TB-Profiler result

Run: ERR987765
Summary

Run ID: ERR987765

Sample name:

Date: 2024-10-05T14:13:41.931691

Number of reads: 3753191

Percentage reads mapped: 87.28

Median coverage: 83.0

Strain: lineage4.6.1.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 1.0
lineage4 Euro-American None 1.0
lineage4.6.1.1 Euro-American RD724 1.0
lineage4.6.1 Euro-American (Uganda) RD724 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6190 c.951A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6208 c.969G>A synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6214 c.975G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6229 c.990G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7539 p.Thr80Ala missense_variant 0.85 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7694 c.393A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7853 c.552C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7906 p.Phe202Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8408 c.1107A>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8585 c.1284C>T synonymous_variant 0.11 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.12 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491316 c.534C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491321 p.Ala180Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491343 c.561C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491349 c.567T>C synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491355 c.573C>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491364 c.582T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491367 c.585G>A synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fgd1 491370 c.588C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
hadA 732265 c.336G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 734451 c.198G>C synonymous_variant 0.14 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.14 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.16 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.17 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760092 p.Ser96Thr missense_variant 0.13 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760130 c.324T>C synonymous_variant 0.17 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.14 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.15 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760208 p.Ile134Met missense_variant 0.15 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.14 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.12 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.12 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>G synonymous_variant 0.23 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760485 p.Pro227Ser missense_variant 0.21 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760616 p.Asp270Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760643 c.837G>A synonymous_variant 0.16 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.14 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Val missense_variant 0.12 rifampicin
rpoB 760858 p.Val351Ala missense_variant 0.16 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Phe missense_variant 0.17 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.16 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.16 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.17 rifampicin Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>T synonymous_variant 0.29 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.14 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.14 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.12 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.12 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.13 rifampicin
rpoB 761615 c.1809A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.12 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>G synonymous_variant 0.14 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.17 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.12 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.16 rifampicin
rpoC 763082 c.-288C>G upstream_gene_variant 0.16 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.16 rifampicin
rpoC 763115 c.-255T>G upstream_gene_variant 0.13 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.14 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.14 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.12 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.12 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763489 c.120G>A synonymous_variant 0.17 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.13 rifampicin
rpoC 763606 c.237C>T synonymous_variant 0.12 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.12 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.12 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.14 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.15 rifampicin
rpoC 763782 p.Ser138Trp missense_variant 0.12 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.14 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.15 rifampicin
rpoC 764060 p.Pro231Ile missense_variant 0.16 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.24 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764236 c.867G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.15 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.15 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.14 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764347 c.978G>C synonymous_variant 0.14 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764443 p.Ile358Met missense_variant 0.14 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.13 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.2 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.2 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.16 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.14 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.15 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765435 p.His689Pro missense_variant 0.85 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.19 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.21 rifampicin
rpoC 765544 c.2175C>G synonymous_variant 0.13 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2180delAGinsTC synonymous_variant 0.13 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.13 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.13 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.13 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.14 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.14 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.15 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.13 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.15 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.15 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.18 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.16 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.16 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.15 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.13 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>G synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.14 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.15 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.16 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.14 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.16 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.13 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.13 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766517 p.Thr1050Ser missense_variant 0.12 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.12 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.12 rifampicin
rpoC 766526 p.Val1053Ile missense_variant 0.12 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.13 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.14 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.14 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.14 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766813 c.3444G>C synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.21 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767011 c.3642G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>G synonymous_variant 0.13 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800693 c.-116A>G upstream_gene_variant 0.15 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.14 linezolid
rplC 801249 c.441T>C synonymous_variant 0.13 linezolid
rplC 801252 c.444G>C synonymous_variant 0.13 linezolid
fbiC 1304403 c.1473T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.12 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.12 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.12 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.12 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>T non_coding_transcript_exon_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.26 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473289 n.1444_1445delTCinsGTAA non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473677 n.20C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053delTinsGCAC non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474712 n.1055G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475217 n.1560T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475586 n.1929C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476691 n.3034T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
inhA 1674503 p.Thr101Ser missense_variant 0.13 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.14 isoniazid
ethionamide
inhA 1674513 c.312C>G synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.15 isoniazid
ethionamide
inhA 1674534 c.333G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.22 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.17 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674585 c.384T>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.24 isoniazid
ethionamide
inhA 1674601 p.Leu134Val missense_variant 0.21 isoniazid
ethionamide
inhA 1674610 p.Ile137Val missense_variant 0.19 isoniazid
ethionamide
inhA 1674621 c.420C>G synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674656 p.Ser152Thr missense_variant 0.19 isoniazid
ethionamide
rpsA 1833685 c.144G>C synonymous_variant 0.12 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.13 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.16 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.17 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.14 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833806 c.265C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.14 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834579 c.1038C>G synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518609 p.Met165Ile missense_variant 0.13 isoniazid
eis 2715188 p.Arg49Cys missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783350 c.693T>C synonymous_variant 0.12 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2681 2996876 c.138A>C synonymous_variant 1.0 capreomycin Not assoc w R
whiB7 3569029 c.-350A>G upstream_gene_variant 1.0 kanamycin Not assoc w R
amikacin Uncertain significance
streptomycin Uncertain significance
mtrB 3625222 c.1392T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625741 c.-831G>A upstream_gene_variant 0.13 rifampicin
bedaquiline
rpoA 3877710 c.798C>G synonymous_variant 0.13 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.14 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.12 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.14 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.14 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.14 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.14 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.17 rifampicin
rpoA 3878159 p.Thr117Ala missense_variant 0.17 rifampicin
rpoA 3878163 c.345C>G synonymous_variant 0.17 rifampicin
rpoA 3878185 p.Gly108Ala missense_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>A synonymous_variant 0.17 rifampicin
rpoA 3878205 c.303T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.13 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039970 c.735G>A synonymous_variant 0.13 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.12 pyrazinamide
clpC1 4040498 c.207G>A synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.13 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
glpK 4139670 p.Cys29Tyr missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248220 c.1707A>G synonymous_variant 0.13 ethambutol Not assoc w R - Interim
ethA 4328329 c.-856C>G upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin