TB-Profiler result

Run: ERR4819809
Summary

Run ID: ERR4819809

Sample name:

Date: 2024-03-26T13:52:37.078395

Number of reads: 1884233

Percentage reads mapped: 63.6

Median coverage: 42.0

Strain: lineage4.6.2.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 0.99
lineage4.6.2 Euro-American RD726 1.0
lineage4.6.2.2 Euro-American (Cameroon) RD726 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7775 c.474C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575785 c.438T>C synonymous_variant 0.14 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.2 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.16 ethionamide
isoniazid
nusG 734472 c.219T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.18 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.16 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.15 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.16 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>T synonymous_variant 0.16 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.16 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.17 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.27 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.28 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.28 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.22 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.27 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.27 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.2 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.2 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.2 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.15 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.28 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.18 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.13 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.13 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.38 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.2 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.19 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.28 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.18 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762369 c.2563T>C synonymous_variant 0.14 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.13 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.13 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.15 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.27 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.19 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.21 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.22 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.17 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.34 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.37 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.45 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.42 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.46 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.42 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.41 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.29 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.25 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.26 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.24 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.19 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.2 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.18 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.18 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.23 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.25 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.22 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.22 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.21 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.2 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.19 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.25 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.26 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.26 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.27 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.28 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.28 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.28 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.21 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.22 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.29 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.28 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.32 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.19 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.15 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.15 rifampicin
rpoC 765908 c.2539C>T synonymous_variant 0.15 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.2 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.19 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.19 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.24 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.22 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.22 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.22 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775886 c.2595A>T synonymous_variant 0.14 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.15 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.25 clofazimine
bedaquiline
mmpL5 778298 c.183G>A synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.14 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.14 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.14 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.14 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.2 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.18 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.17 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.18 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.24 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.23 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.28 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.29 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.29 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.26 streptomycin Uncertain significance
rplC 800654 c.-155T>C upstream_gene_variant 0.17 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.27 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.27 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.27 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.29 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.25 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.26 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.27 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.25 linezolid
rplC 800964 c.156G>C synonymous_variant 0.16 linezolid
rplC 800985 c.177A>G synonymous_variant 0.16 linezolid
rplC 801237 c.429G>A synonymous_variant 0.15 linezolid
fbiC 1303512 c.582T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303536 c.606G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364847 c.435G>C synonymous_variant 0.14 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.14 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.15 pyrazinamide
sigE 1364871 c.459C>T synonymous_variant 0.16 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 0.16 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.16 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.16 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.19 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.18 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.18 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
inhA 1674718 c.517A>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674742 p.Lys181Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1674745 p.Tyr182Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1674753 c.552G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.25 ethionamide
isoniazid
rpsA 1833628 c.87G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.17 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.13 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.31 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.24 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.12 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.16 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.24 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.23 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.17 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.17 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.18 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.18 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.18 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.17 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.19 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.17 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.17 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063187 c.1542C>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2155389 c.723C>G synonymous_variant 1.0 isoniazid Not assoc w R
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.3 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.29 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.26 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.28 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.27 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.18 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.16 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.22 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.18 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.15 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.14 isoniazid
kasA 2518787 c.673_675delCGGinsGT frameshift_variant&missense_variant 0.13 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.13 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.13 isoniazid
Rv2477c 2783395 c.648T>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783426 p.Pro206Asn missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996208 p.Ala35Asp missense_variant 0.98 capreomycin Uncertain significance
thyX 3067474 p.Pro158Ala missense_variant 0.97 para-aminosalicylic_acid
Rv3083 3448567 p.His22Asp missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3612571 c.546C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
Rv3236c 3612910 p.Leu69Phe missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624675 p.Asn79Ser missense_variant 0.16 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624725 c.186G>T synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625711 c.903C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625753 p.Ala287Gln missense_variant 0.17 bedaquiline
rifampicin
lpqB 3625762 c.-852A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625828 c.-918G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
rpoA 3877647 c.861C>T synonymous_variant 0.18 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.23 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.17 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.27 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.31 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.28 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.26 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.24 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.16 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.15 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.14 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.25 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.27 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.28 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.28 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.22 rifampicin
rpoA 3878247 c.261G>A synonymous_variant 0.2 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.2 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.2 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
clpC1 4038563 c.2142C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.25 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038818 c.1887G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.22 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039118 c.1587C>A synonymous_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.38 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.27 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.25 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.4 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.39 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039832 c.873C>A synonymous_variant 0.12 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040249 c.456A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.15 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.15 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>T synonymous_variant 0.17 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.18 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.15 pyrazinamide
panD 4044210 c.72C>T synonymous_variant 0.14 pyrazinamide
panD 4044213 c.69C>G synonymous_variant 0.15 pyrazinamide
glpK 4138703 c.1053C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139594 c.162C>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139602 c.154C>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139647 p.Ala37Thr missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139648 c.108T>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139652 p.His35Ala missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139672 c.84C>G synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240717 c.855T>C synonymous_variant 0.16 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.36 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.36 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.35 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.27 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.27 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4242550 c.2688C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242872 p.Asp1004Thr missense_variant 0.15 ethambutol
embC 4242878 p.Thr1006Val missense_variant 0.17 ethambutol
embA 4245071 c.1839G>C synonymous_variant 0.14 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.14 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.14 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.14 ethambutol
embA 4245094 p.Ile621Thr missense_variant 0.14 ethambutol
embA 4245125 c.1893G>C synonymous_variant 0.12 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.2 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.2 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.21 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.22 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.25 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.25 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.29 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.28 ethambutol Uncertain significance
embB 4248233 c.1720C>T synonymous_variant 0.3 ethambutol
embB 4248242 p.Val577Ile missense_variant 0.3 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.24 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.24 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.25 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.2 ethambutol
aftB 4267272 p.Lys522Arg missense_variant 1.0 ethambutol Not assoc w R
ethA 4326739 c.735C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethR 4328004 c.456G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin