TB-Profiler result

Run: SRR11972417
Summary

Run ID: SRR11972417

Sample name:

Date: 03-04-2023 05:40:52

Number of reads: 1760772

Percentage reads mapped: 82.04

Strain: lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.9 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.81 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.91 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.79 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289252 c.-11A>G upstream_gene_variant 1.0 pyrazinamide
thyX 3067961 c.-16C>T upstream_gene_variant 1.0 para-aminosalicylic_acid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7010 p.Leu591Met missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 761006 c.1200C>G synonymous_variant 0.13
rpoB 761015 c.1209G>C synonymous_variant 0.14
rpoB 761027 c.1221A>C synonymous_variant 0.13
rpoB 761032 p.Gln409Leu missense_variant 0.12
rpoB 761036 c.1230G>C synonymous_variant 0.12
rpoB 761037 c.1231T>C synonymous_variant 0.12
rpoB 761051 c.1245G>C synonymous_variant 0.12
rpoB 761057 c.1251G>C synonymous_variant 0.12
rpoB 761058 p.Val418Thr missense_variant 0.12
rpoB 761063 c.1257C>G synonymous_variant 0.12
rpoB 761084 c.1278C>G synonymous_variant 0.11
rpoB 761132 c.1326G>C synonymous_variant 0.11
rpoB 761133 c.1327T>C synonymous_variant 0.11
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763497 p.Lys43Met missense_variant 0.14
rpoC 763501 p.Asp44Glu missense_variant 0.86
rpoC 763507 c.138G>C synonymous_variant 0.18
rpoC 763517 p.Lys50Arg missense_variant 0.18
rpoC 763528 c.159G>C synonymous_variant 0.17
rpoC 763531 c.162G>C synonymous_variant 0.17
rpoC 763534 c.165T>C synonymous_variant 0.17
rpoC 763537 c.168C>G synonymous_variant 0.17
rpoC 763546 c.177A>G synonymous_variant 0.18
rpoC 763570 c.201G>C synonymous_variant 0.19
rpoC 763589 p.Ile74Val missense_variant 0.18
rpoC 763609 c.240C>G synonymous_variant 0.18
rpoC 763614 c.246_251delGACCCG disruptive_inframe_deletion 0.16
rpoC 763622 p.Ala85Thr missense_variant 0.16
rpoC 763627 c.258_259insTCCTCC conservative_inframe_insertion 0.16
rpoC 763642 c.273G>C synonymous_variant 0.16
rpoC 763652 p.Ile95Val missense_variant 0.15
rpoC 763660 c.291T>C synonymous_variant 0.14
rpoC 763666 c.297G>C synonymous_variant 0.14
rpoC 764359 c.990C>G synonymous_variant 0.12
rpoC 764371 c.1002G>C synonymous_variant 0.13
rpoC 764377 c.1008C>G synonymous_variant 0.12
rpoC 764380 c.1011G>C synonymous_variant 0.14
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.14
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.22
rpoC 764410 c.1041G>C synonymous_variant 0.22
rpoC 764428 c.1059G>C synonymous_variant 0.23
rpoC 764431 c.1062G>C synonymous_variant 0.22
rpoC 764434 c.1065A>G synonymous_variant 0.22
rpoC 764435 c.1066A>C synonymous_variant 0.22
rpoC 764441 p.Ile358Leu missense_variant 0.23
rpoC 764449 c.1080G>C synonymous_variant 0.24
rpoC 764452 c.1083T>C synonymous_variant 0.23
rpoC 764455 c.1086G>C synonymous_variant 0.23
rpoC 764458 c.1089G>C synonymous_variant 0.24
rpoC 764461 c.1092A>G synonymous_variant 0.25
rpoC 764470 c.1101C>G synonymous_variant 0.25
rpoC 764485 c.1116G>C synonymous_variant 0.29
rpoC 764497 c.1128A>G synonymous_variant 0.3
rpoC 764500 c.1131C>G synonymous_variant 0.28
rpoC 764503 c.1134G>C synonymous_variant 0.28
rpoC 764507 p.Ala380Ser missense_variant 0.31
rpoC 764521 c.1152T>C synonymous_variant 0.32
rpoC 764530 c.1161C>T synonymous_variant 0.33
rpoC 764533 c.1164C>T synonymous_variant 0.34
rpoC 764536 c.1167G>C synonymous_variant 0.36
rpoC 764539 c.1170C>G synonymous_variant 0.37
rpoC 764560 c.1191T>C synonymous_variant 0.34
rpoC 764566 c.1197C>G synonymous_variant 0.31
rpoC 764575 c.1206T>C synonymous_variant 0.29
rpoC 764581 c.1212T>C synonymous_variant 0.28
rpoC 764582 p.Leu405Met missense_variant 0.27
rpoC 764602 c.1233C>G synonymous_variant 0.25
rpoC 764605 c.1236G>C synonymous_variant 0.26
rpoC 764611 c.1242G>C synonymous_variant 0.23
rpoC 764632 c.1263T>C synonymous_variant 0.22
rpoC 764635 c.1266C>G synonymous_variant 0.21
rpoC 764644 c.1275G>C synonymous_variant 0.15
rpoC 764646 p.Gly426Ala missense_variant 0.15
rpoC 764650 c.1281G>C synonymous_variant 0.16
rpoC 764653 c.1284G>C synonymous_variant 0.15
rpoC 764663 p.Val432Asn missense_variant 0.19
rpoC 764677 c.1308C>G synonymous_variant 0.24
rpoC 764680 p.Lys437Asn missense_variant 0.25
rpoC 764705 p.Leu446Thr missense_variant 0.19
rpoC 764716 c.1347G>C synonymous_variant 0.2
rpoC 764722 c.1353G>C synonymous_variant 0.14
rpoC 764731 c.1362G>C synonymous_variant 0.14
rpoC 764737 c.1368G>C synonymous_variant 0.12
rpoC 764746 c.1377G>C synonymous_variant 0.13
rpoC 764749 c.1380G>C synonymous_variant 0.13
rpoC 764752 c.1383G>C synonymous_variant 0.13
rpoC 764755 p.Asp462Glu missense_variant 0.13
rpoC 764760 p.Asn464Ser missense_variant 0.15
rpoC 764774 p.Ile469Val missense_variant 0.16
rpoC 764780 p.Ser471Ala missense_variant 0.12
rpoC 764785 c.1416C>G synonymous_variant 0.12
rpoC 764791 c.1422C>G synonymous_variant 0.12
rpoC 764804 p.Gln479Ala missense_variant 0.12
rpoC 764813 p.Gln482Glu missense_variant 0.11
rpoC 764818 c.1449G>C synonymous_variant 0.13
rpoC 764824 c.1455T>C synonymous_variant 0.14
rpoC 764833 c.1464A>G synonymous_variant 0.14
rpoC 764843 p.Ala492Thr missense_variant 0.15
rpoC 764858 c.1489T>C synonymous_variant 0.15
rpoC 764916 p.Leu516Pro missense_variant 0.92
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1305410 p.Ala827Val missense_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.3
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.56
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.56
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.77
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.72
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.73
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.71
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.71
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.7
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.7
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.7
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.7
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.71
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.7
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.7
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.71
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.73
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.71
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.71
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.68
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.66
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.56
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.5
rrs 1472436 n.591G>T non_coding_transcript_exon_variant 0.53
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.56
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.56
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.54
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.51
rrs 1472451 n.606C>A non_coding_transcript_exon_variant 0.56
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.51
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.53
rrs 1472461 n.616G>T non_coding_transcript_exon_variant 0.55
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.5
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.53
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.63
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.63
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.63
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.56
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.58
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.53
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.56
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.6
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.67
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.72
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.74
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.75
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.75
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.77
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.75
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.75
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.78
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.77
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.79
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.8
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.79
rrs 1472666 n.821G>A non_coding_transcript_exon_variant 0.75
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.75
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.73
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.73
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.73
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.79
rrs 1472694 n.849C>T non_coding_transcript_exon_variant 0.78
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.78
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.81
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.74
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.74
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.74
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.7
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.67
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.67
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.66
rrs 1472856 n.1012delA non_coding_transcript_exon_variant 0.66
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.68
rrs 1472864 n.1019C>T non_coding_transcript_exon_variant 0.68
rrs 1472865 n.1020C>T non_coding_transcript_exon_variant 0.68
rrs 1472873 n.1028C>A non_coding_transcript_exon_variant 0.68
rrs 1472876 n.1032delT non_coding_transcript_exon_variant 0.7
rrs 1472880 n.1036_1037dupCA non_coding_transcript_exon_variant 0.7
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.77
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.83
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.83
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.83
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.86
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.87
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.78
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.79
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.79
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.79
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.83
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.84
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.86
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.86
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.88
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.88
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.88
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.88
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.88
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.88
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.9
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.89
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.92
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.9
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.9
rrs 1473286 n.1441C>T non_coding_transcript_exon_variant 0.84
rrs 1473292 n.1447G>T non_coding_transcript_exon_variant 0.84
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.84
rrl 1473722 n.65G>T non_coding_transcript_exon_variant 0.18
rrl 1473729 n.72T>A non_coding_transcript_exon_variant 0.18
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.17
rrl 1473740 n.83G>A non_coding_transcript_exon_variant 0.17
rrl 1473743 n.86C>G non_coding_transcript_exon_variant 0.14
rrl 1473746 n.89T>A non_coding_transcript_exon_variant 0.13
rrl 1473754 n.97G>C non_coding_transcript_exon_variant 0.13
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.13
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.13
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.13
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.19
rrl 1473789 n.132G>C non_coding_transcript_exon_variant 0.16
rrl 1473792 n.135C>G non_coding_transcript_exon_variant 0.14
rrl 1473794 n.137A>G non_coding_transcript_exon_variant 0.14
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.14
rrl 1473801 n.144T>C non_coding_transcript_exon_variant 0.14
rrl 1473803 n.146G>C non_coding_transcript_exon_variant 0.14
rrl 1473806 n.149C>G non_coding_transcript_exon_variant 0.14
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.15
rrl 1473815 n.158T>A non_coding_transcript_exon_variant 0.15
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.15
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.33
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.35
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.29
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.31
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.27
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.27
rrl 1474110 n.453A>G non_coding_transcript_exon_variant 0.13
rrl 1474124 n.467G>C non_coding_transcript_exon_variant 0.42
rrl 1474128 n.471G>A non_coding_transcript_exon_variant 0.42
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.5
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.62
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.6
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.64
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.64
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.58
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.56
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.59
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.59
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.66
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.58
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.69
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.72
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.68
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.7
rrl 1474352 n.696_699delACAT non_coding_transcript_exon_variant 0.7
rrl 1474359 n.703_704insGTGG non_coding_transcript_exon_variant 0.66
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.66
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.56
rrl 1474406 n.749T>C non_coding_transcript_exon_variant 0.4
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.43
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.6
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.62
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.62
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.62
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.6
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.6
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.58
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.61
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.69
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.72
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.67
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.82
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.91
rrl 1474636 n.979A>G non_coding_transcript_exon_variant 0.91
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.91
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.91
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.91
rrl 1474651 n.995delT non_coding_transcript_exon_variant 0.93
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.95
rrl 1474662 n.1005C>G non_coding_transcript_exon_variant 0.95
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.95
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.96
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.95
rrl 1474688 n.1031G>C non_coding_transcript_exon_variant 0.95
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.95
rrl 1474709 n.1053delT non_coding_transcript_exon_variant 0.96
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.92
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.89
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.88
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.88
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.86
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.87
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.87
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.87
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.86
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.87
rrl 1474777 n.1120T>A non_coding_transcript_exon_variant 0.88
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.9
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.88
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.88
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.87
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.82
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.79
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.75
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.75
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.74
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.46
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.48
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.37
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.25
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.25
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.25
rrl 1475068 n.1411A>G non_coding_transcript_exon_variant 0.25
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.2
rrl 1475078 n.1421T>C non_coding_transcript_exon_variant 0.2
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.18
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.17
rrl 1475089 n.1432A>T non_coding_transcript_exon_variant 0.17
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.17
rrl 1475093 n.1436C>T non_coding_transcript_exon_variant 0.18
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.18
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.18
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.18
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.18
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.18
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.18
rrl 1475129 n.1472G>T non_coding_transcript_exon_variant 0.17
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.5
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.52
rrl 1475515 n.1858G>A non_coding_transcript_exon_variant 0.52
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.65
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.67
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.69
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.69
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.69
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.69
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.81
rrl 1475602 n.1945G>T non_coding_transcript_exon_variant 0.81
rrl 1475628 n.1971G>A non_coding_transcript_exon_variant 0.84
rrl 1475632 n.1976_1980delGGGAT non_coding_transcript_exon_variant 0.84
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.85
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.86
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.86
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.94
rrl 1475706 n.2049A>C non_coding_transcript_exon_variant 0.94
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.94
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.94
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.94
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.94
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.94
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.94
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.94
rrl 1475767 n.2110G>A non_coding_transcript_exon_variant 0.94
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.94
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.94
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.93
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.89
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.92
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.92
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.92
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.94
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.92
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.9
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.91
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.91
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.89
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.9
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.92
rrl 1475996 n.2339T>A non_coding_transcript_exon_variant 0.92
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.92
rrl 1476026 n.2369T>G non_coding_transcript_exon_variant 0.85
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.85
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.83
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.85
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.83
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.85
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.81
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.81
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.81
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.83
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.82
rrl 1476081 n.2424A>T non_coding_transcript_exon_variant 0.8
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.82
rrl 1476085 n.2429_2430delGC non_coding_transcript_exon_variant 0.86
rrl 1476089 n.2432_2433insTC non_coding_transcript_exon_variant 0.86
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.86
rrl 1476100 n.2443A>T non_coding_transcript_exon_variant 0.84
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.84
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.88
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.86
rrl 1476113 n.2456T>A non_coding_transcript_exon_variant 0.86
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.88
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.89
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.89
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.91
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.94
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.93
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.94
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.94
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.94
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.94
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.94
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.94
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.92
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.92
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.92
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.92
rrl 1476261 n.2604A>G non_coding_transcript_exon_variant 0.92
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.92
rrl 1476268 n.2611A>G non_coding_transcript_exon_variant 0.92
rrl 1476275 n.2618T>C non_coding_transcript_exon_variant 0.92
rrl 1476276 n.2619C>A non_coding_transcript_exon_variant 0.92
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.92
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.93
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.92
rrl 1476299 n.2642C>A non_coding_transcript_exon_variant 0.92
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.92
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.92
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.92
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.87
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.85
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.85
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.86
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.77
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.77
rrl 1476443 n.2786G>A non_coding_transcript_exon_variant 0.73
rrl 1476455 n.2798C>T non_coding_transcript_exon_variant 0.68
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.68
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.57
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.53
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.5
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.51
rrl 1476528 n.2871A>T non_coding_transcript_exon_variant 0.51
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.52
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.51
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.52
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.42
rrl 1476572 n.2915G>T non_coding_transcript_exon_variant 0.33
rrl 1476573 n.2916A>G non_coding_transcript_exon_variant 0.33
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.27
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.18
rrl 1476596 n.2939C>T non_coding_transcript_exon_variant 0.18
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.11
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.12
rrl 1476624 n.2967T>C non_coding_transcript_exon_variant 0.12
rrl 1476625 n.2968C>G non_coding_transcript_exon_variant 0.12
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.13
rpsA 1833661 c.120A>G synonymous_variant 0.13
rpsA 1833668 p.Ile43Val missense_variant 0.11
rpsA 1833721 c.180A>G synonymous_variant 0.11
rpsA 1833727 c.186G>C synonymous_variant 0.13
rpsA 1833734 p.Ala65Ser missense_variant 0.14
rpsA 1833742 c.201A>G synonymous_variant 0.14
rpsA 1833770 p.Asn77Gly missense_variant 0.14
rpsA 1833781 c.240T>C synonymous_variant 0.12
rpsA 1833782 p.Ser81Ala missense_variant 0.12
rpsA 1833790 c.249T>C synonymous_variant 0.12
rpsA 1833797 p.Val86Ile missense_variant 0.12
rpsA 1833802 c.261A>G synonymous_variant 0.12
rpsA 1833808 c.267G>C synonymous_variant 0.12
rpsA 1833811 c.270G>C synonymous_variant 0.12
rpsA 1833815 p.Thr92Gln missense_variant 0.13
rpsA 1833829 c.288A>G synonymous_variant 0.12
rpsA 1833832 c.291G>A synonymous_variant 0.14
rpsA 1833841 c.300C>G synonymous_variant 0.13
rpsA 1833847 c.306C>G synonymous_variant 0.13
rpsA 1833856 c.315A>G synonymous_variant 0.13
rpsA 1833862 c.321G>C synonymous_variant 0.13
rpsA 1833874 c.333T>C synonymous_variant 0.12
rpsA 1833970 c.429G>T synonymous_variant 0.14
rpsA 1833979 c.438T>C synonymous_variant 0.22
rpsA 1833985 c.444G>C synonymous_variant 0.31
rpsA 1833994 c.453G>C synonymous_variant 0.3
rpsA 1833997 c.456G>C synonymous_variant 0.29
rpsA 1834000 c.459G>C synonymous_variant 0.28
rpsA 1834009 c.468C>T synonymous_variant 0.29
rpsA 1834012 c.471G>C synonymous_variant 0.28
rpsA 1834015 c.474G>C synonymous_variant 0.28
rpsA 1834018 c.477C>T synonymous_variant 0.29
rpsA 1834024 c.483G>C synonymous_variant 0.3
rpsA 1834030 c.489C>G synonymous_variant 0.3
rpsA 1834034 p.Ile165Val missense_variant 0.29
rpsA 1834040 p.Lys167Gln missense_variant 0.29
rpsA 1834054 c.513C>G synonymous_variant 0.27
rpsA 1834069 c.528G>C synonymous_variant 0.25
rpsA 1834093 c.552G>C synonymous_variant 0.24
rpsA 1834099 c.558C>G synonymous_variant 0.2
rpsA 1834102 c.561T>C synonymous_variant 0.18
rpsA 1834110 p.Trp190Tyr missense_variant 0.16
rpsA 1834118 p.Gln193Glu missense_variant 0.17
rpsA 1834131 p.Glu197Ala missense_variant 0.13
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834222 c.681T>C synonymous_variant 0.16
rpsA 1834225 c.684C>G synonymous_variant 0.15
rpsA 1834231 c.690T>C synonymous_variant 0.16
rpsA 1834240 c.699T>C synonymous_variant 0.15
rpsA 1834243 c.702G>C synonymous_variant 0.15
rpsA 1834249 c.708T>C synonymous_variant 0.16
rpsA 1834261 c.720A>G synonymous_variant 0.21
rpsA 1834264 c.723G>C synonymous_variant 0.2
rpsA 1834294 c.753G>C synonymous_variant 0.2
rpsA 1834298 p.Gln253Glu missense_variant 0.2
rpsA 1834303 c.762T>C synonymous_variant 0.2
rpsA 1834307 p.Asp256Gln missense_variant 0.2
rpsA 1834310 p.Glu257Lys missense_variant 0.21
rpsA 1834317 p.Thr259Lys missense_variant 0.2
rpsA 1834327 c.786G>C synonymous_variant 0.22
rpsA 1834330 c.789C>G synonymous_variant 0.22
rpsA 1834348 c.807T>C synonymous_variant 0.24
rpsA 1834354 c.813G>C synonymous_variant 0.23
rpsA 1834357 c.816T>C synonymous_variant 0.23
rpsA 1834360 c.819G>C synonymous_variant 0.24
rpsA 1834361 c.820T>C synonymous_variant 0.24
rpsA 1834366 c.825A>G synonymous_variant 0.24
rpsA 1834369 c.828C>G synonymous_variant 0.24
rpsA 1834378 c.837T>C synonymous_variant 0.24
rpsA 1834384 c.843A>G synonymous_variant 0.26
rpsA 1834390 c.849G>C synonymous_variant 0.28
rpsA 1834395 p.Arg285Gln missense_variant 0.3
rpsA 1834398 p.His286Leu missense_variant 0.32
rpsA 1834411 c.870T>C synonymous_variant 0.32
rpsA 1834417 c.876G>C synonymous_variant 0.3
rpsA 1834423 c.882G>C synonymous_variant 0.3
rpsA 1834424 p.Gln295Glu missense_variant 0.3
rpsA 1834427 p.Ile296Val missense_variant 0.3
rpsA 1834435 c.894G>C synonymous_variant 0.29
rpsA 1834451 c.910T>C synonymous_variant 0.25
rpsA 1834456 c.915T>C synonymous_variant 0.23
rpsA 1834459 c.918G>C synonymous_variant 0.23
rpsA 1834465 c.924T>C synonymous_variant 0.22
rpsA 1834468 c.927A>G synonymous_variant 0.23
rpsA 1834486 p.Glu315Asp missense_variant 0.24
rpsA 1834489 c.948T>C synonymous_variant 0.24
rpsA 1834501 c.960G>C synonymous_variant 0.28
rpsA 1834523 p.Glu328Gln missense_variant 0.21
rpsA 1834534 c.993C>G synonymous_variant 0.18
rpsA 1834537 p.Glu332Asp missense_variant 0.19
rpsA 1834538 p.Val333Leu missense_variant 0.19
rpsA 1834546 p.Asp335Glu missense_variant 0.17
rpsA 1834552 c.1011G>C synonymous_variant 0.17
rpsA 1834555 c.1014T>C synonymous_variant 0.17
rpsA 1834556 p.Ala339Thr missense_variant 0.17
rpsA 1834563 p.Gly341Asp missense_variant 0.17
rpsA 1834565 p.Asp342Gln missense_variant 0.16
rpsA 1834572 p.Ala344Val missense_variant 0.17
rpsA 1834574 p.Met345Phe missense_variant 0.17
rpsA 1834600 c.1059G>C synonymous_variant 0.15
rpsA 1834606 c.1065C>T synonymous_variant 0.15
rpsA 1834609 c.1068T>C synonymous_variant 0.15
rpsA 1834619 c.1078T>C synonymous_variant 0.15
rpsA 1834624 c.1083G>C synonymous_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918057 p.Val40Leu missense_variant 0.15
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169269 c.1344A>G synonymous_variant 0.19
PPE35 2169272 c.1341C>G synonymous_variant 0.19
PPE35 2169278 c.1335T>C synonymous_variant 0.19
PPE35 2169281 c.1332T>G synonymous_variant 0.17
PPE35 2170048 p.Leu189Val missense_variant 0.3
PPE35 2170053 p.Thr187Ser missense_variant 0.27
Rv1979c 2222553 c.612G>T synonymous_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289741 c.-501dupG upstream_gene_variant 1.0
kasA 2518626 p.Cys171Phe missense_variant 0.11
ahpC 2726553 p.Ala121Ser missense_variant 0.12
Rv2752c 3064901 p.Leu431Met missense_variant 0.12
thyA 3074336 p.Thr46Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339410 p.Ala98Gly missense_variant 0.12
Rv3083 3449738 p.His412Arg missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4244659 p.Leu476Pro missense_variant 0.14
embA 4245130 p.Pro633Leu missense_variant 1.0
embB 4246544 p.Thr11Pro missense_variant 0.21
embB 4246548 p.Pro12Gln missense_variant 0.16
embB 4246555 c.42G>C synonymous_variant 0.17
embB 4246556 p.Ala15Pro missense_variant 0.17
embB 4246563 p.Leu17Trp missense_variant 0.17
embB 4246567 c.54G>T synonymous_variant 0.17
aftB 4267647 p.Asp397Gly missense_variant 1.0
ethA 4327250 p.Ile75Thr missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0