TB-Profiler result

Run: ERR9786444
Summary

Run ID: ERR9786444

Sample name:

Date: 2024-10-04T00:17:06.602869

Number of reads: 2984070

Percentage reads mapped: 83.96

Median coverage: 130.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.97
lineage4.8 Euro-American (mainly T) RD219 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8426 c.1125G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8597 c.1296C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8684 c.1383G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8789 c.1488C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8982 p.Cys561Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
mshA 575695 c.348C>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.18 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575953 c.606G>C synonymous_variant 0.16 isoniazid
ethionamide
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.19 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760466 c.660C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.23 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.2 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.17 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.17 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.17 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.2 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.19 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.19 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761435 c.1629T>C synonymous_variant 0.16 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.15 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.16 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.16 rifampicin
rpoB 761627 c.1821C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.18 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.19 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.17 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.16 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.17 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.17 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.17 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.19 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.2 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.23 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.24 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.23 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.27 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.22 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.22 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.23 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.24 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.22 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.22 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.22 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.23 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.2 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>G synonymous_variant 0.2 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.24 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.24 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.22 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.21 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.19 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.17 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.17 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.29 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.26 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763136 c.-234C>G upstream_gene_variant 0.2 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.18 rifampicin
rpoC 763178 c.-192G>C upstream_gene_variant 0.2 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.19 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.18 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.17 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.17 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.19 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.21 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.22 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.25 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.25 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.23 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.22 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.23 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.21 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.23 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.21 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.19 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.16 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.17 rifampicin
rpoC 763859 p.Asp164Asn missense_variant 0.16 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.17 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.18 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.2 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.2 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763972 c.603C>T synonymous_variant 0.21 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.22 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.2 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.18 rifampicin
rpoC 764002 c.633C>T synonymous_variant 0.19 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.2 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.21 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.24 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.25 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764152 c.783C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.22 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.22 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.2 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.21 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.21 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.19 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.19 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.2 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.2 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.2 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.25 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.23 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.21 rifampicin
rpoC 764585 c.1216_1218delCTCinsTTG synonymous_variant 0.19 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.21 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.23 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.19 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.17 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.17 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.16 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.16 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.17 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 765013 c.1644C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765292 c.1923G>T synonymous_variant 0.15 rifampicin
rpoC 765325 c.1956C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765330 p.Ser654Asn missense_variant 0.15 rifampicin Uncertain significance
rpoC 765370 c.2001G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.19 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.19 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.17 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.17 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.16 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.21 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.21 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365_2367delTTGinsCTC synonymous_variant 0.24 rifampicin
rpoC 765739 c.2370G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.21 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.21 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.27 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.29 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.28 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.27 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.21 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.2 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Thr missense_variant 0.16 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.17 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.17 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.16 rifampicin
rpoC 766061 p.Val898Leu missense_variant 0.18 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.16 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.15 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.18 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.19 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.2 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.2 rifampicin
rpoC 766486 c.3117A>C synonymous_variant 0.2 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.23 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.18 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.18 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.19 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 766568 p.Val1067Ile missense_variant 0.19 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.18 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.17 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.18 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.18 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.18 rifampicin Not assoc w R
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.18 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.19 rifampicin
rpoC 766696 c.3327G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766708 c.3339A>G synonymous_variant 0.2 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.2 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.28 rifampicin
rpoC 766882 c.3513C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.28 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.27 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.25 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.24 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.22 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.19 rifampicin
rpoC 767020 c.3651C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.19 streptomycin
rpsL 781664 c.105C>T synonymous_variant 0.19 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.18 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.17 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.17 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.17 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.17 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.18 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.18 streptomycin
rpsL 781817 c.258G>A synonymous_variant 0.18 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.16 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.16 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.18 streptomycin
rpsL 781910 c.351C>T synonymous_variant 0.18 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.17 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.16 streptomycin
rplC 801385 c.577C>T synonymous_variant 0.15 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674428 p.Gly76Asp missense_variant 0.14 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674443 p.Ala81Glu missense_variant 0.15 isoniazid
ethionamide
inhA 1674450 c.249G>T synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674452 p.Ala84Glu missense_variant 0.18 isoniazid
ethionamide
inhA 1674465 c.264C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674501 c.300G>A synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.21 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674570 c.369G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.29 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674651 c.450C>T synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.34 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674696 c.495G>A synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674703 c.502_504delTTGinsCTC synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.24 isoniazid
ethionamide
inhA 1674756 c.555T>A synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674762 c.561T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674780 c.579T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674799 c.598_600delAGTinsTCC synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674804 c.603G>C synonymous_variant 0.19 isoniazid
ethionamide Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.19 isoniazid
ethionamide
inhA 1674849 c.648G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674858 c.657G>A synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674879 c.678T>G synonymous_variant 0.15 isoniazid
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833771 p.Asn77Ser missense_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833868 c.327C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833895 c.354G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833991 c.450C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833995 c.454C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834087 c.546C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834150 c.609G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.2 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGT synonymous_variant 0.25 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.2 pyrazinamide
tsnR 1853370 c.-236G>T upstream_gene_variant 0.14 linezolid
tsnR 1853381 c.-225C>T upstream_gene_variant 0.15 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289808 c.-567C>T upstream_gene_variant 1.0 pyrazinamide
Rv2477c 2783038 p.Ala335Thr missense_variant 0.17 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783080 c.963G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783110 c.933C>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783170 c.873C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783173 c.870C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783200 c.843G>A synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783206 c.837G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783800 c.243G>A synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783812 c.231G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783950 c.93C>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
Rv2752c 3065979 c.213T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065990 p.Glu68* stop_gained 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065993 p.Val67Ile missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066637 c.-446C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066653 c.-462A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066658 c.-467A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066660 c.-469C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066676 c.-485C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066686 c.-495G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066690 c.-499C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066696 c.-505T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066714 c.-523G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
ald 3086796 c.-24C>T upstream_gene_variant 1.0 cycloserine
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
lpqB 3625630 c.-720C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625637 p.Ala326Asp missense_variant 0.15 rifampicin
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625675 c.-765G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625695 c.-785C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.18 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625867 c.747A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625909 c.-999T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625912 c.702G>C synonymous_variant 0.19 rifampicin
bedaquiline
mtrB 3625915 c.699G>C synonymous_variant 0.2 rifampicin
bedaquiline
mtrB 3625927 c.687T>C synonymous_variant 0.17 rifampicin
bedaquiline
mtrB 3625930 c.684C>G synonymous_variant 0.17 rifampicin
bedaquiline
mtrB 3626006 p.Ser203Asn missense_variant 0.16 rifampicin
bedaquiline
mtrB 3626009 p.Ala202Lys missense_variant 0.16 rifampicin
bedaquiline
mtrB 3626017 c.597T>C synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3626798 c.-185T>A upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626879 c.-266G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626885 c.-272A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626966 c.-353C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626999 c.-386G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627056 c.294C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
rpoA 3877695 c.813C>T synonymous_variant 0.15 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.18 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>C synonymous_variant 0.19 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.19 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877941 c.567C>T synonymous_variant 0.18 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.19 rifampicin
rpoA 3877968 c.540C>G synonymous_variant 0.19 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.19 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.19 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.2 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.2 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.21 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.22 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.24 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.24 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.23 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.25 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.24 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.3 rifampicin
rpoA 3878284 p.Glu75Ala missense_variant 0.28 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.26 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.25 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.26 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.26 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.26 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.25 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.24 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.24 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.21 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.21 rifampicin
rpoA 3878451 c.57C>G synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.21 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.18 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.15 rifampicin
rpoA 3878698 c.-191A>C upstream_gene_variant 0.22 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878755 c.-248G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878758 c.-251G>T upstream_gene_variant 0.29 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.29 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.34 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878950 c.-443C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.27 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.29 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.19 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.16 rifampicin
clpC1 4038908 c.1797C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
glpK 4138464 p.Gly431Ala missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239027 c.-836A>G upstream_gene_variant 0.16 ethambutol
embC 4239042 c.-821A>G upstream_gene_variant 0.18 ethambutol
embC 4239057 c.-806A>G upstream_gene_variant 0.18 ethambutol
embC 4239062 c.-801C>G upstream_gene_variant 0.19 ethambutol
embC 4239065 c.-798G>C upstream_gene_variant 0.19 ethambutol
embC 4239068 c.-795A>T upstream_gene_variant 0.19 ethambutol
embC 4239071 c.-792A>G upstream_gene_variant 0.19 ethambutol Uncertain significance
embC 4239076 c.-787C>T upstream_gene_variant 0.19 ethambutol
embC 4239079 c.-784_-783delCAinsGG upstream_gene_variant 0.19 ethambutol
embC 4239101 c.-762C>T upstream_gene_variant 0.21 ethambutol
embC 4239110 c.-753C>G upstream_gene_variant 0.21 ethambutol
embC 4239111 c.-752G>A upstream_gene_variant 0.2 ethambutol
embC 4239125 c.-738C>G upstream_gene_variant 0.19 ethambutol
embC 4240688 c.826C>T synonymous_variant 0.15 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.15 ethambutol
embC 4240717 p.His285Gln missense_variant 0.18 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240747 c.885C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240771 c.909G>A synonymous_variant 0.2 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.22 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.22 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.24 ethambutol
embC 4240801 c.939C>T synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.24 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.23 ethambutol
embC 4240831 c.969T>C synonymous_variant 0.24 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.22 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.21 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.2 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.21 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.2 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.22 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.22 ethambutol
embC 4240912 c.1050G>C synonymous_variant 0.25 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.24 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.22 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.22 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.22 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.22 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.22 ethambutol
embC 4240979 p.Thr373Gln missense_variant 0.24 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.23 ethambutol
embC 4240987 c.1125G>C synonymous_variant 0.23 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.24 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.25 ethambutol
embC 4241008 c.1146G>C synonymous_variant 0.25 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.25 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.25 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.25 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.25 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.25 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.25 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.25 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.26 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.24 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.26 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.25 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.22 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.17 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.16 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.17 ethambutol
embC 4241498 p.Val546Ile missense_variant 0.16 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.16 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.17 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.17 ethambutol
embC 4241533 c.1671T>C synonymous_variant 0.17 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.18 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241542 c.1680C>G synonymous_variant 0.18 ethambutol
embC 4241545 c.1683T>C synonymous_variant 0.19 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.19 ethambutol
embC 4241554 c.1692G>C synonymous_variant 0.22 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.21 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.22 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.22 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.22 ethambutol
embC 4241591 p.Leu577Ile missense_variant 0.24 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.25 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.25 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.29 ethambutol
embC 4241631 p.Phe590Tyr missense_variant 0.3 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.25 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241657 p.Ser599Pro missense_variant 0.17 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.17 ethambutol
embC 4241677 c.1815G>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4246080 p.Pro950Ser missense_variant 0.15 ethambutol
embA 4246085 p.Glu951Asp missense_variant 0.15 ethambutol Not assoc w R
embA 4246088 c.2856A>G synonymous_variant 0.16 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.18 ethambutol
embB 4246109 c.-405C>G upstream_gene_variant 0.16 ethambutol
embB 4246115 c.-399T>G upstream_gene_variant 0.16 ethambutol
embA 4246126 p.Glu965Gly missense_variant 0.18 ethambutol
embA 4246128 p.Ser966Thr missense_variant 0.18 ethambutol
embA 4246138 p.Arg969Gln missense_variant 0.18 ethambutol
embB 4246140 c.-374T>C upstream_gene_variant 0.17 ethambutol
embA 4246150 c.2919delA frameshift_variant 0.17 ethambutol Uncertain significance
embA 4246154 c.2922_2923insC frameshift_variant 0.17 ethambutol Uncertain significance
embB 4246157 c.-357A>G upstream_gene_variant 0.17 ethambutol
embA 4246164 c.2932T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.17 ethambutol
embB 4246187 c.-327C>G upstream_gene_variant 0.17 ethambutol
embA 4246204 p.Arg991His missense_variant 0.18 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.18 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.17 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4246227 p.Ile999Val missense_variant 0.17 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4246250 c.-264G>C upstream_gene_variant 0.16 ethambutol
embB 4248100 c.1587C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4248118 c.1605T>C synonymous_variant 0.16 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.17 ethambutol
embB 4248133 c.1620C>T synonymous_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.17 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.17 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.21 ethambutol
embB 4248173 p.Val554Met missense_variant 0.2 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248200 p.Ile563Val missense_variant 0.23 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.23 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.24 ethambutol Uncertain significance
embB 4248232 c.1719G>C synonymous_variant 0.22 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.22 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4248295 c.1782C>T synonymous_variant 0.21 ethambutol
embB 4248313 c.1800C>G synonymous_variant 0.18 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.17 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.17 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R