TB-Profiler result

Run: SRR11972367
Summary

Run ID: SRR11972367

Sample name:

Date: 2024-04-15T02:46:09.758512

Number of reads: 728322

Percentage reads mapped: 73.78

Median coverage: 20.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 714 c.714C>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
gyrB 6169 c.930C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6181 c.942C>A synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6202 c.963C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6203 p.Ser322Ala missense_variant 0.4 levofloxacin
moxifloxacin
gyrB 6208 c.969G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6430 c.-872A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6487 c.-815C>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6511 c.-791A>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6556 c.-746C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8354 c.1053G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8357 c.1056G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.88 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734439 c.186C>G synonymous_variant 0.29 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.36 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.36 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.32 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.38 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.32 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.27 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.28 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.33 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.3 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.27 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.42 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.38 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.32 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760457 c.651C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.23 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.33 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.29 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877_879delTTGinsCT frameshift_variant&synonymous_variant 0.25 rifampicin
rpoB 760703 c.897C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761791 p.Arg662His missense_variant 0.38 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.29 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.72 rifampicin Not assoc w R
rpoC 763052 c.-318G>C upstream_gene_variant 0.38 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.33 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.5 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.3 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.28 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.26 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.35 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.29 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.31 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.24 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.29 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.29 rifampicin
rpoC 765754 p.Asp795Glu missense_variant 0.32 rifampicin Uncertain significance
rpoC 765811 c.2442T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.36 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.47 streptomycin
rpsL 781655 c.96T>A synonymous_variant 0.33 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.31 streptomycin
rpsL 781682 c.123T>G synonymous_variant 0.32 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.31 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.34 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.29 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.36 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.35 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.32 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.32 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.32 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.26 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.26 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.27 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.2 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.23 streptomycin
rplC 800648 c.-161A>C upstream_gene_variant 0.17 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.23 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.26 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
sigE 1364799 c.387G>C synonymous_variant 0.18 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472022 n.178_181delGGAC non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185delGinsCTTGCT non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195delTinsGC non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472048 n.203T>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473670 n.13A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473728 n.71A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473830 n.173T>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_649delTCCTTTTCCTCTCCGGAGGAinsCTCACTTTGT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474418 n.761_762delCAinsTCC non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474421 n.765_768delCGCA non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474428 n.771C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474430 n.773C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474432 n.775C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474433 n.776G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474434 n.777T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474631 n.974G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474950 n.1296_1297delCA non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474955 n.1298T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474959 n.1302_1303insA non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474966 n.1309_1315delGTGGGTGinsTGGT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474990 n.1333C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474995 n.1338T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474997 n.1340A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474999 n.1342C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475008 n.1351C>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475010 n.1353G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475015 n.1358_1360delCCGinsTCTA non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475221 n.1564C>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid Uncertain significance
rrl 1475247 n.1590G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475253 n.1598C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475264 n.1607G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475268 n.1611T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475271 n.1614A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475291 n.1634A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475296 n.1639G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
inhA 1674903 c.702T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.35 ethionamide
isoniazid
rpsA 1833589 c.48A>C synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.19 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.19 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.18 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.26 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.27 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834234 c.693G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.47 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.32 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.31 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.26 isoniazid
Rv2752c 3064689 c.1503C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066435 c.-244T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612760 c.357C>A synonymous_variant 1.0 pyrazinamide
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.38 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.37 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.36 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.35 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.35 rifampicin
rpoA 3877896 c.610_612delCCGinsGT frameshift_variant&missense_variant 0.35 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.36 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.33 rifampicin
rpoA 3877929 c.579C>T synonymous_variant 0.33 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.42 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.41 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.39 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.37 rifampicin
rpoA 3878001 c.505_507delTCAinsAGC synonymous_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.26 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.29 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.27 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.29 rifampicin
clpC1 4038519 p.Arg729Gln missense_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.18 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038839 c.1866G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038920 c.1785C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038998 c.1707C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.25 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039009 c.1696C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039238 c.1467C>A synonymous_variant 0.17 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.29 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.24 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.28 pyrazinamide
clpC1 4039355 c.1350G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsCC frameshift_variant&synonymous_variant 0.18 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.24 pyrazinamide
clpC1 4039613 c.1092C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.26 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039922 c.783C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039955 c.750G>T synonymous_variant 0.24 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039997 c.708C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>A synonymous_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.24 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338473 p.Arg17Gly missense_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R