TB-Profiler result

Run: ERR4831621
Summary

Run ID: ERR4831621

Sample name:

Date: 2024-10-04T17:52:58.065972

Number of reads: 650096

Percentage reads mapped: 56.03

Median coverage: 21.0

Strain: lineage2.2.1.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
lineage2.2.1.1 East-Asian (Beijing) RD105;RD207;RD181;RD150 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu430Pro Assoc w R
p.Met434Ile Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761095 p.Leu430Pro missense_variant 0.86 rifampicin Assoc w R
rpoB 761108 p.Met434Ile missense_variant 0.86 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpsL 781822 p.Lys88Arg missense_variant 0.65 streptomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247429 p.Met306Val missense_variant 0.71 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7135 c.-167G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7159 c.1920C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7162 c.1923C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491490 c.708C>T synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491499 c.717G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491500 p.Glu240Lys missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491523 c.741G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491536 c.754C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491548 p.Ala256Pro missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491562 c.780C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491571 c.789C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491574 c.792C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.27 pretomanid
delamanid
clofazimine
mshA 575907 p.Ala187Val missense_variant 0.88 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.24 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.23 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.26 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.26 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.27 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.26 rifampicin Uncertain significance
rpoB 760730 c.924T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.34 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.34 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.32 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.32 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.33 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.33 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.36 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.37 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.41 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.41 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.41 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.27 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.27 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.31 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>T synonymous_variant 0.26 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.41 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.42 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.4 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.41 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.3 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.26 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762350 c.2544C>T synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.33 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.33 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.33 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.32 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.39 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.45 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.42 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.33 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.33 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.26 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.26 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.26 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.24 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.64 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.34 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>T upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.25 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.22 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.44 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763588 c.219C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.42 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.35 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.34 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.3 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.31 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.27 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.27 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.33 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.28 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.25 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.34 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.39 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.41 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.4 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.4 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.39 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.35 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.35 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.32 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.34 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.29 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.25 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.23 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.23 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.23 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.23 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.24 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.3 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.29 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.25 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.35 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.41 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.41 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.5 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.48 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.4 rifampicin
rpoC 764512 c.1143G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.37 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.39 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.41 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.38 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.39 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.38 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.38 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.29 rifampicin
rpoC 766027 c.2658G>T synonymous_variant 0.28 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775829 c.2652C>G synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 0.95 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpL5 777117 p.Asp455Gly missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.34 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.35 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.46 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.44 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.38 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.35 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.35 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.34 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.33 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.34 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.34 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.32 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.32 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.32 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800543 c.-266C>T upstream_gene_variant 0.29 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.28 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.3 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.32 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.32 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.32 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.31 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.32 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.33 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.35 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.36 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.35 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304613 c.1683T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.52 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rpsA 1833676 c.135A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.34 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.41 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.26 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.4 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.44 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.29 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.3 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.31 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.3 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518756 c.642G>C synonymous_variant 0.22 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.2 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.21 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.21 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.21 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.21 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.21 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.26 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.26 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.23 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.26 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.26 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.21 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.25 isoniazid
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3626978 p.Asp124Glu missense_variant 0.23 rifampicin Uncertain significance
bedaquiline
mtrB 3626999 c.-386G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627002 c.-389G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627005 c.-392G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627032 c.-419G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627041 p.Ile103Val missense_variant 0.33 rifampicin
bedaquiline
mtrB 3627044 c.-431C>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627059 c.-446G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
rpoA 3877668 c.840A>G synonymous_variant 0.31 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.24 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.24 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.25 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.29 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.27 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.35 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.33 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.35 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.37 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.37 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.37 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.39 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.37 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.44 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 0.47 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.4 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.33 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.29 rifampicin
rpoA 3878187 c.321C>A synonymous_variant 0.41 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.43 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.58 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.58 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.59 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.62 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.65 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.57 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
clpC1 4038815 c.1890G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.29 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.27 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.23 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.46 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.3 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247449 c.936C>T synonymous_variant 0.33 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.33 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.37 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.35 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.42 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.41 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.5 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.48 ethambutol
embB 4247536 c.1023C>A synonymous_variant 0.48 ethambutol
embB 4248115 c.1602C>T synonymous_variant 0.77 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R