TB-Profiler result

Run: ERR2513121
Summary

Run ID: ERR2513121

Sample name:

Date: 2024-03-27T03:11:17.214183

Number of reads: 1658248

Percentage reads mapped: 73.65

Median coverage: 51.0

Strain: lineage3.1.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
lineage3.1.3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6242 p.Arg335Lys missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7424 c.123G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7433 c.132G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7460 c.159C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7463 c.162G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 c.268_270delGCGinsTC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7886 c.585T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7890 c.589C>T synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8489 c.1188A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8555 c.1254G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8952 p.Gln551Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
rpoB 760151 c.345G>A synonymous_variant 0.13 rifampicin
rpoB 760196 c.390C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.17 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.18 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.26 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.26 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760407 p.Ser201Gly missense_variant 0.22 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.15 rifampicin
rpoB 761027 c.1221A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.22 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.24 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.18 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.19 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.18 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.22 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.27 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.26 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.27 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.29 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.29 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.19 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.72 rifampicin Not assoc w R
rpoC 762443 c.-927G>C upstream_gene_variant 0.3 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 762911 c.-459C>T upstream_gene_variant 0.22 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.26 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.26 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.33 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.3 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.25 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>T upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.24 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.18 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.16 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.15 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.14 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.16 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.22 rifampicin
rpoC 763492 c.123G>T synonymous_variant 0.21 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.22 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>G synonymous_variant 0.14 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.12 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.15 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.14 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.16 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.17 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.16 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.14 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.16 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.19 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.16 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.23 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.2 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764374 c.1005C>T synonymous_variant 0.15 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.21 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.13 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.16 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.13 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.13 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.13 rifampicin
rpoC 767068 c.3699G>T synonymous_variant 0.21 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.14 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.15 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.15 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.15 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.15 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781814 c.255C>T synonymous_variant 0.14 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.15 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.16 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.16 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.16 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.16 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.15 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.15 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.16 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.14 streptomycin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472037 n.192A>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474102 n.445_446insTGAAC non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474106 n.449_453delATCAAinsG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_646delTCCTTTTCCTCTCCGGAinsCTCGACTTT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474305 n.648G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAAT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rpsA 1833694 c.153G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.13 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.18 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.14 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.13 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.17 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834157 c.616_618delTTGinsCA frameshift_variant&missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834162 c.621A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.13 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.14 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918474 p.Pro179Ser missense_variant 1.0 capreomycin Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222732 c.432delT frameshift_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2752c 3066008 p.Pro62Ser missense_variant 0.93 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877887 c.621G>C synonymous_variant 0.17 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.16 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.15 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.14 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.13 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.14 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.14 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.14 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
clpC1 4038519 p.Arg729Gln missense_variant 0.16 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.13 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.13 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.13 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.13 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.13 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.12 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.28 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.28 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.27 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039109 c.1596C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.22 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039673 c.1032G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.13 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138703 c.1053C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138709 c.1047G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138784 c.972G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4249195 c.2682C>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408175 p.Ala10Pro missense_variant 1.0 streptomycin Uncertain significance