TB-Profiler result

Run: ERR4769418
Summary

Run ID: ERR4769418

Sample name:

Date: 2024-10-04T19:06:06.574318

Number of reads: 2000035

Percentage reads mapped: 50.08

Median coverage: 60.0

Strain: La1.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2 M.bovis None 0.99
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7821 c.520C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8741 c.1440C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13280 c.279C>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 761998 c.2193_2195delGTC disruptive_inframe_deletion 0.16 rifampicin
rpoB 762005 c.2200_2201insAGC disruptive_inframe_insertion 0.16 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762009 p.Leu735Val missense_variant 0.16 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Ile missense_variant 0.16 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.16 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.16 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762092 c.2286G>A synonymous_variant 0.16 rifampicin
rpoB 762098 c.2292C>T synonymous_variant 0.14 rifampicin
rpoB 762101 c.2295C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762104 p.Asp766Glu missense_variant 0.14 rifampicin
rpoB 762887 c.3081G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762905 p.Asp1033Glu missense_variant 0.26 rifampicin
rpoC 762923 c.-447C>T upstream_gene_variant 0.37 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.4 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.48 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.54 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.5 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.52 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.53 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.54 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.47 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>T upstream_gene_variant 0.5 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.45 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>A upstream_gene_variant 0.4 rifampicin
rpoC 763109 c.-261C>T upstream_gene_variant 0.4 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763130 p.Glu1108Asp missense_variant 0.33 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.24 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>C upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763178 c.-192G>C upstream_gene_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763471 c.102C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.24 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.23 rifampicin
rpoC 763517 p.Lys50Arg missense_variant 0.24 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.25 rifampicin
rpoC 763531 c.162G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763534 c.165T>C synonymous_variant 0.24 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763549 c.180C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.21 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763578 p.Phe70Tyr missense_variant 0.28 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.17 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.17 rifampicin Uncertain significance
rpoC 763630 c.261G>C synonymous_variant 0.19 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.21 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGT synonymous_variant 0.2 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.22 rifampicin
rpoC 764438 p.Leu357Met missense_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.25 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>T synonymous_variant 0.24 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.28 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.32 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.31 rifampicin
rpoC 764509 c.1140G>T synonymous_variant 0.32 rifampicin
rpoC 764512 c.1143G>C synonymous_variant 0.32 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.29 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.33 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.39 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>T synonymous_variant 0.44 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.45 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.5 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.5 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>A synonymous_variant 0.42 rifampicin
rpoC 764644 c.1275G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764659 c.1290C>T synonymous_variant 0.38 rifampicin
rpoC 764660 p.Val431Ile missense_variant 0.38 rifampicin
rpoC 764687 p.Gln440Glu missense_variant 0.35 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.22 rifampicin
rpoC 764754 c.1386_1389delCCTC frameshift_variant 0.17 rifampicin
rpoC 764761 p.Asn464Lys missense_variant 0.16 rifampicin
rpoC 764763 c.1394_1395delATinsGAGTAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.25 rifampicin
rpoC 764785 c.1416C>T synonymous_variant 0.25 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.27 rifampicin
rpoC 764800 c.1431G>A synonymous_variant 0.27 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764813 p.Gln482Glu missense_variant 0.27 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.34 rifampicin
rpoC 764838 p.Val490Ala missense_variant 0.38 rifampicin
rpoC 764843 p.Ala492Ser missense_variant 0.4 rifampicin
rpoC 764857 c.1488G>C synonymous_variant 0.36 rifampicin
rpoC 764858 p.Leu497Met missense_variant 0.37 rifampicin
rpoC 764863 c.1494G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.34 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.35 rifampicin
rpoC 764913 p.Met515Lys missense_variant 0.34 rifampicin
rpoC 764917 c.1548G>C synonymous_variant 0.32 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.32 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764926 c.1557C>T synonymous_variant 0.31 rifampicin
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764952 p.Val528Ala missense_variant 0.3 rifampicin
rpoC 764959 c.1590G>A synonymous_variant 0.31 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.15 rifampicin
rpoC 767017 c.3648C>T synonymous_variant 0.15 rifampicin
rpoC 767023 p.Asp1218Glu missense_variant 0.15 rifampicin
rpoC 767026 c.3657G>C synonymous_variant 0.15 rifampicin
rpoC 767035 c.3666G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767038 c.3669G>C synonymous_variant 0.18 rifampicin
rpoC 767041 c.3672G>A synonymous_variant 0.18 rifampicin
rpoC 767062 c.3693C>T synonymous_variant 0.17 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.17 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.16 rifampicin
rpoC 767077 c.3708G>T synonymous_variant 0.16 rifampicin
rpoC 767087 p.Cys1240Arg missense_variant 0.16 rifampicin
rpoC 767093 c.3724_3725delAGinsTC synonymous_variant 0.16 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767099 p.Lys1244Gln missense_variant 0.15 rifampicin
rpoC 767106 p.Asn1246Ile missense_variant 0.17 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.18 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
sigE 1364961 c.549A>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.52 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471928 n.83T>G non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471930 n.85_89delGGAGAinsTTGCAGGG non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.51 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.79 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453delGinsCCA non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472307 n.462_466delCTCTCinsTGGT non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.469_470delAT non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 0.44 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsAT non_coding_transcript_exon_variant 0.78 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472670 n.825_831delGGGTTTCinsAGGGGT non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472686 n.841G>C non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472690 n.845C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>C non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246G>C non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>C non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473112 n.1267A>C non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473120 n.1275C>G non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473132 n.1287T>C non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.74 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474182 n.525C>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474183 n.526T>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629_636delCTCCTTTTinsA non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474311 n.654_655insT non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475514 n.1857G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475694 n.2037_2038insAAC non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475698 n.2042delC non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475704 n.2047C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2107delACCCGCAinsG non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476028 n.2372_2375delAACC non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476034 n.2377_2378insATGT non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476048 n.2391G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476049 n.2392C>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476050 n.2393G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476080 n.2423T>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476116 n.2459A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476523 n.2867delC non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476607 n.2950C>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476624 n.2967T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833949 c.408T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834025 p.Gln162Asp missense_variant 0.29 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.3 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.29 pyrazinamide
rpsA 1834076 p.Asn179His missense_variant 0.32 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.18 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834523 p.Glu328Gln missense_variant 0.19 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834567 p.Asp342Glu missense_variant 0.23 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.23 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2062946 p.Ser595Gly missense_variant 0.98 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102106 p.Gly313Arg missense_variant 1.0 isoniazid Not assoc w R - Interim
delamanid Uncertain significance
ethionamide Uncertain significance
ndh 2103173 c.-132delG upstream_gene_variant 1.0 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156465 c.-354C>T upstream_gene_variant 1.0 isoniazid Not assoc w R - Interim
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3065888 p.Val102Ile missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
thyX 3067786 p.Thr54Ala missense_variant 0.96 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
fbiD 3339154 p.Ile13Leu missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
Rv3083 3448745 p.Ile81Ser missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623730 p.Ser394Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624593 c.318G>A synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624710 c.201G>A synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3878630 c.-124delC upstream_gene_variant 1.0 rifampicin Not assoc w R
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4239487 c.-376T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247173 c.660G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407743 p.Arg154Trp missense_variant 1.0 streptomycin Uncertain significance