TB-Profiler result

Run: SRR12708371
Summary

Run ID: SRR12708371

Sample name:

Date: 2024-04-14T05:53:34.426529

Number of reads: 649661

Percentage reads mapped: 56.96

Median coverage: 19.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.1.3 Euro-American (X-type) RD193 1.0
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 705 c.705A>G synonymous_variant 0.23 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.23 isoniazid
dnaA 714 c.714C>T synonymous_variant 0.28 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.29 isoniazid
gyrB 6745 c.1506T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6772 c.1533C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8846 c.1545C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734460 c.207G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760910 c.1104C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.54 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.26 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.26 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.47 rifampicin Uncertain significance
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.19 rifampicin
rpoC 762956 c.-414G>C upstream_gene_variant 0.23 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.24 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.16 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.36 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764666 c.1297_1299delGGCinsCT frameshift_variant&missense_variant 0.62 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.29 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.3 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.27 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765421 c.2052C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.3 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.25 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.28 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781817 c.258G>T synonymous_variant 0.29 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.39 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.37 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.32 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.28 streptomycin
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
atpE 1461161 c.117C>G synonymous_variant 0.21 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.21 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.18 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.21 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.22 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.21 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404_1408delCAAGGinsAAGA non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475761 n.2104_2108delCGCAAinsACTTCG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867delCinsGA non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833676 c.135A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.47 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.45 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.37 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.44 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.27 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.25 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.23 isoniazid
Rv2477c 2783485 c.558G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783491 c.552C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783515 c.528C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626786 c.564A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.39 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878217 c.289_291delCTAinsGG frameshift_variant&missense_variant 0.32 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039646 p.Glu353Asp missense_variant 0.26 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039652 c.1051_1053delACGinsTC frameshift_variant&missense_variant 0.25 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.34 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.58 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.28 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040429 c.274_276delTTGinsCC frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4243190 c.-43G>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407798 c.405G>T synonymous_variant 1.0 streptomycin Not assoc w R