TB-Profiler result

Run: SRR21732980
Summary

Run ID: SRR21732980

Sample name:

Date: 2024-10-04T10:16:15.561652

Number of reads: 2889360

Percentage reads mapped: 91.74

Median coverage: 100.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.23 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6868 c.-434G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8576 c.1275C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9641 c.2340C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.15 ethionamide
nusG 734451 c.198G>C synonymous_variant 0.16 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.18 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.16 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.16 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.17 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.31 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.31 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.34 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.34 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.34 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.31 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.16 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.17 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.2 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.2 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.18 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.2 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.15 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.3 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.2 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.2 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.2 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.19 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.17 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.24 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.19 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.18 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.23 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.27 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.31 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.34 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.32 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.31 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.29 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.23 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.29 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.28 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763112 c.-258G>A upstream_gene_variant 0.21 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.25 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.22 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.23 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.23 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.26 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.19 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.19 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.29 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.25 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763835 p.Ala156Thr missense_variant 0.15 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.26 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.26 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.27 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.33 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.29 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.28 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.31 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.16 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.19 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.24 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.29 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.28 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.3 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.3 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.39 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.3 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765499 c.2130C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.15 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.16 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.16 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.17 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.21 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.22 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.23 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.25 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.17 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.19 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.22 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.21 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.21 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.23 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.27 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.26 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.26 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.25 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.29 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.33 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.34 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.31 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.3 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.3 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.33 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.33 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.31 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.35 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.42 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.41 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.41 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.34 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.27 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.22 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.18 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.21 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.26 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.28 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.31 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.31 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.35 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.35 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.35 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.31 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.34 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.17 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.16 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.16 linezolid
fbiC 1303785 c.855G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.21 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
atpE 1461107 c.63C>G synonymous_variant 0.15 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.16 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.18 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.18 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.19 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.2 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.2 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.17 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.18 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471728 n.-118A>C upstream_gene_variant 0.99 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674561 c.360C>T synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.18 isoniazid
ethionamide
inhA 1674597 c.396G>A synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.16 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.18 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.28 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834684 c.1143C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.23 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.21 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.19 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.19 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.15 isoniazid
kasA 2518919 p.Gly269Ser missense_variant 0.94 isoniazid
Rv2477c 2783230 c.813T>G synonymous_variant 0.15 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.41 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyA 3073868 p.Thr202Ala missense_variant 0.99 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877571 p.Pro313Ala missense_variant 0.15 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.22 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.2 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.21 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.21 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.19 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.21 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.21 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.2 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.24 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.23 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.24 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.21 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.25 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.39 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.41 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.42 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.39 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.38 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.43 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.41 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.41 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.41 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.36 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.32 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.3 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.28 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.28 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.25 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.28 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.35 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.31 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.29 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.4 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.41 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.43 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.44 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.42 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.39 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.41 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.41 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.38 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878950 c.-443C>T upstream_gene_variant 0.59 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.31 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.16 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.93 pyrazinamide Not assoc w R
clpC1 4038392 c.2313C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.18 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.18 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.15 pyrazinamide
embC 4242182 p.Ala774Ser missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243317 p.Gly29Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4246256 c.-258G>T upstream_gene_variant 0.18 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.19 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.21 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.27 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.27 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.26 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.24 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.25 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.21 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.17 ethambutol
embA 4246359 p.Ala1043Ser missense_variant 0.17 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.17 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.15 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.16 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.19 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.19 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.25 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.24 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.25 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.24 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.24 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.23 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.23 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.21 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.19 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.19 ethambutol
embB 4247638 c.1125G>T synonymous_variant 0.16 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.18 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.18 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.18 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.18 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.17 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.26 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.26 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.25 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.26 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.25 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.25 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.26 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.25 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.23 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.23 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.24 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.23 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.26 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.21 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.21 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.25 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.24 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.24 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.24 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.24 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.23 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.26 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.21 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.23 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.24 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.24 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.25 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.24 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.28 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.25 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.29 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.31 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.26 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.26 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.24 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.21 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.19 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.19 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.17 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.17 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.18 ethambutol
embB 4249133 c.2620C>T synonymous_variant 1.0 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.15 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.21 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.21 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.2 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.17 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4249532 p.Ala1007Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4249568 p.Ser1019Thr missense_variant 0.16 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.16 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.15 ethambutol
aftB 4268117 c.720G>C synonymous_variant 0.17 ethambutol
aftB 4268123 p.Ser238Gly missense_variant 0.18 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.18 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.16 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.16 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.17 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.17 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.18 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.18 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.19 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.19 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.19 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338600 c.-79T>G upstream_gene_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338602 c.-81A>T upstream_gene_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 0.99 streptomycin Not assoc w R