TB-Profiler result

Run: SRR1510066
Summary

Run ID: SRR1510066

Sample name:

Date: 2024-04-15T12:38:07.491216

Number of reads: 5480616

Percentage reads mapped: 78.59

Median coverage: 119.0

Strain: lineage1.2.1.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.2 Indo-Oceanic RD239 0.94
lineage1 Indo-Oceanic RD239 0.93
lineage1.2.1.2.1 Indo-Oceanic RD239 1.0
lineage1.2.1 Indo-Oceanic RD239 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.467delA Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
gid 4407735 c.467delA frameshift_variant 0.15 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 571 c.571T>C synonymous_variant 0.17 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.17 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 786 c.786C>T synonymous_variant 0.13 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.12 isoniazid
dnaA 1302 c.1302C>A synonymous_variant 1.0 isoniazid Not assoc w R
gyrB 6112 p.Met291Ile missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6169 c.930C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Asn missense_variant 0.14 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7457 c.156T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7799 c.498A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8099 c.798T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.84 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8462 c.1161A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9233 c.1932C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9260 c.1959G>C synonymous_variant 0.87 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13175 c.384T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491144 p.Ala121Glu missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491532 c.750G>T synonymous_variant 0.13 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575368 c.21T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R
ccsA 620340 c.450C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.18 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.16 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620631 c.741T>C synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.14 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.14 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.14 ethionamide
Rv0565c 657656 c.-186C>T upstream_gene_variant 0.14 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.14 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.9 rifampicin Not assoc w R
nusG 734407 p.Val52Ile missense_variant 0.13 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.16 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.15 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.19 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.15 rifampicin
nusG 734481 c.228C>G synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.15 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.18 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.16 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.15 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.17 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.18 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.17 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.24 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.16 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.19 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.21 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.26 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.25 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.2 rifampicin
rpoB 761373 p.Val523His missense_variant 0.18 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.16 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.19 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.14 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.13 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.17 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.17 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.17 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.16 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.2 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.14 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.15 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.14 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.15 rifampicin
rpoC 762443 c.-927G>T upstream_gene_variant 0.13 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.14 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.2 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.28 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.2 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.2 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.15 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.2 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.17 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.16 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.2 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>C synonymous_variant 0.77 rifampicin Not assoc w R
rpoC 763546 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.22 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.18 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.23 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.19 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.19 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.17 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.18 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.15 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.17 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.15 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.9 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.9 rifampicin Not assoc w R
rpoC 763960 c.591T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.18 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.2 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.22 rifampicin
rpoC 764015 c.646C>T synonymous_variant 0.23 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.25 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.24 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.17 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.16 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.17 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.19 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.16 rifampicin
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.15 rifampicin
rpoC 764389 p.Leu340Phe missense_variant 0.14 rifampicin Uncertain significance
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.15 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.15 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.2 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.2 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.14 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.18 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.19 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.16 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.16 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.14 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.13 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.17 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.18 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766069 c.2700G>A synonymous_variant 0.14 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.16 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.16 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.14 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.14 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.17 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.16 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766444 c.3075C>G synonymous_variant 0.21 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.21 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.13 rifampicin Uncertain significance
rpoC 766489 c.3120G>T synonymous_variant 0.13 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.16 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.15 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.2 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.25 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.24 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.21 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.2 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.19 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.18 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.24 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.32 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.29 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.2 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.14 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775981 p.Leu834Met missense_variant 0.15 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.14 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.14 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.16 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.16 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.19 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.15 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.15 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.16 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.99 linezolid Not assoc w R
rplC 800648 c.-161A>C upstream_gene_variant 0.17 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.17 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.22 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 800817 c.9A>T synonymous_variant 0.14 linezolid
rplC 800844 c.36T>C synonymous_variant 0.15 linezolid
rplC 800889 c.81C>G synonymous_variant 0.15 linezolid
rplC 800907 c.99C>G synonymous_variant 0.18 linezolid
rplC 800916 c.108A>G synonymous_variant 0.18 linezolid
rplC 800939 p.Arg44His missense_variant 0.13 linezolid
rplC 800955 c.147C>G synonymous_variant 0.15 linezolid
rplC 800967 c.159C>G synonymous_variant 0.14 linezolid
rplC 800982 c.174C>T synonymous_variant 0.14 linezolid
rplC 801222 c.414T>C synonymous_variant 0.15 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303836 c.906G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0 streptomycin Not assoc w R
isoniazid Not assoc w R
pyrazinamide Not assoc w R
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460907 c.-138T>C upstream_gene_variant 0.99 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475819 n.2162C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
inhA 1674162 c.-40C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Not assoc w R
inhA 1674321 c.120G>C synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.15 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.14 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674564 c.363C>T synonymous_variant 0.15 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674636 c.435C>G synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833724 c.183C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.13 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.14 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834624 c.1083G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.17 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102050 c.993T>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102053 c.990G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102059 c.984T>C synonymous_variant 0.15 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.13 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156726 c.-615A>G upstream_gene_variant 0.14 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.13 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2519048 p.Gly312Ser missense_variant 0.99 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
folC 2747065 c.534C>G synonymous_variant 0.14 para-aminosalicylic_acid
Rv2477c 2783015 p.Ser343Thr missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783485 c.558G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3066066 c.126T>C synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.15 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339417 c.300A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
whiB7 3568488 c.191delG frameshift_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
lpqB 3624077 c.834G>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624094 c.817A>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624335 c.576C>T synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 0.15 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 0.14 bedaquiline
rifampicin
lpqB 3624371 c.540T>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624452 c.459T>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624486 p.Asp142Gly missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624680 c.231T>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.18 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625592 p.Ser341Asn missense_variant 0.14 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.14 bedaquiline
rifampicin Uncertain significance
mtrB 3625797 p.Val273Met missense_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCC frameshift_variant&missense_variant 0.16 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
fbiA 3640557 c.15T>C synonymous_variant 0.99 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.16 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877830 c.678C>T synonymous_variant 0.19 rifampicin
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.16 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877953 c.555G>A synonymous_variant 0.14 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.16 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.15 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.16 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.16 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.16 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.18 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.18 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.16 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.16 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.17 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.17 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.17 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.3 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.31 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.31 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.31 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.35 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.35 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.34 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.34 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.29 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.25 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.2 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.15 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.14 rifampicin
rpoA 3878665 c.-158A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878672 c.-165A>T upstream_gene_variant 0.18 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878989 c.-482G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879037 c.-530G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.18 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.15 rifampicin
clpC1 4038302 c.2403C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.16 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.16 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.18 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038611 c.2094C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.13 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.14 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.13 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.15 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAC frameshift_variant&missense_variant 0.14 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.18 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040699 c.6C>T synonymous_variant 0.13 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.16 pyrazinamide
panD 4045144 c.-863G>A upstream_gene_variant 0.33 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138583 c.1173G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139575 p.Val61Ile missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.157_159delGCCinsAG frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139630 c.126C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.21 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.19 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.24 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.26 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.27 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.2 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.2 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.19 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.18 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.16 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.14 ethambutol Not assoc w R
embC 4240990 c.1128A>G synonymous_variant 0.15 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.19 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.17 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.14 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.19 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.83 ethambutol Not assoc w R
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243580 c.348G>A synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244420 c.1188G>C synonymous_variant 0.98 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.15 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.16 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.18 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.16 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.17 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.15 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.18 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.16 ethambutol
embA 4245885 p.Asp885Asn missense_variant 0.15 ethambutol
embA 4245969 p.Pro913Ser missense_variant 0.99 ethambutol Not assoc w R
embB 4247437 c.924A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.15 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.15 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.15 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.14 ethambutol
embB 4247578 c.1065G>A synonymous_variant 0.93 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248085 c.1572T>C synonymous_variant 0.19 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.21 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.22 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.21 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.22 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.22 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.2 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.2 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.15 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.14 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.14 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269864 c.-32delG upstream_gene_variant 0.99 ethambutol Not assoc w R
whiB6 4338361 p.Arg54Gln missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338592 c.-71G>A upstream_gene_variant 0.32 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R