TB-Profiler result

Run: ERR2513259

Summary

Run ID: ERR2513259

Sample name:

Date: 2024-04-15T01:45:08.460959

Number of reads: 3023777

Percentage reads mapped: 75.35

Median coverage: 90.5

Strain: lineage3

Spoligotype:

Drug-resistance: Other


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 1.0 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490994 p.Gly71Asp missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734508 c.255C>G synonymous_variant 0.12 rifampicin
nusG 734541 c.288A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Pro missense_variant 0.11 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.12 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760157 c.351A>G synonymous_variant 0.12 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.13 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.13 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.13 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.12 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.12 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.12 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAGC synonymous_variant 0.17 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>A synonymous_variant 0.18 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.21 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.22 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.16 rifampicin
rpoB 762032 c.2226C>G synonymous_variant 0.12 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.21 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.18 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.21 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.2 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762182 c.2376C>T synonymous_variant 0.23 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.2 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.17 rifampicin
rpoB 762245 c.2439G>T synonymous_variant 0.14 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 762917 c.-453C>T upstream_gene_variant 0.16 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.21 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.23 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.26 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.73 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.2 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.14 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763525 c.156C>T synonymous_variant 0.13 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.16 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.16 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.15 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.14 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.16 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.15 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.15 rifampicin Uncertain significance
rpoC 764215 c.846A>T synonymous_variant 0.15 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.16 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.19 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764242 c.873C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.23 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.23 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.19 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.22 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.23 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.2 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.24 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.18 rifampicin
rpoC 764341 c.972G>C synonymous_variant 0.16 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.12 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.11 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.14 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.14 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.14 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.17 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.17 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.19 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.18 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764764 p.His465Gln missense_variant 0.21 rifampicin
rpoC 764767 c.1398G>A synonymous_variant 0.17 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.19 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>T synonymous_variant 0.16 rifampicin
rpoC 764869 c.1500C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.16 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.15 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.15 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.18 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764902 c.1533C>G synonymous_variant 0.18 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.14 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.13 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.14 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.14 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.14 rifampicin
rpoC 764939 c.1570C>T synonymous_variant 0.14 rifampicin
rpoC 764947 c.1578G>C synonymous_variant 0.12 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.12 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.12 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.12 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.12 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.11 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.12 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.12 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>T synonymous_variant 0.15 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.14 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.19 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.21 rifampicin
rpoC 767023 p.Asp1218Glu missense_variant 0.19 rifampicin
rpoC 767026 c.3657G>C synonymous_variant 0.2 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.23 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.23 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767087 p.Cys1240Ser missense_variant 0.22 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.19 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800648 c.-161A>G upstream_gene_variant 0.11 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001_1002insA non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1005delT non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473812 n.155G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_172insCT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474627 n.970G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474722 n.1065T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101delAinsGTT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475762 n.2106_2108delCAA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476029 n.2373_2377delACCTC non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833709 c.168C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833736 c.195C>T synonymous_variant 0.13 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833770 p.Asn77Ser missense_variant 0.2 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.2 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.2 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.14 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834299 p.Gln253Pro missense_variant 0.12 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.14 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834340 c.799_801delATGinsCC frameshift_variant&missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.11 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.15 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.14 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168812 p.Thr601Ala missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
alr 3841473 c.-53G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877629 c.879C>G synonymous_variant 0.12 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.13 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.12 rifampicin
rpoA 3877674 c.834C>T synonymous_variant 0.14 rifampicin
rpoA 3877680 c.828G>T synonymous_variant 0.18 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>T synonymous_variant 0.17 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.18 rifampicin
rpoA 3877746 c.762G>C synonymous_variant 0.17 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.18 rifampicin
rpoA 3877765 p.Ala248Ser missense_variant 0.17 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>T synonymous_variant 0.16 rifampicin
rpoA 3877791 c.717C>G synonymous_variant 0.16 rifampicin
rpoA 3877794 c.714G>T synonymous_variant 0.17 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>T synonymous_variant 0.15 rifampicin
rpoA 3877845 c.663G>C synonymous_variant 0.12 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.14 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.13 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.12 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.12 rifampicin
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.12 rifampicin
rpoA 3877936 p.Lys191Arg missense_variant 0.12 rifampicin
ddn 3987095 c.252G>A synonymous_variant 1.0 delamanid Not assoc w R - Interim
pretomanid
clpC1 4038749 c.1956C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.2 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038896 c.1809C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038986 p.Asp573Glu missense_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039046 c.1659C>A synonymous_variant 0.22 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039088 c.1617G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039091 c.1614G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039133 c.1572C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.12 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039640 c.1065C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.14 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.13 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.14 pyrazinamide
clpC1 4039820 c.885T>A synonymous_variant 0.13 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039996 p.Glu237Gln missense_variant 0.18 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.16 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.13 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.13 pyrazinamide
clpC1 4040018 c.687G>T synonymous_variant 0.13 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.12 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.95 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R