TB-Profiler result

Run: SRR6832787
Summary

Run ID: SRR6832787

Sample name:

Date: 2024-10-04T21:04:45.691582

Number of reads: 1536226

Percentage reads mapped: 71.78

Median coverage: 32.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5254 c.15A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5284 c.45G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 5287 c.48T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 5293 c.54C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 5302 c.63A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 5305 c.66G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 5308 c.69G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 5341 c.102T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 5359 c.120C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5363 c.124_126delTTAinsCTG synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5377 c.138T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5422 c.183T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 5425 c.186A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 5426 p.Thr63Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 5431 c.192A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 5434 c.195G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 5436 p.Asn66Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5440 c.201A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 5449 c.210T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 5455 c.216T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5470 c.231C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6181 c.942C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6313 c.-989C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7766 c.465C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8121 c.820T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8510 c.1209G>A synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8513 c.1212C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>A synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8562 c.1261C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8795 c.1494C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8796 p.Ile499Val missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8981 c.1680G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9065 c.1764C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9218 c.1917C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.55 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9257 c.1956C>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9323 c.2022C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9371 c.2070G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9401 c.2100G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
fgd1 490851 c.69A>T synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 490853 p.Ala24Gly missense_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 490863 c.81C>A synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 490869 c.87C>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575629 c.282A>T synonymous_variant 0.18 isoniazid
ethionamide
mshA 575633 p.Ala96Thr missense_variant 0.18 isoniazid
ethionamide
mshA 575652 p.Arg102Gln missense_variant 0.2 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575686 c.339G>A synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.38 isoniazid
ethionamide
mshA 575692 c.345G>A synonymous_variant 0.39 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.35 isoniazid
ethionamide
mshA 575732 c.385_387delCTTinsTTG synonymous_variant 0.32 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.31 isoniazid
ethionamide
mshA 575770 c.423G>C synonymous_variant 0.32 isoniazid
ethionamide
mshA 575772 p.Val142Ala missense_variant 0.32 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.32 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575848 c.501C>T synonymous_variant 0.24 isoniazid
ethionamide
mshA 575872 c.525C>T synonymous_variant 0.17 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.15 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.88 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620397 c.507C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.2 ethionamide
nusG 734407 p.Val52Ile missense_variant 0.19 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.24 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.29 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
mmaA3 737280 c.870G>A synonymous_variant 0.2 isoniazid
mmaA3 737307 p.Met281Ile missense_variant 0.22 isoniazid
mmaA3 737310 c.840A>G synonymous_variant 0.23 isoniazid
mmaA3 737316 c.834G>A synonymous_variant 0.23 isoniazid
rpoB 759644 c.-163T>A upstream_gene_variant 0.32 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoB 759661 c.-146G>C upstream_gene_variant 0.39 rifampicin
rpoB 759670 c.-137C>T upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoB 759671 c.-136G>T upstream_gene_variant 0.29 rifampicin
rpoB 759675 c.-132T>C upstream_gene_variant 0.29 rifampicin
rpoB 759676 c.-131A>G upstream_gene_variant 0.29 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760142 c.336C>G synonymous_variant 0.21 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.29 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.3 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760343 c.537G>C synonymous_variant 0.32 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>G synonymous_variant 0.25 rifampicin
rpoB 760868 c.1062C>G synonymous_variant 0.26 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.32 rifampicin
rpoB 760920 c.1114C>T synonymous_variant 0.32 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760994 c.1188G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.31 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.24 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.24 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761150 c.1344A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>T synonymous_variant 0.24 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.22 rifampicin
rpoB 761201 c.1395G>A synonymous_variant 0.26 rifampicin
rpoB 761204 c.1398C>G synonymous_variant 0.22 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.22 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.16 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.2 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.32 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.31 rifampicin
rpoB 762024 p.Val740Ile missense_variant 0.29 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762071 c.2265C>T synonymous_variant 0.32 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762119 c.2313C>T synonymous_variant 0.44 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.39 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762860 c.-510G>T upstream_gene_variant 0.19 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.74 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.43 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>T upstream_gene_variant 0.43 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763124 c.-246C>T upstream_gene_variant 0.37 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.21 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.55 rifampicin
rpoC 763561 c.192G>A synonymous_variant 0.27 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.21 rifampicin
rpoC 763639 c.270G>A synonymous_variant 0.2 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.32 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.31 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.27 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.26 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.29 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763781 p.Ser138Ala missense_variant 0.28 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.24 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.21 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.21 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.19 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.42 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.44 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.43 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.48 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.48 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.48 rifampicin
rpoC 764272 c.903G>T synonymous_variant 0.48 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.52 rifampicin
rpoC 764317 c.948C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>T synonymous_variant 0.31 rifampicin
rpoC 764347 c.978G>C synonymous_variant 0.29 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.33 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>A synonymous_variant 0.35 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.38 rifampicin
rpoC 764536 c.1167G>A synonymous_variant 0.36 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 764648 c.1279C>A synonymous_variant 0.38 rifampicin
rpoC 764653 c.1284G>C synonymous_variant 0.41 rifampicin
rpoC 764656 c.1287C>T synonymous_variant 0.43 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764674 c.1305G>A synonymous_variant 0.43 rifampicin
rpoC 764681 c.1312C>T synonymous_variant 0.44 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.36 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.33 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.23 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.21 rifampicin
rpoC 764833 c.1464A>G synonymous_variant 0.22 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.21 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.22 rifampicin
rpoC 764918 p.Val517Ile missense_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.19 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765757 c.2388C>T synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>A synonymous_variant 0.22 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.2 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.16 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.24 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.31 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766306 c.2937C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.31 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.3 rifampicin
rpoC 766324 c.2955C>T synonymous_variant 0.35 rifampicin
rpoC 766351 c.2982C>G synonymous_variant 0.4 rifampicin
rpoC 766360 c.2991C>T synonymous_variant 0.37 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.39 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.39 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.31 rifampicin
rpoC 766397 c.3028C>T synonymous_variant 0.31 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.34 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.35 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.23 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.22 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766534 c.3165C>G synonymous_variant 0.21 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.21 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.21 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.19 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.21 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.17 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 0.16 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 1.0 rifampicin Not assoc w R
rpoC 766765 c.3396A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766795 c.3426C>T synonymous_variant 0.24 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.27 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.32 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.33 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.29 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 0.97 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 0.97 streptomycin Not assoc w R
rpsL 781608 p.Ser17Ala missense_variant 0.19 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.24 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.3 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.24 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.2 streptomycin
rpsL 781664 c.105C>T synonymous_variant 0.22 streptomycin
rpsL 781667 c.108C>G synonymous_variant 0.23 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.22 streptomycin
rpsL 781721 c.162C>G synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.16 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.21 streptomycin
rplC 800567 c.-242A>G upstream_gene_variant 0.16 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.18 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.17 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.21 linezolid
rplC 800797 c.-12T>G upstream_gene_variant 0.16 linezolid
rplC 800799 c.-10G>C upstream_gene_variant 0.16 linezolid
rplC 800800 c.-9G>T upstream_gene_variant 0.16 linezolid
rplC 800801 c.-8A>G upstream_gene_variant 0.16 linezolid
rplC 800817 c.9A>C synonymous_variant 0.21 linezolid
rplC 800844 c.36T>C synonymous_variant 0.24 linezolid
rplC 800865 c.57A>G synonymous_variant 0.3 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.29 linezolid
rplC 800877 c.69A>C synonymous_variant 0.3 linezolid
rplC 800907 c.99C>G synonymous_variant 0.29 linezolid
rplC 800913 c.105G>C synonymous_variant 0.28 linezolid
rplC 800916 c.108A>T synonymous_variant 0.28 linezolid
rplC 800922 c.114C>G synonymous_variant 0.26 linezolid
rplC 800934 c.126C>G synonymous_variant 0.23 linezolid
rplC 800937 c.129A>G synonymous_variant 0.23 linezolid
rplC 800946 c.138T>G synonymous_variant 0.23 linezolid
rplC 800949 c.141T>C synonymous_variant 0.23 linezolid
rplC 800955 c.147C>G synonymous_variant 0.21 linezolid
rplC 800958 c.150G>A synonymous_variant 0.21 linezolid
rplC 801246 c.438C>G synonymous_variant 0.33 linezolid
rplC 801252 c.444G>C synonymous_variant 0.3 linezolid
rplC 801267 c.459A>T synonymous_variant 0.27 linezolid
rplC 801276 c.468G>C synonymous_variant 0.28 linezolid
rplC 801297 c.489C>T synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801312 c.504G>C synonymous_variant 0.24 linezolid
fbiC 1303681 c.751_753delTTGinsCTC synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303689 c.759T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304628 c.1698G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304649 c.1719C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304679 c.1749G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
sigE 1364706 c.294G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471984 n.139T>A non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673916 c.-286A>T upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673919 c.-283G>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673925 c.-277C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673946 c.-256C>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673960 c.-242_-241delCAinsTC upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673982 c.-220G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673988 c.-214G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673991 c.-211C>G upstream_gene_variant 0.21 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.4 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.47 pyrazinamide
rpsA 1833593 p.Ser18Thr missense_variant 0.47 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.5 pyrazinamide
rpsA 1833610 c.69C>A synonymous_variant 0.5 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.43 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833718 c.177C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834024 c.483G>A synonymous_variant 0.5 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.38 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.34 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.31 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.21 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.3 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.36 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.38 linezolid
tsnR 1853393 c.-213C>T upstream_gene_variant 0.38 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.38 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064296 c.433T>C synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064297 c.432C>T synonymous_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102263 c.780G>A synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102287 c.756C>A synonymous_variant 0.32 isoniazid
delamanid
ethionamide
ndh 2102302 c.741G>C synonymous_variant 0.32 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.21 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.26 isoniazid
kasA 2518252 c.138C>T synonymous_variant 0.26 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.28 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.3 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.21 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.23 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.19 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.19 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.29 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.29 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.29 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.26 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.2 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726378 c.186T>G synonymous_variant 0.21 isoniazid
ahpC 2726393 c.201G>C synonymous_variant 0.23 isoniazid
ahpC 2726397 p.Ser69Gly missense_variant 0.22 isoniazid
ahpC 2726408 c.216T>C synonymous_variant 0.24 isoniazid
ahpC 2726430 p.Ala80Thr missense_variant 0.23 isoniazid
folC 2747442 c.157T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747467 p.Asp44Glu missense_variant 0.2 para-aminosalicylic_acid
folC 2747491 c.108A>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747497 c.102C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747500 c.99A>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747503 c.96T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747509 c.90T>C synonymous_variant 0.24 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782496 p.Asp516Ala missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782498 c.1545C>T synonymous_variant 0.27 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782504 c.1539G>A synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783188 c.855G>A synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783308 c.735G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>T synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783356 c.687C>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859468 c.951G>T synonymous_variant 0.27 bedaquiline
clofazimine
pepQ 2859489 p.Val310Ala missense_variant 0.55 bedaquiline
clofazimine
pepQ 2859510 c.909T>C synonymous_variant 0.53 bedaquiline
clofazimine
Rv2681 2997134 c.396A>C synonymous_variant 0.15 capreomycin
Rv2681 2997149 c.411T>C synonymous_variant 0.19 capreomycin
Rv2681 2997155 c.417G>A synonymous_variant 0.19 capreomycin
Rv2752c 3065625 c.567G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067304 c.642A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067331 c.615C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.31 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.77 pyrazinamide Not assoc w R - Interim
lpqB 3623492 c.1419T>C synonymous_variant 0.3 rifampicin
bedaquiline
lpqB 3624071 c.840C>T synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624080 c.831G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625291 c.-381A>G upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3625301 p.Ala438Gly missense_variant 0.71 rifampicin
bedaquiline
lpqB 3625309 c.-399C>T upstream_gene_variant 0.71 rifampicin
bedaquiline
lpqB 3625327 c.-417A>G upstream_gene_variant 0.67 rifampicin
bedaquiline
lpqB 3625345 c.-435T>C upstream_gene_variant 0.57 rifampicin
bedaquiline
lpqB 3625366 c.-456C>A upstream_gene_variant 0.47 rifampicin
bedaquiline
lpqB 3625588 c.-678G>A upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625612 c.-702G>T upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625615 c.-705G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625684 c.-774G>A upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625747 c.-837G>T upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.54 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625819 c.795G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626711 c.-98T>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626723 c.-110C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626776 c.-163A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
fbiA 3640298 c.-245A>G upstream_gene_variant 0.24 pretomanid
delamanid
clofazimine
fbiA 3640318 c.-225A>T upstream_gene_variant 0.24 pretomanid
delamanid
clofazimine
fbiA 3640365 c.-178C>G upstream_gene_variant 0.17 pretomanid
delamanid
clofazimine
rpoA 3877620 c.888G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>A synonymous_variant 0.24 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877659 c.849G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877674 c.834C>T synonymous_variant 0.27 rifampicin
rpoA 3877704 c.804G>C synonymous_variant 0.3 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.26 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.28 rifampicin
rpoA 3877737 c.771G>T synonymous_variant 0.25 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.25 rifampicin
rpoA 3877752 c.756C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877755 c.753C>A synonymous_variant 0.27 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.32 rifampicin
rpoA 3877886 c.622C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878058 c.450G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878061 c.447G>C synonymous_variant 0.32 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.33 rifampicin
rpoA 3878085 c.423G>A synonymous_variant 0.37 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.29 rifampicin
rpoA 3878126 c.382C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878127 c.381G>C synonymous_variant 0.26 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.37 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.32 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.36 rifampicin
rpoA 3878211 c.297G>A synonymous_variant 0.38 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.37 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.35 rifampicin
rpoA 3878262 c.246C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.31 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.31 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878472 p.Asp12Glu missense_variant 0.24 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.25 rifampicin
rpoA 3878483 c.25C>T synonymous_variant 0.26 rifampicin
rpoA 3878490 c.18C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878496 c.12A>T synonymous_variant 0.3 rifampicin
rpoA 3878698 c.-191A>C upstream_gene_variant 0.4 rifampicin
rpoA 3878713 c.-206G>C upstream_gene_variant 0.38 rifampicin
rpoA 3878719 c.-212G>A upstream_gene_variant 0.41 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.4 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.4 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.43 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.44 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.43 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878791 c.-284C>T upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.41 rifampicin
rpoA 3878833 c.-326C>T upstream_gene_variant 0.35 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878920 c.-413C>T upstream_gene_variant 0.33 rifampicin
ddn 3986984 c.141G>T synonymous_variant 0.18 pretomanid
delamanid
clpC1 4038456 p.Val750Glu missense_variant 0.24 pyrazinamide
clpC1 4038508 c.2197C>T synonymous_variant 0.31 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.34 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.32 pyrazinamide
clpC1 4038533 c.2172C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038800 c.1905C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038995 c.1710G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039009 c.1696C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039958 c.747G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040091 c.613_614delTCinsAG synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040636 c.69C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
embC 4239044 c.-819G>C upstream_gene_variant 0.18 ethambutol
embC 4240150 c.288A>G synonymous_variant 0.18 ethambutol
embC 4240151 p.Ser97Pro missense_variant 0.18 ethambutol
embC 4240831 c.969T>C synonymous_variant 0.2 ethambutol
embC 4240858 c.996G>A synonymous_variant 0.16 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.36 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244856 p.Ala542Pro missense_variant 0.23 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.18 ethambutol
embB 4245662 c.-852G>C upstream_gene_variant 0.32 ethambutol
embA 4245674 c.2442A>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4245677 c.-837G>C upstream_gene_variant 0.31 ethambutol
embB 4245683 c.-831C>T upstream_gene_variant 0.32 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.38 ethambutol
embB 4245714 c.-800C>T upstream_gene_variant 0.43 ethambutol
embB 4246004 c.-510T>C upstream_gene_variant 0.33 ethambutol
embB 4246005 c.-509C>T upstream_gene_variant 0.33 ethambutol
embB 4246013 c.-501T>C upstream_gene_variant 0.32 ethambutol
embA 4246020 p.Ala930Thr missense_variant 0.32 ethambutol
embB 4246070 c.-444G>C upstream_gene_variant 0.37 ethambutol
embB 4246244 c.-270G>A upstream_gene_variant 0.25 ethambutol
embA 4246254 p.Leu1008Met missense_variant 0.32 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.31 ethambutol
embA 4246265 c.3033C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4246268 c.-246G>A upstream_gene_variant 0.31 ethambutol
embA 4246279 p.Ala1016Val missense_variant 0.37 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.22 ethambutol
embB 4246307 c.-207G>C upstream_gene_variant 0.23 ethambutol
embB 4246316 c.-198T>C upstream_gene_variant 0.24 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.24 ethambutol
embA 4246359 p.Ala1043Ser missense_variant 0.16 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.21 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.28 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.27 ethambutol
embB 4247555 p.Leu348Ile missense_variant 0.28 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.26 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.26 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247608 c.1095G>C synonymous_variant 0.23 ethambutol
embB 4247611 c.1098G>C synonymous_variant 0.21 ethambutol
embB 4247948 p.Val479Leu missense_variant 0.29 ethambutol Uncertain significance
embB 4248094 c.1581C>T synonymous_variant 0.3 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.32 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.24 ethambutol
embB 4248154 c.1641G>T synonymous_variant 0.23 ethambutol
embB 4248157 c.1644A>T synonymous_variant 0.21 ethambutol
embB 4248163 c.1650G>A synonymous_variant 0.22 ethambutol
embB 4248169 c.1656C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248175 c.1662G>A synonymous_variant 0.24 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.23 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.28 ethambutol Uncertain significance
embB 4248214 c.1701C>G synonymous_variant 0.27 ethambutol
embB 4248217 c.1704C>G synonymous_variant 0.27 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.28 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.29 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.29 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.24 ethambutol
embB 4248424 c.1911G>A synonymous_variant 0.19 ethambutol
embB 4248430 c.1917T>C synonymous_variant 0.19 ethambutol
embB 4248448 c.1935C>T synonymous_variant 0.16 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.19 ethambutol
embB 4249568 p.Ser1019Asn missense_variant 0.19 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.23 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.21 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.73 ethambutol Not assoc w R
aftB 4268978 c.-142C>T upstream_gene_variant 0.34 ethambutol
aftB 4268994 c.-158T>C upstream_gene_variant 0.39 ethambutol
aftB 4269000 c.-164G>A upstream_gene_variant 0.39 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.41 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.39 ethambutol
aftB 4269027 c.-191C>G upstream_gene_variant 0.37 ethambutol
aftB 4269030 c.-194C>G upstream_gene_variant 0.39 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.37 ethambutol
aftB 4269045 c.-209G>C upstream_gene_variant 0.37 ethambutol
ubiA 4269177 c.657G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4269180 c.-344G>T upstream_gene_variant 0.19 ethambutol
aftB 4269195 c.-359C>T upstream_gene_variant 0.2 ethambutol
aftB 4269216 c.-380C>T upstream_gene_variant 0.2 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
ubiA 4269225 c.609C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
ethA 4326535 c.939G>C synonymous_variant 0.18 ethionamide
ethR 4326556 c.-993A>G upstream_gene_variant 0.24 ethionamide
ethA 4326563 p.Ala304Gly missense_variant 0.22 ethionamide
ethR 4326565 c.-984C>A upstream_gene_variant 0.24 ethionamide
ethR 4326591 c.-958A>G upstream_gene_variant 0.21 ethionamide
ethA 4326598 c.876A>G synonymous_variant 0.22 ethionamide Not assoc w R - Interim
whiB6 4338593 c.-73delT upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338596 c.-75G>C upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R