TB-Profiler result

Run: ERR4818561
Summary

Run ID: ERR4818561

Sample name:

Date: 2024-04-15T21:27:43.111421

Number of reads: 77911

Percentage reads mapped: 8.02

Median coverage: 1.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.9 Euro-American (H37Rv-like) None 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
nusG 734451 c.198G>C synonymous_variant 0.87 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.87 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.88 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.89 rifampicin
nusG 734532 c.279A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Gln missense_variant 0.93 rifampicin
nusG 734549 p.Gln99Arg missense_variant 0.93 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.93 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.92 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.75 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Ala missense_variant 0.77 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.86 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.86 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.95 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Leu missense_variant 0.96 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.96 rifampicin
rpoB 760565 c.759A>G synonymous_variant 1.0 rifampicin
rpoB 760568 c.762G>C synonymous_variant 1.0 rifampicin
rpoB 760571 c.765G>C synonymous_variant 1.0 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.94 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.94 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.94 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.92 rifampicin
rpoB 760652 c.846C>G synonymous_variant 0.92 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.92 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761111 c.1305C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761162 c.1356G>C synonymous_variant 0.9 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.94 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 1.0 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.9 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.94 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.93 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.93 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>G synonymous_variant 1.0 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 1.0 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 1.0 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 1.0 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 1.0 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 1.0 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 1.0 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 1.0 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 1.0 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 1.0 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.93 rifampicin Uncertain significance
rpoB 762905 p.Asp1033Glu missense_variant 0.95 rifampicin
rpoC 762917 c.-453C>A upstream_gene_variant 1.0 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 1.0 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 1.0 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 1.0 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 1.0 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763052 c.-318G>C upstream_gene_variant 0.92 rifampicin
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.92 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.91 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.9 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 1.0 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.88 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.9 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.82 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.92 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.92 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.92 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.96 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.96 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.96 rifampicin
rpoC 763765 c.396T>C synonymous_variant 1.0 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 1.0 rifampicin
rpoC 763796 p.Met143Gln missense_variant 1.0 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764239 c.870T>C synonymous_variant 1.0 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764263 c.894G>C synonymous_variant 1.0 rifampicin
rpoC 764266 c.897T>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 1.0 rifampicin
rpoC 764308 c.939G>C synonymous_variant 1.0 rifampicin
rpoC 764320 c.951C>G synonymous_variant 1.0 rifampicin
rpoC 764353 c.984G>C synonymous_variant 1.0 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.96 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.96 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.97 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.97 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 1.0 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 1.0 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 1.0 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.96 rifampicin
rpoC 764755 c.1386C>T synonymous_variant 0.95 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.93 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.93 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.93 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.93 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.93 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.82 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.82 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.92 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.93 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.9 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.9 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.9 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.9 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.91 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.86 rifampicin
rpoC 764953 c.1584G>C synonymous_variant 0.87 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 1.0 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765544 c.2175C>G synonymous_variant 0.93 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.93 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.93 rifampicin
rpoC 765569 p.Ala734Ser missense_variant 1.0 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 1.0 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 1.0 rifampicin
rpoC 765590 p.Arg741Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 1.0 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 1.0 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.92 rifampicin
rpoC 766931 c.3562_3564delGCAinsTC frameshift_variant&missense_variant 0.85 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766948 c.3579G>C synonymous_variant 0.85 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766990 c.3621G>C synonymous_variant 0.93 rifampicin
rpsL 781802 c.243G>C synonymous_variant 0.92 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.92 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.92 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.92 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.92 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.88 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.88 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.9 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.91 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.91 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.91 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.95 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.96 streptomycin
rpsL 781898 c.339A>G synonymous_variant 1.0 streptomycin
rpsL 781901 c.342C>G synonymous_variant 0.95 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.95 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.94 streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473130 n.1285G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473844 n.187C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473870 n.213G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474718 n.1061_1062delAGinsGTGAGAA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474822 n.1165G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833874 c.333T>C synonymous_variant 0.95 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.92 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.93 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.97 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.96 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.89 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.84 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.88 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.84 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.88 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Thr missense_variant 0.91 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.91 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.92 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834366 c.825A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834384 c.843A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.9 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.91 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.96 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.96 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834556 c.1015_1017delGCCinsTG frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834573 c.1032G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.85 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834700 c.1159_1161delCAGinsAC frameshift_variant&missense_variant 0.8 pyrazinamide Uncertain significance
rpsA 1834733 p.Ala398Pro missense_variant 0.88 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.86 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.92 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.9 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.9 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834804 c.1263C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.92 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.92 pyrazinamide
katG 2155716 c.396T>C synonymous_variant 1.0 isoniazid
katG 2155722 c.390G>C synonymous_variant 1.0 isoniazid
rpoA 3877613 p.Ile299Val missense_variant 1.0 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 1.0 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 1.0 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877659 c.849G>T synonymous_variant 1.0 rifampicin
rpoA 3877662 c.846C>T synonymous_variant 1.0 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 1.0 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 1.0 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 1.0 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 1.0 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 1.0 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 1.0 rifampicin
rpoA 3877764 c.742_744delGCCinsTG frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877770 c.736_738delTCAinsGG frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 1.0 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 1.0 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 1.0 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877898 p.Pro204Ala missense_variant 1.0 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 1.0 rifampicin
rpoA 3877902 p.Ile202Met missense_variant 1.0 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877935 p.Lys191Arg missense_variant 1.0 rifampicin
rpoA 3877938 c.570C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 1.0 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 1.0 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 1.0 rifampicin
rpoA 3877998 c.510G>C synonymous_variant 1.0 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878061 c.447G>C synonymous_variant 1.0 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 1.0 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 1.0 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 1.0 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 1.0 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 1.0 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 1.0 rifampicin
rpoA 3878217 c.289_291delCTAinsGG frameshift_variant&missense_variant 0.85 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 1.0 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.87 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.86 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.86 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.87 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.85 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.83 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.77 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.77 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038761 c.1944C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 1.0 pyrazinamide
clpC1 4038808 c.1896_1897insC frameshift_variant 1.0 pyrazinamide
clpC1 4038811 c.1893delT frameshift_variant 1.0 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038899 c.1806C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.93 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.94 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.85 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.81 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.8 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.8 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.83 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.83 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.83 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.82 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039244 c.1461G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039642 p.Thr355Ala missense_variant 0.69 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.69 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.87 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.95 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.94 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.94 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.92 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039994 c.709_711delGAGinsAC frameshift_variant&missense_variant 0.83 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.76 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.76 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.77 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.83 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 1.0 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.58 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.67 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.67 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.75 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.79 pyrazinamide
clpC1 4040501 c.204C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>A synonymous_variant 0.85 pyrazinamide