TB-Profiler result

Run: SRR21732980
Summary

Run ID: SRR21732980

Sample name:

Date: 2024-03-26T20:04:35.139177

Number of reads: 2889360

Percentage reads mapped: 91.74

Median coverage: 99.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.16 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.17 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6868 c.-434G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8576 c.1275C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9641 c.2340C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.15 ethionamide
nusG 734451 c.198G>C synonymous_variant 0.16 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.18 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.16 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.16 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.17 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.31 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.31 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.34 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.34 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.34 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.31 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.17 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.2 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.2 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.18 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.2 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.15 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.3 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.2 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.2 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.2 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.19 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.17 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.24 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.19 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.18 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.23 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.27 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.31 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.34 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.32 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.31 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.29 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.23 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.29 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.28 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763112 c.-258G>A upstream_gene_variant 0.21 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.25 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.22 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.23 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.23 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.26 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.19 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.19 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.29 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.25 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763835 p.Ala156Thr missense_variant 0.15 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.26 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.26 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.27 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.33 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.29 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.28 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.31 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764392 c.1023C>T synonymous_variant 0.16 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.19 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.24 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.29 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.28 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.3 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.3 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.39 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.3 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765499 c.2130C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.15 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.16 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.16 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.17 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.21 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.22 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.23 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.25 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.19 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.22 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.21 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.21 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.23 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.27 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.26 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.25 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.29 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.33 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.34 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.31 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.3 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.3 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.33 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.33 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.31 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.35 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.42 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.41 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.41 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.34 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.27 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.22 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.18 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.21 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.26 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.28 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.31 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.35 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.35 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.35 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.31 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.34 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.16 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.16 linezolid
fbiC 1303785 c.855G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
atpE 1461107 c.63C>G synonymous_variant 0.15 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.16 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.18 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.18 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.19 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.2 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.2 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.17 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.18 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471728 n.-118A>C upstream_gene_variant 0.99 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674561 c.360C>T synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.18 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.16 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.18 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834684 c.1143C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.23 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.21 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.19 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.19 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.15 isoniazid
kasA 2518919 p.Gly269Ser missense_variant 0.94 isoniazid
Rv2477c 2783230 c.813T>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyA 3073868 p.Thr202Ala missense_variant 0.99 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877571 p.Pro313Ala missense_variant 0.15 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.22 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.2 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.21 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.21 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.19 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.21 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.21 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.2 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.24 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.23 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.24 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.21 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.25 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.39 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.41 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.42 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.39 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.38 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.43 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.41 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.41 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.41 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.36 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.32 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.3 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.28 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.28 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.25 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.28 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.35 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.31 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.29 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.4 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.41 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.43 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.44 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.42 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.39 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.41 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.41 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.38 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878950 c.-443C>T upstream_gene_variant 0.59 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.31 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.16 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.93 pyrazinamide Not assoc w R
clpC1 4038392 c.2313C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.18 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.18 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.15 pyrazinamide
embC 4242182 p.Ala774Ser missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243317 p.Gly29Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4246256 c.-258G>T upstream_gene_variant 0.18 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.19 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.21 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.27 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.27 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.26 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.24 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.25 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.21 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.17 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.17 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.15 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.16 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.19 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.19 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.25 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.24 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.25 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.24 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.24 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.23 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.23 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.23 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.21 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.19 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.19 ethambutol
embB 4247638 c.1125G>T synonymous_variant 0.16 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.18 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.18 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.18 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.18 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.17 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.26 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.26 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.25 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.26 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.25 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.25 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.26 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.25 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.23 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.23 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.24 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.23 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.26 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.21 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.21 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.25 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.24 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.24 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.24 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.24 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.23 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.26 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.21 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.23 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.24 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.24 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.25 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.24 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.28 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.25 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.29 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.31 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.26 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.26 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.24 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.21 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.19 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.19 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.17 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.17 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.18 ethambutol
embB 4249133 c.2620C>T synonymous_variant 1.0 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.15 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.21 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.21 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.2 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.17 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4249532 p.Ala1007Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4249568 p.Ser1019Thr missense_variant 0.16 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.16 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.15 ethambutol
aftB 4268117 c.720G>C synonymous_variant 0.17 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.18 ethambutol Uncertain significance
aftB 4268129 c.708T>G synonymous_variant 0.18 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.16 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.16 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.17 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.17 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.18 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.18 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.19 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.19 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.19 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338600 c.-79T>G upstream_gene_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338602 c.-81A>T upstream_gene_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 0.99 streptomycin Not assoc w R