TB-Profiler result

Run: ERR11049020
Summary

Run ID: ERR11049020

Sample name:

Date: 2024-10-04T13:51:45.346333

Number of reads: 2418913

Percentage reads mapped: 89.65

Median coverage: 73.5

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.12
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 882 c.882C>T synonymous_variant 0.14 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.15 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.15 isoniazid
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 576347 p.Thr334Ala missense_variant 1.0 isoniazid Uncertain significance
ethionamide Uncertain significance
ccsA 620346 c.456C>G synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.19 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.2 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620461 p.Val191Ile missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620678 p.Pro263Leu missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620769 c.879C>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620790 c.900C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620796 c.906C>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620809 c.919C>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
Rv0565c 656265 c.1206G>C synonymous_variant 0.16 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.16 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.15 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.17 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.16 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.28 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.29 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.3 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.29 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.34 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.38 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.42 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.42 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.42 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.18 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.19 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.19 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.2 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.15 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.18 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.16 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.17 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.18 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.21 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.21 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.24 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.23 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.39 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.39 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.38 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.36 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.36 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.18 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.19 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.3 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.29 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.25 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.28 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.29 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.29 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.22 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.22 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.14 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.15 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.19 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.17 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.14 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.15 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.14 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.14 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.16 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.17 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.15 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.14 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.18 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.23 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.25 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.33 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.34 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.34 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.3 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.28 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.24 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.25 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.25 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.25 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.31 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.32 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.34 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.35 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.32 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.3 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.31 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.3 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.22 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.19 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.19 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.21 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.15 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.14 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.26 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.29 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.24 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.32 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.34 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.34 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.28 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.28 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.29 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.26 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.17 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.19 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.27 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.32 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.3 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.31 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.32 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.25 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.26 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.16 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.16 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.15 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.15 rifampicin
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.2 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.2 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.19 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.22 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.25 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.25 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.27 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.32 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.3 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.33 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.34 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.31 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.3 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.31 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.29 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.15 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.25 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.34 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.44 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.49 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.49 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.42 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.42 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.29 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.26 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.31 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.25 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.26 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.26 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.29 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.3 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.3 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.33 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.33 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.38 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.35 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.34 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.32 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.32 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.33 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.32 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.33 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.33 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.34 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.35 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.34 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.34 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.34 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.3 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.29 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.16 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.15 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.16 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.23 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.23 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.21 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.2 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.18 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.18 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.2 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.19 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.26 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.27 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.23 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.31 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.32 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.34 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.25 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775909 p.Leu858Phe missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775913 c.2568C>G synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775921 c.2560C>T synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775937 c.2544G>C synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775943 c.2538C>G synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.19 bedaquiline
clofazimine
mmpL5 775973 c.2506_2508delTTGinsCTC synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.18 bedaquiline
clofazimine
mmpL5 775991 c.2490G>A synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 776000 p.Leu827Ile missense_variant 0.16 bedaquiline
clofazimine
mmpL5 776005 p.Ile826Leu missense_variant 0.16 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 776030 c.2451G>A synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 777101 c.1380C>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777110 c.1371T>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777115 p.Met456Leu missense_variant 0.19 bedaquiline
clofazimine
mmpL5 777116 c.1365C>T synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777133 p.Val450Ile missense_variant 0.2 bedaquiline
clofazimine
mmpL5 777158 c.1323C>G synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 777164 c.1317C>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.21 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777206 c.1275A>G synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 777212 p.Ala423Thr missense_variant 0.19 bedaquiline
clofazimine
mmpL5 777215 c.1266C>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777218 c.1263G>A synonymous_variant 0.18 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.22 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.29 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.31 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.41 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.39 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.4 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.38 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.38 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.37 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.4 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.41 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.41 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.34 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.34 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.35 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.33 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.32 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.29 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.28 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.28 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.31 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.32 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.3 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.36 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.21 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.26 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.26 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.29 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.31 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.36 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.36 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.41 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.38 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.37 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.29 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.3 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.29 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.29 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.3 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.24 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.18 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.16 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.17 linezolid
rplC 800814 c.6A>G synonymous_variant 0.19 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 800865 c.57A>G synonymous_variant 0.16 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.16 linezolid
rplC 800875 p.Val23Ile missense_variant 0.14 linezolid
rplC 800880 c.72A>G synonymous_variant 0.15 linezolid
rplC 800889 c.81C>G synonymous_variant 0.18 linezolid
rplC 800892 c.84G>C synonymous_variant 0.18 linezolid
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.15 linezolid
rplC 801174 c.366T>C synonymous_variant 0.15 linezolid
rplC 801195 c.387G>C synonymous_variant 0.22 linezolid
rplC 801246 c.438C>T synonymous_variant 0.23 linezolid
rplC 801249 c.441T>C synonymous_variant 0.23 linezolid
rplC 801255 c.447C>T synonymous_variant 0.24 linezolid
rplC 801264 c.456C>T synonymous_variant 0.22 linezolid
rplC 801267 c.459A>T synonymous_variant 0.22 linezolid
rplC 801270 c.462T>C synonymous_variant 0.2 linezolid
rplC 801276 c.468G>C synonymous_variant 0.19 linezolid
rplC 801279 c.471G>C synonymous_variant 0.19 linezolid
rplC 801282 c.474G>C synonymous_variant 0.19 linezolid
rplC 801285 c.477G>C synonymous_variant 0.19 linezolid
rplC 801300 c.492C>G synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.18 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801321 c.513C>T synonymous_variant 0.2 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.18 linezolid
rplC 801341 p.Leu178His missense_variant 0.14 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.15 linezolid
rplC 801402 c.594T>C synonymous_variant 0.14 linezolid
rplC 801423 c.615G>C synonymous_variant 0.15 linezolid
rplC 801426 c.618C>G synonymous_variant 0.16 linezolid
rplC 801427 p.Met207Val missense_variant 0.17 linezolid
rplC 801438 c.630T>C synonymous_variant 0.2 linezolid
rplC 801442 p.Ile212Val missense_variant 0.22 linezolid
fbiC 1303785 c.855G>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
sigE 1364847 c.435G>C synonymous_variant 0.17 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.17 pyrazinamide
sigE 1364862 c.450C>A synonymous_variant 0.18 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.18 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.18 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.19 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.18 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.21 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.15 pyrazinamide
atpE 1460831 c.-214T>C upstream_gene_variant 0.14 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.14 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.15 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.17 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.2 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.2 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.19 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.18 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.18 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.18 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.17 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.37 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673985 c.-217C>G upstream_gene_variant 0.14 isoniazid
ethionamide
rpsA 1833568 c.27G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.36 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834654 p.Glu371Asp missense_variant 0.17 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.29 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.28 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.29 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.23 pyrazinamide
tsnR 1853370 c.-236G>T upstream_gene_variant 0.14 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.16 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.14 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101804 c.1239T>G synonymous_variant 0.15 isoniazid
delamanid
ethionamide
ndh 2101808 p.Thr412Ser missense_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2101830 p.Ile405Val missense_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.2 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101858 p.LeuIle394PheAla missense_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101872 p.Ile391Phe missense_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101960 c.1083A>G synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2101963 c.1080G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223491 c.-327C>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.32 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.2 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.19 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.13 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.14 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.17 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.19 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.21 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.23 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.23 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.21 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.22 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.25 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.23 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.26 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.28 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.27 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.27 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.26 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.24 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.22 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
Rv2477c 2782912 p.Ser377Thr missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782928 p.Thr372Glu missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782966 c.1077C>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.48 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
thyX 3067652 c.294T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074100 p.Asp124Asn missense_variant 0.18 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.17 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.17 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.15 para-aminosalicylic_acid
ald 3087420 p.Ile201Val missense_variant 1.0 cycloserine
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
mtrB 3626704 c.-91C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.21 rifampicin
bedaquiline
rpoA 3877515 c.993G>C synonymous_variant 0.15 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.22 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.24 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.28 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.3 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.34 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.3 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.37 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.39 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.35 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.34 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.37 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.34 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.34 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.33 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.33 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.31 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.31 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.3 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.3 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.28 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.28 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.27 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.26 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.26 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.27 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.24 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.24 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.23 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.28 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.26 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.25 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.24 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.23 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.26 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.26 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.23 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.2 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.18 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.2 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.24 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.28 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.27 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.28 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.24 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.25 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.24 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.26 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.22 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.23 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.21 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.2 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.16 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.14 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.19 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.22 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.23 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.29 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.29 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.28 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.14 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.14 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.14 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.15 pretomanid
delamanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.14 pretomanid
delamanid
clpC1 4038671 c.2034T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.28 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.18 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.15 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.17 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.16 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138763 c.993G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138769 c.987G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138774 p.Ser328Ala missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138778 c.978C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138796 c.960A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138802 c.954G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138808 c.948G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138817 c.939T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138822 p.Asn312Asp missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.14 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.19 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.16 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.16 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.17 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.17 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.16 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.15 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.16 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.15 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.15 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.2 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.24 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.23 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.18 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4249532 p.Ala1007Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4249543 c.3030G>C synonymous_variant 0.15 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.15 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.14 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.14 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.14 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.13 ethambutol
aftB 4268096 c.741C>G synonymous_variant 0.17 ethambutol
aftB 4268099 c.738G>C synonymous_variant 0.18 ethambutol
aftB 4268102 c.735C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
aftB 4268117 c.720G>C synonymous_variant 0.23 ethambutol
aftB 4268123 p.Ser238Gly missense_variant 0.22 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.22 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.22 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.22 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.21 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.21 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.22 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.23 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.22 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.21 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.21 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R