TB-Profiler result

Run: SRR1165423
Summary

Run ID: SRR1165423

Sample name:

Date: 2024-04-15T22:11:52.372134

Number of reads: 6393427

Percentage reads mapped: 84.54

Median coverage: 140.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.98
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser431Cys Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761097 p.Ser431Cys missense_variant 0.13 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6280 c.1041T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7457 c.156T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7883 c.582G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8270 c.969G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.89 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.96 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619634 c.-257T>A upstream_gene_variant 0.14 capreomycin
amikacin
kanamycin
Rv0565c 657269 p.Ser68Pro missense_variant 0.91 ethionamide Uncertain significance
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.19 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.17 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.15 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.14 ethionamide
hadA 731753 c.-177A>G upstream_gene_variant 0.14 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.16 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.14 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.14 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.13 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.14 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.14 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.14 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.15 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.13 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.14 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.14 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.15 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.14 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.14 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.14 isoniazid
rpoB 760115 c.309C>T synonymous_variant 0.89 rifampicin Not assoc w R
rpoB 760130 p.Asp108Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.14 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.18 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.18 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.22 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.16 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.14 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.13 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.13 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.15 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.14 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.16 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.18 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.23 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.26 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.21 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.15 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.17 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.18 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.22 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.17 rifampicin
rpoB 761373 p.Val523His missense_variant 0.16 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761815 p.Ala670Asp missense_variant 0.13 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.19 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.19 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.18 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.14 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.17 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.19 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.19 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.19 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.19 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.19 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.16 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.15 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.17 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.13 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.12 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.16 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.27 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.17 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.13 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.16 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.22 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.23 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.21 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.16 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.17 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.19 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.19 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.16 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.18 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.2 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.18 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.16 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.14 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.18 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.19 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.18 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.22 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.2 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.16 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764196 p.Ser276* stop_gained 0.12 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.15 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.14 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.16 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.15 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.15 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.22 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.18 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.22 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.17 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.16 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765349 c.1980T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.18 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.2 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.19 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.17 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.16 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.15 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.2 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.16 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.16 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.19 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.2 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.18 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.18 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.21 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.17 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.17 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.2 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.22 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.19 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.14 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.16 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.16 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.15 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.19 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.18 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.19 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.17 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.17 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.16 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.14 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.27 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.27 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.22 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.23 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.2 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.19 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.16 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.15 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.15 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.21 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.19 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.18 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.14 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.15 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.15 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.15 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.16 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.15 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.17 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.17 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.16 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.13 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.14 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.14 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.15 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.14 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.16 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.18 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.19 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.19 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.19 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.17 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.16 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.16 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.16 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.16 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.16 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.15 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.15 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.15 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.15 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 800877 c.69A>C synonymous_variant 0.13 linezolid
rplC 800880 c.72A>G synonymous_variant 0.15 linezolid
rplC 800889 c.81C>G synonymous_variant 0.14 linezolid
rplC 800907 c.99C>G synonymous_variant 0.18 linezolid
rplC 800916 c.108A>G synonymous_variant 0.18 linezolid
fbiC 1303846 p.Phe306Val missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
atpE 1461159 p.Val39Ile missense_variant 0.15 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.17 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.16 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.15 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.14 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.15 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
inhA 1674542 p.Ala114Glu missense_variant 0.12 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.13 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.14 ethionamide
isoniazid
rpsA 1833541 c.-1T>C upstream_gene_variant 0.15 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.15 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.14 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.2 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.2 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917934 c.-6T>C upstream_gene_variant 0.99 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
katG 2155632 c.480A>C synonymous_variant 0.17 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.2 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.19 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.18 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.15 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.14 isoniazid
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.19 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.14 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.14 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.14 isoniazid
Rv2477c 2783020 c.1023G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.19 capreomycin Uncertain significance
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.22 capreomycin Uncertain significance
Rv2752c 3065687 p.Gly169Ser missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073812 c.660C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073824 c.648A>C synonymous_variant 0.13 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.13 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.93 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625572 p.Thr348Ser missense_variant 0.13 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.15 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625882 c.732G>A synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.15 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.17 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.16 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.2 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.13 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.14 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.14 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.15 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.2 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.21 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.27 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.16 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.14 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.12 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.14 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879016 c.-509A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.14 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.14 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.16 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.14 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.13 rifampicin
clpC1 4038244 p.Thr821Ala missense_variant 0.2 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.18 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.17 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.14 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.14 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.18 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.19 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.14 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.13 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.15 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.14 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.18 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 0.98 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.15 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.15 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.15 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.13 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.98 ethambutol Not assoc w R
embB 4248220 c.1707A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.16 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.13 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.14 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin