpoB 762257 c.2451C>G synonymous_variant 0.32
rpoB 762266 c.2460T>C synonymous_variant 0.29
rpoB 762275 c.2469C>G synonymous_variant 0.26
rpoB 762284 c.2478G>C synonymous_variant 0.25
rpoB 762293 c.2487T>C synonymous_variant 0.25
rpoB 762297 p.Leu831Met missense_variant 0.25
rpoB 762317 c.2511A>G synonymous_variant 0.18
rpoB 762318 p.Ser838Ala missense_variant 0.18
rpoB 762325 p.Lys840Thr missense_variant 0.16
rpoC 762395 c.-975G>C upstream_gene_variant 0.16
rpoC 762398 c.-972T>G upstream_gene_variant 0.16
rpoC 762401 c.-969G>C upstream_gene_variant 0.16
rpoC 762404 c.-966T>C upstream_gene_variant 0.22
rpoC 762410 c.-960T>C upstream_gene_variant 0.3
rpoC 762416 c.-954A>G upstream_gene_variant 0.31
rpoC 762419 c.-951C>G upstream_gene_variant 0.33
rpoC 762434 c.-936T>C upstream_gene_variant 0.41
rpoC 762443 c.-927G>C upstream_gene_variant 0.42
rpoB 762474 p.Gly890Ser missense_variant 0.46
rpoC 762488 c.-882G>C upstream_gene_variant 0.44
rpoC 762491 c.-879T>C upstream_gene_variant 0.36
rpoC 762509 c.-861T>G upstream_gene_variant 0.2
rpoB 762878 p.Ile1024Met missense_variant 0.14
rpoB 762879 p.Met1025Leu missense_variant 0.14
rpoC 762899 c.-471G>C upstream_gene_variant 0.31
rpoC 762902 c.-468C>T upstream_gene_variant 0.31
rpoC 762929 c.-441G>T upstream_gene_variant 0.32
rpoC 762938 c.-432G>C upstream_gene_variant 0.34
rpoC 762995 c.-375G>C upstream_gene_variant 0.36
rpoB 763005 p.Cys1067Val missense_variant 0.28
rpoC 763013 c.-357C>A upstream_gene_variant 0.22
rpoB 763014 p.Met1070Leu missense_variant 0.17
rpoB 763017 p.Gln1071Glu missense_variant 0.18
rpoC 763022 c.-348C>G upstream_gene_variant 0.16
rpoC 763028 c.-342T>C upstream_gene_variant 0.16
rpoC 763031 c.-339T>C upstream_gene_variant 0.16
rpoB 763036 p.Tyr1077Trp missense_variant 0.15
rpoB 763038 p.Thr1078Ala missense_variant 0.15
rpoC 763053 c.-317T>C upstream_gene_variant 0.22
rpoC 763070 c.-300T>C upstream_gene_variant 0.15
rpoC 763085 c.-285C>G upstream_gene_variant 0.17
rpoC 763094 c.-276G>C upstream_gene_variant 0.17
rpoC 763115 c.-255T>C upstream_gene_variant 0.18
rpoC 763127 c.-243G>C upstream_gene_variant 0.19
rpoC 763142 c.-228C>G upstream_gene_variant 0.18
rpoC 763456 c.87A>G synonymous_variant 0.23
rpoC 763462 c.93G>C synonymous_variant 0.32
rpoC 763486 c.117T>C synonymous_variant 0.46
rpoC 763492 c.123G>C synonymous_variant 0.45
rpoC 763496 p.Lys43Arg missense_variant 0.42
rpoC 763528 c.159G>T synonymous_variant 0.48
rpoC 763531 c.162G>C synonymous_variant 0.47
rpoC 763534 c.165T>C synonymous_variant 0.47
rpoC 763537 c.168C>G synonymous_variant 0.48
rpoC 763546 c.177A>G synonymous_variant 0.5
rpoC 763573 c.204G>C synonymous_variant 0.53
rpoC 763576 c.207C>G synonymous_variant 0.55
rpoC 763621 c.252C>T synonymous_variant 0.38
rpoC 763622 p.Ala85Ser missense_variant 0.38
rpoC 763625 p.Lys86Gly missense_variant 0.38
rpoC 763630 c.261G>C synonymous_variant 0.39
rpoC 763633 c.264T>C synonymous_variant 0.38
rpoC 763636 c.267T>G synonymous_variant 0.43
rpoC 763648 c.279C>T synonymous_variant 0.44
rpoC 763660 c.291T>G synonymous_variant 0.48
rpoC 763666 c.297G>C synonymous_variant 0.49
rpoC 763669 c.300C>G synonymous_variant 0.5
rpoC 763696 c.327T>C synonymous_variant 0.41
rpoC 763699 c.330G>T synonymous_variant 0.41
rpoC 763705 c.336G>C synonymous_variant 0.42
rpoC 763708 c.339G>C synonymous_variant 0.41
rpoC 763714 c.345G>C synonymous_variant 0.41
rpoC 763717 c.348T>C synonymous_variant 0.39
rpoC 763723 c.354G>C synonymous_variant 0.35
rpoC 763727 p.Leu120Ile missense_variant 0.34
rpoC 763751 p.Ile128Val missense_variant 0.3
rpoC 763765 c.396T>G synonymous_variant 0.24
rpoC 763768 c.399C>G synonymous_variant 0.23
rpoC 763772 p.Val135Met missense_variant 0.24
rpoC 763783 c.414G>C synonymous_variant 0.13
rpoC 764365 c.996C>T synonymous_variant 0.2
rpoC 764371 c.1002G>C synonymous_variant 0.2
rpoC 764377 c.1008C>G synonymous_variant 0.2
rpoC 764380 c.1011G>C synonymous_variant 0.26
rpoC 764387 c.1018T>C synonymous_variant 0.3
rpoC 764398 c.1029G>C synonymous_variant 0.37
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.4
rpoC 764419 c.1050C>G synonymous_variant 0.46
rpoC 764431 c.1062G>C synonymous_variant 0.46
rpoC 764434 c.1065A>G synonymous_variant 0.46
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.44
rpoC 764441 p.Ile358Leu missense_variant 0.47
rpoC 764446 c.1077T>C synonymous_variant 0.49
rpoC 764461 c.1092A>G synonymous_variant 0.48
rpoC 764497 c.1128A>G synonymous_variant 0.42
rpoC 764498 p.Ser377Ala missense_variant 0.41
rpoC 764507 p.Ala380Ser missense_variant 0.45
rpoC 764521 c.1152T>C synonymous_variant 0.41
rpoC 764527 c.1158C>T synonymous_variant 0.41
rpoC 764530 c.1161C>T synonymous_variant 0.4
rpoC 764536 c.1167G>T synonymous_variant 0.39
rpoC 764539 c.1170C>G synonymous_variant 0.39
rpoC 764542 c.1173C>G synonymous_variant 0.38
rpoC 764548 c.1179G>C synonymous_variant 0.37
rpoC 764560 c.1191T>C synonymous_variant 0.38
rpoC 764566 c.1197C>G synonymous_variant 0.41
rpoC 764573 p.Leu402Ile missense_variant 0.37
rpoC 764578 c.1209C>G synonymous_variant 0.37
rpoC 764581 c.1212T>C synonymous_variant 0.38
rpoC 764582 p.Leu405Met missense_variant 0.38
rpoC 764587 c.1218C>G synonymous_variant 0.37
rpoC 764611 c.1242G>T synonymous_variant 0.51
rpoC 764632 c.1263T>C synonymous_variant 0.4
rpoC 764644 c.1275G>C synonymous_variant 0.43
rpoC 764650 c.1281G>T synonymous_variant 0.44
rpoC 764705 p.Leu446Ala missense_variant 0.52
rpoC 764751 p.Val461Asp missense_variant 0.53
rpoC 764758 c.1389C>G synonymous_variant 0.48
rpoC 764764 c.1395T>C synonymous_variant 0.49
rpoC 764767 c.1398G>C synonymous_variant 0.47
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.42
rpoC 764791 c.1422C>G synonymous_variant 0.42
rpoC 764803 c.1434C>G synonymous_variant 0.38
rpoC 764812 c.1443C>G synonymous_variant 0.32
rpoC 764813 p.Gln482Val missense_variant 0.32
rpoC 764824 c.1455T>C synonymous_variant 0.33
rpoC 764827 c.1458G>C synonymous_variant 0.31
rpoC 764843 p.Ala492Ser missense_variant 0.28
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777974 c.507C>T synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781706 c.147T>G synonymous_variant 0.13
rpsL 781709 c.150G>C synonymous_variant 0.13
rpsL 781715 c.156T>G synonymous_variant 0.14
rpsL 781728 c.169T>C synonymous_variant 0.15
rpsL 781731 p.Thr58Ser missense_variant 0.15
rpsL 781738 p.Gln60Pro missense_variant 0.16
rpsL 781739 c.181_182dupGT frameshift_variant 0.16
rpsL 781748 c.189C>G synonymous_variant 0.2
rpsL 781751 c.192G>C synonymous_variant 0.18
rpsL 781754 c.195G>C synonymous_variant 0.21
rpsL 781760 c.201T>C synonymous_variant 0.23
rpsL 781768 p.Glu70Val missense_variant 0.31
rpsL 781772 c.213C>T synonymous_variant 0.32
rpsL 781802 c.243G>C synonymous_variant 0.42
rpsL 781805 c.246G>T synonymous_variant 0.44
rpsL 781811 c.252C>T synonymous_variant 0.46
rpsL 781817 c.258G>T synonymous_variant 0.42
rpsL 781832 c.273T>G synonymous_variant 0.39
rpsL 781835 c.276T>C synonymous_variant 0.39
rpsL 781838 c.279G>C synonymous_variant 0.4
rpsL 781863 c.304C>T synonymous_variant 0.41
rpsL 781868 c.309T>C synonymous_variant 0.38
rpsL 781871 c.312G>C synonymous_variant 0.37
rpsL 781892 c.333A>G synonymous_variant 0.33
rpsL 781898 c.339A>T synonymous_variant 0.31
rpsL 781906 p.Arg116Leu missense_variant 0.22
rpsL 781916 c.357T>G synonymous_variant 0.2
rplC 800618 c.-191T>C upstream_gene_variant 0.15
rplC 800632 c.-177_-176delATinsTC upstream_gene_variant 0.19
rplC 800639 c.-170C>G upstream_gene_variant 0.2
rplC 800645 c.-164C>T upstream_gene_variant 0.21
rplC 800648 c.-161A>G upstream_gene_variant 0.21
rplC 800654 c.-155T>C upstream_gene_variant 0.23
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.24
rplC 800672 c.-137G>C upstream_gene_variant 0.24
rplC 800693 c.-116A>C upstream_gene_variant 0.24
rplC 800703 c.-106T>C upstream_gene_variant 0.25
rplC 800726 c.-83G>C upstream_gene_variant 0.21
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.15
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.21
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.22
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.23
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.33
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.33
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.32
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.29
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.24
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.21
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.19
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.17
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.15
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.16
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.21
rrs 1472368 n.523A>G non_coding_transcript_exon_variant 0.27
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.32
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.31
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.29
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.25
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.25
rrs 1472438 n.593T>A non_coding_transcript_exon_variant 0.24
rrs 1472439 n.594C>A non_coding_transcript_exon_variant 0.24
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.26
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.29
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.28
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.29
rrs 1472471 n.626G>T non_coding_transcript_exon_variant 0.29
rrs 1472472 n.627G>T non_coding_transcript_exon_variant 0.28
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.14
rrs 1472522 n.677T>G non_coding_transcript_exon_variant 0.15
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.29
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.28
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.29
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.29
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.3
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.3
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.41
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.43
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.49
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.45
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.44
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.46
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.45
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.45
rrs 1472685 n.840G>T non_coding_transcript_exon_variant 0.45
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.46
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.28
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.18
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.18
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.19
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.22
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21
rrs 1472971 n.1126G>A non_coding_transcript_exon_variant 0.22
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.22
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.24
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.21
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.22
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.22
rrs 1473029 n.1184C>G non_coding_transcript_exon_variant 0.31
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.26
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.38
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.5
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.5
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.52
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.54
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.5
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.5
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.54
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.59
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.63
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.5
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.47
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.43
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.41
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.38
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.38
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.36
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.27
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.26
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.26
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.27
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.27
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.25
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.14
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.22
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17
rrl 1474264 n.607T>A non_coding_transcript_exon_variant 0.2
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.2
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.12
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.11
rrl 1474450 n.793T>C non_coding_transcript_exon_variant 0.14
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.17
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.36
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.39
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.43
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.45
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.48
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.48
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.52
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.5
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.47
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.48
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.49
rrl 1474587 n.930G>A non_coding_transcript_exon_variant 0.24
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.26
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.45
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.43
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.43
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.44
rrl 1474800 n.1143T>A non_coding_transcript_exon_variant 0.41
rrl 1474801 n.1144G>T non_coding_transcript_exon_variant 0.38
rrl 1474802 n.1145T>A non_coding_transcript_exon_variant 0.39
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.43
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.4
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.43
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.43
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.43
rrl 1474853 n.1196A>G non_coding_transcript_exon_variant 0.47
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.25
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.19
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.19
rrl 1474917 n.1260G>T non_coding_transcript_exon_variant 0.2
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.14
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.13
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.13
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.14
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.14
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.14
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.17
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.21
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.24
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.19
rrl 1475752 n.2095C>G non_coding_transcript_exon_variant 0.18
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.18
rrl 1475757 n.2101_2104delACCC non_coding_transcript_exon_variant 0.2
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.19
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.19
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 0.19
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.19
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.2
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.2
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.19
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.19
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.48
rrl 1475880 n.2223C>T non_coding_transcript_exon_variant 0.46
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.46
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.46
rrl 1475892 n.2235A>C non_coding_transcript_exon_variant 0.45
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.44
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.44
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.44
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.36
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.33
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.26
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.25
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.19
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.19
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.17
rrl 1475991 n.2334T>A non_coding_transcript_exon_variant 0.17
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.17
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.16
rrl 1475999 n.2342G>A non_coding_transcript_exon_variant 0.16
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.16
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.18
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.14
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.21
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.21
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.22
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.24
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.24
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.28
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.29
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.32
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.32
rrl 1476213 n.2556G>T non_coding_transcript_exon_variant 0.31
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.31
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.31
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.32
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.29
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.29
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.31
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.29
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.29
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.21
rrl 1476316 n.2659G>A non_coding_transcript_exon_variant 0.18
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.4
rrl 1476363 n.2706A>G non_coding_transcript_exon_variant 0.42
rrl 1476366 n.2709A>C non_coding_transcript_exon_variant 0.41
rrl 1476374 n.2717T>G non_coding_transcript_exon_variant 0.48
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.52
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.56
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.55
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.57
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.51
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.53
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.53
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.53
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.51
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.53
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.53
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.53
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.51
rrl 1476572 n.2915G>T non_coding_transcript_exon_variant 0.34
rpsA 1833847 c.306C>G synonymous_variant 0.16
rpsA 1833856 c.315A>G synonymous_variant 0.2
rpsA 1833862 c.321G>C synonymous_variant 0.21
rpsA 1833874 c.333T>C synonymous_variant 0.23
rpsA 1833886 c.345C>G synonymous_variant 0.24
rpsA 1833893 p.Ala118Lys missense_variant 0.25
rpsA 1833896 p.Leu119Ile missense_variant 0.27
rpsA 1833904 c.363G>A synonymous_variant 0.25
rpsA 1833905 p.Lys122Glu missense_variant 0.26
rpsA 1833912 p.Glu124Gly missense_variant 0.28
rpsA 1833915 p.Ala125Val missense_variant 0.28
rpsA 1833921 p.Lys127Thr missense_variant 0.28
rpsA 1833927 p.Thr129Lys missense_variant 0.33
rpsA 1833931 c.390C>G synonymous_variant 0.39
rpsA 1833952 c.411C>T synonymous_variant 0.52
rpsA 1833959 p.Leu140Ile missense_variant 0.44
rpsA 1833970 c.429G>C synonymous_variant 0.47
rpsA 1833979 c.438T>C synonymous_variant 0.5
rpsA 1834034 p.Ile165Val missense_variant 0.49
rpsA 1834040 p.Lys167Gln missense_variant 0.47
rpsA 1834046 p.Ile169Leu missense_variant 0.46
rpsA 1834054 c.513C>G synonymous_variant 0.47
rpsA 1834102 c.561T>C synonymous_variant 0.38
rpsA 1834105 c.564C>T synonymous_variant 0.31
rpsA 1834108 c.567C>G synonymous_variant 0.31
rpsA 1834114 c.573G>C synonymous_variant 0.28
rpsA 1834261 c.720A>G synonymous_variant 0.15
rpsA 1834287 p.Ser249Cys missense_variant 0.15
rpsA 1834294 c.753G>C synonymous_variant 0.17
rpsA 1834298 p.Gln253Glu missense_variant 0.16
rpsA 1834303 c.762T>C synonymous_variant 0.17
rpsA 1834306 c.765T>C synonymous_variant 0.17
rpsA 1834307 p.Asp256Gln missense_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155716 c.396T>G synonymous_variant 0.29
katG 2155728 c.384G>T synonymous_variant 0.29
katG 2155735 p.Met126Gln missense_variant 0.28
katG 2155741 p.Gly124Thr missense_variant 0.3
katG 2155743 c.369G>T synonymous_variant 0.3
katG 2155764 p.His116Gln missense_variant 0.26
katG 2155767 p.Ile115Val missense_variant 0.26
katG 2155770 c.342C>G synonymous_variant 0.26
katG 2155773 c.339C>T synonymous_variant 0.27
katG 2155785 c.327T>G synonymous_variant 0.27
katG 2155788 c.324C>T synonymous_variant 0.3
katG 2155794 c.318G>C synonymous_variant 0.29
katG 2155806 p.Phe102Met missense_variant 0.28
katG 2155815 c.297G>C synonymous_variant 0.27
katG 2155828 p.Tyr95Phe missense_variant 0.17
Rv1979c 2222155 p.Pro337Leu missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746995 p.Val202Ile missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3640346 c.-196delA upstream_gene_variant 1.0
clpC1 4038332 c.2373C>T synonymous_variant 1.0
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.23
clpC1 4038801 p.Tyr635Phe missense_variant 0.23
clpC1 4038806 p.Glu633Asp missense_variant 0.3
clpC1 4038810 p.Gln632Pro missense_variant 0.33
clpC1 4038812 c.1893T>C synonymous_variant 0.33
clpC1 4038836 c.1869G>C synonymous_variant 0.71
clpC1 4038839 p.Val622Ile missense_variant 0.71
clpC1 4038875 c.1830C>G synonymous_variant 0.75
clpC1 4038878 c.1827A>G synonymous_variant 0.75
clpC1 4038896 c.1809C>T synonymous_variant 0.64
clpC1 4038905 c.1800A>C synonymous_variant 0.55
clpC1 4038911 c.1794G>C synonymous_variant 0.55
clpC1 4038916 p.Ala597Ser missense_variant 0.5
clpC1 4038923 p.Leu594Met missense_variant 0.25
clpC1 4038932 c.1773G>C synonymous_variant 0.25
clpC1 4039430 c.1275T>C synonymous_variant 0.19
clpC1 4039442 c.1263A>G synonymous_variant 0.23
clpC1 4039448 c.1257A>G synonymous_variant 0.27
clpC1 4039454 c.1251A>T synonymous_variant 0.31
clpC1 4039463 c.1242C>G synonymous_variant 0.3
clpC1 4039466 c.1239T>C synonymous_variant 0.32
clpC1 4039469 c.1236T>C synonymous_variant 0.32
clpC1 4039477 p.Met410Leu missense_variant 0.28
clpC1 4039481 c.1224T>C synonymous_variant 0.27
clpC1 4039487 c.1218G>C synonymous_variant 0.28
clpC1 4039517 c.1188C>G synonymous_variant 0.24
clpC1 4039526 c.1179G>C synonymous_variant 0.23
clpC1 4039532 p.Asn391Gln missense_variant 0.23
clpC1 4039694 c.1011G>C synonymous_variant 0.22
clpC1 4039714 p.Tyr331His missense_variant 0.22
clpC1 4039727 c.978C>T synonymous_variant 0.38
clpC1 4039733 c.972G>C synonymous_variant 0.43
clpC1 4039748 c.957G>C synonymous_variant 0.45
clpC1 4039751 c.954A>G synonymous_variant 0.45
clpC1 4039757 c.948A>G synonymous_variant 0.46
clpC1 4039766 c.939T>C synonymous_variant 0.51
clpC1 4039769 c.936C>G synonymous_variant 0.51
clpC1 4039773 p.Lys311Met missense_variant 0.5
clpC1 4039778 c.927A>G synonymous_variant 0.49
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.48
clpC1 4039796 c.909C>T synonymous_variant 0.51
clpC1 4039817 c.888A>T synonymous_variant 0.5
clpC1 4039820 c.885T>G synonymous_variant 0.49
clpC1 4039831 c.874T>C synonymous_variant 0.5
clpC1 4039838 p.Leu289Ile missense_variant 0.43
clpC1 4039850 c.855T>C synonymous_variant 0.32
clpC1 4039855 c.850C>T synonymous_variant 0.3
clpC1 4039865 c.840T>C synonymous_variant 0.27
clpC1 4039874 p.Asn277Lys missense_variant 0.23
clpC1 4039898 c.807C>G synonymous_variant 0.15
clpC1 4040551 c.154T>C synonymous_variant 0.15
clpC1 4040555 c.150G>A synonymous_variant 0.15
clpC1 4040561 p.Ser48Ala missense_variant 0.15
clpC1 4040576 c.129C>T synonymous_variant 0.15
clpC1 4040579 c.126A>G synonymous_variant 0.14
clpC1 4040582 c.123G>T synonymous_variant 0.14
clpC1 4040585 c.120A>G synonymous_variant 0.14
clpC1 4040588 c.117T>C synonymous_variant 0.14
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.15
clpC1 4040603 c.102T>G synonymous_variant 0.15
clpC1 4040606 c.99T>C synonymous_variant 0.16
clpC1 4040644 c.61A>C synonymous_variant 0.18
clpC1 4040651 p.Glu18Asp missense_variant 0.17
clpC1 4040657 c.48T>C synonymous_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408352 c.-150C>A upstream_gene_variant 0.16