TB-Profiler result

Run: ERR4816717
Summary

Run ID: ERR4816717

Sample name:

Date: 01-04-2023 14:35:22

Number of reads: 1605624

Percentage reads mapped: 29.0

Strain: lineage3.1.2.1

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
lineage3.1 East-African-Indian Non-CAS1-Delhi RD750 1.0
lineage3.1.2 East-African-Indian CAS;CAS2 RD750 1.0
lineage3.1.2.1 East-African-Indian CAS2 RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.67 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.83 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.78 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.76 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6266 p.Pro343Asp missense_variant 0.24
gyrB 6280 c.1041T>C synonymous_variant 0.37
gyrB 6283 c.1044C>T synonymous_variant 0.37
gyrB 6286 c.1047T>C synonymous_variant 0.38
gyrB 6292 c.1053G>C synonymous_variant 0.38
gyrB 6295 c.1056A>G synonymous_variant 0.39
gyrB 6302 p.Ala355Thr missense_variant 0.41
gyrA 6307 c.-995T>G upstream_gene_variant 0.42
gyrB 6323 p.Val362Ile missense_variant 0.41
gyrB 6326 p.Ser363Ala missense_variant 0.39
gyrA 6331 c.-971A>G upstream_gene_variant 0.42
gyrA 6362 c.-940T>C upstream_gene_variant 0.25
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
ccsA 619968 c.78G>A synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 760997 c.1191G>C synonymous_variant 0.17
rpoB 761015 c.1209G>C synonymous_variant 0.18
rpoB 761027 c.1221A>C synonymous_variant 0.34
rpoB 761036 c.1230G>C synonymous_variant 0.46
rpoB 761037 c.1231T>C synonymous_variant 0.46
rpoB 761051 c.1245G>C synonymous_variant 0.68
rpoB 761054 c.1248G>C synonymous_variant 0.69
rpoB 761060 c.1254C>G synonymous_variant 0.71
rpoB 761064 p.Ala420Ser missense_variant 0.72
rpoB 761084 c.1278C>G synonymous_variant 0.74
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.7
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.68
rpoB 761102 c.1296A>G synonymous_variant 0.68
rpoB 761132 c.1326G>C synonymous_variant 0.61
rpoB 761133 c.1327T>C synonymous_variant 0.59
rpoB 761147 c.1341C>G synonymous_variant 0.37
rpoB 761150 c.1344A>C synonymous_variant 0.35
rpoB 761156 c.1350G>C synonymous_variant 0.29
rpoB 761165 c.1359G>C synonymous_variant 0.19
rpoB 761204 c.1398C>G synonymous_variant 0.17
rpoB 761219 c.1413G>C synonymous_variant 0.17
rpoB 761222 c.1416G>C synonymous_variant 0.17
rpoB 761549 c.1743G>C synonymous_variant 0.18
rpoB 761552 c.1746G>C synonymous_variant 0.18
rpoB 761562 p.Ala586Ser missense_variant 0.18
rpoB 761565 p.Met587Leu missense_variant 0.18
rpoB 761570 c.1764T>C synonymous_variant 0.18
rpoB 761573 c.1767C>G synonymous_variant 0.18
rpoB 761575 p.Phe590Tyr missense_variant 0.17
rpoB 761627 c.1821C>T synonymous_variant 0.17
rpoB 761908 p.Cys701Ser missense_variant 0.12
rpoB 761912 c.2106T>G synonymous_variant 0.13
rpoB 761916 p.Asp704Gln missense_variant 0.13
rpoB 761925 p.Met707Leu missense_variant 0.13
rpoB 761930 c.2124G>C synonymous_variant 0.13
rpoB 761945 c.2139G>C synonymous_variant 0.15
rpoB 761954 c.2148C>G synonymous_variant 0.14
rpoB 761955 p.Ile717Tyr missense_variant 0.14
rpoB 761961 p.Pro719Ser missense_variant 0.12
rpoB 761974 p.His723Leu missense_variant 0.21
rpoB 762003 p.Asn733Gln missense_variant 0.29
rpoB 762008 c.2202C>G synonymous_variant 0.29
rpoB 762009 p.Leu735Met missense_variant 0.29
rpoB 762015 p.Glu737Ser missense_variant 0.29
rpoB 762020 p.Glu738Asp missense_variant 0.31
rpoB 762029 c.2223C>G synonymous_variant 0.44
rpoB 762053 c.2247T>C synonymous_variant 0.56
rpoB 762062 c.2256T>C synonymous_variant 0.57
rpoB 762065 c.2259T>C synonymous_variant 0.55
rpoB 762080 c.2274G>C synonymous_variant 0.38
rpoB 762083 c.2277T>C synonymous_variant 0.37
rpoB 762086 c.2280G>C synonymous_variant 0.38
rpoB 762101 c.2295C>G synonymous_variant 0.55
rpoB 762114 p.Ile770Val missense_variant 0.6
rpoB 762122 p.Asp772Glu missense_variant 0.53
rpoB 762125 p.Glu773Asp missense_variant 0.47
rpoB 762132 p.Ala776Ser missense_variant 0.41
rpoB 762136 p.Asp777Ala missense_variant 0.38
rpoB 762143 c.2337T>C synonymous_variant 0.3
rpoB 762149 c.2343G>C synonymous_variant 0.27
rpoB 762156 p.Val784Ile missense_variant 0.27
rpoB 762160 p.Arg785His missense_variant 0.28
rpoB 762167 c.2361T>C synonymous_variant 0.26
rpoB 762175 c.2370_2372delTCG disruptive_inframe_deletion 0.27
rpoB 762181 c.2375_2376insGGC disruptive_inframe_insertion 0.27
rpoB 762218 c.2412T>C synonymous_variant 0.6
rpoB 762233 c.2427G>C synonymous_variant 0.66
rpoB 762254 c.2448T>C synonymous_variant 0.65
rpoB 762257 c.2451C>G synonymous_variant 0.65
rpoB 762266 c.2460T>C synonymous_variant 0.64
rpoB 762273 p.Ala823Ser missense_variant 0.66
rpoB 762293 c.2487T>C synonymous_variant 0.61
rpoB 762296 c.2490G>C synonymous_variant 0.6
rpoB 762305 c.2499G>C synonymous_variant 0.5
rpoB 762317 c.2511A>G synonymous_variant 0.3
rpoB 762325 p.Lys840Thr missense_variant 0.15
rpoB 762387 p.Glu861Gln missense_variant 0.2
rpoC 762398 c.-972T>C upstream_gene_variant 0.29
rpoC 762404 c.-966T>C upstream_gene_variant 0.39
rpoC 762410 c.-960T>C upstream_gene_variant 0.47
rpoC 762416 c.-954A>G upstream_gene_variant 0.48
rpoB 762426 p.Ser874Thr missense_variant 0.56
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 762443 c.-927G>C upstream_gene_variant 0.64
rpoC 762449 c.-921C>G upstream_gene_variant 0.64
rpoC 762452 c.-918G>C upstream_gene_variant 0.64
rpoB 762474 p.Gly890Ser missense_variant 0.62
rpoC 762482 c.-888C>T upstream_gene_variant 0.45
rpoC 762488 c.-882G>C upstream_gene_variant 0.56
rpoC 762491 c.-879T>G upstream_gene_variant 0.56
rpoC 762503 c.-867G>C upstream_gene_variant 0.52
rpoB 762507 p.Leu901Met missense_variant 0.48
rpoC 762818 c.-552C>G upstream_gene_variant 0.19
rpoB 762832 p.Ser1009Thr missense_variant 0.34
rpoB 762849 p.Tyr1015Asp missense_variant 0.46
rpoB 762855 p.Val1017Ile missense_variant 0.46
rpoB 762858 p.Thr1018Ser missense_variant 0.47
rpoC 762863 c.-507T>G upstream_gene_variant 0.47
rpoB 762870 p.Met1022Gln missense_variant 0.46
rpoB 762879 p.Met1025Leu missense_variant 0.59
rpoC 762929 c.-441G>C upstream_gene_variant 0.59
rpoC 762980 c.-390T>C upstream_gene_variant 0.47
rpoC 762983 c.-387C>T upstream_gene_variant 0.44
rpoC 762989 c.-381G>C upstream_gene_variant 0.4
rpoC 762995 c.-375G>C upstream_gene_variant 0.35
rpoB 763005 p.Cys1067Val missense_variant 0.28
rpoB 763014 p.Met1070Leu missense_variant 0.26
rpoB 763017 p.Gln1071Glu missense_variant 0.26
rpoC 763022 c.-348C>G upstream_gene_variant 0.28
rpoC 763028 c.-342T>C upstream_gene_variant 0.29
rpoC 763031 c.-339T>G upstream_gene_variant 1.0
rpoB 763050 p.Leu1082Ile missense_variant 0.34
rpoC 763053 c.-317T>C upstream_gene_variant 0.36
rpoB 763072 c.3268_3270delACC conservative_inframe_deletion 0.29
rpoB 763078 c.3272_3273insGCA disruptive_inframe_insertion 0.3
rpoC 763082 c.-288C>T upstream_gene_variant 0.29
rpoC 763088 c.-282C>G upstream_gene_variant 0.3
rpoC 763094 c.-276G>C upstream_gene_variant 0.28
rpoC 763103 c.-267G>C upstream_gene_variant 0.28
rpoC 763115 c.-255T>C upstream_gene_variant 0.28
rpoB 763118 p.Glu1104Asp missense_variant 0.26
rpoC 763127 c.-243G>C upstream_gene_variant 0.21
rpoC 763456 c.87A>G synonymous_variant 0.14
rpoC 763468 c.99G>C synonymous_variant 0.24
rpoC 763483 c.114G>C synonymous_variant 0.34
rpoC 763486 c.117T>C synonymous_variant 0.36
rpoC 763501 p.Asp44Glu missense_variant 0.45
rpoC 763504 c.135C>T synonymous_variant 0.44
rpoC 763511 p.Cys48Asp missense_variant 0.44
rpoC 763517 p.Lys50Arg missense_variant 0.43
rpoC 763534 c.165T>C synonymous_variant 0.56
rpoC 763546 c.177A>G synonymous_variant 0.56
rpoC 763570 c.201G>C synonymous_variant 0.58
rpoC 763621 c.252C>G synonymous_variant 0.65
rpoC 763633 c.264T>C synonymous_variant 0.64
rpoC 763660 c.291T>G synonymous_variant 0.68
rpoC 763675 c.306C>G synonymous_variant 0.67
rpoC 763696 c.327T>C synonymous_variant 0.71
rpoC 763705 c.336G>C synonymous_variant 0.72
rpoC 763708 c.339G>C synonymous_variant 0.72
rpoC 763714 c.345G>C synonymous_variant 0.69
rpoC 763717 c.348T>C synonymous_variant 0.69
rpoC 763726 c.357C>T synonymous_variant 0.67
rpoC 763732 c.363C>G synonymous_variant 0.64
rpoC 763741 c.372C>T synonymous_variant 0.6
rpoC 763765 c.396T>C synonymous_variant 0.5
rpoC 763772 p.Val135Met missense_variant 0.47
rpoC 763783 c.414G>C synonymous_variant 0.16
rpoC 763786 c.417C>G synonymous_variant 0.14
rpoC 764297 p.Met310Leu missense_variant 0.21
rpoC 764308 c.939G>C synonymous_variant 0.36
rpoC 764311 c.942C>G synonymous_variant 0.37
rpoC 764317 c.948C>G synonymous_variant 0.38
rpoC 764320 c.951C>G synonymous_variant 0.44
rpoC 764344 c.975C>T synonymous_variant 0.57
rpoC 764359 c.990C>G synonymous_variant 0.57
rpoC 764371 c.1002G>C synonymous_variant 0.57
rpoC 764377 c.1008C>G synonymous_variant 0.56
rpoC 764380 c.1011G>C synonymous_variant 0.55
rpoC 764383 c.1014C>G synonymous_variant 0.54
rpoC 764387 c.1018T>C synonymous_variant 0.55
rpoC 764404 c.1035C>T synonymous_variant 0.5
rpoC 764405 c.1036A>C synonymous_variant 0.5
rpoC 764410 c.1041G>C synonymous_variant 0.54
rpoC 764428 c.1059G>C synonymous_variant 0.43
rpoC 764434 c.1065A>G synonymous_variant 0.44
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.44
rpoC 764441 p.Ile358Leu missense_variant 0.44
rpoC 764449 c.1080G>C synonymous_variant 0.47
rpoC 764452 c.1083T>C synonymous_variant 0.47
rpoC 764458 c.1089G>C synonymous_variant 0.54
rpoC 764461 c.1092A>G synonymous_variant 0.56
rpoC 764470 c.1101C>G synonymous_variant 0.58
rpoC 764472 p.Asn368Ser missense_variant 0.58
rpoC 764497 c.1128A>G synonymous_variant 0.55
rpoC 764498 p.Ser377Ala missense_variant 0.57
rpoC 764507 p.Ala380Ser missense_variant 0.68
rpoC 764521 c.1152T>C synonymous_variant 0.76
rpoC 764527 c.1158C>G synonymous_variant 0.77
rpoC 764533 c.1164C>T synonymous_variant 0.75
rpoC 764536 c.1167G>C synonymous_variant 0.74
rpoC 764539 c.1170C>G synonymous_variant 0.76
rpoC 764560 c.1191T>C synonymous_variant 0.76
rpoC 764566 c.1197C>G synonymous_variant 0.75
rpoC 764572 c.1203G>C synonymous_variant 0.73
rpoC 764575 c.1206T>G synonymous_variant 0.72
rpoC 764578 c.1209C>G synonymous_variant 0.71
rpoC 764581 c.1212T>C synonymous_variant 0.7
rpoC 764582 p.Leu405Met missense_variant 0.7
rpoC 764611 c.1242G>C synonymous_variant 0.71
rpoC 764621 c.1252_1254delCTCinsTTG synonymous_variant 0.72
rpoC 764632 c.1263T>C synonymous_variant 0.74
rpoC 764635 c.1266C>G synonymous_variant 0.76
rpoC 764650 c.1281G>C synonymous_variant 0.75
rpoC 764665 c.1296C>G synonymous_variant 0.77
rpoC 764677 c.1308C>G synonymous_variant 0.79
rpoC 764681 p.Leu438Met missense_variant 0.77
rpoC 764706 p.Leu446Gln missense_variant 0.75
rpoC 764713 c.1344G>C synonymous_variant 0.74
rpoC 764731 c.1362G>C synonymous_variant 0.66
rpoC 764746 c.1377G>C synonymous_variant 0.59
rpoC 764758 c.1389C>G synonymous_variant 0.48
rpoC 764764 c.1395T>C synonymous_variant 0.43
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.31
rpoC 764791 c.1422C>G synonymous_variant 0.32
rpoC 764804 p.Gln479Phe missense_variant 0.18
rpoC 764812 c.1443C>G synonymous_variant 0.19
rpoC 764815 c.1446A>G synonymous_variant 0.19
rpoC 764818 c.1449G>C synonymous_variant 0.18
rpoC 764824 c.1455T>C synonymous_variant 0.18
rpoC 764830 c.1461C>G synonymous_variant 0.19
rpoC 764833 c.1464A>G synonymous_variant 0.19
rpoC 764837 p.Val490Ile missense_variant 0.2
rpoC 764843 p.Ala492Thr missense_variant 0.25
rpoC 764858 c.1489T>C synonymous_variant 0.31
rpoC 764863 c.1494G>C synonymous_variant 0.32
rpoC 764872 c.1503A>C synonymous_variant 0.29
rpoC 764887 c.1518G>C synonymous_variant 0.21
rpoC 764888 c.1519T>C synonymous_variant 0.21
rpoC 764893 c.1524T>G synonymous_variant 0.21
rpoC 764911 c.1542A>G synonymous_variant 0.27
rpoC 764912 p.Met515Gln missense_variant 0.27
rpoC 764923 c.1554A>G synonymous_variant 0.32
rpoC 764935 c.1566T>C synonymous_variant 0.23
rpoC 764948 c.1579T>C synonymous_variant 0.19
rpoC 764953 c.1584G>C synonymous_variant 0.19
rpoC 764956 c.1587T>C synonymous_variant 0.2
rpoC 764957 p.Glu530Ser missense_variant 0.19
rpoC 764968 c.1599T>C synonymous_variant 0.21
rpoC 764971 c.1602C>G synonymous_variant 0.23
rpoC 764983 c.1614T>C synonymous_variant 0.24
rpoC 765962 c.2593T>C synonymous_variant 0.11
rpoC 766322 p.Thr985Ser missense_variant 0.14
rpoC 766327 c.2958C>G synonymous_variant 0.17
rpoC 766330 p.Lys987Asn missense_variant 0.17
rpoC 766336 c.2967C>G synonymous_variant 0.18
rpoC 766345 c.2976T>C synonymous_variant 0.19
rpoC 766348 c.2979A>G synonymous_variant 0.19
rpoC 766354 c.2985C>G synonymous_variant 0.21
rpoC 766361 p.Val998Ile missense_variant 0.19
rpoC 766369 c.3000C>G synonymous_variant 0.19
rpoC 766384 c.3015A>G synonymous_variant 0.2
rpoC 766387 c.3018C>G synonymous_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781751 c.192G>C synonymous_variant 0.47
rpsL 781760 c.201T>C synonymous_variant 0.55
rpsL 781766 c.207C>T synonymous_variant 0.58
rpsL 781793 c.234G>C synonymous_variant 0.56
rpsL 781796 p.Met79Ile missense_variant 0.54
rpsL 781802 c.243G>C synonymous_variant 0.53
rpsL 781814 c.255C>T synonymous_variant 0.51
rpsL 781817 c.258G>T synonymous_variant 0.51
rpsL 781829 c.270G>C synonymous_variant 0.49
rpsL 781832 c.273T>C synonymous_variant 0.49
rpsL 781835 c.276T>C synonymous_variant 0.49
rpsL 781841 c.282C>G synonymous_variant 0.46
rpsL 781851 p.Ile98Val missense_variant 0.16
rplC 800618 c.-191T>C upstream_gene_variant 0.17
rplC 800633 c.-176T>C upstream_gene_variant 0.19
rplC 800639 c.-170C>G upstream_gene_variant 0.19
rplC 800648 c.-161A>G upstream_gene_variant 0.19
rplC 800654 c.-155T>C upstream_gene_variant 0.2
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.18
rplC 800672 c.-137G>C upstream_gene_variant 0.24
rplC 800693 c.-116A>G upstream_gene_variant 0.24
rplC 800703 c.-106T>C upstream_gene_variant 0.2
rplC 800715 c.-94A>G upstream_gene_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472094 n.249T>G non_coding_transcript_exon_variant 0.73
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.79
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.83
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.87
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.89
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.78
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.29
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.67
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.67
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 1.0
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 1.0
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 1.0
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 1.0
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 1.0
rrs 1472505 n.660G>A non_coding_transcript_exon_variant 1.0
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 1.0
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 1.0
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.94
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.94
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.94
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.94
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.94
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.93
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.67
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.67
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 1.0
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 1.0
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.96
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.83
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.83
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.83
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.8
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.67
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.87
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.9
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.94
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.94
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.94
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.94
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.95
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.9
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.89
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.91
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.95
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.95
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.95
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.96
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.32
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.98
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.98
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.97
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.97
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.97
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.97
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.97
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.97
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.95
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.89
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.77
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.79
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.75
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.75
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.79
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.82
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.81
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.81
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.79
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.78
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.6
rrl 1474171 n.514C>T non_coding_transcript_exon_variant 0.6
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.5
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.5
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.62
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.6
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.83
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.8
rrl 1474284 n.631_633delCCT non_coding_transcript_exon_variant 0.82
rrl 1474293 n.637_651delCCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.9
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.82
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.6
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.5
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 0.5
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.5
rrl 1474355 n.698A>C non_coding_transcript_exon_variant 0.5
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.5
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.4
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.5
rrl 1474406 n.749T>G non_coding_transcript_exon_variant 0.5
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.83
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.29
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.87
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.93
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.93
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.88
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.88
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.93
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.93
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.88
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.78
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.67
rrl 1474633 n.977_981delTCACC non_coding_transcript_exon_variant 0.67
rrl 1474640 n.983_984insTTGCT non_coding_transcript_exon_variant 0.75
rrl 1474658 n.1001A>T non_coding_transcript_exon_variant 0.8
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.8
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.44
rrl 1474675 n.1018C>T non_coding_transcript_exon_variant 0.44
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.44
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.44
rrl 1474691 n.1034A>T non_coding_transcript_exon_variant 0.38
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.5
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.5
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.43
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.43
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.6
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.75
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.75
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.6
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.6
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.6
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.6
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.6
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.5
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.5
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.5
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.6
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.5
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.67
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.67
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.96
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 1.0
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 1.0
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 1.0
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.96
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.95
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.95
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.94
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.94
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.94
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.94
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.94
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.92
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.92
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.85
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.82
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.82
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.83
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.83
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.83
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.77
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.33
rrl 1476079 n.2422G>A non_coding_transcript_exon_variant 0.33
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.45
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.45
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.5
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.5
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.57
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.57
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.57
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.57
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.57
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.29
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.64
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.84
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.86
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.93
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.95
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.79
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.77
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.38
rpsA 1833734 p.Ala65Ser missense_variant 0.16
rpsA 1833742 c.201A>G synonymous_variant 0.16
rpsA 1833761 p.Val74Ile missense_variant 0.15
rpsA 1833769 c.228C>G synonymous_variant 0.14
rpsA 1833770 p.Asn77Asp missense_variant 0.14
rpsA 1833782 p.Ser81Ala missense_variant 0.12
rpsA 1833787 c.246C>G synonymous_variant 0.12
rpsA 1833793 c.252C>T synonymous_variant 0.18
rpsA 1833802 c.261A>G synonymous_variant 0.21
rpsA 1833805 c.264C>T synonymous_variant 0.21
rpsA 1833811 c.270G>C synonymous_variant 0.22
rpsA 1833829 c.288A>G synonymous_variant 0.15
rpsA 1833832 c.291G>A synonymous_variant 0.16
rpsA 1833838 c.297G>C synonymous_variant 0.16
rpsA 1833841 c.300C>G synonymous_variant 0.16
rpsA 1833847 c.306C>G synonymous_variant 0.16
rpsA 1833856 c.315A>G synonymous_variant 0.18
rpsA 1833874 c.333T>C synonymous_variant 0.18
rpsA 1833928 c.387G>C synonymous_variant 0.25
rpsA 1833949 c.408T>C synonymous_variant 0.28
rpsA 1833955 c.414G>C synonymous_variant 0.28
rpsA 1833961 c.420C>G synonymous_variant 0.27
rpsA 1833979 c.438T>C synonymous_variant 0.51
rpsA 1833988 c.447C>G synonymous_variant 0.57
rpsA 1833994 c.453G>C synonymous_variant 0.6
rpsA 1834012 c.471G>C synonymous_variant 0.64
rpsA 1834039 c.498C>G synonymous_variant 0.6
rpsA 1834040 p.Lys167Gln missense_variant 0.6
rpsA 1834043 p.Glu168Lys missense_variant 0.6
rpsA 1834093 c.552G>C synonymous_variant 0.35
rpsA 1834114 c.573G>C synonymous_variant 0.17
rpsA 1834189 c.648G>C synonymous_variant 0.15
rpsA 1834195 c.654G>C synonymous_variant 0.31
rpsA 1834213 c.672G>C synonymous_variant 0.35
rpsA 1834219 c.678C>G synonymous_variant 0.35
rpsA 1834222 c.681T>C synonymous_variant 0.35
rpsA 1834225 c.684C>G synonymous_variant 0.36
rpsA 1834231 c.690T>G synonymous_variant 0.42
rpsA 1834234 c.693G>C synonymous_variant 0.48
rpsA 1834240 c.699T>C synonymous_variant 0.49
rpsA 1834249 c.708T>C synonymous_variant 0.58
rpsA 1834261 c.720A>G synonymous_variant 0.6
rpsA 1834264 c.723G>C synonymous_variant 0.61
rpsA 1834285 c.744G>C synonymous_variant 0.55
rpsA 1834294 c.753G>C synonymous_variant 0.45
rpsA 1834298 p.Gln253Glu missense_variant 0.44
rpsA 1834303 c.762T>C synonymous_variant 0.43
rpsA 1834306 c.765T>C synonymous_variant 0.43
rpsA 1834307 p.Asp256Gln missense_variant 0.43
rpsA 1834333 p.Asp264Glu missense_variant 0.45
rpsA 1834336 c.795C>G synonymous_variant 0.41
rpsA 1834348 c.807T>C synonymous_variant 0.31
rpsA 1834354 c.813G>C synonymous_variant 0.23
rpsA 1834357 c.816T>G synonymous_variant 0.24
rpsA 1834360 c.819G>C synonymous_variant 0.26
rpsA 1834361 c.820T>C synonymous_variant 0.24
rpsA 1834366 c.825A>C synonymous_variant 0.23
rpsA 1834369 c.828C>G synonymous_variant 0.22
rpsA 1834375 c.834G>C synonymous_variant 0.23
rpsA 1834378 c.837T>C synonymous_variant 0.24
rpsA 1834395 p.Arg285Gln missense_variant 0.25
rpsA 1834397 p.His286Thr missense_variant 0.2
rpsA 1834435 c.894G>C synonymous_variant 0.13
rpsA 1834451 c.910T>C synonymous_variant 0.15
rpsA 1834456 c.915T>G synonymous_variant 0.16
rpsA 1834459 c.918G>C synonymous_variant 0.15
rpsA 1834465 c.924T>C synonymous_variant 0.16
rpsA 1834468 c.927A>G synonymous_variant 0.17
rpsA 1834474 c.933C>G synonymous_variant 0.19
rpsA 1834480 c.939C>G synonymous_variant 0.18
rpsA 1834486 p.Glu315Asp missense_variant 0.18
rpsA 1834489 c.948T>C synonymous_variant 0.17
rpsA 1834498 c.957C>T synonymous_variant 0.2
rpsA 1834524 p.Glu328Val missense_variant 0.16
rpsA 1834528 c.987T>C synonymous_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168604 p.Pro670Leu missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
pncA 2289905 c.-664T>C upstream_gene_variant 0.12
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
pepQ 2860575 c.-157G>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449236 c.733A>C synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878331 c.177A>G synonymous_variant 0.14
rpoA 3878334 c.174T>C synonymous_variant 0.14
rpoA 3878337 c.171T>C synonymous_variant 0.14
rpoA 3878346 c.162T>C synonymous_variant 0.16
rpoA 3878355 c.153C>G synonymous_variant 0.16
rpoA 3878361 c.147G>C synonymous_variant 0.16
rpoA 3878364 c.144A>C synonymous_variant 0.16
rpoA 3878370 c.138T>C synonymous_variant 0.16
clpC1 4038860 c.1845G>C synonymous_variant 0.36
clpC1 4038875 c.1830C>G synonymous_variant 0.27
clpC1 4038878 c.1827A>G synonymous_variant 0.32
clpC1 4038905 c.1800A>G synonymous_variant 0.23
clpC1 4038911 c.1794G>C synonymous_variant 0.23
clpC1 4038917 c.1788C>G synonymous_variant 0.15
clpC1 4038923 c.1782A>G synonymous_variant 0.15
clpC1 4039817 c.888A>C synonymous_variant 0.34
clpC1 4039820 c.885T>G synonymous_variant 0.34
clpC1 4039823 c.882T>G synonymous_variant 0.34
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.36
clpC1 4039838 p.Leu289Ile missense_variant 0.36
clpC1 4039844 c.861C>T synonymous_variant 0.38
clpC1 4039850 c.855T>C synonymous_variant 0.38
clpC1 4039865 c.840T>G synonymous_variant 0.36
clpC1 4039875 p.Asn277Arg missense_variant 0.36
clpC1 4039898 c.807C>G synonymous_variant 0.29
clpC1 4039901 c.804C>G synonymous_variant 0.2
clpC1 4039904 c.801A>G synonymous_variant 0.19
clpC1 4039916 c.789T>C synonymous_variant 0.22
clpC1 4039925 c.780C>G synonymous_variant 0.21
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.22
clpC1 4039931 c.774T>C synonymous_variant 0.22
clpC1 4039934 c.771G>C synonymous_variant 0.24
clpC1 4039943 c.762G>C synonymous_variant 0.22
clpC1 4039946 c.759A>C synonymous_variant 0.22
clpC1 4039949 c.756G>C synonymous_variant 0.21
clpC1 4039952 c.753T>C synonymous_variant 0.24
clpC1 4039958 c.747G>C synonymous_variant 0.4
clpC1 4039967 p.Gln246His missense_variant 0.56
clpC1 4039979 c.726C>G synonymous_variant 0.51
clpC1 4039982 c.723G>C synonymous_variant 0.48
clpC1 4039988 c.717C>G synonymous_variant 0.45
clpC1 4039991 c.714G>C synonymous_variant 0.45
clpC1 4039994 p.Glu237Asp missense_variant 0.48
clpC1 4039997 c.708C>G synonymous_variant 0.48
clpC1 4040001 p.His235Arg missense_variant 0.51
clpC1 4040015 c.690G>C synonymous_variant 0.62
clpC1 4040021 c.684A>C synonymous_variant 0.63
clpC1 4040024 c.681A>G synonymous_variant 0.65
clpC1 4040027 c.678C>G synonymous_variant 0.65
clpC1 4040033 c.672G>C synonymous_variant 0.65
clpC1 4040063 c.642G>C synonymous_variant 0.62
clpC1 4040069 c.636G>C synonymous_variant 0.57
clpC1 4040090 c.615T>C synonymous_variant 0.59
clpC1 4040093 c.612C>G synonymous_variant 0.58
clpC1 4040114 p.Ile197Met missense_variant 0.26
clpC1 4040117 c.588A>G synonymous_variant 0.23
clpC1 4040123 p.Glu194Phe missense_variant 0.23
clpC1 4040129 c.576C>G synonymous_variant 0.24
clpC1 4040135 c.570C>G synonymous_variant 0.24
clpC1 4040147 c.558A>G synonymous_variant 0.19
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0