TB-Profiler result

Run: ERR9786592
Summary

Run ID: ERR9786592

Sample name:

Date: 2024-04-16T12:58:10.819838

Number of reads: 2126929

Percentage reads mapped: 81.05

Median coverage: 98.0

Strain: lineage4.3.4.2

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Assoc w R - Interim
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1305494 c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant&stop_lost&splice_region_variant 1.0 delamanid Assoc w R - Interim
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6817 c.1578G>A synonymous_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7631 c.330G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8774 c.1473C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Pro missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8843 c.1542G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8909 c.1608C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8952 p.Gln551Ala missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13418 c.141G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
fgd1 491133 c.351A>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491138 p.Glu119Ala missense_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491142 c.360C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
rpoB 760196 c.390C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.16 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.16 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.16 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.17 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.23 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.17 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.17 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.16 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.16 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.16 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.16 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.17 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.17 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.17 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.17 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760658 c.852G>A synonymous_variant 0.16 rifampicin
rpoB 760661 c.855A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.16 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.16 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.17 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.17 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.14 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.14 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.14 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.14 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.14 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.16 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761126 c.1320G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761217 c.1411_1413delCCGinsGC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761765 c.1959T>C synonymous_variant 0.14 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>A synonymous_variant 0.16 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.15 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.13 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.14 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.14 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.18 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.18 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.18 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.24 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.19 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.15 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.16 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.28 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.28 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.19 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.18 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.2 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763783 c.414G>C synonymous_variant 0.17 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.16 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.18 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.16 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.16 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.15 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.14 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.14 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.13 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.15 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.19 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.19 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.17 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765871 c.2502T>C synonymous_variant 0.13 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.13 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.13 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.13 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.14 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.13 rifampicin
rpoC 765964 p.Leu865Phe missense_variant 0.13 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781929 p.Gly124Ser missense_variant 0.13 streptomycin Uncertain significance
fbiC 1304544 c.1614T>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304547 c.1617C>G synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>T synonymous_variant 0.12 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
inhA 1674477 c.276G>T synonymous_variant 0.13 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674503 p.Thr101Ser missense_variant 0.14 ethionamide
isoniazid
rpsA 1834162 c.621A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.21 pyrazinamide
rpsA 1834432 c.891G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156815 c.-704A>G upstream_gene_variant 1.0 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
eis 2714432 p.Val301Ile missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
thyA 3073868 p.Thr202Ala missense_variant 0.99 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877803 c.705G>C synonymous_variant 0.15 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.15 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.17 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.19 rifampicin
rpoA 3877929 c.579C>T synonymous_variant 0.19 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.19 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.21 rifampicin
rpoA 3877998 c.510G>C synonymous_variant 0.21 rifampicin
rpoA 3878001 c.505_507delTCAinsAGC synonymous_variant 0.2 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.21 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.21 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.21 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.22 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.21 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.22 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.23 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.22 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.21 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.21 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.19 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.19 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.15 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.14 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.14 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.17 rifampicin
rpoA 3878154 c.354G>C synonymous_variant 0.18 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878244 c.264G>A synonymous_variant 0.14 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.14 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038941 c.1764G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039067 c.1638G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.14 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.14 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039274 c.1431G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039277 c.1428C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039321 p.Ala462Ser missense_variant 0.12 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.13 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039361 c.1344C>A synonymous_variant 0.13 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.14 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.16 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039829 p.Leu292Phe missense_variant 0.14 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.13 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.13 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040177 c.528C>T synonymous_variant 0.16 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.16 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.16 pyrazinamide
clpC1 4040228 c.477G>A synonymous_variant 0.16 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.2 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.17 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040300 c.405C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040306 c.399G>C synonymous_variant 0.15 pyrazinamide
embC 4239763 c.-100C>T upstream_gene_variant 0.99 ethambutol Not assoc w R
embC 4240382 p.Gly174Arg missense_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R