TB-Profiler result

Run: ERR176518
Summary

Run ID: ERR176518

Sample name:

Date: 2024-04-15T06:26:30.144746

Number of reads: 2051335

Percentage reads mapped: 76.04

Median coverage: 48.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.97
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 648 c.648C>T synonymous_variant 0.14 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.12 isoniazid
dnaA 663 c.663A>C synonymous_variant 0.13 isoniazid
dnaA 666 c.666C>G synonymous_variant 0.13 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.13 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.12 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.12 isoniazid
dnaA 690 c.690G>C synonymous_variant 0.15 isoniazid
dnaA 693 c.693A>T synonymous_variant 0.15 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.13 isoniazid
dnaA 1255 p.Ala419Thr missense_variant 0.95 isoniazid Uncertain significance
gyrB 6140 p.Val301Leu missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6904 c.-398C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7415 c.114C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8189 c.888G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8261 c.960C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.12 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9267 p.Asn656Gly missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 c.1999_2001delGCCinsTG frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9329 c.2028C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.12 levofloxacin
moxifloxacin
ccsA 620649 c.759A>G synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620691 c.801G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620724 c.834C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
nusG 734505 c.252G>C synonymous_variant 0.14 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.31 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760271 c.465C>G synonymous_variant 0.29 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.14 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.15 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.15 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.15 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.14 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760563 c.757delCinsAT frameshift_variant&synonymous_variant 0.15 rifampicin
rpoB 760566 p.Ser254Ala missense_variant 0.15 rifampicin
rpoB 760567 c.762delG frameshift_variant 0.15 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.13 rifampicin
rpoB 760625 c.819C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.22 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.16 rifampicin Uncertain significance
rpoB 761133 c.1327T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.21 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.13 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.21 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.19 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.19 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.14 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.16 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.14 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.14 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.23 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.2 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763100 c.-270G>A upstream_gene_variant 0.21 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.21 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.17 rifampicin
rpoC 763699 c.330G>C synonymous_variant 0.2 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.11 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.13 rifampicin
rpoC 764491 c.1122G>C synonymous_variant 0.14 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.15 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.16 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.38 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.23 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 765904 c.2535C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.21 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765958 c.2589C>G synonymous_variant 0.21 rifampicin
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.19 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766518 p.Thr1050Ser missense_variant 0.19 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775937 c.2544G>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.24 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776042 c.2439C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777188 c.1293T>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 777209 c.1272C>T synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 777215 c.1266C>T synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777225 p.Asn419Ser missense_variant 0.17 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781709 c.150G>C synonymous_variant 0.12 streptomycin Not assoc w R - Interim
rpsL 781718 c.159C>T synonymous_variant 0.12 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.15 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.13 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.12 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.15 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781814 c.255C>T synonymous_variant 0.22 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.23 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.25 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.24 streptomycin
rpsL 781889 c.330C>T synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.24 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.19 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.2 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.19 streptomycin
rplC 800693 c.-116A>C upstream_gene_variant 0.14 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.14 linezolid
fbiC 1303525 p.Ser199Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303542 c.612C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304664 c.1734G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1305330 c.2400C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305331 p.Glu801Gln missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305339 c.2409C>T synonymous_variant 0.15 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305351 c.2421G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>T non_coding_transcript_exon_variant 0.12 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.12 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTGT non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473728 n.71A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053delT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1674542 p.Ala114Glu missense_variant 0.12 ethionamide
isoniazid
rpsA 1833772 c.231C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.22 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833817 c.276C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833820 c.279G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.22 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834432 c.891G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.15 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.13 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834699 p.Glu386Asp missense_variant 0.16 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.23 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.18 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.16 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.23 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782528 c.1515G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783651 p.His131Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783672 p.Arg124Ala missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073998 c.474G>A synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.13 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
rpoA 3877644 c.864C>T synonymous_variant 0.16 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.16 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.19 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.22 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877872 c.636C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.19 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.2 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.2 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>C synonymous_variant 0.24 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.19 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.14 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
ddn 3986615 c.-229C>A upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986624 c.-220G>C upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.16 delamanid
pretomanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.14 delamanid
pretomanid
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038569 c.2136C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGT synonymous_variant 0.24 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038971 c.1734T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039526 c.1179G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039559 c.1146C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039566 p.Val380Ala missense_variant 0.19 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.23 pyrazinamide
clpC1 4039997 c.708C>A synonymous_variant 0.24 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.25 pyrazinamide
glpK 4138775 c.981C>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138799 c.957T>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139594 c.162C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139603 c.153C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139608 p.Leu50Met missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139639 c.117G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139648 c.108T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243566 p.Asp112His missense_variant 0.98 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R