TB-Profiler result

Run: 4d7dfdc1-e6b6-4646-9fc2-df1f813b8cc3
Summary

Run ID: 4d7dfdc1-e6b6-4646-9fc2-df1f813b8cc3

Sample name:

Date: 06-10-2023 11:32:33

Number of reads: 272055

Percentage reads mapped: 3.09

Median coverage: 3

Strain: lineage4

Spoligotype:

Drug-resistance: RR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - interim
isoniazid
ethambutol
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R - interim
kanamycin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.8 rifampicin Assoc w R - interim
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
aminoglycosides Uncertain significance
amikacin Uncertain significance
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.86 kanamycin Assoc w R
capreomycin Assoc w R
aminoglycosides Uncertain significance
amikacin Assoc w R - interim
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rpoB 760991 c.1185G>C synonymous_variant 0.6 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.6 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.6 rifampicin
rpoB 761013 p.Val403Ile missense_variant 0.6 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.8 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.62 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.73 rifampicin
rpoB 761153 c.1347G>C synonymous_variant 0.85 rifampicin
rpoB 761156 c.1350G>C synonymous_variant 0.85 rifampicin
rpoB 761162 c.1356G>C synonymous_variant 0.85 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.85 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.85 rifampicin
rpoB 761178 c.1372_1374delTCAinsAGC synonymous_variant 0.79 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.85 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.85 rifampicin
rpoB 761196 p.Leu464Val missense_variant 0.85 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.88 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.88 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.88 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.88 rifampicin
rpoB 761252 c.1446C>G synonymous_variant 0.88 rifampicin
rpoB 761261 c.1455G>C synonymous_variant 0.9 rifampicin
rpoB 762844 p.Phe1013Tyr missense_variant 0.6 rifampicin
rpoB 762849 p.Tyr1015Asp missense_variant 0.6 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.7 rifampicin
rpoC 762863 c.-507T>C upstream_gene_variant 0.64 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.8 rifampicin
rpoC 762896 c.-474G>A upstream_gene_variant 0.85 rifampicin
rpoC 762899 c.-471G>C upstream_gene_variant 0.85 rifampicin
rpoC 762917 c.-453C>G upstream_gene_variant 0.87 rifampicin
rpoC 762923 c.-447C>G upstream_gene_variant 0.83 rifampicin
rpoC 762929 c.-441G>C upstream_gene_variant 0.85 rifampicin
rpoC 762959 c.-411G>C upstream_gene_variant 0.88 rifampicin
rpoC 762962 c.-408C>T upstream_gene_variant 0.89 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.88 rifampicin
rpoC 762995 c.-375G>T upstream_gene_variant 0.88 rifampicin
rpoB 763005 p.Cys1067Val missense_variant 0.87 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.91 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.91 rifampicin
rpoC 763031 c.-339T>G upstream_gene_variant 0.95 rifampicin
rpoC 763034 c.-336C>G upstream_gene_variant 0.86 rifampicin
rpoB 763038 p.Thr1078Ala missense_variant 0.86 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.9 rifampicin
rpoC 763053 c.-317T>C upstream_gene_variant 0.9 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.91 rifampicin
rpoB 763075 p.Thr1090Ile missense_variant 0.89 rifampicin
rpoB 763077 p.Val1091Leu missense_variant 0.88 rifampicin
rpoC 763094 c.-276G>C upstream_gene_variant 0.85 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.8 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.58 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.7 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.7 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.73 rifampicin
rpoC 763511 p.Cys48Gly missense_variant 0.73 rifampicin
rpoC 763517 p.Lys50Gln missense_variant 0.73 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.75 rifampicin
rpoC 763532 p.Thr55Ser missense_variant 0.75 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.77 rifampicin
rpoC 763551 p.Tyr61Ser missense_variant 0.75 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.8 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.8 rifampicin
rpoC 763576 c.207C>G synonymous_variant 0.8 rifampicin
rpoC 763589 p.Ile74Val missense_variant 0.77 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.79 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.64 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.83 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin
rpoC 764432 p.Lys355Arg missense_variant 0.17 rifampicin
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.83 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.17 rifampicin
rpoC 764446 p.Asp359Glu missense_variant 0.73 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.15 rifampicin
rpoC 764450 p.Gly361Arg missense_variant 0.62 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin
rpoC 764461 p.Glu364Asp missense_variant 0.8 rifampicin
rpoC 764468 p.Val367Met missense_variant 0.67 rifampicin
rpoC 764471 p.Asn368Arg missense_variant 0.67 rifampicin
rpoC 764479 c.1110G>A synonymous_variant 0.67 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.83 rifampicin
rpoC 764489 c.1120C>T synonymous_variant 0.67 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.83 rifampicin
rpoC 764498 p.Ser377Ala missense_variant 0.83 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.83 rifampicin
rpoC 764509 c.1140G>A synonymous_variant 0.67 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.64 rifampicin
rpoC 764593 c.1224C>A synonymous_variant 0.14 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.19 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.84 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.55 rifampicin
rpoC 764626 c.1257C>A synonymous_variant 0.18 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.79 rifampicin
rpoC 764635 c.1266C>G synonymous_variant 0.21 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.56 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.83 rifampicin
rpoC 764660 p.Val431Ile missense_variant 0.27 rifampicin
rpoC 764665 c.1296C>T synonymous_variant 0.28 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.86 rifampicin
rpoC 764672 p.Gln435Glu missense_variant 0.55 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.39 rifampicin
rpoC 764678 p.Lys437Arg missense_variant 0.39 rifampicin
rpoC 764686 c.1317C>T synonymous_variant 0.35 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.33 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.33 rifampicin
rpoC 764705 p.Leu446Lys missense_variant 0.33 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.32 rifampicin
rpoC 764719 c.1350G>A synonymous_variant 0.3 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.79 rifampicin
rpoC 764740 p.Met457Ile missense_variant 0.77 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.73 rifampicin
rpoC 764750 p.Val461Ile missense_variant 0.73 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.71 rifampicin
rpoC 764760 p.Asn464Ser missense_variant 0.71 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.73 rifampicin
rpoC 764767 c.1398G>T synonymous_variant 0.73 rifampicin
rpoC 764780 p.Ser471Ala missense_variant 0.68 rifampicin
rpoC 764785 c.1416C>G synonymous_variant 0.68 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.68 rifampicin
rpoC 764804 p.Gln479Ser missense_variant 0.67 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.67 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.67 rifampicin
rpoC 764833 c.1464A>G synonymous_variant 0.47 rifampicin
rpoC 764837 p.Val490Ile missense_variant 0.4 rifampicin
rpoC 764843 p.Ala492Arg missense_variant 0.27 rifampicin
rpsL 781760 c.201T>C synonymous_variant 0.64 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.64 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.57 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.57 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.58 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.64 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.64 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.58 streptomycin
rpsL 781851 p.Ile98Val missense_variant 0.5 streptomycin
rpsL 781856 c.297C>T synonymous_variant 0.5 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.5 streptomycin
rpsL 781860 p.Ser101Ala missense_variant 0.5 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.47 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.47 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.47 streptomycin
rpsL 781876 p.Gly106Ala missense_variant 0.44 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.4 streptomycin
rpsL 781921 p.Lys121Met missense_variant 0.33 streptomycin
rrs 1472092 n.247C>G non_coding_transcript_exon_variant 0.8 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.82 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.86 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.88 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.86 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472120 n.275G>C non_coding_transcript_exon_variant 0.86 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.86 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.9 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.93 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.87 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.91 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.89 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.87 linezolid
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.87 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.88 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472507 n.662C>A non_coding_transcript_exon_variant 0.94 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.95 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.95 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.88 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.85 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472666 n.821G>A non_coding_transcript_exon_variant 0.85 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.81 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.81 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472686 n.841G>T non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472694 n.849C>T non_coding_transcript_exon_variant 0.81 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.81 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.82 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.79 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.8 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.92 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.92 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.88 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.92 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.88 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.88 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.88 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.88 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.88 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.88 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.91 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.93 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.93 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.93 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.95 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.95 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.95 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.98 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.98 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.98 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.96 linezolid
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.94 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.98 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.93 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.93 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.92 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.91 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.91 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.9 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.9 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
aminoglycosides
streptomycin
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.82 linezolid
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.77 linezolid Uncertain significance
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474291 n.635_646delTTCCTCTCCGGA non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474305 n.648G>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474376 n.719T>A non_coding_transcript_exon_variant 0.59 linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.53 linezolid
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.27 linezolid
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.56 linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.71 linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.74 linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.84 linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.89 linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.89 linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.96 linezolid
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.98 linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.94 linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.93 linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.93 linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.93 linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.93 linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.83 linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.82 linezolid
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.83 linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.69 linezolid
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.82 linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474752 n.1096delA non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474770 n.1113G>A non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.79 linezolid
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.81 linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.86 linezolid
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.83 linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.84 linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.8 linezolid
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.83 linezolid
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475752 n.2095C>G non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475757 n.2101_2104delACCC non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.88 linezolid
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.89 linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.89 linezolid
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.85 linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.85 linezolid
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.85 linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.85 linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.85 linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.84 linezolid
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.84 linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.8 linezolid
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.8 linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.8 linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.75 linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.75 linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.75 linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.98 linezolid
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476336 n.2679C>G non_coding_transcript_exon_variant 0.31 linezolid
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.67 linezolid
rrl 1476356 n.2699C>G non_coding_transcript_exon_variant 0.39 linezolid
rrl 1476357 n.2700T>A non_coding_transcript_exon_variant 0.39 linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.41 linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.56 linezolid
rrl 1476384 n.2727G>C non_coding_transcript_exon_variant 0.56 linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.6 linezolid
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.6 linezolid
rrl 1476428 n.2771C>A non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476443 n.2786G>C non_coding_transcript_exon_variant 0.48 linezolid
rrl 1476455 n.2798C>G non_coding_transcript_exon_variant 0.48 linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.48 linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 1.0 linezolid Uncertain significance
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.43 linezolid
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.89 linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476544 n.2887T>A non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476566 n.2909A>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 1.0 linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.67 linezolid
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.67 linezolid Uncertain significance
rrl 1476601 n.2944G>A non_coding_transcript_exon_variant 0.67 linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.67 linezolid
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.57 linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.33 linezolid
rrl 1476630 n.2973A>T non_coding_transcript_exon_variant 0.33 linezolid
rpsA 1833970 c.429G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834061 p.Ile174Leu missense_variant 0.67 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.58 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039937 p.Val256Ile missense_variant 0.58 pyrazinamide
clpC1 4039940 c.765G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.58 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.83 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.83 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.83 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.83 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040051 c.654C>G synonymous_variant 0.75 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.73 pyrazinamide