TB-Profiler result

Run: ERR4816717
Summary

Run ID: ERR4816717

Sample name:

Date: 2024-04-16T04:57:32.437328

Number of reads: 1605624

Percentage reads mapped: 29.0

Median coverage: 36.0

Strain: lineage3.1.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
lineage3.1.2 East-African-Indian RD750 1.0
lineage3.1.2.1 East-African-Indian RD750 1.0
lineage3.1 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.67 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.78 amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.76 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6266 p.Pro343Asp missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6283 c.1044C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6302 p.Ala355Thr missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6307 c.1068T>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6323 p.Val362Ile missense_variant 0.41 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619968 c.78G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760997 c.1191G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761064 p.Ala420Ser missense_variant 0.72 rifampicin Uncertain significance
rpoB 761084 c.1278C>G synonymous_variant 0.74 rifampicin
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.7 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.68 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>G synonymous_variant 0.37 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.29 rifampicin
rpoB 761204 c.1398C>G synonymous_variant 0.17 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761222 c.1416G>C synonymous_variant 0.17 rifampicin
rpoB 761974 p.His723Leu missense_variant 0.21 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.29 rifampicin
rpoB 762009 p.Leu735Met missense_variant 0.29 rifampicin
rpoB 762015 p.Glu737Ser missense_variant 0.29 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.31 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.38 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.6 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.53 rifampicin
rpoB 762125 p.Glu773Asp missense_variant 0.47 rifampicin
rpoB 762132 p.Ala776Ser missense_variant 0.41 rifampicin
rpoB 762136 p.Asp777Ala missense_variant 0.38 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.3 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 762160 p.Arg785His missense_variant 0.28 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762175 c.2370_2372delTCG disruptive_inframe_deletion 0.27 rifampicin
rpoB 762181 c.2375_2376insGGC disruptive_inframe_insertion 0.27 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.6 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.65 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.64 rifampicin
rpoB 762273 p.Ala823Ser missense_variant 0.66 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762305 c.2499G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762387 p.Glu861Gln missense_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.29 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.47 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762426 p.Ser874Thr missense_variant 0.56 rifampicin Uncertain significance
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 762443 c.-927G>C upstream_gene_variant 0.64 rifampicin
rpoC 762449 c.-921C>G upstream_gene_variant 0.64 rifampicin
rpoB 762452 c.2646G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762474 p.Gly890Ser missense_variant 0.62 rifampicin
rpoC 762482 c.-888C>T upstream_gene_variant 0.45 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762491 c.-879T>G upstream_gene_variant 0.56 rifampicin
rpoC 762503 c.-867G>C upstream_gene_variant 0.52 rifampicin
rpoB 762507 c.2701_2703delCTTinsAG frameshift_variant&missense_variant 0.48 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762832 p.Ser1009Thr missense_variant 0.34 rifampicin Uncertain significance
rpoB 762849 p.Tyr1015Asp missense_variant 0.46 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.46 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.47 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.47 rifampicin
rpoB 762870 p.Met1022Gln missense_variant 0.46 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.59 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.47 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.44 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.4 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.28 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.26 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.26 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.28 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.71 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763050 c.3244_3246delCTGinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763072 c.3268_3270delACC conservative_inframe_deletion 0.29 rifampicin
rpoB 763078 c.3272_3273insGCA disruptive_inframe_insertion 0.3 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.28 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763118 p.Glu1104Asp missense_variant 0.26 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.34 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763501 p.Asp44Glu missense_variant 0.45 rifampicin Uncertain significance
rpoC 763504 c.135C>T synonymous_variant 0.44 rifampicin
rpoC 763511 p.Cys48Asp missense_variant 0.44 rifampicin
rpoC 763517 p.Lys50Arg missense_variant 0.43 rifampicin
rpoC 763534 c.165T>C synonymous_variant 0.56 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>G synonymous_variant 0.65 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.72 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.72 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763726 c.357C>T synonymous_variant 0.67 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.64 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.6 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.5 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.47 rifampicin
rpoC 764297 p.Met310Leu missense_variant 0.21 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.36 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.37 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.38 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.44 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.57 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.57 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.54 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764404 c.1035C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.54 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764441 c.1072_1074delATCinsCG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.47 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.47 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.58 rifampicin
rpoC 764472 p.Asn368Ser missense_variant 0.58 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.57 rifampicin
rpoC 764507 c.1138_1140delGCGinsTC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>G synonymous_variant 0.77 rifampicin
rpoC 764533 c.1164C>T synonymous_variant 0.75 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 0.74 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.73 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.71 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.7 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.7 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.71 rifampicin
rpoC 764621 c.1252_1254delCTCinsTG frameshift_variant&missense_variant 0.72 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.76 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 0.75 rifampicin
rpoC 764665 c.1296C>G synonymous_variant 0.77 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764681 p.Leu438Met missense_variant 0.77 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.75 rifampicin Uncertain significance
rpoC 764713 c.1344G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764731 c.1362G>C synonymous_variant 0.66 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.59 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.31 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764804 p.Gln479Phe missense_variant 0.18 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.19 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764818 c.1449G>C synonymous_variant 0.18 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764833 c.1464A>G synonymous_variant 0.19 rifampicin
rpoC 764837 p.Val490Ile missense_variant 0.2 rifampicin Uncertain significance
rpoC 764843 p.Ala492Thr missense_variant 0.25 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.29 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>G synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.27 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 766322 p.Thr985Ser missense_variant 0.14 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.17 rifampicin
rpoC 766330 p.Lys987Asn missense_variant 0.17 rifampicin
rpoC 766336 c.2967C>G synonymous_variant 0.18 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.19 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766354 c.2985C>G synonymous_variant 0.21 rifampicin
rpoC 766361 c.2992_2994delGTGinsAC frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.19 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781751 c.192G>C synonymous_variant 0.47 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.55 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.58 streptomycin Not assoc w R - Interim
rpsL 781793 c.234G>C synonymous_variant 0.56 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.54 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.53 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.51 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.51 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.49 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.49 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.49 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.46 streptomycin
rpsL 781851 c.292_294delATCinsGG frameshift_variant&missense_variant 0.16 streptomycin Uncertain significance
rplC 800672 c.-137G>C upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.24 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>G upstream_gene_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472094 n.249T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474658 n.1001A>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475758 n.2101delAinsGG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.51 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834024 c.483_485delGCAinsC frameshift_variant&synonymous_variant 0.61 pyrazinamide Uncertain significance
rpsA 1834039 c.498C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.6 pyrazinamide
rpsA 1834043 p.Glu168Lys missense_variant 0.6 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.42 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834285 c.744G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.44 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.43 pyrazinamide Uncertain significance
rpsA 1834333 p.Asp264Glu missense_variant 0.45 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834366 c.825A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834395 p.Arg285Gln missense_variant 0.25 pyrazinamide
rpsA 1834397 p.His286Thr missense_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.18 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.2 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156752 c.-641A>G upstream_gene_variant 1.0 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168604 p.Pro670Leu missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
pepQ 2860575 c.-157G>C upstream_gene_variant 1.0 clofazimine
bedaquiline
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449236 c.733A>C synonymous_variant 1.0 ethionamide
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878355 c.153C>G synonymous_variant 0.16 rifampicin
rpoA 3878361 c.147G>C synonymous_variant 0.16 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.16 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.16 rifampicin
clpC1 4038860 c.1845G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038875 c.1830C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039865 c.840T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.36 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039967 p.Gln246His missense_variant 0.56 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.48 pyrazinamide
clpC1 4039997 c.708C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.51 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.62 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.65 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.65 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040069 c.636G>C synonymous_variant 0.57 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040114 p.Ile197Met missense_variant 0.26 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R