TB-Profiler result

Run: SRR8758877
Summary

Run ID: SRR8758877

Sample name:

Date: 2024-04-15T13:11:45.840968

Number of reads: 1255976

Percentage reads mapped: 32.38

Median coverage: 22.0

Strain: lineage4.1.1.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.95
lineage4.1.1.1 Euro-American (X-type) RD183 0.76
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu430Pro Assoc w R
p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid inhA p.Ser94Ala Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide inhA p.Ser94Ala Assoc w R - Interim
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761095 p.Leu430Pro missense_variant 0.9 rifampicin Assoc w R
rpoB 761127 p.Ser441Ala missense_variant 0.23 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.65 amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.42 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
inhA 1674481 p.Ser94Ala missense_variant 1.0 ethionamide Assoc w R - Interim
isoniazid Assoc w R - Interim Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657303 c.168C>T synonymous_variant 0.95 ethionamide Not assoc w R - Interim
rpoB 760493 c.687C>A synonymous_variant 0.85 rifampicin Not assoc w R
rpoB 761132 c.1326G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761196 c.1390_1392delCTGinsGC frameshift_variant&missense_variant 0.19 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.28 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.36 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>G synonymous_variant 0.4 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761289 p.Ser495Ala missense_variant 0.41 rifampicin
rpoB 761292 p.Val496Ser missense_variant 0.4 rifampicin
rpoB 761296 p.Tyr497Phe missense_variant 0.42 rifampicin
rpoB 761304 p.Val500Ile missense_variant 0.44 rifampicin
rpoB 761310 c.1504_1506delCCGinsTC frameshift_variant&missense_variant 0.42 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.31 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.32 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.56 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.54 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.51 rifampicin
rpoB 763014 c.3208_3210delATGinsCC frameshift_variant&missense_variant 0.49 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.5 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.51 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763038 c.3232_3234delACCinsGG frameshift_variant&missense_variant 0.5 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.51 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.48 rifampicin
rpoB 763075 p.Thr1090Ile missense_variant 0.52 rifampicin
rpoB 763077 p.Val1091Leu missense_variant 0.48 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.5 rifampicin
rpoB 763126 p.Pro1107Gln missense_variant 0.39 rifampicin
rpoC 763551 p.Tyr61Ser missense_variant 0.18 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.2 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoC 763708 c.339G>T synonymous_variant 0.19 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.2 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763727 p.Leu120Met missense_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.21 rifampicin
rpoC 764316 p.Ala316Val missense_variant 0.3 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.36 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.29 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.45 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.57 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.59 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764660 c.1291_1293delGTGinsAC frameshift_variant&missense_variant 0.52 rifampicin
rpoC 764665 c.1296C>G synonymous_variant 0.56 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.51 rifampicin Uncertain significance
rpoC 764713 c.1344G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.34 rifampicin
rpoC 764740 p.Met457Ile missense_variant 0.31 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.29 rifampicin
rpoC 764750 c.1381_1383delGTGinsAC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764760 p.Asn464Ser missense_variant 0.23 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>T synonymous_variant 0.25 rifampicin
rpoC 764780 p.Ser471Ala missense_variant 0.27 rifampicin
rpoC 764785 c.1416C>G synonymous_variant 0.29 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764804 p.Gln479Ser missense_variant 0.24 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.21 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 766070 c.2701C>T synonymous_variant 0.94 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.18 streptomycin
rpsL 781685 c.126G>C synonymous_variant 0.2 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.19 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.28 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.33 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.47 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.48 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.51 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.5 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.43 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.44 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.42 streptomycin
rpsL 781851 c.292_294delATCinsGT frameshift_variant&missense_variant 0.24 streptomycin Uncertain significance
rpsL 781856 c.297C>T synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781860 c.301_303delTCGinsGC frameshift_variant&missense_variant 0.22 streptomycin Uncertain significance
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781876 p.Gly106Ala missense_variant 0.18 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.18 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.16 streptomycin
rplC 800219 c.-590T>C upstream_gene_variant 0.92 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472092 n.247C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472120 n.275G>C non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472666 n.821G>A non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472694 n.849C>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrl 1473828 n.173_174delTG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473834 n.178_179insTAG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473883 n.226A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474291 n.635_646delTTCCTCTCCGGA non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474305 n.648G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474752 n.1096delA non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474770 n.1113G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475084 n.1427G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475752 n.2095C>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475757 n.2101_2104delACCC non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476544 n.2887T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476566 n.2909A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rpsA 1833949 c.408T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833959 p.Leu140Val missense_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.19 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
folC 2746255 p.Asp448Glu missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448328 c.-176G>A upstream_gene_variant 1.0 ethionamide
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
fbiA 3641447 p.Thr302Met missense_variant 0.92 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
rpoA 3877553 p.Glu319Lys missense_variant 0.88 rifampicin Not assoc w R
clpC1 4039904 c.801A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.21 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039937 c.766_768delGTGinsAC frameshift_variant&missense_variant 0.22 pyrazinamide
clpC1 4039940 c.765G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.4 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.38 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.38 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.24 pyrazinamide
embC 4240897 c.1035C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4249408 c.2895G>A synonymous_variant 0.95 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408236 c.-34A>G upstream_gene_variant 0.96 streptomycin Uncertain significance