Run ID: ERR4818347
Sample name:
Date: 2024-10-04T05:25:02.473916
Number of reads: 2054603
Percentage reads mapped: 72.58
Median coverage: 48.0
Strain: lineage4.1.2
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.1 | Euro-American | None | 0.97 |
lineage4.1.2 | Euro-American | None | 1.0 |
La1.2.BCG | M.bovis | None | 0.07 |
lineage4 | Euro-American | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.His312Arg | Mutation from literature | |
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ethR | p.Phe110Leu | Uncertain significance | Mutation from literature |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
embB | 4247448 | p.His312Arg | missense_variant | 0.18 | ethambutol | Mutation from literature | |
ethR | 4327876 | p.Phe110Leu | missense_variant | 1.0 | ethionamide | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 30 | c.30C>G | synonymous_variant | 0.16 | isoniazid | |
dnaA | 534 | c.534T>C | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
dnaA | 558 | c.558G>T | synonymous_variant | 0.2 | isoniazid | |
dnaA | 561 | c.561C>T | synonymous_variant | 0.2 | isoniazid | |
dnaA | 567 | c.567C>G | synonymous_variant | 0.21 | isoniazid | |
dnaA | 571 | c.571T>C | synonymous_variant | 0.2 | isoniazid | |
dnaA | 582 | c.582A>C | synonymous_variant | 0.2 | isoniazid | Not assoc w R - Interim |
dnaA | 585 | c.585A>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 588 | c.588A>C | synonymous_variant | 0.19 | isoniazid | |
dnaA | 591 | c.591C>G | synonymous_variant | 0.21 | isoniazid | |
dnaA | 600 | c.600T>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 741 | c.741T>C | synonymous_variant | 0.2 | isoniazid | Not assoc w R - Interim |
dnaA | 750 | c.750C>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 756 | c.756T>C | synonymous_variant | 0.19 | isoniazid | |
dnaA | 768 | c.768C>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 771 | c.771A>C | synonymous_variant | 0.17 | isoniazid | |
dnaA | 777 | c.777A>G | synonymous_variant | 0.18 | isoniazid | |
dnaA | 786 | c.786C>T | synonymous_variant | 0.17 | isoniazid | |
dnaA | 897 | c.897A>G | synonymous_variant | 0.16 | isoniazid | |
dnaA | 912 | c.912T>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 918 | c.918C>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 921 | c.921A>G | synonymous_variant | 0.18 | isoniazid | Not assoc w R - Interim |
dnaA | 942 | c.942C>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 945 | c.945G>A | synonymous_variant | 0.17 | isoniazid | |
dnaA | 955 | c.955A>C | synonymous_variant | 0.15 | isoniazid | |
dnaA | 960 | c.960C>A | synonymous_variant | 0.13 | isoniazid | |
gyrB | 6268 | c.1029C>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6280 | c.1041T>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6286 | c.1047T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6289 | c.1050C>T | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6292 | c.1053G>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6307 | c.1068T>G | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6319 | c.1080G>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrB | 6346 | c.1107C>T | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6362 | c.-940T>C | upstream_gene_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6376 | c.-926G>A | upstream_gene_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6382 | c.-920A>G | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6388 | c.-914T>C | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6403 | c.-899T>C | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6841 | c.1602T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6844 | c.-458T>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7147 | c.-155G>C | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7165 | c.-137C>G | upstream_gene_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7178 | c.-124T>C | upstream_gene_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7186 | c.1947C>G | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7216 | c.1977G>C | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7335 | p.Leu12Val | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7347 | p.Glu16Gln | missense_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7355 | c.54T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7361 | c.60C>T | synonymous_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7391 | c.90C>T | synonymous_variant | 0.35 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7394 | c.93T>C | synonymous_variant | 0.33 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7406 | c.105G>C | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7412 | c.111C>G | synonymous_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7427 | c.126G>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7436 | c.135C>T | synonymous_variant | 0.29 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7442 | c.141G>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7451 | c.150C>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7457 | c.156T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7475 | c.174A>G | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7480 | p.Phe60Tyr | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7484 | c.183T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7514 | c.213C>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7523 | c.222C>A | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8111 | c.810G>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8121 | c.820T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8129 | c.828T>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8135 | c.834C>G | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8156 | c.855T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8177 | c.876A>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8186 | c.885G>A | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8189 | c.888G>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8219 | c.918T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8225 | c.924T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8234 | c.933T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8247 | p.Ile316Val | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8264 | c.963T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8267 | c.966G>C | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8270 | c.969G>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8276 | c.975G>A | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8283 | p.Ile328Leu | missense_variant | 0.24 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8288 | c.987T>C | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8294 | c.993T>C | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8330 | c.1029C>G | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8339 | c.1038A>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8340 | p.Ala347Ser | missense_variant | 0.18 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8372 | c.1071G>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8375 | c.1074G>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 8382 | p.Leu361Met | missense_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8387 | c.1086C>T | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8391 | p.Tyr364His | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8405 | c.1104C>T | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8420 | c.1119T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8672 | c.1371A>G | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8678 | c.1377G>A | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8693 | c.1392T>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8696 | c.1395G>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8699 | c.1398A>G | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8711 | c.1410A>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8714 | c.1413A>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8729 | c.1428T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8730 | p.Gly477Arg | missense_variant | 0.16 | levofloxacin | Uncertain significance |
moxifloxacin | ||||||
gyrA | 9204 | p.Ser635Thr | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9252 | p.Val651Ile | missense_variant | 0.22 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 490803 | c.21T>A | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490812 | c.30A>G | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490815 | c.33G>C | synonymous_variant | 0.28 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490827 | c.45C>T | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490848 | c.66A>G | synonymous_variant | 0.27 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fgd1 | 490851 | c.69A>T | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490868 | p.Ala29Gly | missense_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491172 | c.390C>A | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491181 | c.399T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491191 | p.Gly137Arg | missense_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491194 | c.412_414delCTAinsTTG | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491202 | c.420G>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491203 | p.Gln141Glu | missense_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491212 | p.Ser144Arg | missense_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491217 | c.435T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491591 | p.Lys270Met | missense_variant | 0.79 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Not assoc w R | |||||
mshA | 575821 | c.474G>C | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
mshA | 575824 | c.477T>G | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
mshA | 575830 | c.483C>G | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
mshA | 575833 | c.486C>G | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575845 | c.498C>T | synonymous_variant | 0.16 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
mshA | 575864 | c.517T>C | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575893 | c.546C>G | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575896 | c.549G>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
mshA | 575908 | c.561A>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
mshA | 575917 | p.Asp190Glu | missense_variant | 0.2 | isoniazid | |
ethionamide | ||||||
mshA | 575920 | c.573C>G | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
mshA | 575924 | p.Gly193Ser | missense_variant | 0.21 | isoniazid | |
ethionamide | ||||||
mshA | 575944 | c.597T>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
mshA | 575965 | c.618C>G | synonymous_variant | 0.17 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
ccsA | 620412 | c.522T>C | synonymous_variant | 0.2 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620415 | c.525T>C | synonymous_variant | 0.19 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
ccsA | 620424 | c.534G>C | synonymous_variant | 0.19 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620433 | c.543C>G | synonymous_variant | 0.19 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
ccsA | 620436 | c.546T>A | synonymous_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620439 | c.549T>C | synonymous_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620442 | c.552G>C | synonymous_variant | 0.16 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620445 | c.555A>G | synonymous_variant | 0.17 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620460 | c.570T>G | synonymous_variant | 0.17 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620461 | p.Val191Ile | missense_variant | 0.17 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620481 | c.591T>G | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620682 | c.792G>A | synonymous_variant | 0.17 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620688 | c.798G>C | synonymous_variant | 0.22 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
Rv0565c | 656088 | c.1383A>G | synonymous_variant | 0.15 | ethionamide | |
Rv0565c | 656091 | c.1380T>C | synonymous_variant | 0.16 | ethionamide | |
Rv0565c | 656219 | p.His418Tyr | missense_variant | 0.14 | ethionamide | |
Rv0565c | 656265 | c.1206G>C | synonymous_variant | 0.17 | ethionamide | |
Rv0565c | 656268 | p.Met401Ile | missense_variant | 0.16 | ethionamide | |
Rv0565c | 656277 | c.1194C>G | synonymous_variant | 0.17 | ethionamide | |
Rv0565c | 656418 | c.1053A>G | synonymous_variant | 0.17 | ethionamide | |
Rv0565c | 656423 | c.1048T>C | synonymous_variant | 0.19 | ethionamide | |
Rv0565c | 656448 | p.Ile341Val | missense_variant | 0.23 | ethionamide | |
Rv0565c | 656454 | c.1017G>C | synonymous_variant | 0.26 | ethionamide | |
Rv0565c | 656457 | c.1014T>C | synonymous_variant | 0.25 | ethionamide | |
Rv0565c | 656469 | c.1002T>C | synonymous_variant | 0.25 | ethionamide | |
Rv0565c | 656475 | c.996A>G | synonymous_variant | 0.24 | ethionamide | |
Rv0565c | 657259 | p.Tyr71Phe | missense_variant | 0.15 | ethionamide | |
Rv0565c | 657264 | c.207T>C | synonymous_variant | 0.16 | ethionamide | |
Rv0565c | 657269 | p.Ser68Pro | missense_variant | 0.79 | ethionamide | Uncertain significance |
Rv0565c | 657300 | c.171C>G | synonymous_variant | 0.26 | ethionamide | |
Rv0565c | 657318 | c.153T>C | synonymous_variant | 0.21 | ethionamide | |
Rv0565c | 657324 | c.147C>G | synonymous_variant | 0.2 | ethionamide | |
Rv0565c | 657327 | c.144C>G | synonymous_variant | 0.19 | ethionamide | |
Rv0565c | 657337 | p.Arg45Gln | missense_variant | 0.18 | ethionamide | Uncertain significance |
Rv0565c | 657342 | c.129T>C | synonymous_variant | 0.17 | ethionamide | |
Rv0565c | 657347 | c.124A>C | synonymous_variant | 0.15 | ethionamide | |
Rv0565c | 657356 | p.Ile39Val | missense_variant | 0.16 | ethionamide | |
Rv0565c | 657632 | c.-162G>A | upstream_gene_variant | 0.15 | ethionamide | |
Rv0565c | 657649 | c.-179G>A | upstream_gene_variant | 0.17 | ethionamide | |
hadA | 731774 | c.-156T>C | upstream_gene_variant | 0.15 | isoniazid | |
hadA | 731792 | c.-138G>A | upstream_gene_variant | 0.15 | isoniazid | |
hadA | 731801 | c.-129C>G | upstream_gene_variant | 0.16 | isoniazid | |
hadA | 731816 | c.-114G>A | upstream_gene_variant | 0.14 | isoniazid | |
hadA | 732321 | p.Glu131Ala | missense_variant | 0.17 | isoniazid | |
hadA | 732329 | p.Leu134Val | missense_variant | 0.19 | isoniazid | Uncertain significance |
hadA | 732337 | c.408G>A | synonymous_variant | 0.22 | isoniazid | |
hadA | 732378 | c.450_452dupAGA | disruptive_inframe_insertion | 0.36 | isoniazid | |
hadA | 732396 | p.Gly156Ala | missense_variant | 0.39 | isoniazid | |
hadA | 732398 | p.Ala157Thr | missense_variant | 0.38 | isoniazid | |
nusG | 734424 | c.171G>A | synonymous_variant | 0.18 | rifampicin | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.19 | rifampicin | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.21 | rifampicin | |
nusG | 734499 | c.246G>C | synonymous_variant | 0.16 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760091 | c.285G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760101 | c.295T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760112 | c.306T>C | synonymous_variant | 0.24 | rifampicin | |
rpoB | 760115 | c.309C>T | synonymous_variant | 0.76 | rifampicin | Not assoc w R |
rpoB | 760118 | c.312T>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760121 | c.315T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.24 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760331 | c.525G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760370 | c.564C>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoB | 760381 | p.Thr192Met | missense_variant | 0.16 | rifampicin | |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760412 | c.606C>G | synonymous_variant | 0.24 | rifampicin | |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.18 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760533 | p.Val243Thr | missense_variant | 0.15 | rifampicin | |
rpoB | 760541 | c.735G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760547 | c.741G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760563 | p.Arg253Met | missense_variant | 0.19 | rifampicin | Uncertain significance |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.22 | rifampicin | |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760646 | c.840C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760655 | c.849A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760661 | c.855A>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760670 | c.864G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760859 | c.1053T>C | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760862 | c.1056G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760869 | p.Val355Ile | missense_variant | 0.25 | rifampicin | Uncertain significance |
rpoB | 760886 | c.1080A>G | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760934 | c.1128C>T | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760982 | c.1176G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 761006 | c.1200C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761021 | c.1215G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.28 | rifampicin | |
rpoB | 761129 | c.1323G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 761132 | c.1326G>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761153 | c.1347G>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.33 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.32 | rifampicin | |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761570 | c.1764T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761588 | c.1782C>T | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761612 | c.1806G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761615 | c.1809A>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761648 | c.1842T>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761657 | c.1851C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761873 | c.2067A>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761885 | c.2079T>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762008 | c.2202C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.15 | rifampicin | |
rpoB | 762167 | c.2361T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 762206 | c.2400C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762246 | c.2440C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.18 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 762398 | c.-972T>C | upstream_gene_variant | 0.18 | rifampicin | |
rpoC | 762401 | c.-969G>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoB | 762404 | c.2598T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoB | 762416 | c.2610A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 762419 | c.-951C>G | upstream_gene_variant | 0.23 | rifampicin | |
rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoB | 762449 | c.2643C>A | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 762467 | c.-903C>T | upstream_gene_variant | 0.22 | rifampicin | |
rpoB | 762488 | c.2682G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 762489 | p.Val895Gln | missense_variant | 0.21 | rifampicin | |
rpoC | 762509 | c.-861T>G | upstream_gene_variant | 0.19 | rifampicin | |
rpoB | 762510 | p.Ala902Pro | missense_variant | 0.19 | rifampicin | Uncertain significance |
rpoC | 762521 | c.-849C>T | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 762947 | c.-423C>A | upstream_gene_variant | 0.27 | rifampicin | |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.17 | rifampicin | |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.25 | rifampicin | |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.26 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763190 | c.-180C>T | upstream_gene_variant | 0.2 | rifampicin | |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763603 | c.234C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763675 | c.306C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763696 | c.327T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763702 | c.333C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763717 | c.348T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763741 | c.372C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763765 | c.396T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763774 | c.405G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763807 | c.438T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763816 | c.447C>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 763835 | p.Ala156Met | missense_variant | 0.24 | rifampicin | |
rpoC | 763853 | p.Val162Ile | missense_variant | 0.24 | rifampicin | |
rpoC | 763858 | c.489A>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 763872 | p.Gly168Ala | missense_variant | 0.23 | rifampicin | |
rpoC | 763876 | p.Glu169Asp | missense_variant | 0.23 | rifampicin | |
rpoC | 763879 | c.510A>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 763888 | c.519G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763891 | c.522G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763900 | c.531G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763945 | c.576T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763951 | c.582G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764102 | p.Val245Ile | missense_variant | 0.26 | rifampicin | |
rpoC | 764112 | p.Tyr248Phe | missense_variant | 0.24 | rifampicin | |
rpoC | 764116 | c.747C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764131 | c.762T>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 764215 | c.846A>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764236 | c.867G>A | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764248 | c.879C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764353 | c.984G>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764381 | c.1012_1013delTCinsAG | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764387 | c.1018_1020delTTGinsCTC | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764405 | c.1036A>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764419 | c.1050C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764428 | c.1059G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764489 | c.1120C>T | synonymous_variant | 0.27 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764510 | c.1141C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764554 | c.1185C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764593 | c.1224C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764872 | c.1503A>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764893 | c.1524T>A | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765019 | c.1650A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765150 | p.Gly594Glu | missense_variant | 0.96 | rifampicin | Not assoc w R |
rpoC | 765292 | c.1923G>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765298 | c.1929G>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765300 | p.Val644Ala | missense_variant | 0.26 | rifampicin | Uncertain significance |
rpoC | 765319 | c.1950A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 765326 | p.His653Ala | missense_variant | 0.26 | rifampicin | Uncertain significance |
rpoC | 765330 | p.Ser654Asn | missense_variant | 0.29 | rifampicin | Uncertain significance |
rpoC | 765346 | c.1977C>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765349 | c.1980T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 765352 | c.1983G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765361 | c.1992C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoC | 765404 | p.Leu679Val | missense_variant | 0.19 | rifampicin | |
rpoC | 765409 | c.2040T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 765559 | c.2190G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 765580 | c.2211G>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765613 | p.His748Gln | missense_variant | 0.32 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.31 | rifampicin | |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 765751 | c.2382C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765787 | c.2418C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765850 | c.2481G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765937 | c.2568T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 766010 | c.2641_2642delTCinsAG | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766021 | c.2652G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766027 | c.2658G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766043 | p.Gln892Glu | missense_variant | 0.21 | rifampicin | |
rpoC | 766054 | c.2685C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766082 | p.Ala905Gln | missense_variant | 0.18 | rifampicin | |
rpoC | 766096 | c.2727G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766129 | c.2760C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766462 | c.3093G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766483 | c.3114G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766484 | p.Val1039Ile | missense_variant | 0.19 | rifampicin | Uncertain significance |
rpoC | 766492 | c.3123T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766528 | c.3159T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766531 | c.3162G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766540 | p.Asp1057Glu | missense_variant | 0.18 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.17 | rifampicin | |
rpoC | 766657 | c.3288A>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766673 | p.Gly1102Asn | missense_variant | 0.17 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766738 | c.3369G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 767009 | c.3640_3642delTCGinsAGC | synonymous_variant | 0.2 | rifampicin | |
rpoC | 767033 | c.3664_3666delTCGinsAGC | synonymous_variant | 0.26 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.29 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 767230 | c.3861G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 767263 | c.3894T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767264 | p.Ala1299Gln | missense_variant | 0.16 | rifampicin | |
rpoC | 767284 | c.3915C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 767288 | c.3919C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 777101 | c.1380C>G | synonymous_variant | 0.16 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777116 | c.1365C>T | synonymous_variant | 0.14 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777133 | p.Val450Ile | missense_variant | 0.18 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777158 | c.1323C>G | synonymous_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777164 | c.1317C>G | synonymous_variant | 0.22 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777170 | c.1311T>C | synonymous_variant | 0.23 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777173 | c.1308C>G | synonymous_variant | 0.23 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777176 | p.Glu435Asp | missense_variant | 0.23 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777191 | c.1290C>G | synonymous_variant | 0.23 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777194 | c.1287A>G | synonymous_variant | 0.22 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777206 | c.1275A>G | synonymous_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777212 | p.Ala423Thr | missense_variant | 0.18 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777215 | c.1266C>G | synonymous_variant | 0.18 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777218 | c.1263G>A | synonymous_variant | 0.18 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781571 | c.12C>T | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781595 | c.36T>C | synonymous_variant | 0.25 | streptomycin | |
rpsL | 781605 | p.Ile16Val | missense_variant | 0.21 | streptomycin | Uncertain significance |
rpsL | 781608 | p.Ser17Ala | missense_variant | 0.21 | streptomycin | |
rpsL | 781628 | c.69T>C | synonymous_variant | 0.29 | streptomycin | Not assoc w R - Interim |
rpsL | 781631 | c.72G>C | synonymous_variant | 0.27 | streptomycin | |
rpsL | 781649 | c.90T>C | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781655 | c.96T>C | synonymous_variant | 0.32 | streptomycin | |
rpsL | 781700 | c.141G>C | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781703 | c.144G>T | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781742 | c.183C>T | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781748 | c.189C>G | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781772 | c.213C>A | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781838 | c.279G>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781841 | c.282C>G | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781877 | c.318T>C | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.22 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.21 | streptomycin | Uncertain significance |
rplC | 800200 | c.-609C>G | upstream_gene_variant | 0.98 | linezolid | |
rplC | 800537 | c.-272C>T | upstream_gene_variant | 0.14 | linezolid | |
rplC | 800546 | c.-263T>G | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800627 | c.-182C>T | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800747 | c.-62C>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800771 | c.-38C>T | upstream_gene_variant | 0.25 | linezolid | |
rplC | 800794 | c.-15A>G | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800796 | c.-13A>G | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800798 | c.-10_-9delGG | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800814 | c.6A>G | synonymous_variant | 0.24 | linezolid | |
rplC | 800817 | c.9A>T | synonymous_variant | 0.2 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.16 | linezolid | |
rplC | 800889 | c.81C>A | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
rplC | 801207 | c.399C>T | synonymous_variant | 0.18 | linezolid | |
rplC | 801246 | c.438C>T | synonymous_variant | 0.19 | linezolid | |
rplC | 801249 | c.441T>C | synonymous_variant | 0.2 | linezolid | |
rplC | 801255 | c.447C>T | synonymous_variant | 0.2 | linezolid | |
rplC | 801264 | c.456C>T | synonymous_variant | 0.16 | linezolid | |
rplC | 801267 | c.459A>T | synonymous_variant | 0.17 | linezolid | |
rplC | 801270 | c.462T>C | synonymous_variant | 0.16 | linezolid | |
rplC | 801276 | c.468G>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801279 | c.471G>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801282 | c.474G>C | synonymous_variant | 0.17 | linezolid | |
rplC | 801285 | c.477G>C | synonymous_variant | 0.19 | linezolid | |
rplC | 801309 | c.501C>G | synonymous_variant | 0.15 | linezolid | |
rplC | 801312 | c.504G>C | synonymous_variant | 0.16 | linezolid | |
rplC | 801321 | c.513C>T | synonymous_variant | 0.14 | linezolid | Not assoc w R - Interim |
rplC | 801324 | c.516T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 801367 | p.Ala187Thr | missense_variant | 0.15 | linezolid | |
fbiC | 1303797 | c.867A>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303818 | c.888C>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303836 | c.906G>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303846 | p.Phe306Val | missense_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303854 | c.924T>C | synonymous_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303860 | c.930A>C | synonymous_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304127 | c.1197A>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304132 | p.Ala401Gly | missense_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304142 | c.1212G>C | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304161 | p.Arg411Ser | missense_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304169 | c.1239T>C | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304174 | p.Val415Ala | missense_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304184 | c.1254G>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304187 | c.1257T>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304208 | c.1278C>T | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304526 | c.1596T>G | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304535 | c.1605G>A | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304544 | c.1614T>C | synonymous_variant | 0.28 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304545 | p.Val539Thr | missense_variant | 0.28 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304553 | c.1623C>T | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304559 | p.Glu543Asp | missense_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304565 | c.1635C>G | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304568 | c.1638T>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304703 | c.1773C>G | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304711 | p.Ala594Glu | missense_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304715 | c.1785G>C | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304724 | c.1794A>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304727 | c.1797A>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304742 | c.1812T>C | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304787 | c.1857T>G | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304829 | c.1899T>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304832 | c.1902C>T | synonymous_variant | 0.37 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304853 | c.1923C>T | synonymous_variant | 0.65 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304856 | c.1926C>G | synonymous_variant | 0.71 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304869 | c.1939C>T | synonymous_variant | 0.5 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304875 | p.Ile649Val | missense_variant | 0.47 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304883 | p.Glu651Asp | missense_variant | 0.42 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304891 | p.Ile654Thr | missense_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304893 | p.Gly655Ser | missense_variant | 0.37 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304907 | c.1977C>G | synonymous_variant | 0.43 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304910 | c.1980G>C | synonymous_variant | 0.42 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304916 | c.1986T>C | synonymous_variant | 0.44 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304928 | c.1998T>C | synonymous_variant | 0.45 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304937 | c.2007G>C | synonymous_variant | 0.49 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.47 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304983 | c.2053C>T | synonymous_variant | 0.43 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304994 | c.2064A>G | synonymous_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304995 | p.Leu689Met | missense_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305006 | c.2076A>G | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305012 | c.2082G>C | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305015 | c.2085G>C | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
atpE | 1460840 | c.-205A>G | upstream_gene_variant | 0.18 | bedaquiline | |
atpE | 1460852 | c.-193C>G | upstream_gene_variant | 0.15 | bedaquiline | |
atpE | 1460855 | c.-190T>C | upstream_gene_variant | 0.15 | bedaquiline | |
atpE | 1461159 | p.Val39Ile | missense_variant | 0.16 | bedaquiline | Uncertain significance |
atpE | 1461170 | c.126A>G | synonymous_variant | 0.2 | bedaquiline | |
atpE | 1461197 | c.153A>G | synonymous_variant | 0.17 | bedaquiline | |
atpE | 1461219 | c.175T>C | synonymous_variant | 0.19 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
inhA | 1673685 | c.-517C>T | upstream_gene_variant | 0.15 | isoniazid | |
ethionamide | ||||||
inhA | 1673710 | c.-492C>A | upstream_gene_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1673716 | c.-486_-485delGCinsAA | upstream_gene_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1673733 | c.-469G>C | upstream_gene_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1673742 | c.-460C>T | upstream_gene_variant | 0.17 | isoniazid | Uncertain significance |
ethionamide | ||||||
inhA | 1673922 | c.-280T>C | upstream_gene_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1673941 | c.-261G>T | upstream_gene_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1673955 | c.-247G>C | upstream_gene_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674114 | c.-88T>A | upstream_gene_variant | 0.17 | isoniazid | Uncertain significance |
ethionamide | Uncertain significance | |||||
inhA | 1674123 | c.-79T>C | upstream_gene_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674126 | c.-76G>C | upstream_gene_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674132 | c.-70T>C | upstream_gene_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674136 | c.-66T>G | upstream_gene_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674141 | c.-61T>C | upstream_gene_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674537 | c.336C>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674542 | p.Ala114Glu | missense_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674546 | c.345T>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674549 | c.348G>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674555 | c.354G>A | synonymous_variant | 0.23 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
inhA | 1674561 | c.360C>T | synonymous_variant | 0.23 | isoniazid | |
ethionamide | ||||||
inhA | 1674582 | c.381T>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1674585 | c.384T>C | synonymous_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674589 | p.Met130Leu | missense_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674601 | p.Leu134Thr | missense_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674604 | c.403C>T | synonymous_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674624 | c.423A>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674630 | c.429C>G | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1674660 | c.459G>C | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
inhA | 1674672 | c.471C>G | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674703 | c.502T>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674708 | c.507G>A | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674741 | c.540C>T | synonymous_variant | 0.15 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
rpsA | 1833554 | p.Thr5Ala | missense_variant | 0.21 | pyrazinamide | Uncertain significance |
rpsA | 1833568 | c.27G>C | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833589 | c.48A>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833595 | c.54T>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833667 | c.126C>G | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833721 | c.180A>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833748 | c.207C>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833971 | c.430C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834169 | p.Thr210Ala | missense_variant | 0.16 | pyrazinamide | Uncertain significance |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834195 | c.654G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834204 | c.663C>T | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1834210 | c.669C>T | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834222 | c.681T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834303 | c.762T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834378 | c.837T>C | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834423 | c.882G>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834435 | c.894G>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834465 | c.924T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834510 | c.969C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834513 | c.972C>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834540 | c.999G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834606 | c.1065C>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834619 | c.1078T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834654 | p.Glu371Asp | missense_variant | 0.25 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834733 | p.Ala398Ser | missense_variant | 0.35 | pyrazinamide | |
rpsA | 1834753 | c.1212T>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.35 | pyrazinamide | |
rpsA | 1834775 | p.Ala412Thr | missense_variant | 0.39 | pyrazinamide | |
rpsA | 1834780 | c.1239A>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834786 | c.1245A>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834789 | c.1248T>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834792 | c.1251G>C | synonymous_variant | 0.34 | pyrazinamide | |
tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2064942 | c.-214G>A | upstream_gene_variant | 0.21 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064948 | c.-220G>C | upstream_gene_variant | 0.21 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064972 | c.-244T>C | upstream_gene_variant | 0.24 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064978 | c.-250G>C | upstream_gene_variant | 0.2 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064979 | c.-251C>T | upstream_gene_variant | 0.2 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064984 | c.-256A>G | upstream_gene_variant | 0.21 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064993 | c.-265T>C | upstream_gene_variant | 0.23 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
katG | 2155641 | p.Lys157Asn | missense_variant | 0.18 | isoniazid | Uncertain significance |
katG | 2155661 | p.Val151Ile | missense_variant | 0.18 | isoniazid | |
katG | 2155677 | c.435C>G | synonymous_variant | 0.22 | isoniazid | |
katG | 2155680 | c.432G>C | synonymous_variant | 0.24 | isoniazid | |
katG | 2155691 | c.421T>C | synonymous_variant | 0.3 | isoniazid | |
katG | 2155695 | c.417C>G | synonymous_variant | 0.34 | isoniazid | |
katG | 2155704 | c.408C>G | synonymous_variant | 0.36 | isoniazid | |
katG | 2155716 | c.396T>G | synonymous_variant | 0.29 | isoniazid | |
katG | 2155722 | c.390G>C | synonymous_variant | 0.29 | isoniazid | |
katG | 2155728 | c.384G>C | synonymous_variant | 0.25 | isoniazid | |
katG | 2155740 | p.Gly124Gln | missense_variant | 0.19 | isoniazid | |
katG | 2155743 | c.369G>C | synonymous_variant | 0.2 | isoniazid | |
PPE35 | 2168303 | c.2310G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
pncA | 2289987 | c.-746C>T | upstream_gene_variant | 0.21 | pyrazinamide | |
pncA | 2289991 | c.-750G>C | upstream_gene_variant | 0.21 | pyrazinamide | |
pncA | 2289994 | c.-753A>G | upstream_gene_variant | 0.21 | pyrazinamide | |
pncA | 2289997 | c.-756G>C | upstream_gene_variant | 0.22 | pyrazinamide | |
kasA | 2517950 | c.-165C>G | upstream_gene_variant | 0.21 | isoniazid | |
kasA | 2518076 | c.-39C>T | upstream_gene_variant | 1.0 | isoniazid | |
kasA | 2518138 | c.24T>C | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518146 | p.Phe11Tyr | missense_variant | 0.19 | isoniazid | |
kasA | 2518162 | c.48G>A | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518174 | c.60A>G | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518190 | p.Ser26Ala | missense_variant | 0.24 | isoniazid | |
kasA | 2518199 | p.Ile29Val | missense_variant | 0.23 | isoniazid | |
kasA | 2518220 | c.106C>T | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518474 | c.360G>A | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518480 | c.366T>C | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518483 | c.369C>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518504 | c.390T>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518506 | p.Ala131Glu | missense_variant | 0.19 | isoniazid | |
kasA | 2518519 | c.405G>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518528 | c.414C>G | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518540 | c.426T>C | synonymous_variant | 0.22 | isoniazid | |
kasA | 2518561 | c.447T>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518567 | c.453G>C | synonymous_variant | 0.2 | isoniazid | |
ahpC | 2726638 | p.Ala149Val | missense_variant | 0.18 | isoniazid | |
ahpC | 2726645 | c.453C>G | synonymous_variant | 0.2 | isoniazid | |
ahpC | 2726657 | c.465A>C | synonymous_variant | 0.2 | isoniazid | Not assoc w R - Interim |
ahpC | 2726672 | c.480G>A | synonymous_variant | 0.16 | isoniazid | Not assoc w R - Interim |
ahpC | 2726687 | c.495C>G | synonymous_variant | 0.16 | isoniazid | |
Rv2477c | 2782912 | p.Ser377Thr | missense_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782927 | p.Thr372Glu | missense_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782936 | c.1107G>T | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782957 | c.1086A>G | synonymous_variant | 0.17 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2782966 | c.1077C>A | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 0.16 | kanamycin | Uncertain significance |
levofloxacin | Uncertain significance | |||||
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
ethambutol | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2783044 | c.999G>A | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783048 | p.Asp332Gly | missense_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783059 | c.984T>C | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783068 | p.Asp325Glu | missense_variant | 0.23 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783077 | c.966T>C | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783140 | c.903C>G | synonymous_variant | 0.22 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783149 | c.894G>C | synonymous_variant | 0.2 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | ||||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783158 | c.885A>C | synonymous_variant | 0.23 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783182 | c.861C>G | synonymous_variant | 0.23 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783185 | c.858G>A | synonymous_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783194 | c.849A>G | synonymous_variant | 0.27 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783221 | c.822G>C | synonymous_variant | 0.24 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783224 | c.819C>G | synonymous_variant | 0.23 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783230 | c.813T>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783235 | c.808T>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783338 | c.705C>T | synonymous_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783350 | c.693T>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783353 | c.690T>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783359 | c.684G>A | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783362 | c.681G>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783628 | p.Ala139Ser | missense_variant | 0.2 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783656 | c.387G>C | synonymous_variant | 0.22 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783659 | c.384A>G | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783665 | c.378A>G | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783674 | c.369T>C | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783683 | c.360A>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783718 | c.325T>C | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783719 | c.324A>G | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783751 | p.Ile98Val | missense_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783758 | p.Asp95Glu | missense_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783761 | c.282G>C | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>C | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783929 | c.114C>G | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783932 | c.111C>T | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783938 | c.105T>C | synonymous_variant | 0.22 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783953 | c.90G>A | synonymous_variant | 0.25 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783962 | c.81T>C | synonymous_variant | 0.23 | kanamycin | Not assoc w R - Interim |
levofloxacin | ||||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783971 | c.72G>C | synonymous_variant | 0.23 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783980 | c.63C>G | synonymous_variant | 0.2 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783992 | c.51T>C | synonymous_variant | 0.16 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2680 | 2996085 | c.-20G>A | upstream_gene_variant | 0.46 | capreomycin | Uncertain significance |
Rv2680 | 2996136 | p.Ser11Asn | missense_variant | 0.21 | capreomycin | |
Rv2752c | 3064914 | c.1278T>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066501 | c.-310G>C | upstream_gene_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066522 | c.-331C>G | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066531 | c.-340C>G | upstream_gene_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066549 | c.-358T>C | upstream_gene_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066561 | c.-370A>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066567 | c.-376C>G | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066573 | c.-382G>C | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066579 | c.-388A>G | upstream_gene_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066583 | c.-392C>G | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyX | 3067373 | c.573C>G | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067391 | c.555G>C | synonymous_variant | 0.25 | para-aminosalicylic_acid | |
thyX | 3067394 | c.552G>C | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067439 | c.507A>G | synonymous_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067445 | c.501C>G | synonymous_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067465 | p.Ile161Val | missense_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067475 | c.471A>G | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067490 | c.456C>G | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067493 | c.453A>G | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067515 | p.Ser144Thr | missense_variant | 0.28 | para-aminosalicylic_acid | |
thyX | 3067530 | p.Ala139Ser | missense_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067545 | p.Glu134Ala | missense_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067549 | p.Thr133Ala | missense_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067556 | p.His130Gln | missense_variant | 0.23 | para-aminosalicylic_acid | |
thyX | 3067559 | c.387C>G | synonymous_variant | 0.23 | para-aminosalicylic_acid | |
thyX | 3067565 | p.Asp127Glu | missense_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067570 | p.Ala126Pro | missense_variant | 0.23 | para-aminosalicylic_acid | |
thyX | 3067577 | c.369G>A | synonymous_variant | 0.22 | para-aminosalicylic_acid | |
thyX | 3067601 | p.Arg115His | missense_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067611 | p.Lys112Thr | missense_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067619 | c.327A>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067661 | c.285C>G | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067685 | c.261A>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067718 | c.228C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067721 | c.225T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067727 | c.219A>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067730 | c.216G>A | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067736 | p.Phe70Leu | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067739 | c.207T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067762 | c.184C>A | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
thyX | 3067765 | p.Leu61Ile | missense_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067781 | c.165C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067793 | c.153T>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067799 | c.147G>A | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067814 | c.132T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067850 | c.96A>C | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073812 | c.660C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3073815 | c.657G>A | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073824 | c.648A>G | synonymous_variant | 0.23 | para-aminosalicylic_acid | |
thyA | 3073827 | c.645A>G | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyA | 3073839 | c.633T>C | synonymous_variant | 0.22 | para-aminosalicylic_acid | |
thyA | 3073860 | c.612C>G | synonymous_variant | 0.26 | para-aminosalicylic_acid | |
thyA | 3073863 | c.609T>C | synonymous_variant | 0.26 | para-aminosalicylic_acid | |
thyA | 3073866 | c.606C>G | synonymous_variant | 0.27 | para-aminosalicylic_acid | |
thyA | 3073872 | p.Ile200Val | missense_variant | 0.26 | para-aminosalicylic_acid | |
thyA | 3073892 | c.580T>C | synonymous_variant | 0.28 | para-aminosalicylic_acid | |
thyA | 3073898 | p.Ala192Ser | missense_variant | 0.25 | para-aminosalicylic_acid | |
thyA | 3073959 | c.513T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3073977 | c.495A>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3087635 | c.816C>T | synonymous_variant | 0.15 | cycloserine | |
ald | 3087649 | p.Gly277Asp | missense_variant | 0.15 | cycloserine | |
lpqB | 3624047 | c.864G>C | synonymous_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624050 | c.861C>G | synonymous_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624077 | c.834G>A | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3624082 | c.829A>C | synonymous_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624092 | c.817_819delAGGinsCGC | synonymous_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624100 | c.811T>C | synonymous_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624101 | c.810C>G | synonymous_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624107 | c.804C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3624116 | c.795A>G | synonymous_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624119 | c.792C>G | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624124 | p.Leu263Val | missense_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624125 | c.786A>G | synonymous_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624143 | c.768T>C | synonymous_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624686 | p.Glu75Gln | missense_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624704 | c.207G>C | synonymous_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624707 | c.204G>C | synonymous_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624722 | c.189C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3624728 | c.183C>T | synonymous_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624749 | c.162G>A | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
lpqB | 3625240 | c.-330T>C | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625243 | c.-333T>G | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625255 | c.-345T>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625267 | c.1347T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625270 | c.-360G>C | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625572 | p.Thr348Ser | missense_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625579 | c.-669A>G | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625594 | c.-684T>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625602 | c.-692T>C | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625616 | p.Arg333Ala | missense_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625624 | c.-714C>G | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625636 | c.978C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625656 | c.958T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625669 | c.-759G>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625687 | c.-777G>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625696 | c.-786A>G | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625705 | c.909C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625711 | c.903C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625714 | c.-804C>T | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625735 | c.-825C>T | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625797 | p.Val273Met | missense_variant | 0.15 | rifampicin | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625807 | c.807C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625837 | c.777C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625843 | c.-933C>G | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625849 | c.-939T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625864 | c.-954T>G | upstream_gene_variant | 0.21 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625876 | c.738G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3626759 | c.591T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3626804 | c.546A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626840 | c.-227C>G | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626846 | c.504G>A | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626861 | c.-248C>G | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626869 | c.481C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626885 | c.-272A>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627167 | c.-554T>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627181 | c.-568T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627182 | c.-569T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627188 | c.162A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627209 | c.-596G>A | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627221 | c.129C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627227 | c.123T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627233 | c.-620T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627236 | c.-623T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627242 | c.108C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627254 | c.-641C>T | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627263 | c.-650C>T | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
fbiA | 3640850 | p.Glu103Gly | missense_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3640857 | c.-678G>C | upstream_gene_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3640866 | c.-669T>C | upstream_gene_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiA | 3640871 | p.Ala110Gly | missense_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3640878 | c.-657T>C | upstream_gene_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3640899 | c.-636G>C | upstream_gene_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiA | 3640900 | p.Gln120Asn | missense_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
alr | 3840263 | c.1158C>T | synonymous_variant | 0.98 | cycloserine | |
rpoA | 3877553 | p.Glu319Gln | missense_variant | 0.15 | rifampicin | |
rpoA | 3877571 | p.Pro313Ala | missense_variant | 0.15 | rifampicin | |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877679 | p.Ala277Ser | missense_variant | 0.17 | rifampicin | |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3877743 | c.765T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877785 | c.723C>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877791 | c.717C>G | synonymous_variant | 0.39 | rifampicin | |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877839 | c.669G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877878 | c.630G>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877890 | c.618C>T | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3877896 | c.612G>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3877900 | p.Ser203Asn | missense_variant | 0.22 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3877909 | p.Asn200Ser | missense_variant | 0.21 | rifampicin | |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3877923 | c.585C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877926 | c.582G>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877986 | c.522G>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3878022 | c.486T>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878040 | c.468T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3878143 | p.Gly122Asp | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoA | 3878157 | c.351C>G | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878163 | c.345C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878172 | c.336G>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878187 | c.321C>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3878199 | c.309T>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3878232 | c.276G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.19 | rifampicin | |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878388 | c.120C>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878761 | c.-254G>C | upstream_gene_variant | 0.29 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3878785 | c.-278T>G | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.23 | rifampicin | Uncertain significance |
rpoA | 3878797 | c.-290G>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878824 | c.-317G>C | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878836 | c.-331_-329delAAGinsTCC | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.24 | rifampicin | Uncertain significance |
rpoA | 3878909 | c.-402A>G | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.22 | rifampicin | Uncertain significance |
rpoA | 3878917 | c.-410G>A | upstream_gene_variant | 0.15 | rifampicin | Uncertain significance |
rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878976 | c.-469A>G | upstream_gene_variant | 0.21 | rifampicin | Uncertain significance |
rpoA | 3878986 | c.-479G>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 0.24 | rifampicin | Uncertain significance |
rpoA | 3879005 | c.-499_-498delAAinsCG | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3879013 | c.-506A>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.29 | rifampicin | |
rpoA | 3879121 | c.-614T>G | upstream_gene_variant | 0.28 | rifampicin | |
rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 0.28 | rifampicin | |
rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3879178 | c.-671T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3879190 | c.-683C>G | upstream_gene_variant | 0.19 | rifampicin | |
ddn | 3986636 | c.-208C>G | upstream_gene_variant | 0.25 | pretomanid | |
delamanid | ||||||
ddn | 3986645 | c.-199G>A | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
ddn | 3986646 | c.-198_-196delCTCinsTTG | upstream_gene_variant | 0.16 | pretomanid | |
delamanid | ||||||
clpC1 | 4038293 | c.2412G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038302 | c.2403C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038308 | c.2397G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038314 | c.2391T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038317 | c.2388G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038320 | c.2385G>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038456 | p.Val750Glu | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038460 | p.Leu749Met | missense_variant | 0.19 | pyrazinamide | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4038683 | c.2022T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038701 | c.2004G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038749 | c.1956C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038845 | c.1860G>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4038923 | c.1780_1782delCTAinsTTG | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.36 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.36 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.37 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.32 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039004 | c.1701C>G | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039186 | c.1519C>T | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039217 | c.1488G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039241 | c.1464G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039286 | c.1419T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039295 | c.1410A>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039319 | c.1386T>C | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039322 | c.1383T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039328 | c.1377A>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039331 | c.1374C>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039337 | p.Thr456Gln | missense_variant | 0.17 | pyrazinamide | |
clpC1 | 4039349 | c.1356C>T | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039352 | c.1353C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039364 | c.1341C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039391 | c.1314T>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039409 | c.1296T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039412 | c.1293T>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039415 | p.Glu430Asp | missense_variant | 0.23 | pyrazinamide | Uncertain significance |
clpC1 | 4039430 | c.1275T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039442 | c.1263A>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039448 | c.1257A>G | synonymous_variant | 0.24 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039454 | c.1251A>G | synonymous_variant | 0.25 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039463 | c.1242C>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039484 | c.1221T>C | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039556 | c.1149G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039562 | c.1143C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039565 | c.1140G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039570 | p.Met379Leu | missense_variant | 0.19 | pyrazinamide | Uncertain significance |
clpC1 | 4039576 | p.Ala377Pro | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4039577 | c.1128T>C | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039589 | c.1116G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039661 | c.1044T>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039700 | c.1005C>T | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039781 | c.924G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039790 | c.915C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039817 | c.888A>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039820 | c.885T>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039826 | c.879C>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039831 | c.874T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039982 | c.723G>A | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039988 | c.717C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039991 | c.714G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039994 | c.711G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4040036 | c.669C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.15 | pyrazinamide | |
panD | 4045028 | c.-747C>G | upstream_gene_variant | 0.17 | pyrazinamide | |
panD | 4045034 | c.-753A>C | upstream_gene_variant | 0.19 | pyrazinamide | |
panD | 4045055 | c.-774T>G | upstream_gene_variant | 0.2 | pyrazinamide | |
panD | 4045067 | c.-786C>G | upstream_gene_variant | 0.18 | pyrazinamide | |
glpK | 4138565 | c.1191G>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138568 | c.1188A>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138571 | c.1185C>G | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138574 | c.1182G>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138580 | c.1176C>T | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138601 | c.1155G>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138606 | c.1150T>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138610 | c.1146C>G | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138622 | c.1134C>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138625 | c.1131G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138634 | c.1122G>A | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4138643 | c.1113A>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138646 | c.1110G>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139126 | c.630G>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139137 | p.Asp207Asn | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139143 | c.613T>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139165 | c.591A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139168 | c.588T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139177 | c.579T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139183 | c.573T>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139186 | c.570G>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139195 | c.561G>T | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139198 | c.558C>G | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139207 | c.549T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4240726 | c.864G>C | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embC | 4240780 | c.918T>C | synonymous_variant | 0.24 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.24 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.22 | ethambutol | |
embC | 4240819 | c.957A>G | synonymous_variant | 0.24 | ethambutol | |
embC | 4240831 | c.969T>G | synonymous_variant | 0.23 | ethambutol | |
embC | 4240867 | c.1005T>C | synonymous_variant | 0.21 | ethambutol | |
embC | 4240870 | c.1008T>C | synonymous_variant | 0.21 | ethambutol | |
embC | 4240873 | c.1011C>G | synonymous_variant | 0.22 | ethambutol | |
embC | 4240879 | c.1017G>C | synonymous_variant | 0.22 | ethambutol | |
embC | 4240880 | p.Ala340Thr | missense_variant | 0.22 | ethambutol | Uncertain significance |
embC | 4240885 | c.1023T>C | synonymous_variant | 0.2 | ethambutol | |
embC | 4241047 | c.1185C>G | synonymous_variant | 0.16 | ethambutol | |
embC | 4241050 | c.1188T>G | synonymous_variant | 0.18 | ethambutol | |
embC | 4241053 | c.1191G>C | synonymous_variant | 0.19 | ethambutol | |
embC | 4241089 | c.1227C>G | synonymous_variant | 0.27 | ethambutol | |
embC | 4241095 | c.1233C>T | synonymous_variant | 0.23 | ethambutol | |
embC | 4241107 | c.1245G>C | synonymous_variant | 0.24 | ethambutol | |
embC | 4241140 | c.1278A>G | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embC | 4241146 | c.1284C>G | synonymous_variant | 0.18 | ethambutol | |
embC | 4241453 | p.Ile531Val | missense_variant | 0.18 | ethambutol | |
embC | 4241587 | c.1725C>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4241591 | p.Leu577Val | missense_variant | 0.18 | ethambutol | |
embC | 4241611 | c.1749G>C | synonymous_variant | 0.18 | ethambutol | |
embC | 4241614 | c.1752A>C | synonymous_variant | 0.18 | ethambutol | |
embC | 4241626 | c.1764T>C | synonymous_variant | 0.21 | ethambutol | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4242742 | c.-491C>G | upstream_gene_variant | 0.23 | ethambutol | |
embA | 4242748 | c.-485A>G | upstream_gene_variant | 0.22 | ethambutol | |
embA | 4242754 | c.-479G>C | upstream_gene_variant | 0.22 | ethambutol | |
embC | 4242764 | p.Val968Leu | missense_variant | 0.24 | ethambutol | |
embA | 4242772 | c.-461G>C | upstream_gene_variant | 0.26 | ethambutol | |
embC | 4242803 | p.Val981Leu | missense_variant | 0.76 | ethambutol | Not assoc w R |
embA | 4242820 | c.-413G>C | upstream_gene_variant | 0.21 | ethambutol | |
embA | 4242823 | c.-410G>C | upstream_gene_variant | 0.2 | ethambutol | |
embA | 4242832 | c.-401A>C | upstream_gene_variant | 0.2 | ethambutol | |
embA | 4242838 | c.-395C>G | upstream_gene_variant | 0.2 | ethambutol | |
embC | 4242841 | c.2979C>T | synonymous_variant | 0.2 | ethambutol | Not assoc w R - Interim |
embA | 4242844 | c.-389A>G | upstream_gene_variant | 0.18 | ethambutol | |
embA | 4242847 | c.-386C>A | upstream_gene_variant | 0.18 | ethambutol | |
embA | 4242859 | c.-374C>T | upstream_gene_variant | 0.17 | ethambutol | |
embA | 4242862 | c.-371A>G | upstream_gene_variant | 0.17 | ethambutol | |
embC | 4242863 | p.Tyr1001Asn | missense_variant | 0.17 | ethambutol | |
embA | 4245137 | c.1905T>C | synonymous_variant | 0.23 | ethambutol | |
embA | 4245146 | c.1914G>A | synonymous_variant | 0.25 | ethambutol | |
embA | 4245149 | c.1917C>G | synonymous_variant | 0.23 | ethambutol | |
embA | 4245153 | p.Ile641Val | missense_variant | 0.22 | ethambutol | |
embA | 4245182 | c.1950T>C | synonymous_variant | 0.27 | ethambutol | |
embA | 4245189 | c.1957C>T | synonymous_variant | 0.27 | ethambutol | |
embA | 4245198 | p.Leu656Ile | missense_variant | 0.23 | ethambutol | |
embA | 4245207 | c.1975T>C | synonymous_variant | 0.2 | ethambutol | |
embA | 4245215 | c.1983A>C | synonymous_variant | 0.18 | ethambutol | |
embA | 4245222 | p.Tyr664Gln | missense_variant | 0.17 | ethambutol | |
embB | 4246256 | c.-258G>T | upstream_gene_variant | 0.17 | ethambutol | |
embB | 4246259 | c.-255G>C | upstream_gene_variant | 0.17 | ethambutol | |
embA | 4246308 | p.Thr1026Ala | missense_variant | 0.18 | ethambutol | |
embB | 4246316 | c.-198T>G | upstream_gene_variant | 0.18 | ethambutol | |
embB | 4246319 | c.-195G>C | upstream_gene_variant | 0.17 | ethambutol | |
embA | 4246329 | p.Thr1033Ala | missense_variant | 0.17 | ethambutol | |
embB | 4247434 | c.921C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4247437 | c.924A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4247440 | c.927C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4247446 | c.933C>T | synonymous_variant | 0.17 | ethambutol | |
embB | 4247464 | c.951C>G | synonymous_variant | 0.21 | ethambutol | |
embB | 4247470 | c.957T>C | synonymous_variant | 0.24 | ethambutol | |
embB | 4247491 | c.978G>C | synonymous_variant | 0.26 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.26 | ethambutol | |
embB | 4247512 | c.999T>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4247539 | c.1026T>C | synonymous_variant | 0.19 | ethambutol | |
embB | 4247554 | c.1041T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4247746 | c.1233C>T | synonymous_variant | 0.18 | ethambutol | |
embB | 4247761 | c.1248T>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247773 | c.1260G>A | synonymous_variant | 0.19 | ethambutol | |
embB | 4247776 | c.1263G>T | synonymous_variant | 0.21 | ethambutol | |
embB | 4247797 | c.1284C>G | synonymous_variant | 0.22 | ethambutol | |
embB | 4247800 | c.1287A>T | synonymous_variant | 0.21 | ethambutol | |
embB | 4247803 | c.1290G>C | synonymous_variant | 0.21 | ethambutol | |
embB | 4247815 | c.1302C>G | synonymous_variant | 0.24 | ethambutol | |
embB | 4247819 | p.Val436Ile | missense_variant | 0.25 | ethambutol | Uncertain significance |
embB | 4247830 | c.1317A>G | synonymous_variant | 0.22 | ethambutol | Not assoc w R - Interim |
embB | 4247836 | c.1323A>G | synonymous_variant | 0.22 | ethambutol | Not assoc w R - Interim |
embB | 4247839 | c.1326G>C | synonymous_variant | 0.21 | ethambutol | Not assoc w R - Interim |
embB | 4247875 | c.1362G>C | synonymous_variant | 0.22 | ethambutol | |
embB | 4247876 | c.1363C>T | synonymous_variant | 0.21 | ethambutol | |
embB | 4247881 | c.1368G>C | synonymous_variant | 0.22 | ethambutol | |
embB | 4247887 | c.1374C>T | synonymous_variant | 0.22 | ethambutol | Not assoc w R - Interim |
embB | 4247893 | c.1380C>T | synonymous_variant | 0.24 | ethambutol | |
embB | 4247899 | p.Met462Ile | missense_variant | 0.29 | ethambutol | |
embB | 4247905 | c.1392G>C | synonymous_variant | 0.28 | ethambutol | Not assoc w R - Interim |
embB | 4247909 | c.1396T>C | synonymous_variant | 0.28 | ethambutol | |
embB | 4247914 | c.1401G>C | synonymous_variant | 0.26 | ethambutol | Not assoc w R - Interim |
embB | 4247932 | c.1419C>G | synonymous_variant | 0.22 | ethambutol | |
embB | 4247940 | p.Leu476Trp | missense_variant | 0.26 | ethambutol | |
embB | 4248007 | c.1494C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248011 | p.Ser500Arg | missense_variant | 0.15 | ethambutol | |
embB | 4248014 | p.Thr501Ala | missense_variant | 0.16 | ethambutol | Uncertain significance |
embB | 4248070 | c.1557T>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4248085 | c.1572T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248130 | c.1617G>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4248133 | c.1620C>G | synonymous_variant | 0.2 | ethambutol | |
embB | 4248139 | c.1626C>G | synonymous_variant | 0.2 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.22 | ethambutol | Not assoc w R - Interim |
embB | 4248172 | c.1659G>C | synonymous_variant | 0.21 | ethambutol | |
embB | 4248304 | c.1791G>C | synonymous_variant | 0.25 | ethambutol | |
embB | 4248316 | c.1803C>G | synonymous_variant | 0.27 | ethambutol | |
embB | 4248319 | c.1806A>G | synonymous_variant | 0.27 | ethambutol | |
embB | 4248343 | c.1830G>C | synonymous_variant | 0.24 | ethambutol | |
embB | 4248373 | c.1860C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4249469 | p.Leu986Met | missense_variant | 0.25 | ethambutol | |
embB | 4249486 | c.2973T>G | synonymous_variant | 0.26 | ethambutol | |
embB | 4249498 | c.2985G>C | synonymous_variant | 0.27 | ethambutol | |
embB | 4249521 | p.Ala1003Val | missense_variant | 0.27 | ethambutol | |
embB | 4249525 | c.3012T>C | synonymous_variant | 0.27 | ethambutol | Not assoc w R - Interim |
embB | 4249529 | p.Ile1006Val | missense_variant | 0.27 | ethambutol | |
embB | 4249532 | p.Ala1007Thr | missense_variant | 0.27 | ethambutol | Uncertain significance |
embB | 4249537 | c.3024A>G | synonymous_variant | 0.29 | ethambutol | |
embB | 4249543 | c.3030G>C | synonymous_variant | 0.31 | ethambutol | |
embB | 4249546 | c.3033G>A | synonymous_variant | 0.29 | ethambutol | |
embB | 4249558 | c.3045A>C | synonymous_variant | 0.24 | ethambutol | |
embB | 4249568 | p.Ser1019Thr | missense_variant | 0.19 | ethambutol | |
aftB | 4267091 | c.1746C>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin |