TB-Profiler result

Run: SRR1166821
Summary

Run ID: SRR1166821

Sample name:

Date: 2024-10-05T14:17:27.730212

Number of reads: 1531524

Percentage reads mapped: 77.12

Median coverage: 34.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 0.97
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.95
lineage4 Euro-American None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.3 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 525 c.525T>C synonymous_variant 0.16 isoniazid
dnaA 534 c.534T>G synonymous_variant 0.2 isoniazid
dnaA 540 c.540C>G synonymous_variant 0.21 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.21 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.24 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.23 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.18 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.16 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.16 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.15 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.16 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.17 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.15 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.17 isoniazid
dnaA 1419 c.1419C>G synonymous_variant 0.19 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.24 isoniazid
gyrB 6133 c.894G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7523 c.222C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7919 p.Glu206Asp missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8786 c.1485T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490851 c.69A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490902 c.120T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.38 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491295 c.513C>G synonymous_variant 0.45 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 491319 c.537G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491331 c.549G>A synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491532 c.750G>T synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491583 c.801G>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.81 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
fgd1 491595 c.813C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.16 pretomanid
delamanid
clofazimine
mshA 575679 p.Asn111Ser missense_variant 0.93 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.3 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.27 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.25 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.23 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.3 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.3 isoniazid
ethionamide
ccsA 619591 c.-300G>C upstream_gene_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 619627 c.-264C>G upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 619648 c.-243C>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619654 c.-237A>C upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 619655 c.-236A>G upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619669 c.-222G>C upstream_gene_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 619672 c.-219A>C upstream_gene_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.38 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.27 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620787 c.897C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
Rv0565c 657219 p.Ala84Val missense_variant 0.21 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.21 ethionamide
Rv0565c 657231 p.Ile80Val missense_variant 0.2 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.21 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.24 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.26 ethionamide
Rv0565c 657267 p.Ser68Pro missense_variant 0.25 ethionamide Uncertain significance
Rv0565c 657291 c.180C>G synonymous_variant 0.22 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.27 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.29 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.29 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.25 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.22 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.21 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.2 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.24 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.27 ethionamide
hadA 731792 c.-138G>A upstream_gene_variant 0.15 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.17 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.16 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.14 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.23 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.23 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.23 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.23 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.16 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.16 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.18 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.18 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.23 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.18 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.2 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.81 rifampicin Not assoc w R
rpoB 760118 c.312T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.23 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.14 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.15 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.24 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.3 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.34 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.37 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.26 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.24 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.31 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.27 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.22 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.19 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.2 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.29 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.3 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.23 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.24 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.21 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.28 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.19 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761813 c.2007T>C synonymous_variant 0.21 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.2 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.15 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.15 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.24 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.19 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.17 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.19 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.2 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.26 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.33 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.22 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.24 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.23 rifampicin
rpoC 762443 c.-927G>T upstream_gene_variant 0.27 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.23 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.17 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>G synonymous_variant 0.19 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.29 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.31 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.24 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.25 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.31 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.26 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.26 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.24 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.23 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.23 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.26 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.27 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.26 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.27 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.25 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.21 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.17 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.16 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.15 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.2 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.21 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.3 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.3 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.3 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.26 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.32 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.33 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.31 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.32 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.36 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765451 c.2082C>G synonymous_variant 0.16 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.16 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.16 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.2 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Glu missense_variant 0.3 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766444 c.3075C>G synonymous_variant 0.2 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.23 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766543 c.3174C>T synonymous_variant 0.34 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.41 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.41 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.39 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.39 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.36 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.26 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.26 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.32 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.21 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.28 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.3 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775898 c.2583G>A synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Phe missense_variant 0.21 bedaquiline
clofazimine
mmpL5 775916 c.2565T>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.18 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.22 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.16 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.24 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.32 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.38 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.4 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.27 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800690 c.-119C>T upstream_gene_variant 0.19 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.22 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.21 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.2 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.2 linezolid
rplC 800889 c.81C>G synonymous_variant 0.16 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.16 linezolid
rplC 801132 c.324T>C synonymous_variant 0.18 linezolid
rplC 801174 c.366T>C synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.22 linezolid
rplC 801228 c.420T>C synonymous_variant 0.22 linezolid
rplC 801246 c.438C>G synonymous_variant 0.3 linezolid
rplC 801249 c.441T>G synonymous_variant 0.3 linezolid
rplC 801255 c.447C>T synonymous_variant 0.3 linezolid
fbiC 1303534 p.Ser202Ala missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303560 c.630G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303881 c.951G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
sigE 1364839 c.427T>C synonymous_variant 0.25 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.33 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.3 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.37 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.33 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.35 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.37 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.31 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.23 isoniazid
ethionamide
inhA 1674909 c.708G>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674915 c.714C>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674942 c.741T>C synonymous_variant 0.23 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.2 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.36 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.19 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.17 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.33 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.19 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.16 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.15 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.26 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917934 c.-6T>C upstream_gene_variant 0.87 capreomycin
tlyA 1917951 c.12T>C synonymous_variant 0.19 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101960 c.1083A>G synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101966 c.1077T>G synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.2 isoniazid
delamanid
ethionamide
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.28 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.2 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.17 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.17 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.16 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.17 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.18 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.18 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.25 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.26 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.31 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.28 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.28 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.26 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.25 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.29 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.29 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.2 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.27 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.35 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.36 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.37 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.36 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.36 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.25 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.21 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.2 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.23 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.3 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.3 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.29 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.28 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.26 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.26 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.23 isoniazid
ahpC 2726735 c.543C>T synonymous_variant 0.14 isoniazid
folC 2747086 c.513A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.15 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.18 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.44 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.41 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.25 capreomycin Uncertain significance
Rv2752c 3065687 p.Gly169Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065901 c.291A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065916 p.Phe92Tyr missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065919 c.273G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065925 p.Ala89Gly missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065928 c.264G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067412 c.534C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067463 p.Ile161Val missense_variant 0.24 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.24 para-aminosalicylic_acid
thyX 3067619 c.327A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067894 c.52T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.23 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.22 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.89 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624166 p.Met249Leu missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624680 c.231T>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624701 c.210T>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624713 c.198C>T synonymous_variant 0.17 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.25 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.33 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.4 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 0.21 rifampicin
bedaquiline
fbiB 3642602 c.1068A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642605 c.1071A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiB 3642659 c.1125C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiB 3642662 c.1128C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
rpoA 3877587 c.921A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.33 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.27 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.21 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.17 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.16 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.19 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.23 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.26 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.25 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.22 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.2 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.22 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.23 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.31 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.31 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.32 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.33 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.35 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.39 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.39 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.51 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.49 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.47 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.41 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.43 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.39 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.35 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.21 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.29 pretomanid
delamanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.27 pretomanid
delamanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.24 pretomanid
delamanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.23 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.22 pretomanid
delamanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.2 pretomanid
delamanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.16 pretomanid
delamanid
clpC1 4038271 p.Pro812Ala missense_variant 0.19 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.19 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038434 c.2271G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.2 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.19 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.32 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.28 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.25 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.26 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.34 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.27 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.34 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.15 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.19 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044974 c.-693C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.22 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.25 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.25 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.29 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.28 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.27 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.26 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.24 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.2 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138594 p.Asn388Asp missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138664 c.1092G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138667 c.1089G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138769 c.987G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138772 p.Ser328Ala missense_variant 0.28 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138781 c.975G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139132 c.622_624delCTAinsTTG synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139135 c.621T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139143 c.613T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139165 c.591A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139168 c.588T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139175 p.Val194Ala missense_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139177 c.579T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.573T>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139186 c.570G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139575 p.Val61Ile missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240183 c.321A>G synonymous_variant 0.27 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.21 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.26 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.26 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.22 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.21 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.29 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.31 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.27 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.24 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.32 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.31 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.24 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.24 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.28 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.2 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.17 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.17 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4240996 c.1134G>C synonymous_variant 0.19 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.19 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.3 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.37 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.26 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.24 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.24 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.24 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.22 ethambutol
embC 4241473 c.1611G>A synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.97 ethambutol Not assoc w R
embA 4245077 c.1845G>C synonymous_variant 0.19 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.18 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.21 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.24 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.25 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.24 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.23 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.2 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.18 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.17 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.17 ethambutol
embA 4245215 c.1983A>G synonymous_variant 0.21 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.2 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.19 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.23 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.24 ethambutol Uncertain significance
embB 4246355 c.-159G>C upstream_gene_variant 0.17 ethambutol
embA 4246359 p.Ala1043Pro missense_variant 0.17 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.16 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.16 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.16 ethambutol
embB 4247358 p.Val282Ala missense_variant 0.17 ethambutol Uncertain significance
embB 4247365 c.852A>C synonymous_variant 0.19 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.23 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.24 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.26 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.26 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.25 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.27 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.26 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.24 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.24 ethambutol
embB 4247800 c.1287A>C synonymous_variant 0.24 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.23 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.28 ethambutol Uncertain significance
embB 4247824 c.1311C>G synonymous_variant 0.27 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.25 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.27 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.21 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.21 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.17 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.17 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.16 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.18 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.19 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin