TB-Profiler result

Run: ERR8665994
Summary

Run ID: ERR8665994

Sample name:

Date: 2024-04-14T02:47:31.654725

Number of reads: 167937

Percentage reads mapped: 24.89

Median coverage: 2.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.9 Euro-American (H37Rv-like) None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1948_1950delCGCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 1.0 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1304878 c.1948_1950delCGCinsAG frameshift_variant&missense_variant 0.9 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 1.0 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 897 c.897A>G synonymous_variant 0.82 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.85 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.85 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.85 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.85 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.85 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.8 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.73 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.73 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.73 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.75 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.75 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.75 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.9 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.9 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.9 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.91 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.92 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.92 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.91 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.83 isoniazid
dnaA 1053 c.1053C>G synonymous_variant 0.85 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>G synonymous_variant 0.85 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.85 isoniazid
dnaA 1071 c.1071C>G synonymous_variant 0.85 isoniazid
dnaA 1074 c.1074C>G synonymous_variant 0.88 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.95 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.95 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.95 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.95 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.96 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.96 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.92 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.91 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.91 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.9 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.9 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.91 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.9 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.95 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.95 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.85 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.82 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.82 isoniazid Not assoc w R - Interim
dnaA 1359 c.1359G>A synonymous_variant 0.86 isoniazid Not assoc w R - Interim
dnaA 1365 c.1365C>G synonymous_variant 0.81 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.82 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.88 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.88 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.93 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.93 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.93 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.87 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.87 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.87 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.86 isoniazid
dnaA 1419 c.1419C>G synonymous_variant 0.87 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.88 isoniazid
dnaA 1461 c.1461C>A synonymous_variant 0.85 isoniazid
dnaA 1464 c.1464T>C synonymous_variant 0.85 isoniazid
dnaA 1470 c.1470C>G synonymous_variant 0.83 isoniazid
dnaA 1473 c.1473T>C synonymous_variant 0.83 isoniazid Not assoc w R - Interim
dnaA 1485 c.1485A>G synonymous_variant 0.83 isoniazid
gyrB 6214 c.975G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.94 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>A synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6652 c.-650C>G upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.96 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.96 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.92 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrB 6937 c.1698G>A synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.88 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrB 6973 c.1734G>A synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6976 c.-326A>G upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>G upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.93 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.91 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.81 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.87 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.86 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9191 c.1890G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
Rv0565c 657189 c.282C>G synonymous_variant 0.93 ethionamide
Rv0565c 657192 p.Met93Thr missense_variant 0.93 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.93 ethionamide
Rv0565c 657219 p.Ala84Val missense_variant 0.93 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.93 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.94 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.94 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 1.0 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 1.0 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 1.0 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 1.0 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 1.0 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.9 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 1.0 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 1.0 ethionamide
hadA 731681 c.-249A>C upstream_gene_variant 1.0 isoniazid
hadA 731690 c.-240A>C upstream_gene_variant 1.0 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 1.0 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 1.0 isoniazid
hadA 731701 c.-229A>G upstream_gene_variant 1.0 isoniazid
hadA 731702 c.-228G>C upstream_gene_variant 1.0 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 1.0 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 1.0 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 1.0 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 1.0 isoniazid
hadA 731741 c.-189G>A upstream_gene_variant 1.0 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 1.0 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 1.0 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 1.0 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.91 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.91 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.91 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.92 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.92 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.92 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.93 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.94 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.91 isoniazid
nusG 734472 c.219T>C synonymous_variant 1.0 rifampicin
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 1.0 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.94 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.93 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.9 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.94 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.94 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.93 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.93 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.93 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.93 rifampicin
nusG 734865 c.612G>C synonymous_variant 1.0 rifampicin
nusG 734882 p.Ala210Gly missense_variant 1.0 rifampicin
nusG 734886 c.633A>G synonymous_variant 1.0 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.85 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.85 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.9 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.95 rifampicin
rpoB 760181 c.375T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.95 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.81 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.83 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.88 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.88 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.89 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.94 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.95 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.95 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.95 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.88 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.83 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.8 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.92 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.92 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.94 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 1.0 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 1.0 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 1.0 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 1.0 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 1.0 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 1.0 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 1.0 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 1.0 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 1.0 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 1.0 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 1.0 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 1.0 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 1.0 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 1.0 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 1.0 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.91 rifampicin
rpoB 761373 p.Val523His missense_variant 0.91 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 1.0 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 1.0 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.94 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.94 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 1.0 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 1.0 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 1.0 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 1.0 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 1.0 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 1.0 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 1.0 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 1.0 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 1.0 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 1.0 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 1.0 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.91 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 1.0 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.96 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.95 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.94 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.92 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.92 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.92 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.92 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>G synonymous_variant 0.95 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 1.0 rifampicin
rpoC 763642 c.273G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 763675 c.306C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.94 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.94 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.94 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.94 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.93 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.92 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.92 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.91 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.91 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.88 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.87 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.93 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 1.0 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 1.0 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 1.0 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 1.0 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 1.0 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 1.0 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 1.0 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.95 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.95 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.95 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.94 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.94 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.94 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.93 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.93 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.93 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.94 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.95 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.95 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.94 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.94 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 1.0 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 1.0 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 1.0 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 1.0 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 1.0 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 1.0 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 1.0 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 1.0 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 1.0 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 1.0 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 1.0 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 1.0 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 1.0 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 1.0 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 1.0 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 1.0 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 1.0 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 1.0 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 1.0 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 1.0 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 1.0 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 1.0 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 1.0 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 1.0 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 1.0 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 1.0 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 1.0 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 1.0 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 1.0 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 1.0 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
mmpL5 775829 c.2652C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775832 c.2647_2649delGCCinsTG frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775847 c.2634G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 1.0 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 1.0 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775898 c.2583G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 1.0 clofazimine
bedaquiline
mmpL5 775912 c.2569C>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.96 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 1.0 clofazimine
bedaquiline
mmpL5 775970 c.2511G>C synonymous_variant 0.92 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 1.0 clofazimine
bedaquiline
rpsL 781682 c.123T>C synonymous_variant 1.0 streptomycin
rpsL 781715 c.156T>C synonymous_variant 1.0 streptomycin
rpsL 781728 c.169T>C synonymous_variant 1.0 streptomycin
rpsL 781736 c.177T>C synonymous_variant 1.0 streptomycin
rpsL 781751 c.192G>C synonymous_variant 1.0 streptomycin
rpsL 781754 c.195G>C synonymous_variant 1.0 streptomycin
rpsL 781760 c.201T>C synonymous_variant 1.0 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 1.0 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 1.0 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 1.0 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 1.0 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 1.0 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 1.0 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.99 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.99 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.97 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.97 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.97 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.97 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.97 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.97 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.97 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.97 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.97 linezolid
rplC 800865 c.57A>G synonymous_variant 1.0 linezolid
rplC 800867 p.Ser20Asn missense_variant 1.0 linezolid
rplC 800874 c.66A>G synonymous_variant 1.0 linezolid
rplC 800877 c.69A>C synonymous_variant 1.0 linezolid
rplC 800880 c.72A>G synonymous_variant 1.0 linezolid
rplC 800889 c.81C>G synonymous_variant 1.0 linezolid
rplC 800907 c.99C>G synonymous_variant 1.0 linezolid
fbiC 1303785 c.855G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.91 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
sigE 1364748 c.336G>C synonymous_variant 0.92 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.93 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.92 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.92 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 1.0 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 1.0 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 1.0 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 1.0 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 1.0 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 1.0 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 1.0 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
atpE 1461149 c.105T>G synonymous_variant 1.0 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 1.0 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 1.0 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 1.0 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 1.0 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 1.0 bedaquiline
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 1.0 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.92 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.95 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.91 ethionamide
isoniazid
rpsA 1833970 c.429G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 1.0 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 1.0 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.96 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.98 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.98 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.98 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 1.0 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
ndh 2102533 c.510A>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102545 c.498G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102559 p.Ser162Arg missense_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102566 c.477A>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102572 c.471A>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102575 c.468G>A synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102581 c.462T>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102589 c.454T>C synonymous_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102590 c.453A>C synonymous_variant 0.83 ethionamide
delamanid
isoniazid
ndh 2102593 c.450C>G synonymous_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102596 c.447C>G synonymous_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102599 c.444T>C synonymous_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102604 p.Leu147Val missense_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102608 c.433_435delTTGinsCC frameshift_variant&missense_variant 0.92 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102635 c.408C>G synonymous_variant 0.92 ethionamide
delamanid
isoniazid
ndh 2102638 c.405A>G synonymous_variant 0.93 ethionamide
delamanid
isoniazid
ndh 2102644 c.399A>G synonymous_variant 0.93 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>G synonymous_variant 0.92 ethionamide
delamanid
isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.91 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.91 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.91 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.92 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.94 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.94 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.93 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.93 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.92 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.93 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.93 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.92 isoniazid
kasA 2518696 c.582C>G synonymous_variant 1.0 isoniazid
kasA 2518702 c.588C>T synonymous_variant 1.0 isoniazid
kasA 2518711 c.597A>G synonymous_variant 1.0 isoniazid
kasA 2518714 c.600A>C synonymous_variant 1.0 isoniazid
kasA 2518732 c.618C>G synonymous_variant 1.0 isoniazid
kasA 2518741 c.627G>C synonymous_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 1.0 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 1.0 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 1.0 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 1.0 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 1.0 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 1.0 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 1.0 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 1.0 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 p.Thr301Met missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067718 c.228C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 1.0 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 1.0 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.93 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.93 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.93 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 1.0 para-aminosalicylic_acid
lpqB 3624266 c.645T>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624276 p.Arg212His missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624317 c.594C>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624323 c.588G>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624335 c.576C>T synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624371 c.540T>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.93 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.93 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.92 bedaquiline
rifampicin
lpqB 3624476 c.435C>G synonymous_variant 0.92 bedaquiline
rifampicin
lpqB 3624482 c.429T>C synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.91 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624491 c.420G>C synonymous_variant 0.91 bedaquiline
rifampicin
lpqB 3624512 c.399C>G synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624518 c.393T>C synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624521 c.390G>C synonymous_variant 0.9 bedaquiline
rifampicin
lpqB 3624556 p.Val119Met missense_variant 0.73 bedaquiline
rifampicin Uncertain significance
lpqB 3624557 c.354T>C synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624563 c.348C>G synonymous_variant 0.73 bedaquiline
rifampicin
lpqB 3624572 c.339C>G synonymous_variant 0.8 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 1.0 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.9 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.83 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 1.0 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 1.0 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 1.0 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 1.0 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 1.0 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 1.0 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 1.0 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 1.0 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 1.0 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 1.0 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 1.0 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 1.0 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 1.0 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 1.0 rifampicin
rpoA 3878838 c.-331A>C upstream_gene_variant 1.0 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 1.0 rifampicin
rpoA 3878842 c.-335G>C upstream_gene_variant 1.0 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 1.0 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 1.0 rifampicin
clpC1 4038359 c.2346A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.93 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 1.0 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 1.0 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.93 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.92 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.92 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.88 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.96 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
embB 4247437 c.924A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 1.0 ethambutol
embB 4248127 c.1614G>C synonymous_variant 1.0 ethambutol
embB 4248133 c.1620C>G synonymous_variant 1.0 ethambutol
embB 4248142 c.1629T>C synonymous_variant 1.0 ethambutol
embB 4248143 c.1630T>C synonymous_variant 1.0 ethambutol
embB 4248157 c.1644A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 1.0 ethambutol
embB 4248220 c.1707A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 1.0 ethambutol
embB 4248265 c.1752C>T synonymous_variant 1.0 ethambutol
embB 4248266 c.1753C>T synonymous_variant 1.0 ethambutol
embB 4248277 c.1764G>C synonymous_variant 1.0 ethambutol
embB 4248298 c.1785C>T synonymous_variant 1.0 ethambutol
embB 4248304 c.1791G>C synonymous_variant 1.0 ethambutol