TB-Profiler result

Run: SRR12708384
Summary

Run ID: SRR12708384

Sample name:

Date: 2024-04-14T05:53:36.489646

Number of reads: 153064

Percentage reads mapped: 11.89

Median coverage: 3.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.85
lineage4.9 Euro-American (H37Rv-like) None 0.9
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.8 isoniazid
dnaA 714 c.714C>T synonymous_variant 0.83 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.85 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.83 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>T synonymous_variant 0.8 isoniazid
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.8 isoniazid Uncertain significance
dnaA 763 p.Lys255Arg missense_variant 0.91 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.92 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.92 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.92 isoniazid
dnaA 804 c.804G>C synonymous_variant 1.0 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 1.0 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 1.0 isoniazid
dnaA 828 c.828T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.92 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.92 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.91 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.91 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.92 isoniazid Not assoc w R - Interim
dnaA 885 c.885T>C synonymous_variant 0.92 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.91 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.8 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.8 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.8 isoniazid
gyrA 7511 c.210C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>A synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8978 c.1677C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
mshA 575785 c.438T>C synonymous_variant 0.73 ethionamide
isoniazid
mshA 575792 p.Asp149Asn missense_variant 0.7 ethionamide
isoniazid
mshA 575795 c.448_450delATCinsCG frameshift_variant&missense_variant 0.7 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575800 c.453G>T synonymous_variant 0.7 ethionamide
isoniazid
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620354 p.Trp155Tyr missense_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620365 p.Asn159Tyr missense_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.82 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 1.0 rifampicin
nusG 734460 c.207G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 1.0 rifampicin
nusG 734532 c.279A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760110 c.304_306delTCTinsAGC synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.86 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.73 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.73 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.75 rifampicin
rpoB 760388 c.582C>T synonymous_variant 0.79 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.8 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.81 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.95 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.93 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.93 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.93 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.93 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.95 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.95 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.95 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.95 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 760674 c.868T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.85 rifampicin
rpoB 760727 c.921C>G synonymous_variant 0.73 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760736 c.930C>G synonymous_variant 0.73 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.67 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.71 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.71 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.83 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.83 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.83 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760943 c.1137C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.83 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.8 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.83 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.88 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.83 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761339 c.1533C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761924 c.2118G>A synonymous_variant 0.9 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.9 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.9 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.92 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.94 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.94 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.93 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.92 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 1.0 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 1.0 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.91 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.93 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.88 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.88 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762894 c.3088C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.88 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.83 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.83 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.83 rifampicin
rpoC 763732 c.363C>A synonymous_variant 0.83 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.76 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.76 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.76 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.69 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.5 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.47 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.53 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.6 rifampicin
rpoC 763991 c.622_624delATCinsCT frameshift_variant&missense_variant 0.6 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.6 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.57 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.56 rifampicin
rpoC 764003 p.Ala212Ser missense_variant 0.59 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.55 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.55 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.57 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.55 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.57 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.64 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.64 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.64 rifampicin
rpoC 764095 c.726C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764147 c.778_780delTCGinsGC frameshift_variant&missense_variant 0.73 rifampicin
rpoC 764150 c.781_783delATCinsGG frameshift_variant&missense_variant 0.73 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.88 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.95 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.86 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.87 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.73 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.71 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.67 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>C synonymous_variant 0.57 rifampicin
rpoC 765382 c.2013G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.57 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.74 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.74 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.84 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.81 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.8 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.79 rifampicin Uncertain significance
rpoC 765826 c.2457T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765841 c.2472G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.71 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.75 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.73 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.82 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.82 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.75 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.73 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 1.0 streptomycin Uncertain significance
rpsL 781586 c.27C>T synonymous_variant 1.0 streptomycin
rpsL 781595 c.36T>C synonymous_variant 1.0 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 1.0 streptomycin
rpsL 781616 c.57C>G synonymous_variant 1.0 streptomycin
rpsL 781628 c.69T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 1.0 streptomycin
rpsL 781655 c.96T>C synonymous_variant 1.0 streptomycin
rpsL 781658 c.99A>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 1.0 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.96 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.95 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.95 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.92 streptomycin Uncertain significance
sigE 1364726 p.Asn105Ser missense_variant 0.79 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.79 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.75 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.92 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.92 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.92 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.92 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.85 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.85 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.85 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.71 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.69 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.69 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.67 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.6 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.75 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.75 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.73 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.9 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.9 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.9 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.94 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.95 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.94 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.95 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.93 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.93 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.93 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.93 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.93 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.93 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.88 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.87 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.8 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.89 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.75 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834534 c.993C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.86 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.8 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.8 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.8 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.81 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.83 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.89 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834698 c.1157_1158insC frameshift_variant 0.85 pyrazinamide Uncertain significance
rpsA 1834701 p.Gln387Pro missense_variant 0.86 pyrazinamide
rpsA 1834704 c.1164delC frameshift_variant 0.85 pyrazinamide Uncertain significance
rpsA 1834720 c.1179C>G synonymous_variant 0.89 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.93 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.92 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.92 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.85 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.83 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.83 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.64 pyrazinamide
rpsA 1834830 p.Ala430Val missense_variant 0.6 pyrazinamide
kasA 2517917 c.-198G>C upstream_gene_variant 0.96 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.95 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.92 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.91 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.6 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.67 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.72 isoniazid
kasA 2518771 c.657C>G synonymous_variant 0.68 isoniazid
kasA 2518774 c.660C>T synonymous_variant 0.65 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.65 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.68 isoniazid
kasA 2518792 c.678C>T synonymous_variant 0.68 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.68 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.68 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.63 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.67 isoniazid
kasA 2518846 c.732G>T synonymous_variant 0.67 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.67 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.67 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.64 isoniazid
Rv2477c 2783302 c.741A>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>T synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>A synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
mtrB 3625705 c.909C>G synonymous_variant 0.77 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625708 c.906C>T synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.88 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.89 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.89 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.86 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.83 bedaquiline
rifampicin Uncertain significance
mtrB 3625761 p.Gln285Glu missense_variant 0.83 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.85 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625783 c.-873C>T upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625813 c.801C>T synonymous_variant 0.76 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625819 p.Glu265Val missense_variant 0.76 bedaquiline
rifampicin Uncertain significance
mtrB 3625837 c.777C>G synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625867 c.747A>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625876 c.738G>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625882 c.732G>A synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.97 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.97 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.97 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.96 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.87 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.73 bedaquiline
rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.89 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.92 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.85 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.81 rifampicin Uncertain significance
rpoA 3877986 c.522G>T synonymous_variant 0.8 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.8 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.83 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.88 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.9 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.89 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.93 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.8 rifampicin
clpC1 4038941 c.1764G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.92 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.9 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.94 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 1.0 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.88 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.88 pyrazinamide Uncertain significance
clpC1 4039418 c.1287C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 1.0 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.93 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.93 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.92 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.92 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.9 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.88 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.89 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039685 c.1020C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.93 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.96 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.86 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.77 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.74 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.79 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.86 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.85 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040441 c.264C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.9 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.9 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.9 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.79 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.84 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.83 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.83 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.83 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.83 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.93 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.93 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.93 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.93 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.93 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
panD 4044167 c.115C>T synonymous_variant 1.0 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 1.0 pyrazinamide
panD 4044174 c.108C>T synonymous_variant 1.0 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 1.0 pyrazinamide
panD 4044186 c.94_96delTTGinsCC frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044189 c.93C>T synonymous_variant 1.0 pyrazinamide
panD 4044194 p.Ala30Pro missense_variant 1.0 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 1.0 pyrazinamide
panD 4044219 c.63C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044232 p.Cys17His missense_variant 1.0 pyrazinamide
panD 4044234 c.48C>G synonymous_variant 1.0 pyrazinamide
glpK 4138550 c.1206C>T synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138556 c.1200G>C synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138559 c.1197G>A synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138562 c.1194G>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>A synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>T synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>A synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.94 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>G synonymous_variant 0.93 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138664 c.1092G>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.94 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138694 p.Pro354Glu missense_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 p.Ala348Asp missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1030_1032delGCAinsTG frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138730 c.1026C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240789 c.927T>C synonymous_variant 1.0 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.93 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.87 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.86 ethambutol