TB-Profiler result

Run: ERR9786440
Summary

Run ID: ERR9786440

Sample name:

Date: 2024-10-04T05:39:45.372025

Number of reads: 3737370

Percentage reads mapped: 86.21

Median coverage: 174.0

Strain: lineage4.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4 Euro-American None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.16 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.17 ethambutol Uncertain significance Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.16 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.18 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.17 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6507 p.Ala423Val missense_variant 0.89 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6598 c.-704C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6728 c.1489C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6745 c.1506T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.16 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 7023 p.Leu595Gln missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7547 c.246C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7622 c.321C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7739 c.438C>T synonymous_variant 0.14 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7772 c.471C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9104 c.1803C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9154 p.Thr618Asn missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9656 c.2355C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490896 c.114C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491151 c.369G>A synonymous_variant 0.14 pretomanid
delamanid
clofazimine
Rv0565c 656470 p.Gly334Asp missense_variant 0.93 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 0.91 ethionamide Uncertain significance
hadA 732398 p.Ala157Thr missense_variant 0.16 isoniazid
nusG 734472 c.219T>C synonymous_variant 0.16 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.2 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.2 rifampicin
rpoB 760319 c.513C>T synonymous_variant 0.21 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.19 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.18 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.21 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.25 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.24 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.25 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.21 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.14 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.23 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.24 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.32 rifampicin
rpoB 761123 c.1317G>C synonymous_variant 0.3 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.28 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.29 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.3 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.24 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.2 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.19 rifampicin
rpoB 761373 p.Val523His missense_variant 0.16 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.17 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.17 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.17 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.17 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.18 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.22 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.19 rifampicin
rpoB 762215 c.2409G>A synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.16 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.16 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.16 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.16 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.15 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.2 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.2 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.17 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.23 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.17 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.18 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.16 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.16 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.18 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.16 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.16 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.16 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.16 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.16 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.16 rifampicin
rpoC 763948 c.579G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763949 c.580C>A synonymous_variant 0.16 rifampicin
rpoC 763954 c.585C>G synonymous_variant 0.16 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.18 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.17 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.17 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.18 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.16 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.16 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.16 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.17 rifampicin
rpoC 764107 c.738C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764112 p.Tyr248Phe missense_variant 0.16 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764236 c.867G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764272 c.903G>C synonymous_variant 0.16 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.21 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.23 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.22 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.22 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.22 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.16 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.95 rifampicin Not assoc w R
rpoC 765187 c.1818C>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.17 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.2 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.21 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.21 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.19 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.17 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.19 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.19 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.19 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.18 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.18 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766462 c.3093G>C synonymous_variant 0.15 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.15 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.16 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.17 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.17 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.15 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.18 rifampicin
rpoC 766625 c.3256C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766630 c.3261G>C synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.17 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.17 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.17 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.19 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.24 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.27 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.24 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.2 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767111 c.3742C>T synonymous_variant 0.16 rifampicin
rpoC 767134 c.3765C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.19 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.2 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.2 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.23 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.17 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.17 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.17 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.18 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.19 streptomycin Uncertain significance
fbiC 1303980 c.1050G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674660 c.459G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674741 c.540C>T synonymous_variant 0.14 isoniazid Not assoc w R - Interim
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156007 c.105C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
PPE35 2168448 p.Gln722Arg missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223421 c.-257G>A upstream_gene_variant 1.0 bedaquiline
clofazimine
kasA 2518579 c.465T>C synonymous_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.17 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.17 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.19 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.19 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.19 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.22 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.23 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.23 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.22 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.2 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.2 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.19 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.18 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.17 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.16 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.15 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.16 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.15 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.14 isoniazid
kasA 2518819 c.705C>T synonymous_variant 0.16 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.16 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.16 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.16 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.16 isoniazid
kasA 2518999 c.885G>A synonymous_variant 0.14 isoniazid
kasA 2519021 p.Ala303Thr missense_variant 0.14 isoniazid
folC 2747569 c.30C>T synonymous_variant 0.99 para-aminosalicylic_acid
Rv2477c 2782841 p.Thr401Asn missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.17 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.2 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2752c 3066436 c.-246_-245delGGinsAA upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067325 c.621A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.23 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.23 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.23 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.23 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.18 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.17 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.18 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.19 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.99 cycloserine
lpqB 3623557 p.Gly452Arg missense_variant 0.14 rifampicin
bedaquiline
lpqB 3623613 p.Thr433Ile missense_variant 0.15 rifampicin Uncertain significance
bedaquiline
lpqB 3623630 c.1281G>C synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3623648 c.1263A>G synonymous_variant 0.15 rifampicin
bedaquiline
lpqB 3623703 p.Ala403Val missense_variant 0.16 rifampicin
bedaquiline
lpqB 3623721 p.Ser397Thr missense_variant 0.15 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626840 c.-227C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626900 c.-287G>A upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626945 c.-332C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627293 c.57G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpoA 3877556 p.Ser318Ala missense_variant 0.88 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.2 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.19 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.2 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.19 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.2 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.18 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.19 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.17 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.17 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.16 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.16 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.17 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.15 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.2 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.2 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.2 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.2 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.21 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.2 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.2 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.2 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.22 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.2 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.21 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.19 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.21 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.21 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.22 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.21 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.23 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.23 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.22 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.23 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.23 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.24 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.25 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.26 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.25 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.24 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.24 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.2 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.2 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.22 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.2 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.22 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.21 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.21 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.23 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.23 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.25 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.15 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.2 rifampicin
rpoA 3878818 c.-311G>A upstream_gene_variant 0.21 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.18 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.3 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.27 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.18 rifampicin
clpC1 4038392 c.2313C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.15 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.14 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.14 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.17 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.18 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.19 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.16 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039951 c.754C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.2 pyrazinamide
clpC1 4040210 c.495G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.2 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.22 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.17 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.16 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.16 pyrazinamide
panD 4044869 c.-588G>A upstream_gene_variant 0.14 pyrazinamide
glpK 4138646 c.1110G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.572dupG frameshift_variant 0.54 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139432 c.324C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139449 p.His103Asn missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
glpK 4139450 c.306G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139453 c.303T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139474 c.282T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139477 c.279A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139483 c.273C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139486 c.270T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139489 c.267G>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139494 c.262T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139504 p.Asp84Asn missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139515 p.Ser81Ala missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139516 c.240A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139524 p.Thr78Ala missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
glpK 4139525 p.Ala77Arg missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139531 c.225C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139868 c.-113G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.16 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.16 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.17 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.17 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.17 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.16 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.16 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.17 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.18 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.18 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.17 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.17 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.17 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.17 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.19 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.2 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.2 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.19 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.19 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.18 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.18 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.94 ethambutol Not assoc w R
embB 4247446 c.933C>T synonymous_variant 0.14 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.16 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.18 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.18 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.21 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.2 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.2 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.18 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.17 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.17 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.17 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.17 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.18 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.18 ethambutol Not assoc w R
embB 4247656 c.1143A>G synonymous_variant 0.17 ethambutol
embB 4247662 c.1149C>G synonymous_variant 0.16 ethambutol
embB 4247683 c.1170C>G synonymous_variant 0.18 ethambutol
embB 4247716 c.1203C>T synonymous_variant 0.16 ethambutol
embB 4247722 c.1209G>T synonymous_variant 0.15 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.16 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.15 ethambutol
embB 4247866 c.1353G>C synonymous_variant 0.16 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.16 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.17 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.16 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.18 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247926 c.1413C>T synonymous_variant 0.2 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.2 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.21 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.2 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.2 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.19 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.18 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.19 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.19 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.16 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.19 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.19 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.17 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.17 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.16 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.16 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.16 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.17 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.16 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.17 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.16 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.17 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.17 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.17 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.17 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.18 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.18 ethambutol
embB 4249579 c.3066G>A synonymous_variant 0.18 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.18 ethambutol
embB 4249606 c.3093C>A synonymous_variant 0.16 ethambutol
embB 4249615 c.3102C>G synonymous_variant 0.17 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin