TB-Profiler result

Run: SRR23961542
Summary

Run ID: SRR23961542

Sample name:

Date: 2024-10-04T13:56:17.303047

Number of reads: 479633

Percentage reads mapped: 43.81

Median coverage: 1.0

Strain: La1;lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.9 Euro-American (H37Rv-like) None 0.87
La1 M.bovis None 0.1
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 756 c.756T>C synonymous_variant 1.0 isoniazid
dnaA 771 c.771A>G synonymous_variant 1.0 isoniazid
dnaA 777 c.777A>G synonymous_variant 1.0 isoniazid
dnaA 786 c.786C>T synonymous_variant 1.0 isoniazid
dnaA 795 c.795A>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 1.0 isoniazid
dnaA 813 c.813C>T synonymous_variant 1.0 isoniazid
dnaA 822 c.822A>G synonymous_variant 1.0 isoniazid
dnaA 828 c.828T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 1.0 isoniazid
dnaA 837 c.837A>G synonymous_variant 1.0 isoniazid
dnaA 840 c.840G>A synonymous_variant 1.0 isoniazid
dnaA 846 c.846T>C synonymous_variant 1.0 isoniazid
dnaA 849 c.849A>G synonymous_variant 1.0 isoniazid
dnaA 852 c.852G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>C synonymous_variant 1.0 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 1.0 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 1.0 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 1.0 isoniazid
dnaA 1179 c.1179G>C synonymous_variant 1.0 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 1.0 isoniazid
dnaA 1195 c.1195_1197delCTTinsTTG synonymous_variant 1.0 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 1.0 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 1.0 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 1.0 isoniazid
gyrB 6215 p.Ser326Thr missense_variant 0.64 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6283 c.1044C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7778 c.477G>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 p.Ile316Val missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 p.Ile328Leu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8492 c.1191G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8543 c.1242C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>A synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8681 c.1380C>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8690 c.1389C>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.91 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.94 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.93 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.94 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8888 c.1587C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
hadA 731690 c.-240_-237delAGACinsCAGCTTTTTTGAAGAA upstream_gene_variant 0.96 isoniazid
hadA 731694 c.-235_-234delCG upstream_gene_variant 0.96 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.96 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.97 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.97 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.97 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.97 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.97 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.96 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.94 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.94 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.92 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.92 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.92 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.92 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.9 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.9 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.81 rifampicin
nusG 734403 c.150C>T synonymous_variant 0.89 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.86 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.89 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.86 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.89 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.95 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.95 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.95 rifampicin
nusG 734481 c.228C>G synonymous_variant 0.95 rifampicin
nusG 734502 c.249G>A synonymous_variant 0.95 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.95 rifampicin
nusG 734565 c.312G>A synonymous_variant 0.95 rifampicin
nusG 734580 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 1.0 rifampicin
nusG 734596 c.343T>C synonymous_variant 1.0 rifampicin
nusG 734610 c.357C>G synonymous_variant 1.0 rifampicin
nusG 734625 c.372T>C synonymous_variant 1.0 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.91 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.91 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.92 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.93 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.93 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.97 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.97 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 1.0 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 1.0 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 1.0 rifampicin
rpoB 760937 c.1131G>A synonymous_variant 1.0 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 1.0 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 1.0 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 1.0 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 1.0 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 1.0 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.94 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.96 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.98 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.98 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.98 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.98 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.98 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.97 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.94 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.94 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.94 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.94 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.94 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.94 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.97 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.97 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.97 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.97 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.97 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.97 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.96 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 1.0 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 1.0 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 1.0 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 1.0 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 1.0 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 1.0 rifampicin
rpoB 761876 c.2070C>T synonymous_variant 1.0 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 1.0 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 1.0 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 1.0 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 1.0 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 1.0 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 1.0 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 1.0 rifampicin
rpoB 761942 c.2136C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.86 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.83 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.87 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.87 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 1.0 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 1.0 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 1.0 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.97 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.97 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.96 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.95 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.95 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.95 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.95 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.95 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.95 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 1.0 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 1.0 rifampicin
rpoC 763504 c.135C>G synonymous_variant 0.91 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.88 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.87 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.9 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.9 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.83 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.83 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.81 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.81 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.78 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.76 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.79 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.75 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.82 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.82 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.73 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.83 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.86 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.88 rifampicin
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.87 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.81 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.79 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.75 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.76 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.82 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.91 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.92 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.95 rifampicin
rpoC 764203 c.834G>T synonymous_variant 1.0 rifampicin
rpoC 764206 c.837T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 1.0 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.85 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.82 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.82 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.9 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 1.0 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 1.0 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764563 c.1194G>C synonymous_variant 1.0 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.92 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.92 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764848 c.1479G>A synonymous_variant 0.9 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 1.0 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 1.0 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 1.0 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 1.0 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 1.0 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 1.0 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.94 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.94 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766303 c.2934C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 1.0 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 1.0 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 1.0 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 1.0 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 1.0 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 1.0 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 1.0 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 1.0 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 1.0 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 1.0 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.89 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.89 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.89 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.89 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.9 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.96 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.96 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.96 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.96 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766816 c.3447C>T synonymous_variant 0.96 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.96 rifampicin
rpoC 766882 c.3513C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>T synonymous_variant 0.96 rifampicin
rpoC 766888 c.3519G>C synonymous_variant 0.96 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.96 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.96 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.92 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.96 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.98 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.98 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>T synonymous_variant 1.0 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 1.0 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.98 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767102 c.3733_3735delCTCinsTTG synonymous_variant 1.0 rifampicin
rpoC 767105 p.Asn1246Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.97 rifampicin
mmpL5 775817 c.2664T>C synonymous_variant 0.86 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775856 c.2625T>C synonymous_variant 0.93 bedaquiline
clofazimine
mmpL5 775865 c.2616T>A synonymous_variant 0.93 bedaquiline
clofazimine
rpsL 781682 c.123T>C synonymous_variant 0.93 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 0.93 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.93 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.94 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.88 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.83 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.89 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.89 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.84 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.84 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.83 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.82 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.82 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.88 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.88 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.94 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.93 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 1.0 linezolid
fbiC 1303695 c.765T>C synonymous_variant 0.82 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.85 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.85 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>C synonymous_variant 0.8 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1303740 c.810C>T synonymous_variant 0.86 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303746 c.816T>C synonymous_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.87 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.88 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.9 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.94 pretomanid
delamanid
clofazimine
fbiC 1304112 c.1182G>A synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304115 c.1185A>G synonymous_variant 0.6 pretomanid
delamanid
clofazimine
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.97 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473752 n.95G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.93 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
inhA 1673633 c.-569G>A upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673646 c.-556T>C upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673657 c.-545_-544delCGinsAA upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673664 c.-538A>C upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673667 c.-535A>G upstream_gene_variant 0.82 isoniazid
ethionamide
inhA 1673679 c.-523T>C upstream_gene_variant 0.85 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673710 c.-492_-490delCTAinsGTC upstream_gene_variant 0.85 isoniazid
ethionamide
inhA 1673724 c.-478A>G upstream_gene_variant 0.85 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.92 isoniazid
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.8 isoniazid
ethionamide
inhA 1673750 c.-452A>G upstream_gene_variant 0.8 isoniazid
ethionamide
inhA 1673769 c.-433C>T upstream_gene_variant 0.91 isoniazid
ethionamide
inhA 1674699 c.498C>T synonymous_variant 0.92 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.91 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.92 isoniazid
ethionamide
inhA 1674718 c.517_519delAGGinsCGA synonymous_variant 0.93 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.93 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.94 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.97 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.97 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.97 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.96 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.96 isoniazid
ethionamide
inhA 1674804 c.603G>C synonymous_variant 0.96 isoniazid
ethionamide Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 1.0 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 1.0 isoniazid
ethionamide
inhA 1674831 c.630G>A synonymous_variant 1.0 isoniazid
ethionamide
inhA 1674840 c.639C>G synonymous_variant 1.0 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 1.0 isoniazid
ethionamide
inhA 1674852 c.651G>C synonymous_variant 1.0 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.84 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.84 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1833772 c.231C>T synonymous_variant 0.95 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.94 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.92 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.96 pyrazinamide
rpsA 1833844 c.303C>T synonymous_variant 0.92 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.96 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.97 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.98 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.99 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833991 c.450C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 1.0 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 1.0 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.97 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.93 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.91 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.88 pyrazinamide
rpsA 1834390 c.849G>A synonymous_variant 0.86 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.85 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.84 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.77 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.83 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.8 pyrazinamide
ndh 2102398 c.645C>T synonymous_variant 0.7 isoniazid
delamanid
ethionamide
ndh 2102401 c.642T>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2102407 c.636T>C synonymous_variant 0.77 isoniazid
delamanid
ethionamide
ndh 2102413 c.630G>T synonymous_variant 0.81 isoniazid
delamanid
ethionamide
ndh 2102422 c.621C>G synonymous_variant 0.82 isoniazid
delamanid
ethionamide
ndh 2102443 p.Ala200Ser missense_variant 0.73 isoniazid
delamanid
ethionamide
ndh 2102450 p.Lys198Arg missense_variant 0.79 isoniazid
delamanid
ethionamide
kasA 2518519 c.405G>C synonymous_variant 0.9 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.92 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.93 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.95 isoniazid
kasA 2518574 p.Ile154Val missense_variant 1.0 isoniazid
kasA 2518579 c.465T>C synonymous_variant 1.0 isoniazid
kasA 2518588 c.474T>C synonymous_variant 1.0 isoniazid
kasA 2518591 c.477G>C synonymous_variant 1.0 isoniazid
kasA 2518606 c.492G>C synonymous_variant 1.0 isoniazid
kasA 2518609 p.Met165Ile missense_variant 1.0 isoniazid
kasA 2518618 c.504G>C synonymous_variant 1.0 isoniazid
kasA 2518627 c.513T>C synonymous_variant 1.0 isoniazid
kasA 2518642 c.528A>G synonymous_variant 1.0 isoniazid
kasA 2518672 c.558G>C synonymous_variant 1.0 isoniazid
Rv2477c 2782894 c.1149C>G synonymous_variant 0.92 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782913 p.Ser377Thr missense_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>T synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783014 p.Ser343Thr missense_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783038 p.Ala335Thr missense_variant 1.0 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.97 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.97 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783110 c.933C>T synonymous_variant 0.98 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.98 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.97 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.97 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.97 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783191 p.Ser284Gly missense_variant 0.93 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.93 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.93 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.92 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.88 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.89 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.94 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.95 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.82 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.82 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.85 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.93 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.93 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.83 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.83 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.83 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.83 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.82 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065901 c.291A>T synonymous_variant 0.91 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065922 c.270T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065925 p.Ala89Gly missense_variant 0.83 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065928 c.264G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065934 c.258C>T synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid
rifampicin
ethambutol
Rv2752c 3065947 p.Gly82Ala missense_variant 0.87 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.87 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.89 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065988 c.204A>G synonymous_variant 0.89 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.89 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.89 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.9 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066003 c.189C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid
rifampicin
ethambutol
thyA 3073800 c.672G>C synonymous_variant 0.9 para-aminosalicylic_acid
thyA 3073803 p.Glu223Asp missense_variant 0.9 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.92 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.92 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.92 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.97 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.97 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCTC synonymous_variant 0.97 para-aminosalicylic_acid
thyA 3073917 c.555C>A synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3074000 c.472C>A synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.98 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.97 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.97 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.96 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.96 para-aminosalicylic_acid
mtrB 3625750 c.864G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 1.0 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625786 c.-876C>T upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 1.0 rifampicin Uncertain significance
bedaquiline Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627032 c.-419G>C upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.91 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.93 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.95 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.95 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.95 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.95 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.94 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.94 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.93 rifampicin
bedaquiline
rpoA 3877524 c.984C>A synonymous_variant 1.0 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 1.0 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 1.0 rifampicin
rpoA 3877653 c.855C>T synonymous_variant 1.0 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 1.0 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 1.0 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877752 c.756C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 1.0 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877821 c.687C>G synonymous_variant 1.0 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.94 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.94 rifampicin
rpoA 3879088 c.-581A>G upstream_gene_variant 0.94 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.89 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.96 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.96 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.93 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.93 rifampicin
rpoA 3879163 c.-656C>T upstream_gene_variant 0.93 rifampicin
rpoA 3879190 c.-683C>T upstream_gene_variant 0.93 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.87 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.87 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.86 rifampicin
rpoA 3879238 c.-731C>T upstream_gene_variant 0.86 rifampicin
clpC1 4038419 c.2286T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038434 c.2271G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 1.0 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 1.0 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 1.0 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 1.0 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 1.0 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 1.0 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 1.0 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 1.0 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 1.0 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 1.0 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039025 c.1680C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039328 p.Ala459Gly missense_variant 0.97 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.97 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.94 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.96 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.96 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.88 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.94 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.95 pyrazinamide
clpC1 4040393 c.312G>T synonymous_variant 0.95 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040438 c.267G>A synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.96 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.96 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.95 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040510 c.195G>A synonymous_variant 1.0 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 1.0 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>T synonymous_variant 1.0 pyrazinamide
embC 4240615 c.753G>C synonymous_variant 0.95 ethambutol
embC 4240630 c.768C>A synonymous_variant 1.0 ethambutol
embC 4240633 p.Met257Ile missense_variant 1.0 ethambutol
embC 4240642 c.780G>C synonymous_variant 1.0 ethambutol
embC 4240645 c.783G>C synonymous_variant 1.0 ethambutol
embC 4240657 c.795G>T synonymous_variant 1.0 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240676 p.Gly272Pro missense_variant 1.0 ethambutol
embC 4240685 p.Thr275Ala missense_variant 1.0 ethambutol
embC 4240693 c.831T>C synonymous_variant 1.0 ethambutol
embC 4240695 p.Ile278Thr missense_variant 1.0 ethambutol
embC 4240699 c.837C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240701 p.Val280Ala missense_variant 1.0 ethambutol Uncertain significance
embC 4240726 c.864G>C synonymous_variant 0.98 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.97 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.95 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.97 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.97 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.97 ethambutol
embC 4240828 c.966G>T synonymous_variant 0.97 ethambutol Not assoc w R - Interim
embC 4240831 c.969T>G synonymous_variant 0.96 ethambutol
embC 4240855 c.993G>C synonymous_variant 0.96 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.98 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.98 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.98 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.98 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.98 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.98 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.98 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.98 ethambutol
embC 4240921 c.1059C>G synonymous_variant 1.0 ethambutol
embC 4240924 c.1062C>G synonymous_variant 1.0 ethambutol
embC 4240936 c.1074A>G synonymous_variant 1.0 ethambutol
embC 4240945 c.1083T>C synonymous_variant 1.0 ethambutol
embC 4240948 c.1086G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240954 p.Ile364Met missense_variant 1.0 ethambutol
embC 4240960 c.1098G>C synonymous_variant 1.0 ethambutol
embC 4240966 c.1104G>C synonymous_variant 1.0 ethambutol
embC 4240972 c.1110C>G synonymous_variant 1.0 ethambutol
embC 4240979 p.Thr373Gln missense_variant 1.0 ethambutol
embC 4240983 p.Ser374Asn missense_variant 1.0 ethambutol
embC 4240988 p.Ala376Thr missense_variant 1.0 ethambutol
embC 4240996 c.1134G>C synonymous_variant 1.0 ethambutol
embC 4241002 c.1140G>C synonymous_variant 1.0 ethambutol
embC 4241013 p.Met384Thr missense_variant 1.0 ethambutol
embC 4241017 c.1155T>C synonymous_variant 1.0 ethambutol
embC 4241023 c.1161T>G synonymous_variant 1.0 ethambutol
embC 4241044 c.1182C>T synonymous_variant 1.0 ethambutol
embC 4241050 c.1188T>G synonymous_variant 1.0 ethambutol
embC 4241089 c.1227C>G synonymous_variant 1.0 ethambutol
embC 4241104 c.1242G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 1.0 ethambutol
embC 4241122 c.1260C>T synonymous_variant 1.0 ethambutol
embC 4241140 c.1278A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 1.0 ethambutol
embC 4241167 c.1305C>G synonymous_variant 1.0 ethambutol
embC 4241170 c.1308G>C synonymous_variant 1.0 ethambutol
embC 4241179 c.1317G>A synonymous_variant 1.0 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.93 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.94 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.94 ethambutol
embC 4241483 p.Val541Ile missense_variant 0.94 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.94 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.94 ethambutol
embC 4241498 p.Val546Ile missense_variant 0.94 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.94 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.95 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.95 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.94 ethambutol
embC 4241536 c.1674A>C synonymous_variant 0.94 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.94 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.94 ethambutol
embC 4241547 p.Ala562Val missense_variant 0.94 ethambutol
embC 4241551 c.1689A>C synonymous_variant 0.94 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.93 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.93 ethambutol
embC 4241578 c.1716G>C synonymous_variant 1.0 ethambutol
embC 4241671 c.1809T>G synonymous_variant 1.0 ethambutol
embC 4241689 c.1827G>C synonymous_variant 1.0 ethambutol
embC 4241690 p.Gly610Ser missense_variant 1.0 ethambutol Uncertain significance
embC 4241694 p.Ala611Val missense_variant 1.0 ethambutol
embC 4241704 c.1842C>A synonymous_variant 1.0 ethambutol
embC 4241707 c.1845G>C synonymous_variant 1.0 ethambutol
embC 4241713 c.1851G>C synonymous_variant 1.0 ethambutol
embC 4241719 c.1857G>C synonymous_variant 1.0 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 1.0 ethambutol
embC 4241731 c.1869C>G synonymous_variant 1.0 ethambutol
embC 4241741 p.Val627Leu missense_variant 1.0 ethambutol
embC 4241747 p.Val629Leu missense_variant 1.0 ethambutol
embC 4241750 p.Leu630Val missense_variant 1.0 ethambutol
embC 4241755 c.1893C>G synonymous_variant 1.0 ethambutol
embC 4241756 c.1894C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241770 c.1908T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim