TB-Profiler result

Run: ERR4818347
Summary

Run ID: ERR4818347

Sample name:

Date: 2024-10-04T05:25:02.473916

Number of reads: 2054603

Percentage reads mapped: 72.58

Median coverage: 48.0

Strain: lineage4.1.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 1.0
La1.2.BCG M.bovis None 0.07
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethR p.Phe110Leu Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.18 ethambutol Mutation from literature
ethR 4327876 p.Phe110Leu missense_variant 1.0 ethionamide Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.16 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>T synonymous_variant 0.2 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.2 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.21 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.2 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.2 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.19 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.21 isoniazid
dnaA 600 c.600T>G synonymous_variant 0.2 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.19 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.17 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.17 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.18 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.17 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.16 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.17 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.17 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.17 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.17 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.15 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.13 isoniazid
gyrB 6268 c.1029C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7347 p.Glu16Gln missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8111 c.810G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8186 c.885G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8219 c.918T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 p.Tyr364His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490803 c.21T>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490812 c.30A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490815 c.33G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 490827 c.45C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 490848 c.66A>G synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490868 p.Ala29Gly missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491172 c.390C>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.79 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575821 c.474G>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.16 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.16 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.16 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.2 isoniazid
ethionamide
mshA 575920 c.573C>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575924 p.Gly193Ser missense_variant 0.21 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575965 c.618C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide
ccsA 620412 c.522T>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.19 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620424 c.534G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.19 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620442 c.552G>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620461 p.Val191Ile missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620481 c.591T>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
Rv0565c 656088 c.1383A>G synonymous_variant 0.15 ethionamide
Rv0565c 656091 c.1380T>C synonymous_variant 0.16 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.14 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.17 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.16 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.17 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.17 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.19 ethionamide
Rv0565c 656448 p.Ile341Val missense_variant 0.23 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.26 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.25 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.25 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.24 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.15 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.16 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 0.79 ethionamide Uncertain significance
Rv0565c 657300 c.171C>G synonymous_variant 0.26 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.2 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.19 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.18 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.17 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.15 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.16 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.15 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.17 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.15 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.15 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.16 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.14 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.17 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.19 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.36 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.39 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.38 isoniazid
nusG 734424 c.171G>A synonymous_variant 0.18 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.19 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.21 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.16 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.24 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.76 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.23 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.19 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.15 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.16 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760381 p.Thr192Met missense_variant 0.16 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.24 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.22 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.2 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.23 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.25 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.25 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.26 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.23 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.23 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.2 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.18 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.28 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.26 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.32 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.19 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.19 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>C synonymous_variant 0.16 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.15 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.22 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.17 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.18 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.19 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.2 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.23 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.22 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.21 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.19 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.19 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.15 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>A upstream_gene_variant 0.27 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.26 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.17 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.2 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.17 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.2 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.21 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.21 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.24 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.19 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.24 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.24 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764083 c.714A>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.26 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.24 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.17 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.25 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.24 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.25 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.25 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.22 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.23 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.28 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.21 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>A synonymous_variant 0.17 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.96 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.26 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.26 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.29 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.29 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765361 c.1992C>G synonymous_variant 0.26 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.23 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.27 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.28 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.29 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.32 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.31 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.21 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.16 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.26 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.23 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.21 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.22 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.18 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.21 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.17 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.19 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.18 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.2 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.2 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.2 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.2 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.18 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.15 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.17 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.17 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.17 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.23 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.27 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.25 rifampicin
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.29 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.16 rifampicin
rpoC 767284 c.3915C>T synonymous_variant 0.15 rifampicin
rpoC 767288 c.3919C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 777101 c.1380C>G synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 777116 c.1365C>T synonymous_variant 0.14 bedaquiline
clofazimine
mmpL5 777133 p.Val450Ile missense_variant 0.18 bedaquiline
clofazimine
mmpL5 777158 c.1323C>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777164 c.1317C>G synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 777173 c.1308C>G synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.23 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 777206 c.1275A>G synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 777212 p.Ala423Thr missense_variant 0.18 bedaquiline
clofazimine
mmpL5 777215 c.1266C>G synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 777218 c.1263G>A synonymous_variant 0.18 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.16 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.25 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.21 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.21 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.27 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.31 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.32 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.2 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.21 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.22 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.23 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.22 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.16 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.18 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.18 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.18 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800200 c.-609C>G upstream_gene_variant 0.98 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.14 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.18 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.16 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.15 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.2 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.2 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.21 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800817 c.9A>T synonymous_variant 0.2 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 800889 c.81C>A synonymous_variant 1.0 linezolid Not assoc w R - Interim
rplC 801207 c.399C>T synonymous_variant 0.18 linezolid
rplC 801246 c.438C>T synonymous_variant 0.19 linezolid
rplC 801249 c.441T>C synonymous_variant 0.2 linezolid
rplC 801255 c.447C>T synonymous_variant 0.2 linezolid
rplC 801264 c.456C>T synonymous_variant 0.16 linezolid
rplC 801267 c.459A>T synonymous_variant 0.17 linezolid
rplC 801270 c.462T>C synonymous_variant 0.16 linezolid
rplC 801276 c.468G>C synonymous_variant 0.17 linezolid
rplC 801279 c.471G>C synonymous_variant 0.17 linezolid
rplC 801282 c.474G>C synonymous_variant 0.17 linezolid
rplC 801285 c.477G>C synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.15 linezolid
rplC 801312 c.504G>C synonymous_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.14 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.15 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.15 linezolid
fbiC 1303797 c.867A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304127 c.1197A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304132 p.Ala401Gly missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304142 c.1212G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304161 p.Arg411Ser missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304169 c.1239T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304174 p.Val415Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304184 c.1254G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304187 c.1257T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304208 c.1278C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304535 c.1605G>A synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.37 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
atpE 1460840 c.-205A>G upstream_gene_variant 0.18 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.15 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.15 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.2 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
inhA 1673685 c.-517C>T upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673742 c.-460C>T upstream_gene_variant 0.17 isoniazid Uncertain significance
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1674114 c.-88T>A upstream_gene_variant 0.17 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674123 c.-79T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674126 c.-76G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1674132 c.-70T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674141 c.-61T>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.21 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.25 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.25 isoniazid
ethionamide
inhA 1674604 c.403C>T synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674741 c.540C>T synonymous_variant 0.15 isoniazid Not assoc w R - Interim
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.25 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834204 c.663C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.25 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.35 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.35 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.39 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.34 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064942 c.-214G>A upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
katG 2155641 p.Lys157Asn missense_variant 0.18 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.18 isoniazid
katG 2155677 c.435C>G synonymous_variant 0.22 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.24 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.3 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.34 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.36 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.29 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.29 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.25 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.19 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.2 isoniazid
PPE35 2168303 c.2310G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289987 c.-746C>T upstream_gene_variant 0.21 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.21 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.22 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.21 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.18 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.19 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.21 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.21 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.24 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.23 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.21 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.17 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.17 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.17 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.19 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.19 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.19 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.22 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.2 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.18 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.2 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726672 c.480G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.16 isoniazid
Rv2477c 2782912 p.Ser377Thr missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.16 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.19 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783338 c.705C>T synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.46 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.21 capreomycin
Rv2752c 3064914 c.1278T>G synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067373 c.573C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.29 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.28 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.24 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.24 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.24 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.23 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.2 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.23 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.19 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.2 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067730 c.216G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067762 c.184C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.16 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073815 c.657G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.26 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.25 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087635 c.816C>T synonymous_variant 0.15 cycloserine
ald 3087649 p.Gly277Asp missense_variant 0.15 cycloserine
lpqB 3624047 c.864G>C synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624050 c.861C>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624077 c.834G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624092 c.817_819delAGGinsCGC synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624116 c.795A>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.2 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624143 c.768T>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.2 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624707 c.204G>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.33 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625240 c.-330T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625243 c.-333T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625255 c.-345T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625270 c.-360G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.19 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.15 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625843 c.-933C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626869 c.481C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
fbiA 3640850 p.Glu103Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640857 c.-678G>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3640866 c.-669T>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiA 3640871 p.Ala110Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640878 c.-657T>C upstream_gene_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3640899 c.-636G>C upstream_gene_variant 0.18 pretomanid
delamanid
clofazimine
fbiA 3640900 p.Gln120Asn missense_variant 0.18 pretomanid
delamanid
clofazimine
alr 3840263 c.1158C>T synonymous_variant 0.98 cycloserine
rpoA 3877553 p.Glu319Gln missense_variant 0.15 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.15 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.15 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.17 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.15 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.24 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.39 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.27 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.26 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.26 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.22 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.22 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.25 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.27 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.26 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.28 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878143 p.Gly122Asp missense_variant 0.15 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.2 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.21 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.28 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.23 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.19 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.19 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.16 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.18 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.18 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.19 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.22 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.17 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.22 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.18 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.23 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.28 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.19 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.25 pretomanid
delamanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.16 pretomanid
delamanid
ddn 3986646 c.-198_-196delCTCinsTTG upstream_gene_variant 0.16 pretomanid
delamanid
clpC1 4038293 c.2412G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.18 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.19 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.39 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.24 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.15 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039682 c.1023C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039994 c.711G>A synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.15 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.17 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.19 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.2 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.18 pyrazinamide
glpK 4138565 c.1191G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138568 c.1188A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138580 c.1176C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138601 c.1155G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138610 c.1146C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138622 c.1134C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138625 c.1131G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139126 c.630G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139137 p.Asp207Asn missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139143 c.613T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139165 c.591A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139168 c.588T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139177 c.579T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.573T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139186 c.570G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240726 c.864G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.24 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.24 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.23 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.21 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.21 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.22 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.22 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.22 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.2 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.16 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.19 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.27 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.23 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.24 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.18 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.18 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.15 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.18 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.18 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.18 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.21 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.23 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.22 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.22 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.24 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.26 ethambutol
embC 4242803 p.Val981Leu missense_variant 0.76 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.21 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.2 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.2 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.2 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.18 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.18 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.17 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.17 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.17 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.23 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.25 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.23 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.22 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.27 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.27 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.23 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.2 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.18 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.17 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.17 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.17 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.18 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.18 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.17 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.17 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.17 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.24 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.26 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.26 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.2 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.19 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.16 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.18 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.17 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.19 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.21 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.22 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.21 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.21 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.24 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.25 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247875 c.1362G>C synonymous_variant 0.22 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.21 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.22 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.24 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.29 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.28 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.22 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.26 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.17 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.15 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.16 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.15 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.16 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.2 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.2 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.2 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.2 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.21 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.25 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.27 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.24 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.15 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.25 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.26 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.27 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.27 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.27 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.27 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.29 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.31 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.29 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.24 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.19 ethambutol
aftB 4267091 c.1746C>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin